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The New England Journal of Medicine, ISSN 0028-4793, 06/2012, Volume 366, Issue 23, pp. 2189 - 2197
Journal Article
Scientific Reports, ISSN 2045-2322, 07/2015, Volume 5, Issue 1, pp. 12633 - 12633
The anti-inflammatory cytokine IL-35 is produced by regulatory T (Treg) cells to suppress autoimmune and inflammatory responses. The role of IL-35 in type 1... 
B-CELLS | AUTOIMMUNE | NEUROPILIN-1 | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION FACTOR FOXP3 | IN-VIVO | HELPER-CELLS | INDUCED ARTHRITIS | TNF-ALPHA | IL-35 | EXPRESSION | Leukocytes, Mononuclear - metabolism | T-Lymphocytes, Regulatory - metabolism | Minor Histocompatibility Antigens | Humans | Diabetes Mellitus, Type 1 - metabolism | Interleukin-10 - blood | Male | Recombinant Proteins - biosynthesis | Interleukins - metabolism | T-Lymphocytes, Regulatory - immunology | Recombinant Proteins - isolation & purification | Interleukins - genetics | Diabetes Mellitus, Experimental - prevention & control | Flow Cytometry | Forkhead Transcription Factors - metabolism | T-Lymphocytes, Helper-Inducer - immunology | T-Lymphocytes, Helper-Inducer - cytology | T-Lymphocytes, Regulatory - cytology | Diabetes Mellitus, Experimental - chemically induced | Receptors, Cytokine - metabolism | Thymus Gland - metabolism | Disease Models, Animal | Interleukin-2 - metabolism | Hyperglycemia - prevention & control | T-Lymphocytes, Helper-Inducer - metabolism | Cytokines - metabolism | Enzyme-Linked Immunosorbent Assay | Interleukins - blood | Diabetes Mellitus, Type 1 - pathology | Transforming Growth Factor beta - blood | Recombinant Proteins - administration & dosage | Diabetes Mellitus, Experimental - immunology | Phenotype | Animals | Interleukins - administration & dosage | Spleen - metabolism | Diabetes Mellitus, Type 1 - blood | Leukocytes, Mononuclear - cytology | Mice, Inbred NOD | Mice | Streptozocin - toxicity | Immunoregulation | Streptozocin | Diabetes mellitus | T cell receptors | Lymphocytes T | Inflammation | Interleukin 17 | Hyperglycemia | Interleukin 2 | Rodents | Interleukin 10 | Interferon | Diabetes | Autoimmune diseases | Index Medicus | Biological Sciences | Naturvetenskap | Natural Sciences | Cellbiologi | Biologiska vetenskaper | Cell Biology
Journal Article
Journal Article
Psychopharmacology, ISSN 0033-3158, 06/2017, Volume 234, Issue 11, pp. 1781 - 1794
Rationale We have reported that levetiracetam, a novel anticonvulsant with analgesic properties, synergizes with ibuprofen/aspirin/paracetamol in a model of... 
Antioxidants | Duloxetine | Diabetic painful neuropathy | Synergism | Gabapentinoids | Levetiracetam | CONTROLLED-TRIAL | MECHANICAL ALLODYNIA | OXIDATIVE STRESS | PSYCHIATRY | CONDUCTION-VELOCITY | ALPHA-LIPOIC ACID | NEUROSCIENCES | NERVE-CONDUCTION | CALCIUM-CHANNELS | PERIPHERAL NEUROPATHY | PHARMACOLOGY & PHARMACY | INFLAMMATORY PAIN | MOLECULAR-MECHANISMS | Diabetic Neuropathies - blood | Pregabalin - administration & dosage | Diabetes Mellitus, Experimental - drug therapy | Mice, Inbred C57BL | Analgesics - administration & dosage | Cyclohexanecarboxylic Acids - administration & dosage | Anticonvulsants - administration & dosage | Male | gamma-Aminobutyric Acid - administration & dosage | Diabetic Neuropathies - drug therapy | Diabetes Mellitus, Experimental - blood | Dose-Response Relationship, Drug | Drug Synergism | Animals | Piracetam - analogs & derivatives | Antioxidants - administration & dosage | Diabetic Neuropathies - pathology | Amines - administration & dosage | Diabetes Mellitus, Experimental - pathology | Duloxetine Hydrochloride - administration & dosage | Piracetam - administration & dosage | Mice | Disease Models, Animal | Diabetic neuropathies | Models | Research | Analgesics | Health aspects | Drugs | Medical research | Lipoic acid | Aspirin | Pain perception | Gabapentin | Streptozocin | Diabetes mellitus | Oral administration | Clinical trials | Neuropathy | Etiracetam | Paracetamol | Anticonvulsants | Acids | Coenzyme Q10 | Ibuprofen | Diabetes | Drug dosages | Index Medicus
Journal Article
Diabetes, ISSN 0012-1797, 06/2019, Volume 68, Issue Supplement 1, p. 1807
Central leptin administration in streptozotocin-induced diabetic rats leads to normalization of blood glucose concentrations, independent of insulin. In... 
