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1. Full Text Crystal Structure of streptococcus pyogenes Sortase A: Implications for sortase mechanism
by Race, Paul R and Bentley, Matthew L and Melvin, Jeff A and Crow, Allister and Hughes, Richard K and Smith, Wendy D and Sessions, Richard B and Kehoe, Michael A and McCafferty, Dewey G and Banfield, Mark J
Journal of Biological Chemistry, ISSN 0021-9258, 03/2009, Volume 284, Issue 11, pp. 6924 - 6933
Sortases are a family of Gram-positive bacterial transpeptidases that anchor secreted proteins to bacterial cell surfaces. These include many proteins that... 
LISTERIA-MONOCYTOGENES | SORTING SIGNAL BINDING | IN-VITRO | SUBSTRATE-SPECIFICITY | CELL-WALL | TRANSPEPTIDASE-SRTA | ACTIVE-SITE | BIOCHEMISTRY & MOLECULAR BIOLOGY | STAPHYLOCOCCUS-AUREUS SORTASE | SURFACE-PROTEINS | IMIDAZOLIUM ION-PAIR | Aminoacyltransferases - antagonists & inhibitors | Cysteine Endopeptidases - chemistry | Protein Structure, Tertiary | Aminoacyltransferases - chemistry | Bacterial Proteins - antagonists & inhibitors | Oxidation-Reduction | Sulfenic Acids - chemistry | Streptococcus pyogenes - enzymology | Bacterial Proteins - chemistry | Crystallography, X-Ray | Kinetics | Catalytic Domain - physiology | Enzyme Catalysis and Regulation
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2. Full Text Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA
by Nishimasu, Hiroshi and Ran, F. Ann and Hsu, Patrick D and Konermann, Silvana and Shehata, Soraya I and Dohmae, Naoshi and Ishitani, Ryuichiro and Zhang, Feng and Nureki, Osamu
Cell, ISSN 0092-8674, 02/2014, Volume 156, Issue 5, pp. 935 - 949
The CRISPR-associated endonuclease Cas9 can be targeted to specific genomic loci by single guide RNAs (sgRNAs). Here, we report the crystal structure of Cas9... 
CRISPR/CAS SYSTEM | ADAPTIVE IMMUNITY | RUVC RESOLVASE | SPECIFICITY | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | TRANSCRIPTION | BACTERIAL IMMUNE-SYSTEM | HOLLIDAY JUNCTION | ONE-STEP GENERATION | CELL BIOLOGY | Protein Structure, Tertiary | Amino Acid Sequence | CRISPR-Associated Proteins - chemistry | DNA, Bacterial - metabolism | RNA, Guide - metabolism | Models, Molecular | Molecular Sequence Data | Crystallography, X-Ray | DNA, Bacterial - chemistry | Streptococcus pyogenes - metabolism | Endonucleases - metabolism | Endonucleases - chemistry | Sequence Alignment | RNA, Guide - chemistry | CRISPR-Associated Proteins - metabolism | RNA, Bacterial - chemistry | Streptococcus pyogenes - enzymology | Bacteria - enzymology | RNA, Bacterial - metabolism | Streptococcus pyogenes - chemistry | Genetic research | RNA | Structure | Genomics | DNA | Crystals
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3. Full Text Homologous role of CovRS two‐component regulatory system in NAD+‐glycohydrolase activity in Streptococcus dysgalactiae subsp. equisimilis as in Streptococcus pyogenes
by Hasegawa, Tadao and Matsumoto, Masakado and Hata, Nanako and Yano, Hisako and Isaka, Masanori and Tatsuno, Ichiro
APMIS, ISSN 0903-4641, 02/2019, Volume 127, Issue 2, pp. 87 - 92
Streptococcal toxic shock syndrome (STSS) is primarily caused by Streptococcus pyogenes , but it may also be caused by Streptococcus dysgalactiae subsp.... 
