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Journal Article
American journal of respiratory and critical care medicine, ISSN 1073-449X, 2014, Volume 190, Issue 5, pp. 522 - 532
Journal Article
PLoS Pathogens, ISSN 1553-7366, 11/2010, Volume 6, Issue 11, p. e1001191
Pneumolysin (PLY) is a key Streptococcus pneumoniae virulence factor and potential candidate for inclusion in pneumococcal subunit vaccines. Dendritic cells... 
HUMAN NEUTROPHILS | DENDRITIC CELLS | PNEUMOCOCCAL INFECTION | MICROBIOLOGY | NALP3 INFLAMMASOME | TOLL-LIKE RECEPTOR-4 | VIROLOGY | IL-17-PRODUCING T-CELLS | HOST-DEFENSE | PORE-FORMING TOXINS | STREPTOCOCCUS-PNEUMONIAE INFECTION | CASPASE-1 ACTIVATION | PARASITOLOGY | Lung - microbiology | Pneumococcal Infections - metabolism | Bone Marrow - immunology | Spleen - immunology | NLR Family, Pyrin Domain-Containing 3 Protein | Dendritic Cells - immunology | Spleen - microbiology | Streptococcus pneumoniae - immunology | Pneumococcal Infections - immunology | Flow Cytometry | Streptococcus pneumoniae - pathogenicity | Bone Marrow - metabolism | Inflammation Mediators - metabolism | Killer Cells, Natural - immunology | Female | Pneumococcal Infections - microbiology | Lung - metabolism | Dendritic Cells - metabolism | Killer Cells, Natural - microbiology | Enzyme-Linked Immunosorbent Assay | Lymphocyte Activation | Streptolysins - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Cytokines - secretion | Toll-Like Receptor 4 - metabolism | Mice, Inbred C3H | Bacterial Proteins - pharmacology | Animals | Carrier Proteins - metabolism | Spleen - metabolism | Dendritic Cells - microbiology | Mice | Mice, Inbred BALB C | Killer Cells, Natural - metabolism | Bone Marrow - microbiology | Lung - immunology | Adoptive transfer | Pneumonia | Vaccines | Cytokines | Kinases | Immune system
Journal Article
Scientific Reports, ISSN 2045-2322, 02/2016, Volume 6, Issue 1, p. 20609
The involvement of pathogenic bacteria in obstructive sleep apnoea syndrome (OSAS) has yet to be elucidated. We investigated the possible role of group A... 
IN-VITRO | CYSTEINYL LEUKOTRIENE RECEPTORS | STREPTOLYSIN-O | MULTIDISCIPLINARY SCIENCES | MAST-CELLS | LIPOPOLYSACCHARIDE | STAPHYLOCOCCUS-AUREUS | PROLIFERATION | IDENTIFICATION | RECURRENT TONSILLITIS | CHILDREN | Leukocytes, Mononuclear - metabolism | Neutrophils - cytology | DNA, Bacterial - metabolism | Humans | Child, Preschool | Infant | Male | Adaptor Proteins, Vesicular Transport - metabolism | Palatine Tonsil - surgery | Case-Control Studies | Streptococcus pyogenes - genetics | Palatine Tonsil - microbiology | Female | Cysteine - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Odds Ratio | Child | Real-Time Polymerase Chain Reaction | B-Lymphocytes - metabolism | Streptococcal Infections - microbiology | B-Lymphocytes - cytology | Streptolysins - metabolism | CD4-Positive T-Lymphocytes - cytology | Bacterial Proteins - genetics | CD4-Positive T-Lymphocytes - metabolism | Neutrophils - immunology | Streptococcus pyogenes - metabolism | Toll-Like Receptor 4 - metabolism | Leukotrienes - metabolism | Palatine Tonsil - pathology | Sleep Apnea, Obstructive - etiology | Streptococcus pyogenes - isolation & purification | DNA, Bacterial - genetics | Streptolysins - genetics | Adolescent | Bacterial Proteins - metabolism | Leukocytes, Mononuclear - cytology | Cell Proliferation - drug effects | Streptococcal Infections - complications | Myeloid Differentiation Factor 88 - metabolism | Microscopy, Fluorescence | CD27 antigen | Cell proliferation | CD19 antigen | Tonsil | Hyperplasia | MAP kinase | Leukocytes (mononuclear) | Sleep apnea | TLR4 protein | CD4 antigen | Sleep disorders | Cell activation | Sleep | Apnea | Lymphocytes B | Leukotrienes | CD38 antigen | Toll-like receptors | MyD88 protein | Interferon
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 04/2010, Volume 223, Issue 1, pp. 215 - 223
Extracellular β‐NAD is known to elevate intracellular levels of calcium ions, inositol 1,4,5‐trisphate and cAMP. Recently, β‐NAD was identified as an agonist... 
