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Cell Stem Cell, ISSN 1934-5909, 01/2015, Volume 16, Issue 1, pp. 51 - 66
Mesenchymal stem cells (MSCs) reside in the perivascular niche of many organs, including kidney, lung, liver, and heart, although their roles in these tissues... 
REGULATOR | ORIGIN | SONIC HEDGEHOG | PATHWAY | BONE-MARROW NICHE | MYOFIBROBLASTS | NG2 PROTEOGLYCAN | EXPRESSION | MESENCHYMAL STEM-CELLS | GROWTH FACTOR-AA | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Organ Specificity - drug effects | Diphtheria Toxin - pharmacology | Neovascularization, Physiologic - drug effects | Pericytes - drug effects | Blood Vessels - metabolism | Blood Vessels - pathology | Humans | Fibrosis - metabolism | Cell Lineage - drug effects | Myofibroblasts - metabolism | Mesenchymal Stromal Cells - cytology | Mesenchymal Stromal Cells - ultrastructure | Kruppel-Like Transcription Factors - metabolism | Pericytes - pathology | Bone Marrow Cells - drug effects | Colony-Forming Units Assay | Aorta - physiopathology | Homeostasis - drug effects | Heart Ventricles - pathology | Receptor, Platelet-Derived Growth Factor beta - metabolism | Mesenchymal Stromal Cells - drug effects | Endothelial Cells - metabolism | Aorta - drug effects | Pericytes - metabolism | Cells, Cultured | Proteoglycans - metabolism | Antigens - metabolism | Aorta - pathology | Myofibroblasts - cytology | Animals | Heart Ventricles - physiopathology | Cell Differentiation - drug effects | Endothelial Cells - cytology | Blood Vessels - drug effects | Mice | Stem Cell Niche - drug effects | Zinc Finger Protein GLI1 | Fibrosis - pathology | Bone Marrow Cells - metabolism | Endothelial Cells - drug effects | Heart Ventricles - drug effects | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 08/2010, Volume 466, Issue 7308, pp. 829 - 834
The cellular constituents forming the haematopoietic stem cell (HSC) niche in the bone marrow are unclear, with studies implicating osteoblasts, endothelial... 
PROGENITOR CELLS | OSTEOBLAST | OSTEOPONTIN | MICROENVIRONMENT | MULTIDISCIPLINARY SCIENCES | SELF-RENEWAL | RECEPTOR | DIFFERENTIATION | NEURAL CREST | COOPERATION | EXPRESSION | Chondrocytes - cytology | Nestin | Multipotent Stem Cells - metabolism | Parathyroid Hormone - pharmacology | Cell Lineage - drug effects | Chondrocytes - drug effects | Mesenchymal Stromal Cells - cytology | Multipotent Stem Cells - drug effects | Sympathetic Nervous System - physiology | Cell Division | Stromal Cells - drug effects | Osteoblasts - cytology | Hematopoietic Stem Cells - drug effects | Mesenchymal Stromal Cells - drug effects | Gene Expression Regulation - genetics | Osteoblasts - drug effects | Stromal Cells - metabolism | Cells, Cultured | Mesenchymal Stromal Cells - metabolism | Mice, Transgenic | Hematopoietic Stem Cells - metabolism | Stem Cell Niche - cytology | Nerve Tissue Proteins - metabolism | Granulocyte Colony-Stimulating Factor - pharmacology | Animals | Chemokine CXCL12 - metabolism | Cell Differentiation - drug effects | Multipotent Stem Cells - cytology | Hematopoietic Stem Cells - cytology | Stem Cell Niche - metabolism | Mice | Stem Cell Niche - drug effects | Osteoblasts - metabolism | Intermediate Filament Proteins - metabolism | Mesenchymal Stem Cell Transplantation | Stromal Cells - cytology | Cell Movement | Physiological aspects | Genetic aspects | Research | Bone marrow cells | Gene expression | Osteoblasts | Hematopoietic stem cells | Studies | Proteins | Bone marrow | Rodents | Stem cells | Index Medicus
Journal Article
Biomaterials, ISSN 0142-9612, 2011, Volume 33, Issue 9, pp. 2629 - 2641
Abstract Micro/nanotopographical modification of biomaterials constitutes a promising approach to direct stem cell osteogenic differentiation to promote... 
