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American journal of physiology. Heart and circulatory physiology, ISSN 0363-6135, 11/2013, Volume 305, Issue 10, pp. H1440 - H1450
Xanthine oxidase (XO) is increased in human and rat left ventricular (LV) myocytes with volume overload (VO... 
Heart failure | Xanthine oxidase | Mitochondria | Volume overload | Cardiac & Cardiovascular Systems | Physiology | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Sarcoplasmic Reticulum - drug effects | Heart Failure - enzymology | Heart Failure - physiopathology | Systole - drug effects | Heart Ventricles - diagnostic imaging | Sarcoplasmic Reticulum - enzymology | Myocytes, Cardiac - enzymology | Time Factors | Adenosine Triphosphate - metabolism | Heart Ventricles - enzymology | Ultrasonography | Diastole - drug effects | Heart Failure - etiology | Xanthine Oxidase - antagonists & inhibitors | Disease Models, Animal | Xanthine Oxidase - metabolism | Ventricular Function, Left - drug effects | Enzyme Inhibitors - pharmacology | Ventricular Pressure - drug effects | Rats | Stroke Volume - drug effects | Cardiotonic Agents - pharmacology | Rats, Sprague-Dawley | Heart Failure - drug therapy | Animals | Myocytes, Cardiac - drug effects | Heart Ventricles - physiopathology | Calcium Signaling - drug effects | Oxygen Consumption - drug effects | Creatine Kinase - metabolism | Allopurinol - pharmacology | Hemodynamics - drug effects | Energy Metabolism - drug effects | Heart Ventricles - drug effects | Oxidases | Physiological aspects | Xanthine | Health aspects | Heart ventricle, Left | Cardiomyocytes | Ultrasonic imaging | Hospitalization | Rodents | Adenosine triphosphatase | Index Medicus | Call for Papers | volume overload | heart failure | xanthine oxidase | mitochondria
Journal Article
American journal of physiology. Heart and circulatory physiology, ISSN 1522-1539, 02/2009, Volume 296, Issue 2, pp. H404 - H412
.... In the present study, we hypothesize that Ac-SDKP prevents Gal-3-induced cardiac inflammation, remodeling, and dysfunction, and these effects are mediated by the transforming growth factor (TGF)-β... 
N-acetyl-seryl-aspartyl-lysyl-proline | Inflammation | Cardiac dysfunction | Fibrosis | Cardiac & Cardiovascular Systems | Physiology | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Inflammation - chemically induced | Phosphorylation | Body Weight - drug effects | Myocardial Contraction - drug effects | Male | Smad3 Protein - metabolism | Heart Rate - drug effects | Inflammation - metabolism | Time Factors | Myocardium - metabolism | Echocardiography, Doppler | Anti-Inflammatory Agents - administration & dosage | Blood Pressure - drug effects | Disease Models, Animal | Macrophages - pathology | Oligopeptides - blood | Anti-Inflammatory Agents - pharmacology | Cardiac Output - drug effects | Ventricular Function, Left - drug effects | Cardiomegaly - physiopathology | Infusions, Parenteral | Rats | Stroke Volume - drug effects | Myocardium - pathology | Cardiotonic Agents - pharmacology | Mast Cells - drug effects | Rats, Sprague-Dawley | Anti-Inflammatory Agents - blood | Collagen - metabolism | Animals | Cardiomegaly - prevention & control | Cardiotonic Agents - administration & dosage | Signal Transduction - drug effects | Cardiotonic Agents - blood | Isoproterenol - pharmacology | Mast Cells - pathology | Cardiomegaly - chemically induced | Galectin 3 | Macrophages - drug effects | Hemodynamics - drug effects | Inflammation - prevention & control | Oligopeptides - administration & dosage | Oligopeptides - pharmacology | Transforming Growth Factor beta - metabolism | Ventricular Remodeling - drug effects | Cardiomegaly - metabolism | Inflammation - physiopathology | Hypertension | Heart | Heart failure | Cystic fibrosis | Peptides | Rodents | Index Medicus | cardiac dysfunction | fibrosis | inflammation
Journal Article
The New England journal of medicine, ISSN 1533-4406, 11/2019, Volume 381, Issue 21, pp. 1995 - 2008
In this randomized, placebo-controlled trial, investigators evaluated the effects of the sodium... 
