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Nature Immunology, ISSN 1529-2908, 05/2013, Volume 14, Issue 5, pp. 489 - 499
Journal Article
Cell Metabolism, ISSN 1550-4131, 04/2011, Volume 13, Issue 4, pp. 376 - 388
Journal Article
Science, ISSN 0036-8075, 6/2010, Volume 328, Issue 5985, pp. 1566 - 1569
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2010, Volume 107, Issue 40, pp. 17321 - 17326
Sterol regulatory element-binding protein 2 (SREBP-2) transcription factor has been identified as a key protein in cholesterol metabolism through the... 
MicroRNA | Hepatocytes | Exons | Introns | HDL lipoproteins | Liver | Genes | Mice | Macrophages | Cholesterols | ABCA1 | Metabolic syndrome | Cholesterol efflux | Macrophage | HOMEOSTASIS | FATTY-ACID SYNTHESIS | liver | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | macrophage | metabolic syndrome | TANGIER-DISEASE | HOST GENES | EFFLUX | REVERSE CHOLESTEROL TRANSPORT | DENSITY-LIPOPROTEIN DEFICIENCY | cholesterol efflux | TRANSGENIC MICE | Cell Line | Cholesterol, HDL - metabolism | Humans | Molecular Sequence Data | MicroRNAs - metabolism | Cholesterol, HDL - genetics | Macrophages - metabolism | Sequence Alignment | Animals | ATP-Binding Cassette Transporters - genetics | Cattle | Base Sequence | Chickens | ATP-Binding Cassette Transporters - metabolism | Female | MicroRNAs - genetics | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | ATP Binding Cassette Transporter 1 | Blood cholesterol | Low density lipoproteins | Biosynthesis | Research | Properties | Binding proteins | Lipoproteins (low density) | Transcription factors | Data processing | Cholesterol | Protein turnover | ABCA1 protein | Apolipoprotein A | Sterol regulatory element-binding protein | ATP-binding protein | miRNA | Lipid metabolism | Lipoproteins (high density) | Peritoneum | Biological Sciences
Journal Article
Molecular Cell, ISSN 1097-2765, 07/2010, Volume 39, Issue 2, pp. 171 - 183
Aberrant activation of the mammalian target of rapamycin complex 1 (mTORC1) is a common molecular event in a variety of pathological settings, including... 
CELLBIO | SIGNALING | Signaling | Cellbio | MAMMALIAN TARGET | RAPAMYCIN | TSC1-TSC2 COMPLEX | KINASE-ACTIVITY | AMINO-ACID | TUBEROUS SCLEROSIS COMPLEX | FATTY-ACID BIOSYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | C-MYC | CELL-GROWTH | TRANSLATIONAL CONTROL | CELL BIOLOGY | Neoplasms - metabolism | Lipids - genetics | Cell Proliferation | Humans | Multiprotein Complexes | Protein Biosynthesis - physiology | Lipids - biosynthesis | Obesity - genetics | Mechanistic Target of Rapamycin Complex 1 | Proteins | Glycolysis - physiology | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Neoplasms - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | Genomics - methods | Sterol Regulatory Element Binding Protein 1 - metabolism | Pentose Phosphate Pathway - physiology | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Gene Expression Regulation - physiology | Transcription Factors - genetics | Metabolomics - methods | Obesity - metabolism | Transcription Factors - metabolism | Transcription, Genetic - physiology | Animals | Sterol Regulatory Element Binding Protein 1 - genetics | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Mice | TOR Serine-Threonine Kinases | Cell Line, Transformed | Phosphates | Metabolites | Oncology, Experimental | Protein biosynthesis | Research | DNA binding proteins | Sugars | Public health | Cancer | Monosaccharides | Bioenergetics
Journal Article
Circulation, ISSN 0009-7322, 08/2013, Volume 128, Issue 6, pp. 632 - 642
BACKGROUND—The molecular basis for the focal nature of atherosclerotic lesions is poorly understood. Here, we explored whether disturbed flow patterns activate... 