Advanced Basic Science | Dentistry | Osteogenic differentiation | Hierarchical topography | Cell spread | Mesenchymal stem cells | Titania nanotubes | MATERIALS SCIENCE, BIOMATERIALS | TIO2 NANOTUBES | ENGINEERING, BIOMEDICAL | PROLIFERATION | FATE | ADHESION | IN-VIVO | GROWTH | GENE-EXPRESSION | ALTERED NANOTUBE DIMENSION | LINEAGE | SURFACES | Mesenchymal Stromal Cells - enzymology | Titanium - pharmacology | Bone Marrow Cells - enzymology | Cell Count | Alkaline Phosphatase - metabolism | Titanium - chemistry | Extracellular Matrix - metabolism | Sincalide - metabolism | Nanotubes - chemistry | Cell Differentiation - genetics | Mesenchymal Stromal Cells - cytology | Mesenchymal Stromal Cells - ultrastructure | Bone Marrow Cells - drug effects | Osteogenesis - genetics | Nanotubes - ultrastructure | Mesenchymal Stromal Cells - drug effects | Calcification, Physiologic - drug effects | Bone Marrow Cells - cytology | Extracellular Matrix - drug effects | Osteogenesis - drug effects | Rats | Cell Adhesion - drug effects | Collagen - secretion | Rats, Sprague-Dawley | Bone Marrow Cells - ultrastructure | Cell Shape - drug effects | Gene Expression Regulation - drug effects | Animals | Cell Differentiation - drug effects | Staining and Labeling | Cell Proliferation - drug effects | Cell Cycle - drug effects | Biological products | Phosphatases | Analysis | Collagen | Genes | Stem cells | Fluorescence | Gene expression | Orthodontics | Index Medicus
Journal Article
Stem Cells, ISSN 1066-5099, 03/2010, Volume 28, Issue 3, pp. 564 - 572
Human mesenchymal stem cells (hMSCs) are multipotent cells that can differentiate into many cell types. Chondrogenesis is induced in hMSCs cultured as a... 
Cell shape | Rac1 | Chondrogenesis | Smooth muscle cells | N-cadherin | Mesenchymal stem cells | MYOBLAST FUSION | CELL & TISSUE ENGINEERING | CELL BIOLOGY | ADHESION | ONCOLOGY | MESENCHYMAL PROGENITOR CELLS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENE-EXPRESSION | CYTOSKELETAL TENSION | DIFFERENTIATION | RHO-GTPASES | PROTEINS | HEMATOLOGY | MODULATION | MAMMARY EPITHELIAL-CELLS | Chondrocytes - cytology | Chondrogenesis - drug effects | Cadherins - metabolism | Humans | Extracellular Matrix - metabolism | Antigens, CD - genetics | Cell Lineage - drug effects | Transforming Growth Factor beta3 - metabolism | Antigens, CD - metabolism | Cell Differentiation - genetics | Chondrocytes - drug effects | Mesenchymal Stromal Cells - cytology | Cadherins - genetics | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - cytology | Myocytes, Smooth Muscle - metabolism | Chondrocytes - metabolism | Transforming Growth Factor beta3 - pharmacology | Mesenchymal Stromal Cells - drug effects | Cell Adhesion - genetics | Muscle Development - physiology | Cells, Cultured | Gene Expression Regulation - physiology | Mesenchymal Stromal Cells - metabolism | Up-Regulation - genetics | Antigens, CD - drug effects | Cadherins - drug effects | Cell Adhesion - drug effects | Cell Lineage - physiology | Cell Shape - drug effects | Gene Expression Regulation - drug effects | Up-Regulation - drug effects | Chondrogenesis - physiology | Muscle Development - drug effects | rac1 GTP-Binding Protein - drug effects | Cell Differentiation - drug effects | Cell Shape - physiology | rac1 GTP-Binding Protein - metabolism | rac1 GTP-Binding Protein - genetics | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 03/2016, Volume 7, Issue 1, pp. 11150 - 11150
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2015, Volume 112, Issue 40, pp. 12516 - 12521
Human pluripotent stem cell-based in vitro models that reflect human physiology have the potential to reduce the number of drug failures in clinical trials and... 