ACTIVATION | PHYSIOLOGY | PERMEABILITY | ENHANCEMENT | RHO GTPASES | ACUTE LUNG INJURY | HUMAN GRANULOCYTES | GROWTH-FACTOR | RAC1 | PNEUMOLYSIN | RESPIRATORY-DISTRESS-SYNDROME | CELL BIOLOGY | Phosphorylation | Cadherins - metabolism | Humans | Actins - metabolism | Capillary Permeability - drug effects | Receptors, Purinergic P2Y1 | RNA, Messenger - metabolism | Antigens, CD - metabolism | RNA Interference | Time Factors | Guanine Nucleotide Exchange Factors - metabolism | Myosin-Light-Chain Phosphatase - metabolism | NAD - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Guanine Nucleotide Exchange Factors - genetics | Signal Transduction | Streptolysins - pharmacology | Cells, Cultured | Intercellular Junctions - metabolism | Electric Impedance | Pulmonary Artery - drug effects | Pulmonary Artery - enzymology | Pulmonary Artery - cytology | Bacterial Proteins - pharmacology | Receptors, Purinergic P2 - metabolism | Lipopolysaccharides - pharmacology | Cytoskeleton - metabolism | Myosin Light Chains - metabolism | Thrombin - metabolism | Endothelial Cells - enzymology | Cytoskeleton - drug effects | rac1 GTP-Binding Protein - metabolism | Endothelial Cells - drug effects | rac1 GTP-Binding Protein - genetics | Gq protein | EPAC1 | P2Y antagonists | P2Y1 and P2Y11 receptors | Gs protein | Rac1 | cAMP | HPAEC
Journal Article
Journal Article
Cell, ISSN 0092-8674, 05/2018, Volume 173, Issue 5, pp. 1083 - 1097.e22
The nervous system, the immune system, and microbial pathogens interact closely at barrier tissues. Here, we find that a bacterial pathogen, , hijacks pain and... 
nociceptor | neuroimmune | pain | infection | streptococcus pyogenes | neuroimmunology | streptolysin | neutrophil | botulinum neurotoxin | CGRP | HYALURONIC-ACID CAPSULE | CUTANEOUS IMMUNITY | NECROTIZING FASCIITIS | GROUP-A STREPTOCOCCUS | BIOCHEMISTRY & MOLECULAR BIOLOGY | AIRWAY INFLAMMATION | STREPTOLYSIN-S | M-PROTEIN | VIRULENCE | SENSORY NEURONS | PEPTIDE | CELL BIOLOGY | Skin - metabolism | Humans | Streptococcal Infections - veterinary | Male | Neurons - cytology | Botulinum Toxins, Type A - administration & dosage | Fasciitis, Necrotizing - pathology | TRPV Cation Channels - deficiency | Fasciitis, Necrotizing - veterinary | Streptococcus pyogenes - pathogenicity | Pain - etiology | Female | Streptococcal Infections - pathology | Bacterial Proteins - immunology | Neurons - metabolism | Calcitonin Gene-Related Peptide - metabolism | Neurons - drug effects | Fasciitis, Necrotizing - etiology | Neutrophils - metabolism | Skin - pathology | Diterpenes - pharmacology | Streptolysins - metabolism | Signal Transduction | Mice, Inbred C57BL | Neutrophils - immunology | Streptococcus pyogenes - metabolism | TRPV Cation Channels - genetics | Mice, Knockout | Animals | Caspase 1 - genetics | Caspase 1 - deficiency | Bacterial Proteins - metabolism | Mice | Streptococcal Infections - complications | Streptolysins - immunology | Bacterial infections | Immune response | Microbiology | Neurons | Health aspects
Journal Article
Journal of Immunology, ISSN 0022-1767, 11/2009, Volume 183, Issue 9, pp. 5823 - 5829
Macrophages play a crucial role in the innate immune response against the human pathogen Streptococcus pyogenes, yet the innate immune response against the... 
