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1. Full Text Adult-onset Still disease
by Fautrel, Bruno, MD, PhD
Best Practice & Research: Clinical Rheumatology, ISSN 1521-6942, 2008, Volume 22, Issue 5, pp. 773 - 792
Adult-onset Still disease (AOSD) is an uncommon inflammatory condition of unknown origin typically characterized by four main (cardinal) symptoms: spiking... 
Rheumatology | anakinra | ferritin | inflammatory arthritides | Still disease | biologics | glycosylated ferritin | autoinflammatory syndrome | JUVENILE IDIOPATHIC ARTHRITIS | REACTIVE HEMOPHAGOCYTIC SYNDROME | RHEUMATOLOGY | SERUM FERRITIN | PROINFLAMMATORY CYTOKINE | DOSE METHOTREXATE TREATMENT | TUMOR-NECROSIS-FACTOR | CLINICAL-MANIFESTATIONS | INTRAVENOUS IMMUNOGLOBULIN | LOW GLYCOSYLATED FERRITIN | OF-THE-LITERATURE | Glucocorticoids - therapeutic use | Humans | Antibodies, Monoclonal - therapeutic use | Male | Methotrexate - therapeutic use | Still's Disease, Adult-Onset - blood | Antibodies, Monoclonal, Humanized | Still's Disease, Adult-Onset - drug therapy | Interleukin 1 Receptor Antagonist Protein - therapeutic use | Ferritins - blood | Female | Still's Disease, Adult-Onset - diagnosis | Chronic Disease | Antirheumatic Agents - therapeutic use | Chronic diseases | Usage | Corticosteroids
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2. Full Text Adult-onset still disease: Manifestations, treatment, outcome, and prognostic factors in 57 patients
by Gerfaud-Valentin, Mathieu and Maucort-Boulch, Delphine and Hot, Arnaud and Iwaz, Jean and Ninet, Jacques and Durieu, Isabelle and Broussolle, Christiane and Sève, Pascal
Medicine (United States), ISSN 0025-7974, 2014, Volume 93, Issue 2, pp. 91 - 99
We conducted a retrospective observational study to describe a cohort and identify the prognostic factors in adult-onset Still disease (AOSD). Patients... 
EFFICACY | SF = serum ferritin | CT = computed tomography | GF = glycosylated ferritin | CLINICAL-FEATURES | AOSD = adult-onset Still disease | MTX = methotrexate | MEDICINE, GENERAL & INTERNAL | ESR = erythrocyte sedimentation rate | TUMOR-NECROSIS-FACTOR | RA = receptor antagonist | INTRAVENOUS IMMUNOGLOBULIN | BM = bone marrow | CSs = corticosteroids | AE = adverse event | ETANERCEPT | CRP = C-reactive protein | IL = interleukin | DIAGNOSTIC-VALUE | IVIg = polyvalent intravenous immunoglobulins | SD = standard deviation | DMARDs = disease-modifying antirheumatic drugs | CLASSIFICATION | REACTIVE HEMOPHAGOCYTIC SYNDROME | RHS = reactive hemophagocytic syndrome | ANAKINRA | CI = confidence interval | TNF-alpha = tumor necrosis factor alpha | PMN = polymorphonuclear neutrophils | 18FDG-PET = 18F-fluorodeoxyglucose positron emission tomography | NSAIDs = nonsteroidal antiinflammatory drugs | EXPERIENCE | OR = odds ratio | Prognosis | Still's Disease, Adult-Onset - physiopathology | Humans | Middle Aged | Risk Factors | Male | Positron-Emission Tomography | Young Adult | Still's Disease, Adult-Onset - drug therapy | Ferritins - blood | Adolescent | Adult | Female | Fluorodeoxyglucose F18 | Still's Disease, Adult-Onset - diagnosis | Aged | Retrospective Studies | Radiopharmaceuticals | Antirheumatic Agents - therapeutic use
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3. Full Text Interleukin-1 receptor antagonist (anakinra) treatment in patients with systemic-onset juvenile idiopathic arthritis or adult onset Still disease: preliminary experience in France
by Lequerré, T and Quartier, P and Rosellini, D and Alaoui, F and De Bandt, M and Mejjad, O and Kone-Paut, I and Michel, M and Dernis, E and Khellaf, M and Limal, N and Job-Deslandre, C and Fautrel, B and Le Loët, X and Sibilia, J and Societe Francophone Rhumatologie and Club Rhumatismes & Inflammation and Club Rhumatismes et Inflammation (CRI) and Société Francophone pour la Rhumatologie et les Maladies Inflammatoires en Pédiatrie (SOFREMIP) and on behalf of the Societe Francophone pour la Rhumatologie et les Maladies Inflammatoires en Pediatrie (SOFREMIP) and the Club Rhumatismes et Inflammation (CRI)
Annals of the Rheumatic Diseases, ISSN 0003-4967, 03/2008, Volume 67, Issue 3, pp. 302 - 308
Background:Anakinra treatment has been reported to be effective in some patients with systemic-onset juvenile idiopathic arthritis (SoJIA) or adult-onset Still... 
