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2012, ISBN 0470874325, xii, 289
Examines new research on the role of cholesterol in regulating ion channels and receptors and its effect on health Drawing together and analyzing all the... 
Ion channels | Metabolism | Cholesterol | Membrane proteins | Life Sciences | Science | Biology | Molecular Biology
Book
Cell Metabolism, ISSN 1550-4131, 05/2012, Volume 15, Issue 5, pp. 725 - 738
Mammalian target of rapamycin complex 2 (mTORC2) phosphorylates and activates AGC kinase family members, including Akt, SGK1, and PKC, in response to... 
TRANSCRIPTION FACTORS | LIPID-METABOLISM | INSULIN-RESISTANCE | ELEMENT-BINDING PROTEIN-1C | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | MOTIF PHOSPHORYLATION | DIABETIC-NEPHROPATHY | GLUCOSE-UTILIZATION | CELL-GROWTH | PHOSPHOINOSITIDE 3-KINASE | CELL BIOLOGY | Glucose Intolerance - metabolism | Phosphorylation | Liver - enzymology | TOR Serine-Threonine Kinases - metabolism | Homeostasis | Glycogen Synthase Kinase 3 beta | Male | Hepatocytes - metabolism | Mechanistic Target of Rapamycin Complex 2 | Hyperglycemia - genetics | Proto-Oncogene Proteins c-akt - genetics | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | Forkhead Transcription Factors - metabolism | Trans-Activators - genetics | Hyperinsulinism - genetics | Insulin - genetics | Lipogenesis | Proto-Oncogene Proteins c-akt - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | Gluconeogenesis | Hyperinsulinism - metabolism | Glucose Intolerance - genetics | Signal Transduction | Liver - metabolism | Glucokinase - genetics | Glucose - genetics | Lipid Metabolism | Forkhead Transcription Factors - genetics | Glucokinase - metabolism | Glycogen Synthase Kinase 3 - metabolism | Mice, Knockout | Hyperglycemia - metabolism | Proteins - genetics | Insulin - metabolism | Animals | Proteins - metabolism | Trans-Activators - deficiency | Glycogen Synthase Kinase 3 - genetics | Sterol Regulatory Element Binding Protein 1 - genetics | Glucose - metabolism | Glycolysis | Trans-Activators - metabolism | Forkhead Box Protein O1 | Mice | Transcription Factors | Glucose metabolism | Hyperglycemia | Glucose | Isoenzymes | Dextrose
Journal Article
Nature Cell Biology, ISSN 1465-7392, 2014, Volume 16, Issue 4, pp. 357 - 366
The YAP and TAZ mediators of the Hippo pathway ( hereafter called YAP/TAZ) promote tissue proliferation and organ growth. However, how their biological... 
ORGAN GROWTH | CHOLESTEROL | YAP/TAZ | TRANSCRIPTION | HIPPO PATHWAY | STATINS | CELL BIOLOGY | Phosphorylation - physiology | Cell Proliferation | Active Transport, Cell Nucleus - physiology | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Drosophila Proteins - metabolism | Phosphoproteins - metabolism | Sterol Regulatory Element Binding Proteins - genetics | Breast Neoplasms - metabolism | Drosophila melanogaster - metabolism | RNA Interference | Tumor Suppressor Proteins - genetics | HEK293 Cells | Trans-Activators - genetics | Female | Transcription, Genetic | Hydroxymethylglutaryl-CoA Reductases, NAD-Dependent - metabolism | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Signal Transduction | HCT116 Cells | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Sterol Regulatory Element Binding Proteins - metabolism | Transcription Factors - genetics | Mevalonic Acid - metabolism | Polyisoprenyl Phosphates - metabolism | Transcription Factors - metabolism | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | rho GTP-Binding Proteins - metabolism | Trans-Activators - metabolism | Mice | Polyisoprenyl Phosphates - biosynthesis | Pyridines - pharmacology | RNA, Small Interfering | Drosophila Proteins - genetics | Adaptor Proteins, Signal Transducing - metabolism | Cell metabolism | Genetic research | Genetic aspects | Research | Cellular control mechanisms
Journal Article
Cell Metabolism, ISSN 1550-4131, 05/2012, Volume 15, Issue 5, pp. 665 - 674
Nonalcoholic fatty liver disease (NAFLD) is associated with increased cardiovascular and liver-related mortality. NAFLD is characterized by both triglyceride... 
