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Nature immunology, ISSN 1529-2916, 2013, Volume 14, Issue 5, pp. 489 - 499
Journal Article
Cell metabolism, ISSN 1550-4131, 2011, Volume 13, Issue 4, pp. 376 - 388
Journal Article
Molecular cell, ISSN 1097-2765, 2010, Volume 39, Issue 2, pp. 171 - 183
...) and sterol regulatory element-binding protein (SREBP1 and SREBP2). We find that SREBP1 and 2... 
CELLBIO | SIGNALING | Signaling | Cellbio | MAMMALIAN TARGET | RAPAMYCIN | TSC1-TSC2 COMPLEX | KINASE-ACTIVITY | AMINO-ACID | TUBEROUS SCLEROSIS COMPLEX | FATTY-ACID BIOSYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | C-MYC | CELL-GROWTH | TRANSLATIONAL CONTROL | CELL BIOLOGY | Neoplasms - metabolism | Lipids - genetics | Cell Proliferation | Humans | Multiprotein Complexes | Protein Biosynthesis - physiology | Lipids - biosynthesis | Obesity - genetics | Mechanistic Target of Rapamycin Complex 1 | Proteins | Glycolysis - physiology | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Neoplasms - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | Genomics - methods | Sterol Regulatory Element Binding Protein 1 - metabolism | Pentose Phosphate Pathway - physiology | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Gene Expression Regulation - physiology | Transcription Factors - genetics | Metabolomics - methods | Obesity - metabolism | Transcription Factors - metabolism | Transcription, Genetic - physiology | Animals | Sterol Regulatory Element Binding Protein 1 - genetics | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Mice | TOR Serine-Threonine Kinases | Cell Line, Transformed | Phosphates | Metabolites | Oncology, Experimental | Protein biosynthesis | Research | DNA binding proteins | Sugars | Public health | Cancer | Monosaccharides | Bioenergetics
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2010, Volume 328, Issue 5985, pp. 1566 - 1569
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2018, Volume 293, Issue 17, pp. 6623 - 6634
Journal Article
Journal Article
Biochemical journal, ISSN 0264-6021, 01/2010, Volume 425, Issue 1, pp. 215 - 223
The transcription factor SREBP1c (sterol-regulatory-element-binding protein 1c) is highly expressed in adipose tissue and plays a central role in several aspects of adipocyte development including the induction of PPAR gamma... 
Adipocyte | CCAAT/enhancer-binding protein(C/EBP) | Sterol-regulatory-element-binding protein 1c(SREBP1c) | Transcription | Lipid | Adipogenesis | transcription | BIOCHEMISTRY & MOLECULAR BIOLOGY | ELEMENT-BINDING PROTEIN-1C | ALPHA | sterol-regulatory-element-binding protein 1c (SREBP1c) | lipid | BETA | adipogenesis | INSULIN-RESISTANCE | adipocyte | LIPODYSTROPHY | ADIPOCYTE DIFFERENTIATION | PPAR-GAMMA | ADD1/SREBP1 | CCAAT/enhancer-binding protein (C/EBP) | MICE | ADIPOSE-TISSUE | CCAAT-Enhancer-Binding Protein-alpha - metabolism | Humans | Adipocytes - cytology | DNA-Binding Proteins - metabolism | Chromatin Immunoprecipitation | RNA Interference | CCAAT-Enhancer-Binding Protein-delta - metabolism | CCAAT-Enhancer-Binding Proteins - genetics | Sterol Regulatory Element Binding Protein 1 - metabolism | CCAAT-Enhancer-Binding Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Promoter Regions, Genetic | CCAAT-Enhancer-Binding Protein-beta - genetics | Cells, Cultured | Gene Expression Regulation | Proto-Oncogene Proteins - genetics | Transcription Factors - genetics | 3T3-L1 Cells | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | CCAAT-Enhancer-Binding Protein-beta - metabolism | RUNX1 Translocation Partner 1 Protein | Transcription Factors - metabolism | Animals | Sterol Regulatory Element Binding Protein 1 - genetics | CCAAT-Enhancer-Binding Protein-delta - genetics | Adipocytes - metabolism | CCAAT-Enhancer-Binding Protein-alpha - genetics | Protein Binding | Mice
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2010, Volume 107, Issue 40, pp. 17321 - 17326
Sterol regulatory element-binding protein 2 (SREBP-2) transcription factor has been identified as a key protein in cholesterol metabolism through the transactivation of the LDL receptor and cholesterol biosynthesis genes... 
