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1. Full Text A Short Formal Total Synthesis of Strychnine with a Samarium Diiodide Induced Cascade Reaction as the Key Step
by Beemelmanns, Christine and Reissig, Hans‐Ulrich
Angewandte Chemie International Edition, ISSN 1433-7851, 10/2010, Volume 49, Issue 43, pp. 8021 - 8025
Brevity is the soul of wit! The power of SmI2‐induced cyclizations has been demonstrated by the shortest formal total synthesis of (±)‐strychnine to date,... 
cascade reactions | indoles | ketyls | strychnine | samarium diiodide | Samarium diiodide | Strychnine | Indoles | Cascade reactions | Ketyls | REDUCTION | SUBSTITUENTS | INDUCED CYCLIZATIONS | (-)-STRYCHNINE | CHEMISTRY, MULTIDISCIPLINARY | (+/-)-STRYCHNINE | ALKALOIDS | Biological Products - chemical synthesis | Biological Products - chemistry | Samarium - chemistry | Strychnine - chemistry | Iodides - chemistry | Iodides - chemical synthesis | Strychnos - chemistry | Strychnine - chemical synthesis
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2. Full Text LC–MS/MS determination and comparative pharmacokinetics of strychnine, brucine and their metabolites in rat plasma after intragastric administration of each monomer and the total alkaloids from Semen Strychni
by Lin, Aihua and Su, Xiaochun and She, Dan and Qiu, Kuncheng and He, Qianmei and Liu, Yiming
Journal of Chromatography B, ISSN 1570-0232, 01/2016, Volume 1008, pp. 65 - 73
A rapid, specific and sensitive liquid chromatography–tandem mass spectrometric (LC–MS/MS) method was developed and validated for the simultaneous... 
Brucine | Strychnine N-oxide | Strychnine | Brucine N-oxide | Pharmacokinetics | Monomer | LC–MS/MS | The total strychnos alkaloids | Rat plasma | LC-MS/MS | CHEMISTRY, ANALYTICAL | BIOCHEMICAL RESEARCH METHODS | MASS-SPECTROMETRY | BLOOD | Animals | Strychnine - pharmacokinetics | Strychnine - blood | Rats | Loganiaceae - chemistry | Chromatography, Liquid - methods | Tandem Mass Spectrometry - methods | Strychnine - administration & dosage | Strychnine - analogs & derivatives | Metabolites | Comparative analysis | Alkaloids | Liquid chromatography | Precipitation (Meteorology) | Mass spectrometry
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3. Full Text Total Synthesis of Strychnine
by Lee, Geun Seok and Namkoong, Gil and Park, Jisook and Chen, David Y.‐K
Chemistry – A European Journal, ISSN 0947-6539, 11/2017, Volume 23, Issue 64, pp. 16189 - 16193
The total synthesis of the flagship Strychnos indole alkaloid, strychnine, has been accomplished. The developed synthetic sequence features a novel vinylogous... 
arylation reactions | natural products | catalysis | strychnine | total synthesis | MICHAEL REACTION | KEY STEP | CONCISE TOTAL-SYNTHESIS | ALPHA-ARYLATION | FORMAL TOTAL-SYNTHESIS | CHEMISTRY, MULTIDISCIPLINARY | (+/-)-STRYCHNINE | WIELAND-GUMLICH ALDEHYDE | ENANTIOSELECTIVE TOTAL-SYNTHESIS | (-)-STRYCHNINE | ALKALOIDS | Stereoisomerism | Strychnine - chemistry | Alkaloids - chemical synthesis | Catalysis | Indoles - chemistry | Palladium - chemistry | Alkaloids - chemistry | Strychnine - chemical synthesis | Substitution reactions | Alkaloids | Palladium | Synthesis | Organic compounds | Salts | Indole | Optical activity | Strychnine | Chemical synthesis
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4. Full Text Collective synthesis of natural products by means of organocascade catalysis
by Jones, Spencer B and Simmons, Bryon and Mastracchio, Anthony and MacMillan, David W. C
Nature, ISSN 0028-0836, 07/2011, Volume 475, Issue 7355, pp. 183 - 188
Organic chemists are now able to synthesize small quantities of almost any known natural product, given sufficient time, resources and effort. However,... 