RHEUMATOID-ARTHRITIS | CLASSIFICATION | RHEUMATOLOGY | ETANERCEPT | Severity of Illness Index | Blood Sedimentation - drug effects | Follow-Up Studies | Humans | Middle Aged | Child, Preschool | Male | Treatment Outcome | Arthritis, Juvenile - blood | Arthritis, Juvenile - drug therapy | Still's Disease, Adult-Onset - blood | Still's Disease, Adult-Onset - drug therapy | C-Reactive Protein - metabolism | Interleukin 1 Receptor Antagonist Protein - therapeutic use | Adolescent | Antirheumatic Agents - adverse effects | Interleukin 1 Receptor Antagonist Protein - adverse effects | Adult | Female | Receptors, Interleukin-1 - antagonists & inhibitors | Child | Antirheumatic Agents - therapeutic use | Demographic aspects | Care and treatment | Juvenile arthritis | Disease | Hematology | Cytokines | Rheumatology | Response rates | Questionnaires | Tumor necrosis factor-TNF | Adults | Inflammation | Drug dosages | Fever
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4. Full Text Adult-onset Still's disease
by Bagnari, Valentina and Colina, Matteo and Ciancio, Giovanni and Govoni, Marcello and Trotta, Francesco
Rheumatology International, ISSN 0172-8172, 05/2010, Volume 30, Issue 7, pp. 855 - 862
Adult-onset Still's disease (AOSD) is a rare systemic inflammatory disorder characterised by high spiking fever, an evanescent salmon pink rash and arthritis,... 
FUO | Adult-onset Still's disease | Systemic diseases | Autoinxammatory syndromes | CRITERIA | JUVENILE IDIOPATHIC ARTHRITIS | CLASSIFICATION | PERIPHERAL-BLOOD | ANAKINRA | RHEUMATOLOGY | FRANCE | INTERLEUKIN-18 | Autoinflammatory syndromes | PERSISTENT PLAQUES | MANIFESTATIONS | URTICARIA | Blood Sedimentation | Arthritis - physiopathology | Diagnosis, Differential | Still's Disease, Adult-Onset - physiopathology | Anti-Inflammatory Agents - pharmacology | Humans | Biomarkers - analysis | Ferritins - analysis | Biomarkers - blood | Disease Progression | Still's Disease, Adult-Onset - drug therapy | Immune System - physiopathology | Ferritins - blood | Anti-Inflammatory Agents - therapeutic use | Arthritis - immunology | Still's Disease, Adult-Onset - diagnosis | Antirheumatic Agents - pharmacology | Arthritis - classification | Antirheumatic Agents - therapeutic use | Lymphomas | Antirheumatic agents | Hyperthermia | Leukemia | Fever | Ferritin
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5. Full Text Adult-onset Still's disease
by Gerfaud-Valentin, Mathieu and Jamilloux, Yvan and Iwaz, Jean and Sève, Pascal
Autoimmunity Reviews, ISSN 1568-9972, 2014, Volume 13, Issue 7, pp. 708 - 722
Abstract First described in 1971, adult-onset Still's disease (AOSD) is a rare multisystemic disorder considered as a complex (multigenic) autoinflammatory... 
