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Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 599 - 13
Infectious diseases have a profound impact on our health and many studies suggest that host genetics play a major role in the pathogenesis of most of them. We... 
GENETIC-VARIATION | ALPHA-ENOLASE | JAPANESE POPULATION | MULTIDISCIPLINARY SCIENCES | HERPES-ZOSTER | DISEASE | INNER-EAR MORPHOGENESIS | MIDDLE-EAR | STEM-CELL ANTIGEN | EXPRESSION | SECRETOR STATUS | Tonsillitis - genetics | Otitis Media - surgery | Hepatitis B - genetics | Humans | Candidiasis, Vulvovaginal - genetics | Male | HLA Antigens - genetics | Rheumatic Fever - genetics | Tuberculin Test | Tuberculosis - diagnosis | Case-Control Studies | Pharyngitis - genetics | Streptococcal Infections - genetics | Hepatitis A - genetics | Sinusitis - genetics | Female | Otitis Media - genetics | Warts - genetics | Pneumonia - genetics | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Urinary Tract Infections - genetics | Mumps - genetics | Common Cold - genetics | Middle Ear Ventilation | Rubella - genetics | Scarlet Fever - genetics | Infectious Mononucleosis - genetics | Chickenpox - genetics | Infection - genetics | Tuberculosis - genetics | Meningitis, Bacterial - genetics | Tonsillectomy | Herpes Labialis - genetics | Herpes Zoster - genetics | Tonsillitis - surgery | Measles - genetics | Chronic Disease | Rubella | Yeast | Hepatitis A virus | Scarlet fever | Pathogenesis | Chronic infection | Amino acids | Mapping | Genomes | Infections | Urinary tract | Immunity | Hepatitis | Embryogenesis | Sinus | Mononucleosis | Measles | Varicella | Bacteria | Meningitis | Genetics | Mumps | Hepatitis B virus | Children | Rheumatic fever | Antigens | Health risks | Pharynx | Loci | Fever | Embryonic growth stage | Warts | Herpes labialis | Tuberculosis | Infectious diseases | Ear | Histocompatibility antigen HLA | Gene mapping | Hepatitis A | Hepatitis B | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 04/2014, Volume 111, Issue 17, pp. E1768 - E1776
Journal Article
PLoS ONE, ISSN 1932-6203, 2014, Volume 9, Issue 9, pp. e106543 - e106543
NK-lysin is an antimicrobial protein produced by cytotoxic T lymphocytes and natural killer cells. In this study, we examined the biological property of a... 
CELLS | DEFENSE | CYNOGLOSSUS-SEMILAEVIS | MULTIDISCIPLINARY SCIENCES | ANTIMICROBIAL PEPTIDE | INNATE | FISH | SYNTHETIC PEPTIDE | IDENTIFICATION | EXPRESSION | GRANULYSIN | Antimicrobial Cationic Peptides - immunology | DNA, Bacterial - metabolism | Streptococcal Infections - veterinary | Molecular Sequence Data | Flatfishes - genetics | Vibrio Infections - immunology | Antimicrobial Cationic Peptides - administration & dosage | Host-Pathogen Interactions - immunology | Vibrio - metabolism | Streptococcal Infections - genetics | Fish Proteins - genetics | Bacterial Infections - genetics | Vibrio Infections - genetics | Proteolipids - immunology | Bacterial Infections - immunology | Fish Diseases - immunology | Antimicrobial Cationic Peptides - genetics | Virus Diseases - genetics | Vibrio Infections - veterinary | Amino Acid Sequence | Proteolipids - administration & dosage | Gene Expression | Fish Diseases - microbiology | Proteolipids - genetics | Virus Diseases - immunology | Fish Proteins - immunology | Flatfishes - immunology | Pseudomonas fluorescens | Bacterial Infections - veterinary | Fish Proteins - administration & dosage | Pseudomonas Infections - genetics | Pseudomonas