MicroRNA | Hepatocytes | Exons | Introns | HDL lipoproteins | Liver | Genes | Mice | Macrophages | Cholesterols | ABCA1 | Metabolic syndrome | Cholesterol efflux | Macrophage | HOMEOSTASIS | FATTY-ACID SYNTHESIS | liver | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | macrophage | metabolic syndrome | TANGIER-DISEASE | HOST GENES | EFFLUX | REVERSE CHOLESTEROL TRANSPORT | DENSITY-LIPOPROTEIN DEFICIENCY | cholesterol efflux | TRANSGENIC MICE | Cell Line | Cholesterol, HDL - metabolism | Humans | Molecular Sequence Data | MicroRNAs - metabolism | Cholesterol, HDL - genetics | Macrophages - metabolism | Sequence Alignment | Animals | ATP-Binding Cassette Transporters - genetics | Cattle | Base Sequence | Chickens | ATP-Binding Cassette Transporters - metabolism | Female | MicroRNAs - genetics | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | ATP Binding Cassette Transporter 1 | Blood cholesterol | Low density lipoproteins | Biosynthesis | Research | Properties | Binding proteins | Lipoproteins (low density) | Transcription factors | Data processing | Cholesterol | Protein turnover | ABCA1 protein | Apolipoprotein A | Sterol regulatory element-binding protein | ATP-binding protein | miRNA | Lipid metabolism | Lipoproteins (high density) | Peritoneum | Biological Sciences
Journal Article
Cell metabolism, ISSN 1550-4131, 2011, Volume 13, Issue 5, pp. 540 - 549
We show that mice with a targeted deficiency in the gene encoding the lipogenic transcription factor SREBP-1a are resistant to endotoxic shock and systemic... 
GAMMA | CECAL LIGATION | GENE | CHOLESTEROL | ROLES | INFLAMMASOME | ENDOCRINOLOGY & METABOLISM | RESISTANCE | TYPHIMURIUM | RECEPTORS | CASPASE-1 ACTIVATION | CELL BIOLOGY | RNA, Small Interfering - genetics | Salmonella Infections - immunology | Caspase 1 - metabolism | Male | Salmonella Infections - metabolism | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Apoptosis Regulatory Proteins - genetics | Bone Marrow | Macrophages - immunology | Interleukin-1beta - secretion | Salmonella Infections - pathology | Cytokines - metabolism | Enzyme-Linked Immunosorbent Assay | Inflammasomes | Salmonella typhimurium - immunology | Mice, Inbred C57BL | RNA, Messenger - genetics | Lipid Metabolism | Macrophages - cytology | Sterol Regulatory Element Binding Protein 1 - physiology | Enzyme Activation - drug effects | Immunity, Innate | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Macrophages - metabolism | Animals | Adaptor Proteins, Signal Transducing - genetics | Apoptosis Regulatory Proteins - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Mice | Adaptor Proteins, Signal Transducing - metabolism | Synthesis | Molecular genetics | Genes | Physiological aspects | Septic shock | Chemical properties | Genetic transcription | Macrophages | Mitogens | Fatty acids | Protein binding | Steroids | Nlrp1 | SREBP-1a deficiency | Nalp1 | Inflammasome | lipogenesis | Macrophage
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2016, Volume 291, Issue 7, pp. 3254 - 3267
.... One way by which HCV promotes the accumulation of intracellular lipids is through enhancing de novo lipogenesis by activating the sterol regulatory element-binding proteins (SREBPs... 