Epinephrine | Fasting | Streptozocin | Diabetes mellitus | Liver | Cyclic AMP | Glucose | Injection | Cyclic AMP response element-binding protein | Insulin | Blood levels | Hypotheses | Leptin | Rodents | Diabetes | Gluconeogenesis
Journal Article
Journal Article
Plant Foods for Human Nutrition, ISSN 0921-9668, 9/2014, Volume 69, Issue 3, pp. 241 - 247
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2018, Volume 13, Issue 10, pp. e0204841 - e0204841
antinociceptive effects of the carbon monoxide-releasing molecule tricarbonyldichloror-uthenium (II) dimer (CORM-2) during chronic pain are well documented,... 
NADPH OXIDASE | OXIDATIVE STRESS | PAIN | CARBON-MONOXIDE | REVERSE CHOLESTEROL TRANSPORT | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | MONOXIDE-RELEASING MOLECULE | EXPRESSION | MOUSE MODELS | HIGH-DENSITY-LIPOPROTEIN | Diabetes Mellitus, Experimental - drug therapy | Diabetic Neuropathies - prevention & control | Drug Administration Schedule | Hyperalgesia - metabolism | Streptozocin | Cholesterol - blood | Lipoproteins, LDL - analysis | Hyperalgesia - prevention & control | Cholesterol - metabolism | Animals | Dyslipidemias - metabolism | Diabetes Mellitus, Experimental - complications | Mice | Oxidative Stress - drug effects | Diabetes Mellitus, Experimental - metabolism | Diabetic Neuropathies - metabolism | Organometallic Compounds - pharmacology | Organometallic Compounds - administration & dosage | Complications and side effects | Diabetic neuropathies | Control | Dyslipidemias | Type 1 diabetes | Diagnosis | Risk factors | Blood cholesterol | Low density lipoproteins | Analysis | Diabetes therapy | Lipoproteins (low density) | Oxidative stress | Spinal cord | Liver | Trafficking | Dyslipidemia | Diabetic neuropathy | Diabetes mellitus (insulin dependent) | Neuropathy | Macrophages | Density | Neuromodulation | Hyperglycemia | Pain | Rodents | Oxidation | Feces | Carbon monoxide | Lipoproteins (high density) | Pain perception | Hypersensitivity | Diabetes mellitus | Inflammation | Metabolism | Cholesterol | Organic chemistry | Side effects | Lipoproteins | Insulin resistance | In vivo methods and tests | Plasma levels | Dimers | Diabetes | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2012, Volume 7, Issue 9, pp. e46196 - e46196
Cerebral aging is often associated with the occurrence of neurodegenerative diseases leading to dementia. Animal models are critical to elucidate mechanisms... 
