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Journal Article
Circulation, ISSN 0009-7322, 08/2013, Volume 128, Issue 6, pp. 632 - 642
BACKGROUND—The molecular basis for the focal nature of atherosclerotic lesions is poorly understood. Here, we explored whether disturbed flow patterns activate... 
atherosclerosis | shear stress | NLRP3 protein, human | sterol regulatory element binding proteins | endothelial cell | NLRP3 protein | CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | CHRONIC GRANULOMATOUS-DISEASE | INTERLEUKIN-1-BETA | RECEPTOR ANTAGONIST | HEART-DISEASE | SHEAR-STRESS | REGIONS | PERIPHERAL VASCULAR DISEASE | MICE | CHOLESTEROL HOMEOSTASIS | human | UP-REGULATION | Human Umbilical Vein Endothelial Cells | RNA, Small Interfering - genetics | Vasculitis - metabolism | Inflammasomes - metabolism | Membrane Glycoproteins - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | NADPH Oxidases - metabolism | NADPH Oxidases - immunology | Stress, Mechanical | Male | MicroRNAs - metabolism | Vasculitis - immunology | Vasculitis - genetics | Sterol Regulatory Element Binding Protein 2 - genetics | Membrane Glycoproteins - immunology | Sterol Regulatory Element Binding Protein 2 - metabolism | Carrier Proteins - immunology | Atherosclerosis - immunology | Endothelial Cells - metabolism | Mice, Transgenic | MicroRNAs - immunology | NADPH Oxidase 2 | Atherosclerosis - metabolism | Endothelial Cells - immunology | Carrier Proteins - genetics | Immunity, Innate - immunology | Animals | Carrier Proteins - metabolism | Apolipoproteins E - genetics | Inflammasomes - immunology | Mice | Sterol Regulatory Element Binding Protein 2 - immunology | Hemodynamics - immunology | Sterols | Atherosclerosis | Physiological aspects | Disease susceptibility | Genetic aspects | Research | Hemodynamics | Binding proteins | Endothelium | Index Medicus | Abridged Index Medicus
Journal Article
Circulation, ISSN 0009-7322, 03/2015, Volume 131, Issue 9, pp. 805 - 814
BACKGROUND—Oxidative stress activates endothelial innate immunity and disrupts endothelial functions, including endothelial nitric oxide synthase–derived... 
Oxidative stress | Sterol regulatory element binding protein 2 | Inflammasomes | MicroRNA-92 | Endothelium | ATHEROSCLEROTIC LESIONS | endothelium | CARDIAC & CARDIOVASCULAR SYSTEMS | microRNA-92 | inflammasomes | sterol regulatory element binding protein 2 | KAPPA-B | SIRT1 | LIPID-ACCUMULATION | HYPERCHOLESTEROLEMIC ZEBRAFISH | FOAM CELL-FORMATION | IN-VIVO | PERIPHERAL VASCULAR DISEASE | MICE | KRUPPEL-LIKE FACTOR-2 | DYSFUNCTION | oxidative stress | Free Radical Scavengers - pharmacology | Human Umbilical Vein Endothelial Cells | Inflammasomes - metabolism | Humans | Middle Aged | Transcriptional Activation | Immunity, Innate - genetics | Oxidative Stress - immunology | Coronary Disease - physiopathology | Male | Recombinant Fusion Proteins - metabolism | Interleukin-1beta - blood | Salicylates - pharmacology | HEK293 Cells | Female | Sterol Regulatory Element Binding Protein 2 - genetics | Angiotensin II - toxicity | Genes, Reporter | Hydrogen Peroxide - toxicity | Coronary Disease - blood | Endothelial Cells - metabolism | Gene Expression Regulation | Oxidative Stress - genetics | Mice, Transgenic | MicroRNAs - biosynthesis | Zebrafish | Sterol Regulatory Element Binding Protein 2 - physiology | Zebrafish Proteins - physiology | Lipoproteins, LDL - toxicity | Animals | Endothelium, Vascular - metabolism | Aged | Mice | MicroRNAs - genetics | Hypercholesterolemia - genetics | Organometallic Compounds - pharmacology | Index Medicus | Abridged Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2010, Volume 107, Issue 40, pp. 17321 - 17326
Sterol regulatory element-binding protein 2 (SREBP-2) transcription factor has been identified as a key protein in cholesterol metabolism through the... 
