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1. Full Text MicroRNA-33 and the SREBP Host Genes Cooperate to Control Cholesterol Homeostasis
by S. Hani Najafi-Shoushtari and Fjoralba Kristo and Yingxia Li and Toshi Shioda and David E. Cohen and Robert E. Gerszten and Anders M. Näär
Science, ISSN 0036-8075, 6/2010, Volume 328, Issue 5985, pp. 1566 - 1569
Proper coordination of cholesterol biosynthesis and trafficking is essential to human health. The sterol regulatory element-binding proteins (SREBPs) are key... 
MicroRNA | Genes | HDL lipoproteins | REPORTS | Cell lines | Stem cells | Journalism | Gene expression regulation | Mice | Macrophages | Cholesterols | ABCA1 | COEXPRESSION | TRANSPORT | EFFLUX | METABOLISM | MECHANISM | INTRONIC MICRORNAS | MULTIDISCIPLINARY SCIENCES | IN-VIVO | LIVER | ATHEROSCLEROSIS | Up-Regulation | Humans | Homeostasis | MicroRNAs - metabolism | Sterol Regulatory Element Binding Proteins - genetics | ATP-Binding Cassette Transporters - genetics | RNA Interference | ATP-Binding Cassette Transporters - metabolism | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | 3' Untranslated Regions | ATP Binding Cassette Transporter 1 | Sterol Regulatory Element Binding Protein 1 - metabolism | Cell Line | Oligonucleotides, Antisense - pharmacology | Introns | Liver - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Sterol Regulatory Element Binding Proteins - metabolism | Cholesterol - metabolism | Macrophages - metabolism | Animals | Diet | Sterol Regulatory Element Binding Protein 1 - genetics | Cholesterol, HDL - blood | MicroRNAs - genetics | Physiological aspects | Genetic aspects | Binding proteins | Cholesterol | Biosynthesis | Cellular biology | Ribonucleic acid--RNA | Gene expression
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2. Full Text Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity
by Kidani, Yoko and Elsaesser, Heidi and Hock, M Benjamin and Vergnes, Laurent and Williams, Kevin J and Argus, Joseph P and Marbois, Beth N and Komisopoulou, Evangelia and Wilson, Elizabeth B and Osborne, Timothy F and Graeber, Thomas G and Reue, Karen and Brooks, David G and Bensinger, Steven J
Nature Immunology, ISSN 1529-2908, 05/2013, Volume 14, Issue 5, pp. 489 - 499
Newly activated CD8(+) T cells reprogram their metabolism to meet the extraordinary biosynthetic demands of clonal expansion; however, the signals that mediate... 
FATTY-ACID SYNTHESIS | CHOLESTEROL | MEMORY | PATHWAY | LYMPHOCYTE ACTIVATION | LIPID RAFTS | LIVER | PROLIFERATION | MICE | IMMUNOLOGY | ANTIGEN RECEPTOR | RNA, Small Interfering - genetics | Cell Proliferation | Mice, Inbred C57BL | Transgenes - genetics | Cells, Cultured | Signal Transduction - genetics | Adaptive Immunity - genetics | Cell Differentiation - genetics | Signal Transduction - immunology | Lymphocyte Activation - genetics | Animals | Sterol Regulatory Element Binding Protein 1 - genetics | Mice, Mutant Strains | CD8-Positive T-Lymphocytes - metabolism | Mice | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | CD8-Positive T-Lymphocytes - immunology | Sterol Regulatory Element Binding Protein 1 - metabolism | Physiological aspects | Genetic aspects | Immune response | Research | Binding proteins | T cells | lipids | metabolism | SREBP | LCMV | proliferation | CD8+ T cell
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3. Full Text Metabolic control of YAP and TAZ by the mevalonate pathway
by Sorrentino, Giovanni and Ruggeri, Naomi and Specchia, Valeria and Cordenonsi, Michelangelo and Mano, Miguel and Dupont, Sirio and Manfrin, Andrea and Ingallina, Eleonora and Sommaggio, Roberta and Piazza, Silvano and Rosato, Antonio and Piccolo, Stefano and Del Sal, Giannino
Nature Cell Biology, ISSN 1465-7392, 2014, Volume 16, Issue 4, pp. 357 - 366
The YAP and TAZ mediators of the Hippo pathway ( hereafter called YAP/TAZ) promote tissue proliferation and organ growth. However, how their biological... 