TARGET | liver injury | OXIDATIVE STRESS | SREBP | hepatitis virus | CHOLESTEROL | INTERLEUKIN-1-BETA | BIOCHEMISTRY & MOLECULAR BIOLOGY | lipid metabolism | NLRP3 inflammasome | DROPLETS | inflammation | PATHWAY | inflammasome | FATTY-ACID | CASPASES | INFECTION | EXPRESSION | Hepatitis C, Chronic - pathology | Inflammasomes - metabolism | Cytoskeletal Proteins - antagonists & inhibitors | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Golgi Apparatus - drug effects | Humans | Hepatitis C, Chronic - virology | Non-alcoholic Fatty Liver Disease - etiology | Caspase 1 - metabolism | Host-Pathogen Interactions - drug effects | Intracellular Signaling Peptides and Proteins - metabolism | Protein Transport - drug effects | Sterol Regulatory Element Binding Protein 1 - agonists | RNA Interference | Hepacivirus - physiology | Sterol Regulatory Element Binding Protein 2 - metabolism | Endopeptidases - metabolism | Carrier Proteins - antagonists & inhibitors | Serine Endopeptidases - chemistry | Cysteine Proteinase Inhibitors - pharmacology | Cell Line, Tumor | Hepatocytes - virology | Sterol Regulatory Element Binding Protein 2 - agonists | Hepatitis C, Chronic - metabolism | Hepatitis C, Chronic - physiopathology | Hepatocytes - pathology | Golgi Apparatus - pathology | Hepatocytes - metabolism | Golgi Apparatus - virology | Caspase 1 - chemistry | Proteolysis - drug effects | Endopeptidases - chemistry | Inflammasomes - drug effects | Enzyme Induction - drug effects | Cytoskeletal Proteins - metabolism | Membrane Proteins - metabolism | Hepatocytes - drug effects | Sterol Regulatory Element Binding Protein 1 - metabolism | Hepacivirus - drug effects | Proprotein Convertases - metabolism | Proprotein Convertases - chemistry | Carrier Proteins - genetics | Carrier Proteins - metabolism | Caspase 1 - genetics | CARD Signaling Adaptor Proteins | Lipogenesis - drug effects | Golgi Apparatus - metabolism | Serine Endopeptidases - metabolism | Microbiology
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2009, Volume 119, Issue 5, pp. 1201 - 1215
.... To assess whether ER stress promotes SREBP-1c activation and thus contributes to lipogenesis, we overexpressed the chaperone glucose-regulated protein 78 (GRP78... 
MEDICINE, RESEARCH & EXPERIMENTAL | GLUCOSE-HOMEOSTASIS | FATTY-ACID SYNTHESIS | ELEMENT-BINDING PROTEIN-1C | ENZYME GENES | LIPOGENIC GENE-EXPRESSION | ENDOPLASMIC-RETICULUM STRESS | COPII PROTEINS | TRANSCRIPTION FACTOR | DIFFERENTIAL REGULATION | LIVER-X-RECEPTOR | Molecular Chaperones - metabolism | Gene Expression - drug effects | Rats, Wistar | Fatty Liver - pathology | Gene Expression - genetics | Endoplasmic Reticulum - metabolism | Fatty Liver - therapy | Male | Hepatocytes - metabolism | Insulin Receptor Substrate Proteins - metabolism | Heat-Shock Proteins - genetics | Insulin Resistance - physiology | Endoplasmic Reticulum - drug effects | Lipid Metabolism - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | Nuclear Proteins - genetics | Hepatocytes - drug effects | Sterol Regulatory Element Binding Protein 1 - metabolism | Insulin - pharmacology | Fatty Liver - metabolism | Heat-Shock Proteins - metabolism | Liver - metabolism | Molecular Chaperones - genetics | Rats | Nuclear Proteins - metabolism | Signal Transduction - genetics | Transcription Factors - genetics | Obesity - metabolism | Rats, Zucker | Transcription Factors - metabolism | Animals | Sterol Regulatory Element Binding Protein 1 - genetics | Models, Biological | Glucose - metabolism | Thapsigargin - pharmacology | Mice, Obese | Mice | Care and treatment | Liver diseases | Physiological aspects | Heat shock proteins | Insulin resistance | Genetic aspects | Research | Endoplasmic reticulum | Health aspects | Risk factors
Journal Article