RAT-LIVER | RISK-FACTORS | MACROPHAGE APOPTOSIS | PROTEIN-KINASE | ENDOCRINOLOGY & METABOLISM | HMG-COA REDUCTASE | STEATOHEPATITIS | 3-HYDROXY-3-METHYLGLUTARYL COENZYME | PREVALENCE | MICRORNA EXPRESSION | MODULATION | CELL BIOLOGY | Sirtuin 1 - metabolism | Up-Regulation | Cholesterol - blood | Humans | Middle Aged | Sterol Esterase - metabolism | Male | MicroRNAs - metabolism | Desmosterol - metabolism | Cardiovascular Diseases - genetics | Cholesterol - genetics | Sirtuin 1 - genetics | Case-Control Studies | Phosphorylation - genetics | Hydroxymethylglutaryl CoA Reductases - metabolism | Adenylate Kinase - metabolism | Non-alcoholic Fatty Liver Disease | Sterol O-Acyltransferase - metabolism | Adult | Female | Lipid Metabolism - genetics | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | Fatty Liver - genetics | Receptors, LDL - genetics | Gene Expression | Fatty Liver - metabolism | Cardiovascular Diseases - metabolism | Fatty Liver - blood | Liver - metabolism | Receptors, LDL - metabolism | Cholesterol - metabolism | Cholesterol, LDL - genetics | Phenotype | Sterol Esterase - genetics | Desmosterol - blood | Cholesterol, LDL - metabolism | MicroRNAs - genetics | Sterol O-Acyltransferase - genetics | Adenylate Kinase - genetics | Hydroxymethylglutaryl CoA Reductases - genetics | Enzymes | Liver diseases | Low density lipoproteins | Genes | Esters | Triglycerides | Cholesterol | MicroRNA | Fatty liver | Blood cholesterol | Physiological aspects | Hydrolases | Blood lipids | Health aspects | Statins | atherosclerosis | Nonalcoholic steatohepatitis | cholesterol | Nonalcoholic fatty liver disease | fatty liver | lipogenesis | hypercholesterolemia | HMG CoA reductase
Journal Article
Science, ISSN 0036-8075, 6/2010, Volume 328, Issue 5985, pp. 1570 - 1573
Cholesterol metabolism is tightly regulated at the cellular level. Here we show that miR-33, an intronic microRNA (miRNA) located within the gene encoding... 
MicroRNA | Hepatocytes | HDL lipoproteins | Liver | Genes | REPORTS | Homeostasis | Gene expression regulation | Macrophages | Cholesterols | Endothelial cells | TANGIER-DISEASE | HDL | LIPID-METABOLISM | CASSETTE TRANSPORTER 1 | CELLULAR CHOLESTEROL | MULTIDISCIPLINARY SCIENCES | IN-VIVO | MUTATIONS | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Membrane Glycoproteins - metabolism | Cholesterol, Dietary - administration & dosage | Lipoproteins - genetics | Lipoproteins, HDL - blood | Humans | Lipoproteins, HDL - metabolism | MicroRNAs - metabolism | Transfection | ATP-Binding Cassette Transporters - genetics | Dietary Fats - administration & dosage | Lipoproteins - metabolism | ATP-Binding Cassette Transporters - metabolism | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | ATP Binding Cassette Transporter 1 | Cell Line | Introns | Liver - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Apolipoprotein A-I - metabolism | Cholesterol - metabolism | Membrane Glycoproteins - genetics | Proteins - genetics | Carrier Proteins - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Mice | MicroRNAs - genetics | Hypercholesterolemia - genetics | Macrophages, Peritoneal - metabolism | Hypercholesterolemia - metabolism | Physiological aspects | Control | Research | High density lipoproteins | Cholesterol metabolism | Lipoproteins | Cellular biology | Ribonucleic acid--RNA | Gene expression | Cholesterol
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2012, Volume 287, Issue 35, pp. 29579 - 29588
Mammalian target of rapamycin complex 2 (mTORC2) is a key activator of protein kinases that act downstream of insulin and growth factor signaling. Here we... 