Allergy and Immunology | Adult-onset still's disease | Hemophagocytic lymphohistiocytosis | Autoinflammatory disorder | Hyperferritinemia | Anakinra | Macrophage activation syndrome | INFLAMMATORY RESPONSE SYNDROME | MIGRATION INHIBITORY FACTOR | JUVENILE IDIOPATHIC ARTHRITIS | REACTIVE HEMOPHAGOCYTIC SYNDROME | THROMBOTIC THROMBOCYTOPENIC PURPURA | CLINICAL-FEATURES | IMMUNOLOGY | TUMOR-NECROSIS-FACTOR | INTRAVENOUS IMMUNOGLOBULIN | DISSEMINATED INTRAVASCULAR COAGULATION | Adult-onset Still's disease | Adaptive Immunity | Still's Disease, Adult-Onset - genetics | Genetic Predisposition to Disease | Still's Disease, Adult-Onset - drug therapy | Prognosis | Humans | Adult | Still's Disease, Adult-Onset - diagnosis | Immunity, Innate | Still's Disease, Adult-Onset - immunology | Ferritin | Life Sciences | Microbiology and Parasitology | Immunology | Bacteriology | Virology
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6. Full Text The neutrophil-to-lymphocyte ratio could be a good diagnostic marker and predictor of relapse in patients with adult-onset Still's disease A STROBE-compliant retrospective observational analysis
by Seo, JY and Suh, CH and Jung, JY and Kim, AR and Yang, JW and Kim, HA
MEDICINE, ISSN 0025-7974, 07/2017, Volume 96, Issue 29, p. e7546
The neutrophil-to-lymphocyte ratio (NLR) is the proportion of absolute neutrophil count to lymphocytes on routine complete blood count (CBC) tests, and has... 
RHEUMATOID-ARTHRITIS | PLATELET | macrophage activation syndrome | diagnosis | ANKYLOSING-SPONDYLITIS | PROGNOSTIC VALUE | BIOMARKERS | MEDICINE, GENERAL & INTERNAL | neutrophil-to-lymphocyte ratio | NEUTROPHIL/LYMPHOCYTE RATIO | adult-onset Still's disease | INFLAMMATORY RESPONSE | CLASSIFICATION CRITERIA | SEVERITY | Blood Sedimentation | Multivariate Analysis | Recurrence | Diagnosis, Differential | Macrophage Activation Syndrome - blood | Prognosis | Age Factors | Follow-Up Studies | Area Under Curve | Humans | Neutrophils | Logistic Models | Male | Lupus Erythematosus, Systemic - blood | Still's Disease, Adult-Onset - blood | Still's Disease, Adult-Onset - drug therapy | Lymphocytes | Adult | Female | ROC Curve | Leukocyte Count | Retrospective Studies | Still's Disease, Adult-Onset - mortality | Still's Disease, Adult-Onset - immunology | Inflammatory bowel diseases | Diagnosis | Research
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7. Full Text New Markers for Adult-Onset Still's Disease
by Mitrovic, Stéphane and Fautrel, Bruno
Joint Bone Spine, ISSN 1297-319X, 05/2018, Volume 85, Issue 3, pp. 285 - 293
Adult-onset Still's disease (AOSD) is a rare systemic auto-inflammatory disorder (SAID). Although the pathogenesis of the disease is complex and far from being... 
Biomarkers | Adult-onset Still's disease | Calprotectin | S100 proteins | Interleukin-18 | Ferritin | DIAGNOSTIC-VALUE | JUVENILE IDIOPATHIC ARTHRITIS | CLASSIFICATION | RHEUMATOLOGY | CYTOKINE PROFILES | CLINICAL-MANIFESTATIONS | MACROPHAGE ACTIVATION SYNDROME | SERUM FERRITIN LEVELS | USEFUL BIOMARKER | ASSOCIATION | Severity of Illness Index | Prognosis | Enzyme-Linked Immunosorbent Assay | Interleukin-18 - blood | Risk Assessment | Still's Disease, Adult-Onset - physiopathology | Humans | Middle Aged | Male | Biomarkers - blood | Leukocyte L1 Antigen Complex - blood | Disease Progression | Still's Disease, Adult-Onset - blood | Ferritins - blood | S100 Proteins - blood | Sensitivity and Specificity | Adult | Female | Medicine, Experimental | Medical research | Skin diseases | Arthritis | Interleukins | Life Sciences | Human health and pathology | Rhumatology and musculoskeletal system
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8. Full Text Reactive hemophagocytic syndrome in adult-onset Still disease: clinical features, predictive factors, and prognosis in 21 patients
by Bae, Chang-Bum and Jung, Ju-Yang and Kim, Hyoun-Ah and Suh, Chang-Hee
Medicine, ISSN 0025-7974, 01/2015, Volume 94, Issue 4, p. e451
Hemophagocytic syndrome (HPS) is a potentially life-threatening complication of systemic inflammatory disorders. Adult-onset Still disease (AOSD) is one of the... 