NEPRILYSIN INHIBITION | OUTCOMES | COTRANSPORTER 2 INHIBITORS | MECHANISM | EMPAGLIFLOZIN | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Glycated Hemoglobin A - analysis | Humans | Middle Aged | Ventricular Dysfunction, Left - complications | Male | Benzhydryl Compounds - adverse effects | Cardiovascular Diseases - mortality | Female | Glucosides - therapeutic use | Drug Therapy, Combination | Benzhydryl Compounds - therapeutic use | Diabetes Mellitus, Type 2 - complications | Glucosides - adverse effects | Heart Failure - complications | Sodium-Glucose Transporter 2 Inhibitors - therapeutic use | Sodium-Glucose Transporter 2 Inhibitors - adverse effects | Kaplan-Meier Estimate | Stroke Volume - drug effects | Combined Modality Therapy | Hospitalization | Heart Failure - drug therapy | Cardiovascular Agents - therapeutic use | Diabetes Mellitus, Type 2 - blood | Ventricular Dysfunction, Left - drug therapy | Aged | Diabetes Mellitus, Type 2 - drug therapy | Type 2 diabetes | Measurement | Heart failure | Dapagliflozin | Patient outcomes | Physiological aspects | Cardiac output | Drug therapy | Testing | Intravenous administration | Renal function | Clinical trials | Hypoglycemia | Evidence-based medicine | Clinical outcomes | Sodium | Hemoglobin | Patient safety | Diabetes | Diabetes mellitus (non-insulin dependent) | Heart diseases | Drug dosages | Ejection fraction | Index Medicus | Abridged Index Medicus | Kardiologi | Clinical Medicine | Cardiac and Cardiovascular Systems | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
Journal Article
Journal Article
Circulation (New York, N.Y.), ISSN 1524-4539, 10/2003, Volume 108, Issue 17, pp. 2066 - 2069
...) inhibitor, is an effective and selective pulmonary vasodilator in PAH. However, the long-term effects of PD-5 inhibition and its mechanism of action in human pulmonary arteries (PAs) are unknown... 
Potassium | Hypertension, pulmonary | Sildenafil | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Large-Conductance Calcium-Activated Potassium Channels | Piperazines - administration & dosage | Phosphoric Diester Hydrolases - biosynthesis | Liver - enzymology | Vasodilator Agents - therapeutic use | Cyclic Nucleotide Phosphodiesterases, Type 5 | Humans | Middle Aged | Hypertension, Pulmonary - physiopathology | Piperazines - economics | Male | Time | Sildenafil Citrate | Purines | Liver - drug effects | Exercise Test - drug effects | Vascular Resistance - drug effects | Adult | Female | Hypertension, Pulmonary - drug therapy | Vasodilator Agents - economics | Sulfones | Muscle, Smooth, Vascular - drug effects | Administration, Oral | Cell Separation | Phosphoric Diester Hydrolases - drug effects | Stroke Volume - drug effects | Treatment Outcome | Piperazines - therapeutic use | Pulmonary Artery - physiopathology | Pulmonary Artery - drug effects | Piperazines - adverse effects | Patch-Clamp Techniques | Pilot Projects | Heart Ventricles - physiopathology | Potassium Channels, Calcium-Activated - drug effects | 3',5'-Cyclic-GMP Phosphodiesterases | Creatinine - analysis | Hemodynamics - drug effects | Vasodilator Agents - adverse effects | In Vitro Techniques | Muscle, Smooth, Vascular - enzymology | Vasodilator Agents - administration & dosage | Heart Ventricles - drug effects | Index Medicus | Abridged Index Medicus
Journal Article
The New England journal of medicine, ISSN 1533-4406, 04/2013, Volume 368, Issue 15, pp. 1408 - 1416
A dose-intense infusional chemotherapy program plus rituximab had a high degree of efficacy in patients with primary mediastinal B-cell lymphoma, which is... 
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Cyclophosphamide - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Follow-Up Studies | Humans | Middle Aged | Antibodies, Monoclonal, Murine-Derived - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Cyclophosphamide - adverse effects | Filgrastim | Dose-Response Relationship, Drug | Young Adult | Vincristine - administration & dosage | Adult | Female | Retrospective Studies | Doxorubicin - administration & dosage | Prednisone - administration & dosage | Etoposide - adverse effects | Lymphoma, Large B-Cell, Diffuse - drug therapy | Prednisone - adverse effects | Kaplan-Meier Estimate | Rituximab | Stroke Volume - drug effects | Etoposide - administration & dosage | Recombinant Proteins - administration & dosage | Disease-Free Survival | Vincristine - adverse effects | Aged | Antibodies, Monoclonal, Murine-Derived - adverse effects | Doxorubicin - adverse effects | Granulocyte Colony-Stimulating Factor - administration & dosage | Drugs | Dose-response relationship (Biochemistry) | Usage | Cyclophosphamide | Patient outcomes | Dosage and administration | Lymphomas | Product/Service Evaluations | Drug therapy, Combination | Drug therapy | Doxorubicin | Medical research | Nuclear magnetic resonance--NMR | Disease | Review boards | Genes | Etoposide | Prednisone | Radiation therapy | Kinases | Vincristine | Patients | Morbidity | Chemotherapy | Lymphocytes B | Remission | Mutation | Hodgkin's disease | B-cell lymphoma | Index Medicus | Abridged Index Medicus
Journal Article
Circulation (New York, N.Y.), ISSN 1524-4539, 05/2019, Volume 139, Issue 22, pp. 2528 - 2536
Journal Article
Journal Article