CASCADE CATALYSIS | OXIDATION | KOPSININE | (+)-ASPIDOSPERMIDINE | MULTIDISCIPLINARY SCIENCES | INDOLE ALKALOIDS | (-)-STRYCHNINE | DERIVATIVES | ASPIDOSPERMA ALKALOIDS | CYCLIZATION | Chemistry, Organic - methods | Strychnine - chemistry | Quinolines - chemistry | Indoles - chemical synthesis | Alkaloids - chemical synthesis | Quinolines - chemical synthesis | Biological Products - chemical synthesis | Biological Products - chemistry | Biomimetics | Cyclization | Indole Alkaloids - chemical synthesis | Catalysis | Indole Alkaloids - chemistry | Indoles - chemistry | Research Design | Alkaloids - chemistry | Strychnine - chemical synthesis | Acids | Collections | Natural products
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5. Full Text Isostrychnine Synthesis Mediated by Hypervalent Iodine Reagent
by Jacquemot, Guillaume and Maertens, Gaëtan and Canesi, Sylvain
Chemistry – A European Journal, ISSN 0947-6539, 05/2015, Volume 21, Issue 21, pp. 7713 - 7715
Althought there are several reported synthetic routes to strychnine, one of the most widely recognized alkaloids, we report an unexplored route with an... 
hypervalent iodine | oxidation | natural products | total synthesis | aromatic ring umpolung | Oxidation | Hypervalent iodine | Natural products | Aromatic ring umpolung | Total synthesis | STRYCHNINE | ASYMMETRIC-SYNTHESIS | OXIDATIVE AMIDATION | FORMAL TOTAL-SYNTHESIS | CHEMISTRY, MULTIDISCIPLINARY | (+/-)-STRYCHNINE | CARBON BOND FORMATION | PHENOL DEAROMATIZATION | ENANTIOSELECTIVE TOTAL-SYNTHESIS | (-)-STRYCHNINE | ALKALOIDS | Iodine - chemistry | Phenol - chemical synthesis | Cyclization | Oxidation-Reduction | Strychnine - chemistry | Phenol - chemistry | Indicators and Reagents - chemistry | Strychnos nux-vomica - chemistry | Isomerism | Strychnine - chemical synthesis | Isomerization | Alkaloids | Synthesis | Cascades | Esters | Strychnine | Transformations | Iodine
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6. Full Text Asymmetric Total Synthesis of (+)-Strychnine
by He, Liping and Wang, Xiaobei and Wu, Xiaoqing and Meng, Zhaoxiang and Peng, Xin and Liu, Xiao-Yu and Qin, Yong
Organic Letters, ISSN 1523-7060, 01/2019, Volume 21, Issue 1, pp. 252 - 255
A synthetic strategy for the catalytic asymmetric total synthesis of (+)-strychnine is disclosed. Key features of this synthesis include an organocatalytic... 
STRYCHNINE | ELECTRON | GEISSOSCHIZINE | PRODUCTS | CHEMISTRY, ORGANIC | FORMAL TOTAL-SYNTHESIS | INDOLE ALKALOID BIOSYNTHESIS | ENANTIOSELECTIVE TOTAL-SYNTHESIS | (-)-STRYCHNINE | (+/-)-STRYCHNINE
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7. Full Text Crystal structure of human glycine receptor-α3 bound to antagonist strychnine
by Huang, Xin and Chen, Hao and Michelsen, Klaus and Schneider, Stephen and Shaffer, Paul L
Nature, ISSN 0028-0836, 10/2015, Volume 526, Issue 7572, pp. 277 - 280
Neurotransmitter-gated ion channels of the Cys-loop receptor family are essential mediators of fast neurotransmission throughout the nervous system and are... 
Strychnine - chemistry | Humans | Models, Molecular | Substrate Specificity | Crystallography, X-Ray | Strychnine - pharmacology | Receptors, Glycine - antagonists & inhibitors | Strychnine - metabolism | Receptors, Glycine - chemistry | Receptors, Glycine - metabolism | Binding Sites | Protein Multimerization - drug effects | Ion Channel Gating - drug effects | Protein Structure, Tertiary - drug effects
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8. Full Text Modified porphyrin-brucine conjugated to gold nanoparticles and their application in photodynamic therapy
by Záruba, Kamil and Králová, Jarmila and ezanka, Pavel and Pou ková, Pavla and Veverková, Lenka and Král, Vladimír
Organic and Biomolecular Chemistry, ISSN 1477-0520, 7/2010, Volume 8, Issue 14, pp. 322 - 326
Two porphyrin-brucine quaternary ammonium salts were immobilized on gold nanoparticles and their suitability for both in vitro and in vivo photodynamic therapy... 
