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Journal Article
Cell, ISSN 0092-8674, 05/2018, Volume 173, Issue 4, pp. 958 - 971.e17
Defects in nucleocytoplasmic transport have been identified as a key pathogenic event in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)... 
ALS | nucleocytoplasmic transport | C9ORF72 | stress granule | NUCLEAR IMPORT | PHASE-SEPARATION | RNA | DIPEPTIDE-REPEAT PROTEINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | AMYOTROPHIC-LATERAL-SCLEROSIS | FRONTOTEMPORAL LOBAR DEGENERATION | HEXANUCLEOTIDE REPEAT | GGGGCC REPEAT | CELL BIOLOGY | C9orf72 Protein - genetics | alpha Karyopherins - metabolism | beta Karyopherins - genetics | alpha Karyopherins - antagonists & inhibitors | ran GTP-Binding Protein - genetics | Membrane Glycoproteins - metabolism | Active Transport, Cell Nucleus - physiology | DNA Repeat Expansion - genetics | Humans | Middle Aged | Male | beta Karyopherins - antagonists & inhibitors | Ataxin-2 - genetics | Frontotemporal Dementia - metabolism | RNA Interference | Arsenites - toxicity | Ataxin-2 - metabolism | HEK293 Cells | Female | C9orf72 Protein - metabolism | Frontotemporal Dementia - pathology | Nuclear Pore Complex Proteins - metabolism | ran GTP-Binding Protein - metabolism | Amyotrophic Lateral Sclerosis - pathology | ran GTP-Binding Protein - antagonists & inhibitors | Sodium Compounds - toxicity | Active Transport, Cell Nucleus - drug effects | Amyotrophic Lateral Sclerosis - metabolism | alpha Karyopherins - genetics | Aged | Oxidative Stress - drug effects | beta Karyopherins - metabolism | Ataxin-2 - antagonists & inhibitors | RNA, Small Interfering - metabolism | Proteins | Medical colleges | Nervous system diseases | Neurosciences | Research institutes | Molecular biology | Dementia | Index Medicus
Journal Article
Journal Article
Journal Article
eLife, ISSN 2050-084X, 09/2016, Volume 5
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 2014, Volume 34, Issue 24, pp. 8083 - 8097
Journal Article