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Journal of Clinical Investigation, ISSN 0021-9738, 08/2017, Volume 127, Issue 8, pp. 2930 - 2940
Programmed death-1-directed (PD-1-directed) immune checkpoint blockade results in durable antitumor activity in many advanced malignancies. Recent studies... 
Immunohistochemistry | Lung Neoplasms - drug therapy | Skin Neoplasms - drug therapy | Humans | Gene Expression Regulation, Neoplastic | Tumor Microenvironment | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Gene Expression Profiling | Interferon-gamma - metabolism | Immune System | Carcinoma - drug therapy | Antibodies, Monoclonal, Humanized - therapeutic use | Signal Transduction | Skin Neoplasms - immunology | Carcinoma - immunology | Programmed Cell Death 1 Receptor - metabolism | Treatment Outcome | Stomach Neoplasms - drug therapy | Stomach Neoplasms - immunology | Carcinoma, Non-Small-Cell Lung - immunology | B7-H1 Antigen - metabolism | Lung Neoplasms - immunology | Pilot Projects | Sequence Analysis, RNA | Biopsy | Melanoma - immunology | Melanoma - drug therapy | ROC Curve | Carcinoma, Non-Small-Cell Lung - drug therapy | CELL LUNG-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | MELANOMA | PEMBROLIZUMAB | LIGANDS | IMMUNOTHERAPY | SAFETY | TOLERANCE | ADAPTIVE IMMUNE RESISTANCE | EXPRESSION | PD-1 protein | Lung cancer | Clinical trials | Cytotoxicity | Biology | Lymphocytes T | Cancer therapies | Metastases | Lymphocytes | Adaptation | Antigen presentation | Squamous cell carcinoma | Cytokines | Melanoma | Inflammation | Gene expression | Immune checkpoint | PD-L1 protein | Head and neck cancer | Antitumor activity | Ligands | Interferon | Chemokines | Apoptosis | Tumors
Journal Article
Cancer Immunology, Immunotherapy, ISSN 0340-7004, 10/2011, Volume 60, Issue 10, pp. 1419 - 1430
Journal Article
Science, ISSN 0036-8075, 12/2015, Volume 350, Issue 6266, pp. 1387 - 1390
Journal Article
Cancer Science, ISSN 1347-9032, 07/2016, Volume 107, Issue 7, pp. 1039 - 1046
Antibody–drug conjugates deliver anticancer agents selectively and efficiently to tumor tissue and have significant antitumor efficacy with a wide therapeutic... 
topoisomerase I inhibitor | T‐DM | HER2 | bystander killing | Antibody‐drug conjugate | T-DM | Antibody-drug conjugate | HODGKINS LYMPHOMA | GEMTUZUMAB OZOGAMICIN | ADVANCED BREAST-CANCER | BRENTUXIMAB VEDOTIN | ACUTE MYELOID-LEUKEMIA | TRASTUZUMAB EMTANSINE | CHALLENGES | THERAPY | ONCOLOGY | EXPRESSION | CATHEPSIN-B | Receptor, ErbB-2 - genetics | Breast Neoplasms - immunology | Humans | Stomach Neoplasms - pathology | Maytansine - pharmacology | Immunoconjugates - immunology | Breast Neoplasms - enzymology | Immunoconjugates - pharmacology | Topoisomerase I Inhibitors - pharmacology | Neoplasms - genetics | Antibodies, Monoclonal, Humanized - pharmacology | Female | Camptothecin - immunology | Receptor, ErbB-2 - immunology | Camptothecin - analogs & derivatives | Stomach Neoplasms - enzymology | Stomach Neoplasms - genetics | Maytansine - analogs & derivatives | Neoplasms - enzymology | Stomach Neoplasms - immunology | Animals | Breast Neoplasms - genetics | Bystander Effect - drug effects | Breast Neoplasms - pathology | Mice, Nude | Neoplasms - immunology | Cell Membrane Permeability - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Antibodies, Monoclonal, Humanized - immunology | Neoplasms - pathology | Camptothecin - pharmacology | Maytansine - immunology | Trastuzumab | Viral antibodies | Epidermal growth factor | Imaging systems | Antibodies | Permeability | Drug therapy | Biopharmaceutics | Tumors | Antigens | Hematology | Laboratories | Toxicity | DNA topoisomerase | Polymerization | Clinical trials | Cytotoxicity | Breast cancer | ErbB-2 protein | Stomach cancer | Hypotheses | Antitumor agents | Xenografts | Antitumor activity | Lymphomas | Drug dosages | Payloads | Index Medicus | Original
Journal Article
Clinical Immunology, ISSN 1521-6616, 2016, Volume 166-167, pp. 48 - 58
Abstract We designed a phase I trial to investigate the safety, immune responses and clinical benefits of a five-peptide cancer vaccine in combination with... 