SYSTEM | CELLS | IN-VITRO | PHOTOTHERMAL THERAPY | CANCER-TREATMENT | PHOTOSENSITIZERS | CHEMISTRY, ORGANIC | AGENTS | DERIVATIVES | DELIVERY | Gold - chemistry | Cell Death - radiation effects | Photochemotherapy - methods | Solvents - chemistry | Strychnine - chemistry | Humans | Metal Nanoparticles - chemistry | Porphyrins - chemistry | Strychnine - pharmacology | Alkylation | Strychnine - therapeutic use | Neoplasms - drug therapy | Strychnine - analogs & derivatives | Animals | Strychnine - metabolism | Biological Transport | Intracellular Space - metabolism | Cell Line, Tumor | Mice | Cell Death - drug effects
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9. Full Text Oxime Ethers of (E)‑11-Isonitrosostrychnine as Highly Potent Glycine Receptor Antagonists
by Mohsen, Amal M. Y and Mandour, Yasmine M and Sarukhanyan, Edita and Breitinger, Ulrike and Villmann, Carmen and Banoub, Maha M and Breitinger, Hans-Georg and Dandekar, Thomas and Holzgrabe, Ulrike and Sotriffer, Christoph and Jensen, Anders A and Zlotos, Darius P
Journal of Natural Products, ISSN 0163-3864, 12/2016, Volume 79, Issue 12, pp. 2997 - 3005
A series of (E)-11-isonitrosostrychnine oxime ethers, 2-aminostrychnine, (strychnine-2-yl)­propionamide, 18-oxostrychnine, and N-propylstrychnine bromide were... 
CHEMISTRY, MEDICINAL | CHEMICAL KINETIC TECHNIQUES | STRYCHNINE ANALOGS | SPINAL-CORD | FUNCTIONAL-CHARACTERIZATION | DRUG-LIKE MOLECULES | GENETIC ALGORITHM | PLANT SCIENCES | SCORING FUNCTION | ACETYLCHOLINE-RECEPTORS | HUMAN HYPEREKPLEXIA | PROTEIN-LIGAND DOCKING | PHARMACOLOGY & PHARMACY | Binding, Competitive | Ethers - chemical synthesis | Glycine - metabolism | Strychnine - chemistry | Humans | Molecular Conformation | Crystallography, X-Ray | Ethers - chemistry | Structure-Activity Relationship | Strychnine - pharmacology | Receptors, Glycine - antagonists & inhibitors | Strychnine - analogs & derivatives | Ethers - pharmacology | Oximes - chemistry | Animals | Inhibitory Concentration 50 | Oximes - pharmacology | Ligands | Molecular Structure | Binding Sites | Glycine - analysis | Strychnine - chemical synthesis
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10. Full Text Brucine, an alkaloid from seeds of Strychnos nux-vomica Linn., represses hepatocellular carcinoma cell migration and metastasis: The role of hypoxia inducible factor 1 pathway
by Shu, Guangwen and Mi, Xue and Cai, Jian and Zhang, Xinlin and Yin, Wu and Yang, Xinzhou and Li, You and Chen, Lvyi and Deng, Xukun
Toxicology Letters, ISSN 0378-4274, 10/2013, Volume 222, Issue 2, pp. 91 - 101
Brucine is an alkaloid derived from the seeds of Linn. which have long been used as a traditional medicine for the treatment of hepatocellular carcinoma (HCC)... 