Infections - immunology | Sequence Homology, Amino Acid | Pseudomonas Infections - veterinary | Animals | Fish Diseases - virology | Host-Pathogen Interactions - genetics | Virus Diseases - veterinary | Streptococcal Infections - immunology | Vibrio - pathogenicity | Peptides | DNA | Aquaculture industry | Fishes | Bacteria | Bacterial genetics | Health aspects | Biological properties | Laboratories | Gram-positive bacteria | Cytotoxicity | Amino acids | Lymphocytes T | Infections | Antiinfectives and antibacterials | Degradation | Killer cells | Clonal deletion | E coli | Lymphocytes | Animal tissues | Antimicrobial peptides | Deletion | Fish | Natural killer cells | Deoxyribonucleic acid--DNA | Biodegradation | Pathogens | Immune response | Staphylococcus infections | Marine biology | Antimicrobial agents | Gene expression | Bactericidal activity | Immune systems | In vivo methods and tests | Cytoplasm | Viral infections | Aquaculture | Index Medicus | Deoxyribonucleic acid
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2017, Volume 127, Issue 12, pp. 4415 - 4420
Primary immunodeficiencies are often monogenic disorders characterized by vulnerability to specific infectious pathogens. Here, we performed whole-exome... 
MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNITY | ACTIVATOR | INTERFERON-GAMMA | MYCOBACTERIAL DISEASE | ALPHA/BETA | MENDELIAN SUSCEPTIBILITY | CLINICAL-FEATURES | DEFICIENCY | SIGNAL TRANSDUCER | INBORN-ERRORS | Bacteremia - immunology | Genetic Diseases, Inborn - microbiology | STAT2 Transcription Factor - immunology | Humans | Genetic Diseases, Inborn - genetics | Genetic Diseases, Inborn - virology | Male | Cytomegalovirus Infections - immunology | Cytomegalovirus Infections - genetics | Bacteremia - microbiology | Streptococcal Infections - genetics | Phosphorylation - genetics | Female | Phosphorylation - immunology | Receptor, Interferon alpha-beta - genetics | Fibroblasts - microbiology | Mycobacterium Infections, Nontuberculous - immunology | Immunologic Deficiency Syndromes - immunology | Receptors, Interferon - genetics | Fibroblasts - virology | Genetic Diseases, Inborn - immunology | Viremia - genetics | Viridans Streptococci - immunology | Bacteremia - genetics | Immunologic Deficiency Syndromes - virology | STAT1 Transcription Factor - genetics | Immunologic Deficiency Syndromes - microbiology | STAT1 Transcription Factor - immunology | Cytomegalovirus - immunology | Mycobacterium abscessus - immunology | Receptor, Interferon alpha-beta - immunology | Receptors, Interferon - immunology | Viremia - virology | STAT2 Transcription Factor - genetics | Immunologic Deficiency Syndromes - genetics | Fibroblasts - immunology | Viremia - immunology | Streptococcal Infections - immunology | Mutation | Mycobacterium Infections, Nontuberculous - genetics | Virus diseases | Usage | Immunotherapy | Genetic aspects | Disease susceptibility | Research | Mutation (Biology) | Stat2 protein | Cytomegalovirus | Phosphorylation | Viremia | Immunodeficiency | Stop codon | C-Terminus | Gene deletion | Bacteremia | Nuclear transport | α-Interferon | Clonal deletion | Fibroblasts | Interferon | Codons | Stat1 protein | Viral infections | Index Medicus | Abridged Index Medicus
Journal Article
Fish and Shellfish Immunology, ISSN 1050-4648, 11/2016, Volume 58, pp. 309 - 317
Mucosal immune system is one of the most important components in the innate immunity and constitutes the front line of host defense against infection,... 