TRANSCRIPTION FACTORS | DIABETES-MELLITUS | LIPID-METABOLISM | AKT/PKB | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIVER | MOTIF PHOSPHORYLATION | RICTOR | MICE | KINASE-B | INDUCED INSULIN-RESISTANCE | Phosphorylation - physiology | Humans | Glycogen Synthase Kinase 3 beta | GTPase-Activating Proteins - metabolism | Phosphoproteins - metabolism | Cholesterol - genetics | Proto-Oncogene Proteins c-akt - genetics | Fatty Acids - genetics | Forkhead Transcription Factors - metabolism | Insulin Resistance - physiology | Tumor Suppressor Proteins - genetics | Trans-Activators - genetics | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | Insulin - genetics | Proto-Oncogene Proteins c-akt - metabolism | Fatty Acids - metabolism | Lipogenesis - physiology | Sterol Regulatory Element Binding Protein 1 - metabolism | Tumor Suppressor Proteins - metabolism | Liver - metabolism | Gene Expression Regulation - physiology | Glucose - genetics | Mice, Transgenic | Phosphoproteins - genetics | Transcription Factors - genetics | Forkhead Transcription Factors - genetics | Glycogen Synthase Kinase 3 - metabolism | Hep G2 Cells | Transcription Factors - metabolism | Insulin - metabolism | Animals | Glycogen Synthase Kinase 3 - genetics | Sterol Regulatory Element Binding Protein 1 - genetics | Adaptor Proteins, Signal Transducing - genetics | Glucose - metabolism | Trans-Activators - metabolism | Forkhead Box Protein O1 | Mice | GTPase-Activating Proteins - genetics | Adaptor Proteins, Signal Transducing - metabolism | Cholesterol - biosynthesis | mTOR Complex (mTORC) | Liver Metabolism | mTOR Complex 2 (mTORC2) | Akt | Metabolism | Lipogenesis | Insulin | Gluconeogenesis
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2004, Volume 279, Issue 19, pp. 20314 - 20326
Hepatic glucokinase (GK) catalyzes the phosphorylation of glucose to glucose 6-phosphate (G6P), a step which is essential for glucose metabolism in liver as... 
FATTY-ACID-SYNTHASE | GLUCOSE-HOMEOSTASIS | CARBOHYDRATE RESPONSE ELEMENT | RAT HEPATOCYTES | STEROL REGULATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ELEMENT-BINDING PROTEIN-1C | PYRUVATE-KINASE GENE | TRANSCRIPTION FACTOR | CARNITINE-PALMITOYLTRANSFERASE-I | TRANSGENIC MICE | Glucokinase - physiology | Liver - enzymology | Fatty Acid Synthases - metabolism | Immunoblotting | Hepatocytes - metabolism | RNA, Messenger - metabolism | DNA-Binding Proteins - metabolism | Cell Nucleus - metabolism | Glycogen - metabolism | Time Factors | CCAAT-Enhancer-Binding Proteins - physiology | Adenoviridae - genetics | Transcription, Genetic | Pentosephosphates - metabolism | RNA - metabolism | CCAAT-Enhancer-Binding Proteins - metabolism | DNA-Binding Proteins - physiology | Pyruvate Kinase - metabolism | Signal Transduction | Liver - metabolism | Mice, Inbred C57BL | Carbohydrate Metabolism | Cells, Cultured | Gene Expression Regulation | Lipid Metabolism | Mice, Transgenic | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Nuclear Proteins | Transcription Factors - metabolism | Blotting, Northern | Animals | Proteins - metabolism | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors | Glucose - metabolism | Mice | Kinetics | Sterol Regulatory Element Binding Protein 1 | Glucose-6-Phosphate - metabolism | Acetyl-CoA Carboxylase - metabolism | Microscopy, Fluorescence | RNA, Small Interfering - metabolism
Journal Article