Allergy and Immunology | Translational research | Five-peptide cancer vaccine | Cyclophosphamide | Regulatory T cells | INTERLEUKIN-2 | IMMUNE-RESPONSE | LUNG | TESTIS ANTIGENS | IMMUNOLOGY | EPITOPE-PEPTIDES | IDENTIFICATION | BREAST-CANCER | IMMUNOTHERAPY | COLORECTAL-CANCER | REGULATORY T-CELLS | Lung Neoplasms - drug therapy | Cyclophosphamide - administration & dosage | Colorectal Neoplasms - genetics | Humans | Middle Aged | HLA-A24 Antigen - genetics | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Epitopes - administration & dosage | Male | Cyclophosphamide - adverse effects | Peptides - administration & dosage | Dose-Response Relationship, Drug | Epitopes - immunology | Neoplasms - genetics | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Colorectal Neoplasms - drug therapy | Leukopenia - chemically induced | Aged, 80 and over | Adult | Female | Vaccines, Subunit - adverse effects | Lung Neoplasms - genetics | Stomach Neoplasms - genetics | HLA-A24 Antigen - immunology | Drug Administration Schedule | Cancer Vaccines - administration & dosage | Peptides - immunology | Kaplan-Meier Estimate | Cancer Vaccines - adverse effects | Treatment Outcome | Cyclophosphamide - immunology | Vaccines, Subunit - immunology | Stomach Neoplasms - drug therapy | Antineoplastic Combined Chemotherapy Protocols - immunology | Neoplasms - drug therapy | Stomach Neoplasms - immunology | Cancer Vaccines - immunology | Lung Neoplasms - immunology | Colorectal Neoplasms - immunology | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Neoplasms - immunology | Vaccines, Subunit - administration & dosage | T-Lymphocytes - immunology | Aged | Cancer vaccines | Antigens | Chemotherapy | Peptides | Vaccination | Colorectal cancer | Clinical trials | Product development | T cells | Cancer | Tumors
Journal Article
Gastric Cancer, ISSN 1436-3291, 1/2017, Volume 20, Issue 1, pp. 156 - 163
The microsatellite-instable gastric cancer subtype, because of its supposed high antigenic potential, is a promising candidate for immunotherapy. We analyzed... 
Chemotherapy | Prognosis | Medicine & Public Health | Mismatch repair | Gastroenterology | Abdominal Surgery | Oncology | Cancer Research | Microsatellite instability | Surgical Oncology | Gastric cancer | ADJUVANT CHEMOTHERAPY | EFFICACY | TUMOR MICROSATELLITE-INSTABILITY | BENEFIT | ONCOLOGY | COLORECTAL-CANCER | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | Lung Neoplasms - drug therapy | Microsatellite Instability | Follow-Up Studies | Humans | Male | Stomach Neoplasms - pathology | DNA Mismatch Repair - genetics | Cisplatin - administration & dosage | Organoplatinum Compounds - administration & dosage | Peritoneal Neoplasms - drug therapy | Fluorouracil - administration & dosage | Lung Neoplasms - secondary | Female | Neoadjuvant Therapy | Chemotherapy, Adjuvant | Liver Neoplasms - secondary | Peritoneal Neoplasms - immunology | Neutrophils - pathology | Peritoneal Neoplasms - secondary | Lung Neoplasms - genetics | Stomach Neoplasms - genetics | Liver Neoplasms - genetics | Biomarkers, Tumor - analysis | Liver Neoplasms - drug therapy | Liver Neoplasms - immunology | Survival Rate | Combined Modality Therapy | Stomach Neoplasms - drug therapy | Stomach Neoplasms - immunology | Lung Neoplasms - immunology | Lymphocytes - pathology | Lymphocytes, Tumor-Infiltrating - pathology | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Peritoneal Neoplasms - genetics | Aged | Neoplasm Staging | Lymphocytes, Tumor-Infiltrating - immunology | Cancer patients | Care and treatment | Immune response | Patient outcomes | Immunotherapy | Metastasis | Stomach cancer | Cancer
Journal Article
International Journal of Cancer, ISSN 0020-7136, 05/2012, Volume 130, Issue 9, pp. 2195 - 2203
Journal Article