atherosclerosis | shear stress | NLRP3 protein, human | sterol regulatory element binding proteins | endothelial cell | NLRP3 protein | CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | CHRONIC GRANULOMATOUS-DISEASE | INTERLEUKIN-1-BETA | RECEPTOR ANTAGONIST | HEART-DISEASE | SHEAR-STRESS | REGIONS | PERIPHERAL VASCULAR DISEASE | MICE | CHOLESTEROL HOMEOSTASIS | human | UP-REGULATION | Human Umbilical Vein Endothelial Cells | RNA, Small Interfering - genetics | Vasculitis - metabolism | Inflammasomes - metabolism | Membrane Glycoproteins - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | NADPH Oxidases - metabolism | NADPH Oxidases - immunology | Stress, Mechanical | Male | MicroRNAs - metabolism | Vasculitis - immunology | Vasculitis - genetics | Sterol Regulatory Element Binding Protein 2 - genetics | Membrane Glycoproteins - immunology | Sterol Regulatory Element Binding Protein 2 - metabolism | Carrier Proteins - immunology | Atherosclerosis - immunology | Endothelial Cells - metabolism | Mice, Transgenic | MicroRNAs - immunology | NADPH Oxidase 2 | Atherosclerosis - metabolism | Endothelial Cells - immunology | Carrier Proteins - genetics | Immunity, Innate - immunology | Animals | Carrier Proteins - metabolism | Apolipoproteins E - genetics | Inflammasomes - immunology | Mice | Sterol Regulatory Element Binding Protein 2 - immunology | Hemodynamics - immunology | Sterols | Atherosclerosis | Physiological aspects | Disease susceptibility | Genetic aspects | Research | Hemodynamics | Binding proteins | Endothelium
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 05/2015, Volume 131, Issue 21, pp. 1861 - 1871
BACKGROUND—Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on glucose and lipid metabolism and insulin sensitivity. It acts... 
Fibroblast growth factor 21 | Hormones | Adipokines | Atherosclerosis | atherosclerosis | fibroblast growth factor 21 | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | LIPID-METABOLISM | hormones | PGC-1-ALPHA | INSULIN SENSITIVITY | PROTECTS | ENERGY-EXPENDITURE | LIVER | PERIPHERAL VASCULAR DISEASE | adipokines | EXPRESSION | TRANSGENIC MICE | FGF21 | Recombinant Proteins - therapeutic use | Adiponectin - biosynthesis | Apolipoproteins E - deficiency | Atherosclerosis - genetics | Adipocytes - drug effects | Adiponectin - physiology | Sterol Regulatory Element Binding Protein 2 - biosynthesis | Membrane Proteins - deficiency | RNA, Messenger - biosynthesis | Liver - drug effects | Membrane Proteins - physiology | Adiponectin - genetics | Adiponectin - deficiency | Sterol Regulatory Element Binding Protein 2 - genetics | Fibroblast Growth Factors - therapeutic use | Hyperlipoproteinemia Type II - complications | Atherosclerosis - drug therapy | Liver - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Fibroblast Growth Factors - deficiency | Atherosclerosis - metabolism | Sterol Regulatory Element Binding Protein 2 - physiology | Mice, Knockout | Gene Expression Regulation - drug effects | Hyperlipoproteinemia Type II - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - physiology | Animals | Signal Transduction - drug effects | Endothelium, Vascular - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - drug effects | Adipocytes - metabolism | Membrane Proteins - drug effects | Endothelium, Vascular - pathology | Mice | Cholesterol - biosynthesis | Atherosclerosis - prevention & control | Hyperlipoproteinemia Type II - genetics | 134 | 147 | Original
Journal Article
Circulation, ISSN 0009-7322, 03/2015, Volume 131, Issue 9, pp. 805 - 814
BACKGROUND—Oxidative stress activates endothelial innate immunity and disrupts endothelial functions, including endothelial nitric oxide synthase–derived... 
Oxidative stress | Sterol regulatory element binding protein 2 | Inflammasomes | MicroRNA-92 | Endothelium | ATHEROSCLEROTIC LESIONS | endothelium | CARDIAC & CARDIOVASCULAR SYSTEMS | microRNA-92 | inflammasomes | sterol regulatory element binding protein 2 | KAPPA-B | SIRT1 | LIPID-ACCUMULATION | HYPERCHOLESTEROLEMIC ZEBRAFISH | FOAM CELL-FORMATION | IN-VIVO | PERIPHERAL VASCULAR DISEASE | MICE | KRUPPEL-LIKE FACTOR-2 | DYSFUNCTION | oxidative stress | Free Radical Scavengers - pharmacology | Human Umbilical Vein Endothelial Cells | Inflammasomes - metabolism | Humans | Middle Aged | Transcriptional Activation | Immunity, Innate - genetics | Oxidative Stress - immunology | Coronary Disease - physiopathology | Male | Recombinant Fusion Proteins - metabolism | Interleukin-1beta - blood | Salicylates - pharmacology | HEK293 Cells | Female | Sterol Regulatory Element Binding Protein 2 - genetics | Angiotensin II - toxicity | Genes, Reporter | Hydrogen Peroxide - toxicity | Coronary Disease - blood | Endothelial Cells - metabolism | Gene Expression Regulation | Oxidative Stress - genetics | Mice, Transgenic | MicroRNAs - biosynthesis | Zebrafish | Sterol Regulatory Element Binding Protein 2 - physiology | Zebrafish Proteins - physiology | Lipoproteins, LDL - toxicity | Animals | Endothelium, Vascular - metabolism | Aged | Mice | MicroRNAs - genetics | Hypercholesterolemia - genetics | Organometallic Compounds - pharmacology
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2012, Volume 287, Issue 35, pp. 29579 - 29588
Mammalian target of rapamycin complex 2 (mTORC2) is a key activator of protein kinases that act downstream of insulin and growth factor signaling. Here we... 