Organoid | Toxicology | Differentiation | Tissue engineering | Machine learning | toxicology | tissue engineering | DEVELOPMENTAL NEUROTOXICITY | differentiation | MULTIDISCIPLINARY SCIENCES | INVOLVEMENT | CLASSIFICATION | NEURODEGENERATION | machine learning | CANCER | organoid | IN-VITRO | MICROGLIA | GENE-EXPRESSION | SYSTEMS | BRAIN | Embryonic Stem Cells - metabolism | Microglia - metabolism | Embryonic Stem Cells - cytology | Humans | Brain - growth & development | Support Vector Machine | Neural Stem Cells - cytology | Xenobiotics - pharmacology | Brain - metabolism | Neurogenesis - genetics | Mesenchymal Stromal Cells - cytology | Xenobiotics - classification | Gene Expression Regulation, Developmental | Cell Differentiation | Neurogenesis - drug effects | Culture Media, Serum-Free - pharmacology | Gene Ontology | Polyethylene Glycols - pharmacology | Microglia - cytology | Mesenchymal Stromal Cells - drug effects | Brain - cytology | Pluripotent Stem Cells - cytology | Tissue Engineering - methods | Microglia - drug effects | Endothelial Cells - metabolism | Cells, Cultured | Neural Stem Cells - drug effects | Mesenchymal Stromal Cells - metabolism | Cell Communication - genetics | Macrophages - cytology | Pluripotent Stem Cells - metabolism | Macrophages - metabolism | Embryonic Stem Cells - drug effects | Endothelial Cells - cytology | Models, Biological | Pluripotent Stem Cells - drug effects | Cell Communication - drug effects | Macrophages - drug effects | Hydrogels - pharmacology | Neural Stem Cells - metabolism | Endothelial Cells - drug effects | Neurotoxicity | Stem cells | Gene expression | Biological assays | Bioinformatics | Artificial intelligence | Index Medicus | Biological Sciences
Journal Article
Biomaterials, ISSN 0142-9612, 2011, Volume 33, Issue 10, pp. 2848 - 2857
Abstract Adult bone marrow derived mesenchymal stem cells are undifferentiated, multipotential cells and have the potential to differentiate into multiple... 
Advanced Basic Science | Dentistry | Cartilage | Silk fibroin | Chitosan | Tissue engineering | Mesenchymal stem cells | PORE-SIZE | MATERIALS SCIENCE, BIOMATERIALS | BOVINE ARTICULAR CHONDROCYTES | ENGINEERING, BIOMEDICAL | REGENERATION | CHITOSAN SCAFFOLDS | MESENCHYMAL STEM-CELLS | TISSUE ENGINEERING APPLICATIONS | 3D SCAFFOLDS | BIOMATERIALS | STROMAL CELLS | Chondrogenesis - drug effects | Rats, Wistar | Male | Cartilage - drug effects | Tissue Scaffolds - chemistry | Mesenchymal Stromal Cells - cytology | Flow Cytometry | Mesenchymal Stromal Cells - ultrastructure | Stromal Cells - drug effects | Chitosan - pharmacology | Bone Marrow Cells - drug effects | Extracellular Matrix Proteins - metabolism | Mesenchymal Stromal Cells - drug effects | Bone Marrow Cells - cytology | Cell Separation | Extracellular Matrix Proteins - genetics | Stromal Cells - metabolism | Cells, Cultured | Fibroins - pharmacology | Mesenchymal Stromal Cells - metabolism | Rats | Cartilage - metabolism | Cell Adhesion - drug effects | Cell Shape - drug effects | Gene Expression Regulation - drug effects | Microscopy, Confocal | Animals | Cell Differentiation - drug effects | Fluorescent Antibody Technique | Cell Proliferation - drug effects | Porosity | Bone Marrow Cells - metabolism | Microscopy, Fluorescence | Stromal Cells - cytology | Silk | Glycosaminoglycans | Biological products | Collagen | Stem cells | Polyelectrolytes | Histochemistry | Index Medicus
Journal Article
Biomaterials, ISSN 0142-9612, 2013, Volume 34, Issue 18, pp. 4404 - 4417
Abstract In bone tissue engineering, a combination of biomimetic nanofibrous scaffolds with renewable stem cells has recently emerged as a new strategy for... 