ADULT-RAT BRAIN | INSULIN | OXIDATIVE STRESS | INDUCED EXPERIMENTAL DEMENTIA | INJECTION | MULTIDISCIPLINARY SCIENCES | ALZHEIMER-LIKE CHANGES | MEMORY IMPAIRMENT | DISEASE | INDUCED MODEL | GROWTH-FACTOR EXPRESSION | Dementia - pathology | Rats, Wistar | Injections, Intraventricular | Rats | Male | Streptozocin - administration & dosage | Brain - drug effects | Brain - metabolism | Magnetic Resonance Imaging | Dementia - metabolism | Animals | Dementia - chemically induced | Brain - pathology | Streptozocin - toxicity | Oxidative Stress - drug effects | Disease Models, Animal | Injections | Usage | Dosage and administration | Brain research | Streptozocin | Immunohistochemistry | Neuroimaging | Drugs | Brain | Oxidative stress | Neuroprotection | Animal models | Nuclear magnetic resonance--NMR | Pathogenesis | Memory | Glucose | Drug development | Glucose metabolism | Signal transduction | Neurotoxicity | Rodents | Dementia disorders | Aging | Lesions | Alzheimer's disease | Drug dosages | Neurodegenerative diseases | Abnormalities | Septum | Inflammation | Metabolism | Insulin | Corpus callosum | Neurological diseases | Gliosis | Magnetic resonance imaging | Insulin resistance | Transduction | Intracerebroventricular administration | Laboratory animals | Alzheimers disease | Dementia | Index Medicus | Nuclear magnetic resonance | NMR
Journal Article
Journal Article
Molecular Neurobiology, ISSN 0893-7648, 10/2017, Volume 54, Issue 8, pp. 6507 - 6522
Alzheimer’s disease (AD) is associated with reduced insulin level and impairment of insulin receptor (IR) signaling in the brain, which correlates to amyloid... 
Neurology | post synaptic neurotoxicity | Neurosciences | Glial activation | Biomedicine | Neurobiology | Insulin receptor dysfunction | Amyloidogenic protein expression | Intranasal insulin | Cell Biology | OXIDATIVE STRESS | ALZHEIMERS-DISEASE | IMPROVES MEMORY | FACTOR-KAPPA-B | DEPENDENT PATHWAY | KINASE-B | BLOOD-BRAIN-BARRIER | NEUROSCIENCES | A-BETA | CENTRAL-NERVOUS-SYSTEM | DEGRADING ENZYME | Microglia - metabolism | Streptozocin | Memory Disorders - metabolism | Male | NF-kappa B - metabolism | Hippocampus - drug effects | Insulin Receptor Substrate Proteins - metabolism | Cerebral Cortex - metabolism | Inflammation - metabolism | Hypoglycemic Agents - administration & dosage | Inflammation - drug therapy | Amyloid beta-Peptides - metabolism | Cerebral Cortex - drug effects | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Hypoglycemic Agents - therapeutic use | Astrocytes - drug effects | Peptide Fragments - metabolism | Cytokines - metabolism | Microglia - drug effects | Rats | Insulin - administration & dosage | Down-Regulation - drug effects | Glycogen Synthase Kinase 3 - metabolism | Administration, Intranasal | Glycogen Synthase Kinase 3 beta - metabolism | Hippocampus - metabolism | Amyloid Precursor Protein Secretases - metabolism | Animals | Memory Disorders - drug therapy | Spatial Memory - drug effects | Signal Transduction - drug effects | Aspartic Acid Endopeptidases - metabolism | Receptor, Insulin - metabolism | Insulin - therapeutic use | Astrocytes - metabolism | Proteins | Medical research | Memory | Medicine, Experimental | Amyloidosis | Alzheimer's disease | Insulin | Amyloidogenesis | Neuroprotection | Brain | Cerebral cortex | Mental disorders | Medical services | Impairment | Activation | Neuronal-glial interactions | Inflammatory diseases | Neurotoxicity | Cell activation | Rodents | Amyloid | Drug therapy | Translocation | b-Site APP cleaving enzyme 1 | Neurodegenerative diseases | Neurons | Glial fibrillary acidic protein | Cortex | Caspase | Inflammation | Hypoglycemia | Pathology | Tumor necrosis factor | Interleukin 10 | Cyclooxygenase-2 | b-Site APP cleaving enzyme | Alzheimers disease | Index Medicus
Journal Article