Streptococcus dysgalactiae | Nga | streptococcal toxic shock syndrome | covRS | subsp | equisimilis | Streptococcus dysgalactiae subsp. equisimilis | STRAINS | INFECTIONS | MICROBIOLOGY | IMMUNOLOGY | PATHOLOGY | VIRULENCE | Streptococcus dysgalactiae subsp | GROUP-A STREPTOCOCCUS | GENE | TOXIC-SHOCK-SYNDROME | GROUP-C | Shock, Septic - pathology | NAD+ Nucleosidase - metabolism | Humans | Bacterial Proteins - genetics | Repressor Proteins - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Streptococcus pyogenes - metabolism | Shock, Septic - microbiology | Streptococcus pyogenes - genetics | Streptococcus pyogenes - isolation & purification | Streptococcus pyogenes - enzymology | Bacterial Proteins - metabolism | Streptococcal Infections - pathology | Intracellular Signaling Peptides and Proteins - genetics | Repressor Proteins - metabolism | Septic shock | Analysis | NAD | Pathogens | Streptococcus | Homology | Toxic shock syndrome | Streptococcal toxic shock syndrome | Gene sequencing | Index Medicus
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4. Full Text Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity
by Ran, F. Ann and Hsu, Patrick D and Lin, Chie-Yu and Gootenberg, Jonathan S and Konermann, Silvana and Trevino, Alexandro E and Scott, David A and Inoue, Azusa and Matoba, Shogo and Zhang, Feng and Zhang, Yi
Cell, ISSN 0092-8674, 09/2013, Volume 154, Issue 6, pp. 1380 - 1389
Targeted genome editing technologies have enabled a broad range of research and medical applications. The Cas9 nuclease from the microbial CRISPR-Cas system is... 
SYSTEM | CELLS | BACTERIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENERATION | KNOCKOUT | NUCLEASE | CELL BIOLOGY | Streptococcus pyogenes - genetics | Gene Targeting - methods | Animals | RNA, Guide - genetics | Base Sequence | Streptococcus pyogenes - enzymology | Zygote - metabolism | Molecular Sequence Data | Mice | Genome | DNA Breaks, Double-Stranded | RNA | Genomics | Index Medicus
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5. Full Text Development and Applications of CRISPR-Cas9 for Genome Engineering
by Hsu, Patrick D and Lander, Eric S and Zhang, Feng
Cell, ISSN 0092-8674, 06/2014, Volume 157, Issue 6, pp. 1262 - 1278
Recent advances in genome engineering technologies based on the CRISPR-associated RNA-guided endonuclease Cas9 are enabling the systematic interrogation of... 
TRANSCRIPTION FACTORS | STREPTOCOCCUS-THERMOPHILUS | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RNA-GUIDED ENDONUCLEASE | DOUBLE-STRAND BREAKS | CAS SYSTEMS | HOMOLOGOUS RECOMBINATION | ZINC-FINGER NUCLEASES | SACCHAROMYCES-CEREVISIAE | ONE-STEP GENERATION | CELL BIOLOGY | Gene Targeting | Humans | Eukaryotic Cells - metabolism | Bacteria - genetics | Streptococcus pyogenes - genetics | Bacteria - immunology | Animals | Genetic Engineering | Streptococcus pyogenes - enzymology | CRISPR-Cas Systems | Bacteria - classification | Genome | Bacteria - virology | Animal genetics | Nucleases | RNA | Genomics | Genetic research | Genomes | Nucleotide sequencing | DNA sequencing
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6. Full Text Multigene editing in the Escherichia coli genome via the CRISPR-Cas9 system
by Jiang, Yu and Chen, Biao and Duan, Chunlan and Sun, Bingbing and Yang, Junjie and Yang, Sheng
Applied and Environmental Microbiology, ISSN 0099-2240, 2015, Volume 81, Issue 7, pp. 2506 - 2514
An efficient genome-scale editing tool is required for construction of industrially useful microbes. We describe a targeted, continual multigene editing... 
RECOMBINATION | GENE REPLACEMENT | RNA | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | AMINO-ACIDS | GROUP-II INTRONS | MICROBIOLOGY | MICROBIAL-PRODUCTION | CAS SYSTEMS | PINK DISEASE | SYNTHETIC BIOLOGY | EXPRESSION | Streptococcus pyogenes - genetics | Genes, Bacterial | Enterobacteriaceae - enzymology | Genome, Bacterial | Recombination, Genetic | Streptococcus pyogenes - enzymology | CRISPR-Cas Systems | Enterobacteriaceae - genetics | Genetics, Microbial - methods | Molecular Biology - methods | Methods
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7. Full Text Cas9 specifies functional viral targets during CRISPR-Cas adaptation
by Heler, Robert and Samai, Poulami and Modell, Joshua W and Weiner, Catherine and Goldberg, Gregory W and Bikard, David and Marraffini, Luciano A
Nature, ISSN 0028-0836, 03/2015, Volume 519, Issue 7542, pp. 199 - 202
Clustered regularly interspaced short palindromic repeat (CRISPR) loci and their associated (Cas) proteins provide adaptive immunity against viral infection in... 