ORGAN GROWTH | CHOLESTEROL | YAP/TAZ | TRANSCRIPTION | HIPPO PATHWAY | STATINS | CELL BIOLOGY | Phosphorylation - physiology | Cell Proliferation | Active Transport, Cell Nucleus - physiology | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Drosophila Proteins - metabolism | Phosphoproteins - metabolism | Sterol Regulatory Element Binding Proteins - genetics | Breast Neoplasms - metabolism | Drosophila melanogaster - metabolism | RNA Interference | Tumor Suppressor Proteins - genetics | HEK293 Cells | Trans-Activators - genetics | Female | Transcription, Genetic | Hydroxymethylglutaryl-CoA Reductases, NAD-Dependent - metabolism | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Signal Transduction | HCT116 Cells | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Sterol Regulatory Element Binding Proteins - metabolism | Transcription Factors - genetics | Mevalonic Acid - metabolism | Polyisoprenyl Phosphates - metabolism | Transcription Factors - metabolism | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | rho GTP-Binding Proteins - metabolism | Trans-Activators - metabolism | Mice | Polyisoprenyl Phosphates - biosynthesis | Pyridines - pharmacology | RNA, Small Interfering | Drosophila Proteins - genetics | Adaptor Proteins, Signal Transducing - metabolism | Cell metabolism | Genetic research | Genetic aspects | Research | Cellular control mechanisms
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4. Full Text MicroRNAs in metabolism and metabolic disorders
by Rottiers, Veerle and Näär, Anders M
Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 04/2012, Volume 13, Issue 4, pp. 239 - 250
MicroRNAs (miRNAs) have recently emerged as key regulators of metabolism. For example, miR-33a and miR-33b have a crucial role in controlling cholesterol and... 
SUBCUTANEOUS ADIPOSE-TISSUE | GLUCOSE-METABOLISM | IN-VIVO | FATTY-ACID-METABOLISM | GENE-EXPRESSION | PANCREATIC BETA-CELLS | ADIPOCYTE DIFFERENTIATION | ELEMENT-BINDING PROTEIN | CHOLESTEROL HOMEOSTASIS | HEPATIC LIPID-METABOLISM | CELL BIOLOGY | Fatty Liver - genetics | Fatty Liver - metabolism | Signal Transduction | Humans | Homeostasis | Lipid Metabolism | Metabolic Syndrome - metabolism | MicroRNAs - metabolism | Sterol Regulatory Element Binding Proteins - metabolism | Oligoribonucleotides, Antisense - pharmacology | Cholesterol - metabolism | Sterol Regulatory Element Binding Proteins - genetics | Obesity - genetics | Obesity - metabolism | Insulin - metabolism | Metabolic Diseases - metabolism | Metabolic Syndrome - genetics | Endocrine System - metabolism | Non-alcoholic Fatty Liver Disease | Glucose - metabolism | Metabolic Diseases - genetics | MicroRNAs - genetics | MicroRNA | Physiological aspects | Metabolic diseases | Genetic aspects | Research | Lipid metabolism | Genetic regulation | Metabolism | Risk factors
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5. Full Text Lipid metabolism in cancer
by Santos, Claudio R and Schulze, Almut
FEBS Journal, ISSN 1742-464X, 08/2012, Volume 279, Issue 15, pp. 2610 - 2623
Lipids form a diverse group of water‐insoluble molecules that include triacylglycerides, phosphoglycerides, sterols and sphingolipids. They play several... 