GROUP-A-STREPTOCOCCUS | PATTERN-RECOGNITION | INTERLEUKIN-1-BETA | INFECTION | SECRETION | IMMUNOLOGY | CASPASE-1 ACTIVATION | ATP | IPAF | NALP3 INFLAMMASOME | INNATE IMMUNITY | NLR Family, Pyrin Domain-Containing 3 Protein | Streptococcal Infections - metabolism | Protein Precursors - secretion | Caspase 1 - metabolism | Multiprotein Complexes - genetics | NF-kappa B - metabolism | Streptococcal Infections - mortality | Streptococcus pyogenes - genetics | Multiprotein Complexes - metabolism | Signal Transduction - immunology | Streptolysins - physiology | Macrophages - secretion | Peritonitis - microbiology | Streptolysins - deficiency | Receptors, Purinergic P2 - genetics | Inflammation Mediators - metabolism | Toll-Like Receptors - physiology | Interleukin-1beta - biosynthesis | Inflammation Mediators - physiology | Macrophages - immunology | Disease Models, Animal | Carrier Proteins - physiology | Interleukin-1beta - secretion | Streptolysins - metabolism | Macrophages - pathology | Streptococcus pyogenes - immunology | Mice, Inbred C57BL | Cells, Cultured | Receptors, Purinergic P2 - physiology | Signal Transduction - genetics | Peritonitis - immunology | Bacterial Proteins - physiology | Peritonitis - mortality | Mice, Knockout | Multiprotein Complexes - physiology | Receptors, Purinergic P2X7 | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Protein Precursors - biosynthesis | NF-kappa B - physiology | Survival Analysis | Bacterial Proteins - metabolism | Mice | Streptococcal Infections - immunology | Receptors, Purinergic P2 - deficiency
Journal Article
Cellular Microbiology, ISSN 1462-5814, 05/2007, Volume 9, Issue 5, pp. 1343 - 1351
Journal Article
Biochemistry, ISSN 0006-2960, 04/2007, Volume 46, Issue 14, pp. 4425 - 4437
Listeriolysin O (LLO) is the most important virulence factor of the intracellular pathogen Listeria monocytogenes. Its main task is to enable escape of... 
PREPORE COMPLEX | BACTERIAL TOXIN PNEUMOLYSIN | STREPTOLYSIN-O | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-MEMBRANE INTERACTIONS | FORMING TOXIN | MONOCYTOGENES INFECTION | SURFACE-PLASMON RESONANCE | LIPID MONOLAYERS | CHOLESTEROL-DEPENDENT CYTOLYSIN | PERFRINGOLYSIN-O | Surface Plasmon Resonance | Sterols - metabolism | Fluoresceins - metabolism | Humans | Cell Membrane Permeability | Fluorescent Dyes - metabolism | Hemolysin Proteins - chemistry | Phosphatidylcholines - metabolism | Erythrocyte Membrane - physiology | Cell Membrane - chemistry | Cholesterol - chemistry | Dose-Response Relationship, Drug | Listeria monocytogenes - metabolism | Cell Membrane - metabolism | Molecular Structure | Dimerization | Cell Membrane - drug effects | Sterols - chemistry | Heat-Shock Proteins - metabolism | Erythrocyte Membrane - metabolism | Virulence Factors - chemistry | Phosphatidylcholines - chemistry | Cholesterol - metabolism | Bacterial Toxins - chemistry | Bacterial Toxins - metabolism | Liposomes - chemistry | Hemagglutinins - chemistry | Cholesterol - pharmacology | Protein Binding | Liposomes - metabolism | Virulence Factors - metabolism | Membrane Microdomains - physiology | Porosity | Hemolysin Proteins - metabolism | Heat-Shock Proteins - chemistry | Hydrogen-Ion Concentration | Measurement | Usage | Sterols | Listeria monocytogenes | Chemical properties | Research | Hydrogen-ion concentration
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2015, Volume 10, Issue 4, p. e0125191
Plasmodium falciparum invades human red blood cells, residing in a parasitophorous vacuole (PV), with a parasitophorous vacuole membrane (PVM) separating the... 
ADP-RIBOSYLATION FACTOR | ARF PROTEINS | STREPTOLYSIN-O | MEMBRANE | MULTIDISCIPLINARY SCIENCES | EXPORT | RED-BLOOD-CELLS | INFECTED ERYTHROCYTES | HOST ERYTHROCYTE | GOLGI-COMPLEX | MAURERS CLEFTS | Green Fluorescent Proteins - metabolism | Parasites - physiology | Protein Sorting Signals - physiology | Humans | Protein Transport - physiology | Amino Acid Motifs - physiology | Malaria, Falciparum - parasitology | Secretory Pathway - physiology | Animals | Protozoan Proteins - metabolism | Parasites - metabolism | Adenylate Kinase - metabolism | Vacuoles - metabolism | ADP-Ribosylation Factor 1 - metabolism | Golgi Apparatus - metabolism | Plasmodium falciparum - metabolism | Cell Membrane - metabolism | Cysteine - metabolism | Lysine - metabolism | Plasmodium falciparum - physiology | Erythrocytes - parasitology | Fluorescence | Plasmodium falciparum | Cysteine | Malaria | ADP-ribosylation factor | Residues | Palmitoylation | Erythrocytes | Amino acids | Genomes | Biochemistry | Parasites | Kinases | ADP | Blood | Myristoylation | Parasitophorous vacuole | Proteins | ADP-ribosylation factor 1 | Red blood cells | Photovoltaic cells | Ribosylation | Fusion protein | Localization | ADP-ribosylation | Vector-borne diseases | Translocation | Solar cells | Parasitology | Secretion | Blood cells | Interdisciplinary aspects | Fatty acids | Exports | Golgi apparatus | Adenylate kinase | Microscopy | Lysine | N-Terminus | Green fluorescent protein | Molecular biology | Cytoplasm
Journal Article