DIAGNOSIS | MEDICINE, GENERAL & INTERNAL | LYMPHOHISTIOCYTOSIS | COMPLICATION | MACROPHAGE ACTIVATION SYNDROME | JUVENILE RHEUMATOID-ARTHRITIS | DISORDERS | KILLER-CELL DYSFUNCTION | CHILDREN | Recurrence | Prognosis | Humans | Middle Aged | Male | Lymphohistiocytosis, Hemophagocytic - mortality | Still's Disease, Adult-Onset - complications | Thrombocytopenia - complications | Still's Disease, Adult-Onset - blood | Ferritins - blood | Splenomegaly - etiology | Adult | Female | Anti-Bacterial Agents - adverse effects | Retrospective Studies | Still's Disease, Adult-Onset - mortality | Hypoalbuminemia - complications | Afibrinogenemia - complications | Lymphohistiocytosis, Hemophagocytic - diagnosis | Lymphohistiocytosis, Hemophagocytic - complications | Anemia - complications | Hypertriglyceridemia - complications | L-Lactate Dehydrogenase - blood | Lymphatic Diseases - etiology | Infection - complications | Hepatomegaly - etiology | Lymphohistiocytosis, Hemophagocytic - blood
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9. Full Text H‐ferritin and CD68+/H‐ferritin+ monocytes/macrophages are increased in the skin of adult‐onset Still's disease patients and correlate with the multi‐visceral involvement of the disease
by Ruscitti, P and Cipriani, P and Ciccia, F and Di Benedetto, P and Liakouli, V and Berardicurti, O and Carubbi, F and Guggino, G and Di Bartolomeo, S and Triolo, G and Giacomelli, R
Clinical & Experimental Immunology, ISSN 0009-9104, 10/2016, Volume 186, Issue 1, pp. 30 - 38
Summary Adult‐onset Still's disease (AOSD) patients may show an evanescent salmon‐pink erythema appearing during febrile attacks and reducing without fever.... 
macrophage | ferritin | hyperferritinaemic syndrome | dermal immune system | adult‐onset Still's disease | Dermal immune system | Hyperferritinaemic syndrome | Adult-onset Still's disease | Ferritin | Macrophage | adult-onset Still's disease | CELLS | CYTOKINE | PLAQUES | IMMUNOLOGY | SUBSET | MACROPHAGE ACTIVATION | SERUM FERRITIN | EXPRESSION | ALTERNATIVE ACTIVATION | SEVERITY | PERSISTENT PRURITIC PAPULES | Leukocytes, Mononuclear - metabolism | Skin - metabolism | Humans | Male | Monocytes - metabolism | Monocytes - immunology | RNA, Messenger - metabolism | Apoferritins - metabolism | Antigens, CD - metabolism | Leukocytes, Mononuclear - immunology | Inflammation Mediators - metabolism | Female | Still's Disease, Adult-Onset - diagnosis | Still's Disease, Adult-Onset - metabolism | Macrophages - immunology | Skin - pathology | Skin - immunology | Gene Expression | Cytokines - metabolism | RNA, Messenger - genetics | Apoferritins - genetics | Macrophages - metabolism | Biopsy | Antigens, Differentiation, Myelomonocytic - metabolism | Biomarkers | Still's Disease, Adult-Onset - immunology | Skin | Original
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10. Full Text A comprehensive review on adult onset Still's disease
by Giacomelli, Roberto and Ruscitti, Piero and Shoenfeld, Yehuda
Journal of Autoimmunity, ISSN 0896-8411, 09/2018, Volume 93, pp. 24 - 36
Adult-onset Still's disease (AOSD) is a systemic inflammatory disorder of unknown etiology usually affecting young adults; spiking fever, arthritis and... 