SYSTEM | STREPTOCOCCUS-THERMOPHILUS | ENDONUCLEASE | STRUCTURAL BASIS | DUAL-RNA | DNA | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | NUCLEOTIDE-SEQUENCE | ADAPTIVE BACTERIAL IMMUNITY | SPACER ACQUISITION | Protein Structure, Tertiary | CRISPR-Cas Systems - immunology | Streptococcus pyogenes - immunology | DNA, Viral - metabolism | Molecular Sequence Data | Substrate Specificity | Streptococcus pyogenes - virology | Streptococcus pyogenes - genetics | DNA, Viral - immunology | Nucleotide Motifs | Base Sequence | CRISPR-Associated Proteins - metabolism | Streptococcus pyogenes - enzymology | Protein Binding | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | Clustered Regularly Interspaced Short Palindromic Repeats - immunology | DNA, Viral - genetics | Staphylococcus aureus | Virus diseases | Enzymes | RNA | Prokaryotes | Genetic aspects | Host-virus relationships | Health aspects | Bacteria | Genomes | Bacteriology | Viral infections | Deoxyribonucleic acid--DNA
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8. Full Text Evolved Cas9 variants with broad PAM compatibility and high DNA specificity
by Hu, Johnny H and Miller, Shannon M and Geurts, Maarten H and Tang, Weixin and Chen, Liwei and Sun, Ning and Zeina, Christina M and Gao, Xue and Rees, Holly A and Lin, Zhi and Liu, David R
Nature, ISSN 0028-0836, 04/2018, Volume 556, Issue 7699, pp. 57 - 63
A key limitation of the use of the CRISPR-Cas9 system for genome editing and other applications is the requirement that a protospacer adjacent motif (PAM) be... 
SYSTEM | CONTINUOUS DIRECTED EVOLUTION | ENDONUCLEASE | RECOGNITION | CRISPR-CAS9 NUCLEASES | MULTIDISCIPLINARY SCIENCES | OFF-TARGET CLEAVAGE | TRANSCRIPTION | CPF1 | GENOMIC DNA | BASE | CRISPR-Associated Proteins - genetics | Humans | Transcriptional Activation | Directed Molecular Evolution | DNA - metabolism | Substrate Specificity - genetics | CRISPR-Cas Systems - genetics | Deoxyribonucleases - metabolism | Genome, Human - genetics | DNA - genetics | Streptococcus pyogenes - genetics | Nucleotide Motifs | CRISPR-Associated Proteins - metabolism | Streptococcus pyogenes - enzymology | HEK293 Cells | Gene Editing - methods | Mutation | DNA Cleavage | Genetic variation | Streptococcus pyogenes | Genetic aspects | Nucleotide sequencing | Observations | Methods | DNA sequencing | CRISPR | Phages | Biological evolution | Cloning | Adenine | Editing | Cell division | Genomes | Research | RNA polymerase | Mammals | Gene expression | Experiments | Mammalian cells | Proteins | Design | Gene disruption | Transcription activation | Evolution | Nuclease | Compatibility | Deoxyribonucleic acid--DNA
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9. Full Text Multiplex Genome Engineering Using CRISPR/Cas Systems
by Le Cong and F. Ann Ran and David Cox and Shuailiang Lin and Robert Barretto and Naomi Habib and Patrick D. Hsu and Xuebing Wu and Wenyan Jiang and Luciano A. Marraffini and Feng Zhang
Science, ISSN 0036-8075, 2/2013, Volume 339, Issue 6121, pp. 819 - 823
Functional elucidation of causal genetic variants and elements requires precise genome editing technologies. The type II prokaryotic CRISPR (clustered... 
REPORTS | STREPTOCOCCUS-THERMOPHILUS | DEFENSE | BACTERIA | IMMUNE-SYSTEM | SMALL RNAS | ENDONUCLEASE | TAL EFFECTORS | DNA | MULTIDISCIPLINARY SCIENCES | CAS SYSTEMS | NUCLEASES | Genetic Engineering - methods | Inverted Repeat Sequences - genetics | Microarray Analysis - methods | Recombinational DNA Repair | Humans | Genome - genetics | Molecular Sequence Data | Genetic Loci | RNA - chemistry | RNA - genetics | DNA - genetics | Streptococcus pyogenes - genetics | DNA - chemistry | Animals | Mutagenesis | Base Sequence | Streptococcus pyogenes - enzymology | CRISPR-Cas Systems | Mice | DNA Cleavage | Nucleases | Genomics | Genetic engineering | Genetic aspects | Research | Properties | Immune system | Deoxyribonucleic acid--DNA | Index Medicus
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