Brucine | Hepatocellular carcinoma | Metastasis | Hypoxia inducible factor 1 | APOPTOSIS | TUMOR | SORAFENIB | CANCER | EPITHELIAL-MESENCHYMAL TRANSITION | IN-VITRO | INVASION | MOUSE MODEL | RECURRENCE | TOXICOLOGY | EXPRESSION | Humans | Male | Neoplasm Proteins - antagonists & inhibitors | Carcinoma, Hepatocellular - secondary | Neoplasm Proteins - metabolism | Strychnos nux-vomica - chemistry | Hypoxia-Inducible Factor 1 - metabolism | Hypoxia-Inducible Factor 1 - genetics | Dose-Response Relationship, Drug | Antineoplastic Agents, Phytogenic - administration & dosage | Carcinoma, Hepatocellular - drug therapy | Lung Neoplasms - secondary | China | Animals, Outbred Strains | Seeds - chemistry | Gene Expression Regulation, Neoplastic - drug effects | Antineoplastic Agents, Phytogenic - therapeutic use | Neoplasm Proteins - genetics | Antineoplastic Agents, Phytogenic - adverse effects | Liver Neoplasms - drug therapy | Strychnine - pharmacology | Random Allocation | Strychnine - administration & dosage | Strychnine - therapeutic use | Strychnine - analogs & derivatives | Xenograft Model Antitumor Assays | Cell Movement - drug effects | Ethnopharmacology | Animals | Strychnine - adverse effects | Lung Neoplasms - prevention & control | Cell Line, Tumor | Mice | Antineoplastic Agents, Phytogenic - pharmacology | Hypoxia-Inducible Factor 1 - antagonists & inhibitors | Index Medicus
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11. Bitter nemesis
: the intimate history of strychnine
by Buckingham, J
2008, ISBN 9781420053159, xix, 298 p., [10] p. of plates
History | Strychnine
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12. Full Text Molecular Complexity and Retrosynthesis
by Proudfoot, John R
The Journal of Organic Chemistry, ISSN 0022-3263, 07/2017, Volume 82, Issue 13, pp. 6968 - 6971
An atom-environment complexity measure, C A, to assess local changes in complexity during synthetic transformations is described. The complexity measure is... 
STRYCHNINE | WIELAND-GUMLICH ALDEHYDE | NATURAL-PRODUCTS | CHEMISTRY, ORGANIC | FORMAL TOTAL-SYNTHESIS | CONVERGENCE | CASCADE | ENANTIOSELECTIVE TOTAL-SYNTHESIS | (-)-STRYCHNINE | (+/-)-STRYCHNINE | ALKALOIDS | Chemical bonds | Usage | Chemical synthesis | Analysis
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13. Full Text Toxicokinetics of strychnine and brucine after the oral administration of Biqi capsule to rats by RRLC–MS/MS
by Zheng, Hao and Wang, Zhe and Liu, Wenwei and Jin, Hongtao and Zhang, Jinlan
Biomedical Chromatography, ISSN 0269-3879, 03/2018, Volume 32, Issue 3, pp. e4117 - n/a
Biqi capsule is a well‐known traditional Chinese medicine formula that has been widely applied for the clinical treatment of such diseases as rheumatoid... 
brucine | toxicokinetics | strychnine | RRLC–MS/MS | Biqi capsule | CHEMISTRY, ANALYTICAL | HUMAN PLASMA | RRLC-MS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | MASS-SPECTROMETRY | MAJOR METABOLITES | LIQUID-CHROMATOGRAPHY | PHARMACOKINETICS | PHARMACOLOGY & PHARMACY | SEMEN STRYCHNI | 3-N-BUTYLPHTHALIDE NBP | Reproducibility of Results | Administration, Oral | Rats | Linear Models | Male | Rats, Sprague-Dawley | Strychnine - analogs & derivatives | Drugs, Chinese Herbal - pharmacokinetics | Strychnine - toxicity | Tandem Mass Spectrometry | Animals | Strychnine - pharmacokinetics | Sensitivity and Specificity | Strychnine - blood | Chromatography, Liquid | Female | Drugs, Chinese Herbal - administration & dosage | Rheumatoid factor | Mass spectrometry | Liquid chromatography | Index Medicus
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14. Full Text Is There No End to the Total Syntheses of Strychnine? Lessons Learned in Strategy and Tactics in Total Synthesis
by Cannon, Jeffrey S and Overman, Larry E
Angewandte Chemie International Edition, ISSN 1433-7851, 04/2012, Volume 51, Issue 18, pp. 4288 - 4311
From the 19th century to the present, the complex indole alkaloid strychnine has engaged the chemical community. In this Review, we examine why strychnine has... 
natural products | synthesis strategy | strychnine | total synthesis | CELL-MIGRATION INHIBITORS | PHENYL-PYRIDINIUM CHLORIDE | FORMAL TOTAL-SYNTHESIS | ASPIDOSPERMATAN-TYPE ALKALOIDS | CHEMISTRY, MULTIDISCIPLINARY | MARINE NATURAL-PRODUCTS | WIELAND-GUMLICH ALDEHYDE | AZA-COPE REARRANGEMENTS | CROSS-COUPLING REACTIONS | DIELS-ALDER REACTION | ENANTIOSELECTIVE TOTAL-SYNTHESIS | Molecular Structure | Cyclization | Strychnine - chemistry | Aldehydes - chemistry | Strychnine - chemical synthesis | Alkaloids | Tactics | Synthesis | Strategy | Strychnine | Evolution | Community relations | Indoles
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