Scophthalmus maximus | TLR9 | Vibrio anguillarum | TLR8 | Streptococcus iniae | Mucosal tissues | JAPANESE FLOUNDER | CARP | RECOGNITION | SIGNATURES | RNA | IMMUNOLOGY | FISHERIES | MARINE & FRESHWATER BIOLOGY | FISH | VETERINARY SCIENCES | MOLECULAR-CLONING | INNATE IMMUNITY | DNA, Complementary - genetics | Immunity, Innate - genetics | Streptococcal Infections - veterinary | Toll-Like Receptor 9 - genetics | Gene Expression Profiling | Flatfishes - genetics | Phylogeny | Vibrio Infections - immunology | RNA, Messenger - metabolism | Streptococcal Infections - genetics | Fish Proteins - genetics | Vibrio Infections - genetics | Vibrio Infections - microbiology | Fish Diseases - immunology | Vibrio - physiology | Toll-Like Receptor 9 - chemistry | Vibrio Infections - veterinary | Flatfishes - classification | Amino Acid Sequence | Streptococcal Infections - microbiology | Toll-Like Receptor 8 - chemistry | Fish Diseases - microbiology | Fish Proteins - chemistry | RNA, Messenger - genetics | Flatfishes - immunology | Gene Expression Regulation | Fish Proteins - metabolism | Streptococcus iniae - physiology | Fish Diseases - genetics | Sequence Homology, Amino Acid | Animals | Mucous Membrane - immunology | Toll-Like Receptor 8 - genetics | Streptococcal Infections - immunology | Toll-Like Receptor 9 - metabolism | DNA, Complementary - metabolism | Toll-Like Receptor 8 - metabolism | Bacterial infections | Cladistic analysis | Analysis | Fishes | Genes | Genetic research | Amino acids | Skin | Liver | Marine sciences | Index Medicus
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2015, Volume 125, Issue 6, pp. 2473 - 2483
Bacterial meningitis is a serious infection of the CNS that results when blood-borne bacteria are able to cross the blood-brain barrier (BBB). Group B... 
EPITHELIAL-MESENCHYMAL TRANSITION | TRANSCRIPTION FACTORS | MEDICINE, RESEARCH & EXPERIMENTAL | ESCHERICHIA-COLI K1 | TIGHT JUNCTION COMPONENTS | LIPOTEICHOIC ACID | DOWN-REGULATION | MICROVASCULAR ENDOTHELIAL-CELLS | GROUP-B STREPTOCOCCUS | NEUTROPHIL SIGNALING PATHWAYS | AGALACTIAE INFECTION | Tight Junctions - genetics | Humans | Claudin-5 - metabolism | Streptococcal Infections - metabolism | Blood-Brain Barrier - microbiology | MAP Kinase Signaling System | Streptococcal Infections - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Streptococcal Infections - pathology | Zonula Occludens-1 Protein - metabolism | Streptococcus agalactiae | Snail Family Transcription Factors | Tight Junctions - metabolism | Zonula Occludens-1 Protein - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Gene Expression Regulation - genetics | Zebrafish Proteins - metabolism | Cells, Cultured | Claudin-5 - genetics | Transcription Factors - genetics | Zebrafish - genetics | Blood-Brain Barrier - metabolism | Transcription Factors - metabolism | Blood-Brain Barrier - pathology | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Zebrafish - metabolism | Zebrafish Proteins - genetics | Tight Junctions - pathology | Mitogen-Activated Protein Kinase 1 - metabolism | Proteins | Data analysis | Bacterial infections | Blood-brain barrier | Rodents | Cloning | Laboratory animals | Gene expression | Experiments | Endothelium | Streptococcus infections | Index Medicus | Abridged Index Medicus | Microbiology | Infectious disease | Vascular Biology
Journal Article
Infection and Immunity, ISSN 0019-9567, 03/2014, Volume 82, Issue 3, pp. 1192 - 1204
Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