MicroRNA | Hepatocytes | Exons | Introns | HDL lipoproteins | Liver | Genes | Mice | Macrophages | Cholesterols | ABCA1 | Metabolic syndrome | Cholesterol efflux | Macrophage | HOMEOSTASIS | FATTY-ACID SYNTHESIS | liver | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | macrophage | metabolic syndrome | TANGIER-DISEASE | HOST GENES | EFFLUX | REVERSE CHOLESTEROL TRANSPORT | DENSITY-LIPOPROTEIN DEFICIENCY | cholesterol efflux | TRANSGENIC MICE | Cell Line | Cholesterol, HDL - metabolism | Humans | Molecular Sequence Data | MicroRNAs - metabolism | Cholesterol, HDL - genetics | Macrophages - metabolism | Sequence Alignment | Animals | ATP-Binding Cassette Transporters - genetics | Cattle | Base Sequence | Chickens | ATP-Binding Cassette Transporters - metabolism | Female | MicroRNAs - genetics | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | ATP Binding Cassette Transporter 1 | Blood cholesterol | Low density lipoproteins | Biosynthesis | Research | Properties | Binding proteins | Proteins | Rodents | Ribonucleic acid--RNA | Metabolism | Gene expression | Binding sites | Cholesterol | Steroids | Index Medicus | Lipoproteins (low density) | Transcription factors | Data processing | Protein turnover | ABCA1 protein | Apolipoprotein A | Sterol regulatory element-binding protein | ATP-binding protein | miRNA | Lipid metabolism | Lipoproteins (high density) | Peritoneum | Biological Sciences
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 06/2017, Volume 488, Issue 1, pp. 136 - 140
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2013, Volume 8, Issue 6, pp. e67532 - e67532
Background: Aberrantly elevated sterol regulatory element binding protein (SREBP), the lipogenic transcription factor, contributes to the development of fatty... 
LIFE-SPAN | ATHEROGENESIS | LIPID-METABOLISM | ACCELERATED ATHEROSCLEROSIS | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | KINASE | DEFICIENT MICE | STRESS | SIRT1 | P53 | Sterol Regulatory Element Binding Protein 1 - chemistry | Sterol Regulatory Element Binding Protein 2 - chemistry | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Male | Aorta - metabolism | Proteolysis - drug effects | Coronary Artery Disease - physiopathology | Interleukin-1beta - metabolism | Swine | Coronary Artery Disease - pathology | Diabetes Complications - pathology | Phosphorylation - drug effects | Sterol Regulatory Element Binding Protein 2 - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | Biomarkers - metabolism | Atherosclerosis - pathology | Diabetes Complications - physiopathology | Atherosclerosis - physiopathology | AMP-Activated Protein Kinases - antagonists & inhibitors | Aorta - drug effects | Coronary Artery Disease - metabolism | Diabetes Complications - metabolism | Serine - metabolism | Atherosclerosis - metabolism | Disease Progression | Aorta - pathology | Gene Expression Regulation - drug effects | Acetylation - drug effects | Animals | Carrier Proteins - metabolism | Signal Transduction - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Vascular Cell Adhesion Molecule-1 - metabolism | Analysis | Liver | Atherosclerosis | Insulin resistance | Inflammation | Research | Protein kinases | Protein binding | Steroids | Cardiovascular disease | Proteins | Proteolysis | Polyphenols | Aorta | Physiology | Bioindicators | Lipogenesis | Binding | NF-κB protein | Liver diseases | AMP | IL-1β | Metabolism | Gene expression | Insulin | SIRT1 protein | Nitric-oxide synthase | Endothelium | Deacetylation | Arteriosclerosis | Aberration | Phosphorylation | Genes | Lipids | Biology | Activation | Kinases | Macrophages | AMP-activated protein kinase | Fatty liver | Sterols | Cell cycle | Lipoprotein (low density) receptors | Lesions | Plaques | Pigs | Diabetes mellitus | Crystals | Cholesterol | Endothelial cells | Medicine | Cores | NAD | Hogs | Biopsy | Coronary vessels | In vivo methods and tests | Diabetes | Cyclooxygenase-2 | Apoptosis | Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 2011, Volume 13, Issue 5, pp. 540 - 549
We show that mice with a targeted deficiency in the gene encoding the lipogenic transcription factor SREBP-1a are resistant to endotoxic shock and systemic... 
ANTHRAX LETHAL TOXIN | X-RECEPTORS | CECAL LIGATION | GENE | INFLAMMASOME | ENDOCRINOLOGY & METABOLISM | HOST-DEFENSE | PPAR-GAMMA | MICE | SEPSIS | CASPASE-1 ACTIVATION | CELL BIOLOGY | RNA, Small Interfering - genetics | Salmonella Infections - immunology | Caspase 1 - metabolism | Male | Salmonella Infections - metabolism | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Apoptosis Regulatory Proteins - genetics | Bone Marrow | Macrophages - immunology | Interleukin-1beta - secretion | Salmonella Infections - pathology | Cytokines - metabolism | Enzyme-Linked Immunosorbent Assay | Inflammasomes | Salmonella typhimurium - immunology | Mice, Inbred C57BL | RNA, Messenger - genetics | Lipid Metabolism | Macrophages - cytology | Sterol Regulatory Element Binding Protein 1 - physiology | Enzyme Activation - drug effects | Immunity, Innate | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Macrophages - metabolism | Animals | Adaptor Proteins, Signal Transducing - genetics | Apoptosis Regulatory Proteins - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Mice | Adaptor Proteins, Signal Transducing - metabolism | Synthesis | Molecular genetics | Genes | Physiological aspects | Septic shock | Chemical properties | Genetic transcription | Macrophages | Mitogens | Fatty acids | Protein binding | Steroids | Index Medicus | Nlrp1 | SREBP-1a deficiency | Nalp1 | Inflammasome | lipogenesis | Macrophage
Journal Article