TRANSCRIPTION FACTORS | DIABETES-MELLITUS | LIPID-METABOLISM | AKT/PKB | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIVER | MOTIF PHOSPHORYLATION | RICTOR | MICE | KINASE-B | INDUCED INSULIN-RESISTANCE | Phosphorylation - physiology | Humans | Glycogen Synthase Kinase 3 beta | GTPase-Activating Proteins - metabolism | Phosphoproteins - metabolism | Cholesterol - genetics | Proto-Oncogene Proteins c-akt - genetics | Fatty Acids - genetics | Forkhead Transcription Factors - metabolism | Insulin Resistance - physiology | Tumor Suppressor Proteins - genetics | Trans-Activators - genetics | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | Insulin - genetics | Proto-Oncogene Proteins c-akt - metabolism | Fatty Acids - metabolism | Lipogenesis - physiology | Sterol Regulatory Element Binding Protein 1 - metabolism | Tumor Suppressor Proteins - metabolism | Liver - metabolism | Gene Expression Regulation - physiology | Glucose - genetics | Mice, Transgenic | Phosphoproteins - genetics | Transcription Factors - genetics | Forkhead Transcription Factors - genetics | Glycogen Synthase Kinase 3 - metabolism | Hep G2 Cells | Transcription Factors - metabolism | Insulin - metabolism | Animals | Glycogen Synthase Kinase 3 - genetics | Sterol Regulatory Element Binding Protein 1 - genetics | Adaptor Proteins, Signal Transducing - genetics | Glucose - metabolism | Trans-Activators - metabolism | Forkhead Box Protein O1 | Mice | GTPase-Activating Proteins - genetics | Adaptor Proteins, Signal Transducing - metabolism | Cholesterol - biosynthesis | mTOR Complex (mTORC) | Liver Metabolism | mTOR Complex 2 (mTORC2) | Akt | Metabolism | Lipogenesis | Insulin | Gluconeogenesis
Journal Article
Science, ISSN 0036-8075, 6/2010, Volume 328, Issue 5985, pp. 1570 - 1573
Cholesterol metabolism is tightly regulated at the cellular level. Here we show that miR-33, an intronic microRNA (miRNA) located within the gene encoding... 
MicroRNA | Hepatocytes | HDL lipoproteins | Liver | Genes | REPORTS | Homeostasis | Gene expression regulation | Macrophages | Cholesterols | Endothelial cells | TANGIER-DISEASE | HDL | LIPID-METABOLISM | CASSETTE TRANSPORTER 1 | CELLULAR CHOLESTEROL | MULTIDISCIPLINARY SCIENCES | IN-VIVO | MUTATIONS | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Membrane Glycoproteins - metabolism | Cholesterol, Dietary - administration & dosage | Lipoproteins - genetics | Lipoproteins, HDL - blood | Humans | Lipoproteins, HDL - metabolism | MicroRNAs - metabolism | Transfection | ATP-Binding Cassette Transporters - genetics | Dietary Fats - administration & dosage | Lipoproteins - metabolism | ATP-Binding Cassette Transporters - metabolism | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | ATP Binding Cassette Transporter 1 | Cell Line | Introns | Liver - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Apolipoprotein A-I - metabolism | Cholesterol - metabolism | Membrane Glycoproteins - genetics | Proteins - genetics | Carrier Proteins - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Mice | MicroRNAs - genetics | Hypercholesterolemia - genetics | Macrophages, Peritoneal - metabolism | Hypercholesterolemia - metabolism | Physiological aspects | Control | Research | High density lipoproteins | Cholesterol metabolism | Lipoproteins | Cellular biology | Ribonucleic acid--RNA | Gene expression | Cholesterol
Journal Article