CARBON CATABOLITE REPRESSION | INFECTIOUS DISEASES | ESSENTIAL GENES | CCPA-MEDIATED REPRESSION | VIRULENCE FACTORS | BACILLUS-SUBTILIS | IN-VIVO | CYSTEINE PROTEASE SPEB | PYOGENES | STAPHYLOCOCCUS-AUREUS | IMMUNOLOGY | EXPRESSION | Soft Tissue Infections - immunology | Virulence Factors - genetics | Genes, Bacterial - genetics | Streptococcal Infections - metabolism | Staphylococcal Skin Infections - metabolism | Virulence Factors - immunology | Phosphoenolpyruvate Sugar Phosphotransferase System - immunology | Mutation - immunology | Exotoxins - metabolism | Streptococcal Infections - genetics | Streptococcus pyogenes - genetics | Genes, Bacterial - immunology | Soft Tissue Infections - genetics | Virulence - genetics | Staphylococcal Skin Infections - immunology | Female | Bacterial Proteins - immunology | Phosphoenolpyruvate Sugar Phosphotransferase System - genetics | Streptococcal Infections - microbiology | Streptolysins - metabolism | Streptococcus pyogenes - immunology | Exotoxins - immunology | Bacterial Proteins - genetics | Streptococcus pyogenes - metabolism | Carbohydrates - immunology | Mutation - genetics | Soft Tissue Infections - metabolism | Animals | Soft Tissue Infections - microbiology | Streptolysins - genetics | Virulence - immunology | Exotoxins - genetics | Phosphoenolpyruvate Sugar Phosphotransferase System - metabolism | Bacterial Proteins - metabolism | Virulence Factors - metabolism | Mice | Streptococcal Infections - immunology | Streptolysins - immunology | Staphylococcal Skin Infections - microbiology | Staphylococcal Skin Infections - genetics | Index Medicus | Molecular Pathogenesis
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 09/2015, Volume 125, Issue 9, pp. 3545 - 3559
Journal Article
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 12/2012, Volume 209, Issue 13, pp. 2367 - 2381
Several of the most significant bacterial pathogens in humans, including Streptococcus pyogenes, express surface proteins that bind IgG antibodies via their... 
NONIMMUNE BINDING | MEDICINE, RESEARCH & EXPERIMENTAL | M1 PROTEIN | FC-RECEPTOR | ESCHERICHIA-COLI | PYOGENES | IMMUNOLOGY | STREPTOCOCCAL-M-PROTEIN | CYSTEINE PROTEINASE | IMMUNOGLOBULIN-G | FIBRINOGEN | IGG FC | Immunoglobulin G - blood | Immunoglobulin Fc Fragments - metabolism | Humans | Molecular Sequence Data | Fasciitis, Necrotizing - genetics | Fasciitis, Necrotizing - immunology | Immunoglobulin G - classification | Shock, Septic - immunology | Antigens, Bacterial - genetics | Microscopy, Immunoelectron | Complement System Proteins - metabolism | Streptococcal Infections - genetics | Streptococcus pyogenes - genetics | Streptococcus pyogenes - pathogenicity | Branchial Region - microbiology | Immunoglobulin Fab Fragments - metabolism | Antibodies, Bacterial - genetics | Adult | Female | Streptococcus pyogenes - ultrastructure | Antibodies, Bacterial - metabolism | Neutrophils - microbiology | Antibodies, Bacterial - blood | Bacterial Outer Membrane Proteins - genetics | Shock, Septic - genetics | Amino Acid Sequence | Streptococcal Infections - microbiology | Streptococcus pyogenes - immunology | Neutrophils - immunology | Antibodies, Bacterial - classification | Shock, Septic - microbiology | Sequence Homology, Amino Acid | Carrier Proteins - genetics | Carrier Proteins - metabolism | Immunoglobulin G - genetics | Bacterial Outer Membrane Proteins - metabolism | Fasciitis, Necrotizing - microbiology | Branchial Region - immunology | Cell Membrane - immunology | Streptococcal Infections - immunology | Antigens, Bacterial - metabolism | Phagocytosis | Immunoglobulin G - metabolism | Index Medicus | Infectious Medicine | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Infektionsmedicin
Journal Article