hypoxia | cancer | fatty acid synthesis | Akt signalling | lipid metabolism | CHOLINE KINASE | ELEMENT-BINDING PROTEIN-1 | INDUCIBLE FACTOR 1-ALPHA | DE-NOVO LIPOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-GROWTH | STEAROYL-COA DESATURASE | POSITRON-EMISSION-TOMOGRAPHY | ATP-CITRATE LYASE | PROSTATE-CANCER | FATTY-ACID SYNTHASE | Neoplasms - metabolism | Cell Proliferation | Oxidative Stress | Signal Transduction | Humans | Homeostasis | Lipid Metabolism | Sterol Regulatory Element Binding Proteins - metabolism | Neoplasm Proteins - metabolism | Sterol Regulatory Element Binding Proteins - genetics | Hypoxia - metabolism | Animals | Energy Metabolism | Neoplasms - genetics | Cell Transformation, Neoplastic | Neoplasm Proteins - genetics | Neoplasms - pathology | Oncogenes | Synthesis | Sterols | Analysis | Oncology, Experimental | Physiological aspects | Lipids | Research | Gene expression | Fatty acids | Cancer
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6. Full Text Regulation of mTORC1 and its impact on gene expression at a glance
by Laplante, Mathieu and Sabatini, David M
Journal of Cell Science, ISSN 0021-9533, 04/2013, Volume 126, Issue 8, pp. 1713 - 1719
The mechanistic (or mammalian) target of rapamycin (mTOR) is a kinase that regulates key cellular functions linked to the promotion of cell growth and... 
MAMMALIAN TARGET | AMINO-ACID | RAG GTPASES | GENETICALLY HETEROGENEOUS MICE | COMPLEX 1 | EXTENDS LIFE-SPAN | ADIPOCYTE DIFFERENTIATION | TUBEROUS SCLEROSIS | DIET-INDUCED OBESITY | INDUCED INSULIN-RESISTANCE | CELL BIOLOGY | TOR Serine-Threonine Kinases - metabolism | Gene Expression - genetics | Humans | Multiprotein Complexes - genetics | PPAR alpha - genetics | Sterol Regulatory Element Binding Proteins - metabolism | Transcription Factors - genetics | PPAR gamma - metabolism | Sterol Regulatory Element Binding Proteins - genetics | Mechanistic Target of Rapamycin Complex 1 | Transcription Factors - metabolism | Multiprotein Complexes - metabolism | Animals | TOR Serine-Threonine Kinases - genetics | Gene Expression - physiology | PPAR alpha - metabolism | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | PPAR gamma - genetics | Cell Science at a Glance
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7. Full Text AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice
by Li, Yu and Xu, Shanqin and Mihaylova, Maria M and Zheng, Bin and Hou, Xiuyun and Jiang, Bingbing and Park, Ogyi and Luo, Zhijun and Lefai, Etienne and Shyy, John Y.-J and Gao, Bin and Wierzbicki, Michel and Verbeuren, Tony J and Shaw, Reuben J and Cohen, Richard A and Zang, Mengwei
Cell Metabolism, ISSN 1550-4131, 04/2011, Volume 13, Issue 4, pp. 376 - 388
AMPK has emerged as a critical mechanism for salutary effects of polyphenols on lipid metabolic disorders in type 1 and type 2 diabetes. Here we demonstrate... 
CELLS | OVEREXPRESSION | ACTIVATED PROTEIN-KINASE | LIPID-METABOLISM | ELEMENT-BINDING PROTEIN-1 | LDL RECEPTOR | TRANSCRIPTION | ENDOCRINOLOGY & METABOLISM | FATTY LIVER | DEFICIENT MICE | EXPRESSION | CELL BIOLOGY | Receptors, LDL - genetics | AMP-Activated Protein Kinases - metabolism | Phosphorylation | Atherosclerosis - drug therapy | Benzopyrans - therapeutic use | Metformin - therapeutic use | Humans | Insulin Resistance | Sterol Regulatory Element Binding Protein 2 - antagonists & inhibitors | Receptors, LDL - metabolism | Male | Fatty Liver - drug therapy | Animals | Sterol Regulatory Element Binding Protein 1 - genetics | Dietary Fats - pharmacology | Sterol Regulatory Element Binding Protein 1 - antagonists & inhibitors | Transcription, Genetic | Mice | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | Lipogenesis | Sterol Regulatory Element Binding Protein 1 - metabolism | Disease Models, Animal | Type 2 diabetes | Liver diseases | Low density lipoproteins | Alcoholism | Oncology, Experimental | Research | Glucose | Gene expression | Dextrose | Atherosclerosis | Polyphenols | Insulin resistance | Binding proteins | Cancer | Protein binding | Medical colleges | Insulin | Cells
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8. Full Text SREBPs: the crossroads of physiological and pathological lipid homeostasis
by Raghow, Rajendra and Yellaturu, Chandrahasa and Deng, Xiong and Park, Edwards A and Elam, Marshall B
Trends in Endocrinology & Metabolism, ISSN 1043-2760, 2007, Volume 19, Issue 2, pp. 65 - 73
The uptake, biosynthesis and metabolism of cholesterol and other lipids are exquisitely regulated by feedback and feed-forward pathways in organisms ranging... 