Pathogenesis | Adult onset Still's disease | Ferritin | Macrophage activation syndrome | JUVENILE IDIOPATHIC ARTHRITIS | KOREAN PATIENTS | THROMBOTIC THROMBOCYTOPENIC PURPURA | IMMUNOLOGY | SERUM FERRITIN | TUMOR-NECROSIS-FACTOR | CYTOKINE PROFILES | CLINICAL-MANIFESTATIONS | H-FERRITIN | FACTOR M-CSF | Medical examination | Analysis | Chronic diseases | Development and progression | Adults | Arthritis | Macrophages | Health aspects | Blood
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11. Full Text Adult‐onset still's disease
by Cagatay, Y and Gul, A and Cagatay, A and Kamali, S and Karadeniz, A and Inanc, M and Ocal, L and Aral, O and Konice, M
International Journal of Clinical Practice, ISSN 1368-5031, 07/2009, Volume 63, Issue 7, pp. 1050 - 1055
Summary Background:  Adult‐onset Still's disease (AOSD) is a febrile disorder of unknown aetiology characterised by typical spiking fever, evanescent rash,... 
UNKNOWN ORIGIN | MEDICINE, GENERAL & INTERNAL | HYPERFERRITINEMIA | FEVER | Still's Disease, Adult-Onset - drug therapy | Humans | Anti-Inflammatory Agents - therapeutic use | Adult | Female | Male | Still's Disease, Adult-Onset - diagnosis | Treatment Outcome | Drug Therapy, Combination | Medical examination | Phosphatases | Ferritin | Aspartate | Arthritis | Universities and colleges | Sedimentation | Hyperthermia | Blood | Fever | Medical diagnosis | Medical disorders | Epidemiology
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12. Full Text Serum S100A12 may be a useful biomarker of disease activity in adult-onset still's disease
by Bae, Chang-Bum and Suh, Chang-Hee and An, Jeong-Mi and Jung, Ju-Yang and Jeon, Ja-Young and Nam, Jin-Young and Kim, Hyoun-Ah
Journal of Rheumatology, ISSN 0315-162X, 12/2014, Volume 41, Issue 12, pp. 2403 - 2408
Objective. S100A12 and soluble receptor for advanced glycation endproducts (sRAGE) have been suggested as biomarkers of disease activity in patients with... 
Adult onset still's disease | S100A12 | Biomarker | Disease activity | Soluble receptor for advanced glycation endproducts | RHEUMATOID-ARTHRITIS | SOLUBLE RECEPTOR FOR ADVANCED GLYCATION ENDPRODUCTS | SYSTEMIC-LUPUS-ERYTHEMATOSUS | BIOMARKER | DISEASE ACTIVITY | JUVENILE IDIOPATHIC ARTHRITIS | MYELOID-RELATED PROTEINS | PROINFLAMMATORY LIGAND | RHEUMATOLOGY | SPLICE VARIANTS | KAWASAKI-DISEASE | PLASMA-LEVELS | ADULT ONSET STILL'S DISEASE | GLYCATION END-PRODUCTS | SOLUBLE RECEPTOR | Severity of Illness Index | Blood Sedimentation | Humans | Middle Aged | Male | Biomarkers - blood | Case-Control Studies | S100A12 Protein | Still's Disease, Adult-Onset - blood | C-Reactive Protein - metabolism | Ferritins - blood | S100 Proteins - blood | Adult | Female | Still's Disease, Adult-Onset - diagnosis | Receptor for Advanced Glycation End Products | Receptors, Immunologic - blood
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13. Full Text Adult-onset Still's disease-pathogenesis, clinical manifestations, and new treatment options
by Kadavath, Sabeeda and Efthimiou, Petros
Annals of Medicine, ISSN 0785-3890, 02/2015, Volume 47, Issue 1, pp. 6 - 14
Abstract Adult-onset Still's disease (AOSD), a systemic inflammatory disorder, is often considered a part of the spectrum of the better-known systemic-onset... 
FUO (fever of unknown origin) | Adult-onset Still's disease | retrospective study | Retrospective study | RHEUMATOID-ARTHRITIS | ANAKINRA TREATMENT | INTERLEUKIN-1 RECEPTOR ANTAGONIST | JUVENILE IDIOPATHIC ARTHRITIS | PERIPHERAL-BLOOD | AUTOINFLAMMATORY DISEASE | UNKNOWN ORIGIN | METHOTREXATE TREATMENT | MEDICINE, GENERAL & INTERNAL | CYTOKINE PROFILES | PATHOLOGICAL TISSUES | Cytokines - therapeutic use | Still's Disease, Adult-Onset - physiopathology | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Humans | Adult | Still's Disease, Adult-Onset - complications | Antirheumatic Agents - therapeutic use | Still's Disease, Adult-Onset - therapy
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