Advanced Basic Science | Dentistry | Cell proliferation | BMP signaling pathway | Integrin | Nanofibrous hydroxyapatite/chitosan | Cell adhesion | Mesenchymal stem cells | MATRIX | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | NETWORKS | INDUCTION | MESENCHYMAL STEM-CELLS | NANOCOMPOSITES | REPAIR | OSTEOBLASTS | DIFFERENTIATION | PROTEINS | CALVARIAL DEFECTS | Bone Regeneration - genetics | Alkaline Phosphatase - metabolism | Integrins - genetics | Integrins - metabolism | Tissue Scaffolds - chemistry | Extracellular Matrix - genetics | Bone Morphogenetic Proteins - metabolism | Mesenchymal Stromal Cells - cytology | Mesenchymal Stromal Cells - ultrastructure | Skull - pathology | Durapatite - pharmacology | Chitosan - pharmacology | Bone Marrow Cells - drug effects | Female | Bone Morphogenetic Proteins - genetics | Osteogenesis - genetics | Nanofibers - chemistry | Bone Regeneration - drug effects | Mesenchymal Stromal Cells - drug effects | Nanofibers - ultrastructure | Implants, Experimental | Bone Marrow Cells - cytology | Cell Separation | Osteocalcin - metabolism | Extracellular Matrix - drug effects | Osteogenesis - drug effects | Membranes, Artificial | Mesenchymal Stromal Cells - metabolism | Rats | Smad Proteins - genetics | Signal Transduction - genetics | Rats, Sprague-Dawley | Bone Marrow Cells - ultrastructure | Cell Shape - drug effects | Gene Expression Regulation - drug effects | Radiography | Animals | Signal Transduction - drug effects | Skull - diagnostic imaging | Cell Proliferation - drug effects | Smad Proteins - metabolism | Tissue engineering | Collagen | Stem cells | Integrins | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 512, Issue 1, pp. 78 - 81
Myeloproliferative neoplasms (MPNs) are diseases caused by mutations in the haematopoietic stem cell (HSC) compartment. Most MPN patients have a common... 
TYROSINE KINASE JAK2 | JAK2-V617F | ACTIVATING MUTATION | POLYCYTHEMIA-VERA | BONE | MULTIDISCIPLINARY SCIENCES | Neuroprotective Agents - therapeutic use | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Sympathetic Nervous System - drug effects | Humans | Hematopoietic Stem Cells - pathology | Myeloproliferative Disorders - pathology | Sympathetic Nervous System - physiopathology | Adrenergic beta-3 Receptor Agonists - pharmacology | Neuroprotective Agents - pharmacology | Interleukin-1beta - metabolism | Neoplastic Stem Cells - pathology | Female | Sympathetic Nervous System - pathology | Schwann Cells - drug effects | Hematopoietic Stem Cells - drug effects | Nerve Fibers - pathology | Mesenchymal Stromal Cells - drug effects | Stem Cell Niche | Janus Kinase 2 - genetics | Nerve Fibers - drug effects | Schwann Cells - pathology | Myeloproliferative Disorders - drug therapy | Receptors, Adrenergic, beta-3 - metabolism | Disease Progression | Neoplasms - drug therapy | Nestin - metabolism | Adrenergic beta-3 Receptor Agonists - therapeutic use | Animals | Mice | Mesenchymal Stromal Cells - pathology | Neoplasms - pathology | Complications and side effects | Development and progression | Health aspects | Peripheral nerve diseases | Hematopoietic stem cells | Myeloproliferative disorders | Tumors | Studies | Mutation | Kinases | Rodents | Stem cells | Apoptosis | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 2014, Volume 20, Issue 11, pp. 1270 - 1278
Osteogenesis during bone modeling and remodeling is coupled with angiogenesis. A recent study showed that a specific vessel subtype, strongly positive for CD31... 
MIGRATION | MEDICINE, RESEARCH & EXPERIMENTAL | CORTICAL BONE | OSTEOCLASTS | RESORPTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | MESENCHYMAL STEM-CELLS | CELL BIOLOGY | BONE-FORMATION | CATHEPSIN-K | MICE | DIFFERENTIATION | Neovascularization, Physiologic - drug effects | Cell Count | Tartrate-Resistant Acid Phosphatase | Osteoclasts - secretion | Culture Media, Conditioned - pharmacology | Femur - diagnostic imaging | X-Ray Microtomography | Protease Inhibitors - pharmacology | Acid Phosphatase - metabolism | Mesenchymal Stromal Cells - cytology | Isoenzymes - metabolism | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Female | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Cathepsin K - antagonists & inhibitors | Mesenchymal Stromal Cells - drug effects | Ovariectomy | Endothelial Cells - metabolism | Femur - metabolism | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Mice, Inbred C57BL | Osteogenesis - drug effects | Mesenchymal Stromal Cells - metabolism | Femur - drug effects | Cell Movement - drug effects | Animals | Cathepsin K - metabolism | Endothelial Cells - cytology | Proto-Oncogene Proteins c-sis - secretion | Osteoclasts - enzymology | Osteoclasts - drug effects | Endothelial Cells - drug effects | Platelet-derived growth factor | Growth | Analysis | Physiological aspects | Bones | Research | Osteoclasts (Biology) | Homeostasis | Angiogenesis | Cell growth | Blood platelets | Index Medicus
Journal Article