Endocrinology & Metabolism | STEROL-REGULATED UBIQUITINATION | FATTY-ACID SYNTHESIS | ELEMENT-BINDING PROTEIN-1C | ENDOCRINOLOGY & METABOLISM | HMG COA REDUCTASE | GENE-EXPRESSION | ENDOPLASMIC-RETICULUM | CHOLESTEROL HOMEOSTASIS | TRANSCRIPTION FACTOR | INSULIN SENSITIVITY | LIVER-X-RECEPTOR | Humans | Endoplasmic Reticulum - metabolism | Molecular Sequence Data | Protein Transport - drug effects | Sterol Regulatory Element Binding Proteins - metabolism | Sterol Regulatory Element Binding Proteins - genetics | Glucagon - pharmacology | Sequence Homology, Nucleic Acid | Protein Processing, Post-Translational - physiology | Cyclic AMP - pharmacology | Gene Expression Regulation - drug effects | Animals | Lipids - pharmacology | Protein Processing, Post-Translational - drug effects | Membrane Proteins - physiology | Models, Biological | Base Sequence | Lipid Metabolism Disorders - genetics | Golgi Apparatus - metabolism | Lipid Metabolism - genetics | Intracellular Signaling Peptides and Proteins - physiology | Sterol Regulatory Element Binding Proteins - physiology | Homeostasis - genetics | Sterol Regulatory Element Binding Proteins - biosynthesis | Synthesis | Proteolysis | Physiological aspects | Lipids | Diabetes | Binding proteins | Fatty acids | Protein binding
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9. Full Text An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer
by Chen, Ming and Zhang, Jiangwen and Sampieri, Katia and Clohessy, John G and Mendez, Lourdes and Gonzalez-Billalabeitia, Enrique and Liu, Xue-Song and Lee, Yu-Ru and Fung, Jacqueline and Katon, Jesse M and Menon, Archita Venugopal and Webster, Kaitlyn A and Ng, Christopher and Palumbieri, Maria Dilia and Diolombi, Moussa S and Breitkopf, Susanne B and Teruya-Feldstein, Julie and Signoretti, Sabina and Bronson, Roderick T and Asara, John M and Castillo-Martin, Mireia and Cordon-Cardo, Carlos and Pandolfi, Pier Paolo
Nature Genetics, ISSN 1061-4036, 02/2018, Volume 50, Issue 2, pp. 206 - 218
Lipids, either endogenously synthesized or exogenous, have been linked to human cancer. Here we found that PML is frequently co-deleted with PTEN in metastatic... 
BREAST-CANCER | PTEN LOSS | ACTIVATION | LIPID-METABOLISM | MOUSE MODEL | GENETICS & HEREDITY | TUMOR-SUPPRESSOR | TUBEROUS SCLEROSIS | FATTY-ACID SYNTHASE | CELL-GROWTH | PROGRESSION | PTEN Phosphohydrolase - genetics | Prostatic Neoplasms - metabolism | Prostatic Neoplasms - pathology | Cell Proliferation - genetics | PC-3 Cells | Humans | Mice, Inbred C57BL | Male | Sterol Regulatory Element Binding Proteins - genetics | Cell Transformation, Neoplastic - metabolism | Mice, Knockout | Metabolic Networks and Pathways - genetics | Neoplasm Metastasis | Animals | Prostatic Neoplasms - genetics | Lipogenesis - genetics | Cell Transformation, Neoplastic - genetics | Cell Line, Tumor | Mice | Sterol Regulatory Element Binding Proteins - physiology | Lipids | Genetic aspects | Research | Diagnosis | Gene mutations | Prostate cancer | Disease | Activation | Metastasis | Kinases | Inactivation | High fat diet | Metastases | Proteins | Rodents | Cooperation | Sterol regulatory element-binding protein | Deactivation | Mortality | MAP kinase | Metabolism | Gene expression | Fatty acids | Diet | Mutation | Prostate | PTEN protein | Cancer | Tumors
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