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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, ISSN 1570-0232, 01/2016, Volume 1008, pp. 65 - 73
Brucine | Strychnine N-oxide | Strychnine | Brucine N-oxide | Pharmacokinetics | Monomer | LC–MS/MS | The total strychnos alkaloids | Rat plasma | LC-MS/MS | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Biochemical Research Methods | Chemistry, Analytical | Science & Technology | Animals | Strychnine - pharmacokinetics | Strychnine - blood | Rats | Loganiaceae - chemistry | Chromatography, Liquid - methods | Tandem Mass Spectrometry - methods | Strychnine - administration & dosage | Strychnine - analogs & derivatives | Metabolites | Comparative analysis | Alkaloids | Liquid chromatography | Precipitation (Meteorology) | Mass spectrometry | Index Medicus
Journal Article
Nature (London), ISSN 0028-0836, 10/2015, Volume 526, Issue 7572, pp. 277 - 280
Strychnine - chemistry | Humans | Models, Molecular | Substrate Specificity | Crystallography, X-Ray | Strychnine - pharmacology | Receptors, Glycine - antagonists & inhibitors | Strychnine - metabolism | Receptors, Glycine - chemistry | Receptors, Glycine - metabolism | Binding Sites | Protein Multimerization - drug effects | Ion Channel Gating - drug effects | Protein Structure, Tertiary - drug effects | Index Medicus
Journal Article
Organic & biomolecular chemistry, ISSN 1477-0520, 7/2010, Volume 8, Issue 14, pp. 322 - 326
Physical Sciences | Chemistry | Chemistry, Organic | Science & Technology | Gold - chemistry | Cell Death - radiation effects | Photochemotherapy - methods | Solvents - chemistry | Strychnine - chemistry | Humans | Metal Nanoparticles - chemistry | Porphyrins - chemistry | Strychnine - pharmacology | Alkylation | Strychnine - therapeutic use | Neoplasms - drug therapy | Strychnine - analogs & derivatives | Animals | Strychnine - metabolism | Biological Transport | Intracellular Space - metabolism | Cell Line, Tumor | Mice | Cell Death - drug effects | Index Medicus
Journal Article
Angewandte Chemie (International ed.), ISSN 1433-7851, 04/2012, Volume 51, Issue 18, pp. 4288 - 4311
natural products | synthesis strategy | strychnine | total synthesis | Physical Sciences | Chemistry | Chemistry, Multidisciplinary | Science & Technology | Molecular Structure | Cyclization | Strychnine - chemistry | Aldehydes - chemistry | Strychnine - chemical synthesis | Index Medicus | Alkaloids | Tactics | Synthesis | Strategy | Strychnine | Evolution | Community relations | Indoles
Journal Article
Toxicology letters, ISSN 0378-4274, 10/2013, Volume 222, Issue 2, pp. 91 - 101
Brucine | Hepatocellular carcinoma | Metastasis | Hypoxia inducible factor 1 | Life Sciences & Biomedicine | Toxicology | Science & Technology | Humans | Male | Neoplasm Proteins - antagonists & inhibitors | Carcinoma, Hepatocellular - secondary | Neoplasm Proteins - metabolism | Strychnos nux-vomica - chemistry | Hypoxia-Inducible Factor 1 - metabolism | Hypoxia-Inducible Factor 1 - genetics | Dose-Response Relationship, Drug | Antineoplastic Agents, Phytogenic - administration & dosage | Carcinoma, Hepatocellular - drug therapy | Lung Neoplasms - secondary | China | Animals, Outbred Strains | Seeds - chemistry | Gene Expression Regulation, Neoplastic - drug effects | Antineoplastic Agents, Phytogenic - therapeutic use | Neoplasm Proteins - genetics | Antineoplastic Agents, Phytogenic - adverse effects | Liver Neoplasms - drug therapy | Strychnine - pharmacology | Random Allocation | Strychnine - administration & dosage | Strychnine - therapeutic use | Strychnine - analogs & derivatives | Xenograft Model Antitumor Assays | Cell Movement - drug effects | Ethnopharmacology | Animals | Strychnine - adverse effects | Lung Neoplasms - prevention & control | Cell Line, Tumor | Mice | Antineoplastic Agents, Phytogenic - pharmacology | Hypoxia-Inducible Factor 1 - antagonists & inhibitors | Index Medicus
Journal Article
Angewandte Chemie (International ed.), ISSN 1433-7851, 10/2010, Volume 49, Issue 43, pp. 8021 - 8025
cascade reactions | indoles | ketyls | strychnine | samarium diiodide | Samarium diiodide | Strychnine | Indoles | Cascade reactions | Ketyls | Biological Products - chemical synthesis | Biological Products - chemistry | Samarium - chemistry | Strychnine - chemistry | Iodides - chemistry | Iodides - chemical synthesis | Strychnos - chemistry | Strychnine - chemical synthesis | Index Medicus
Journal Article
Nature (London), ISSN 0028-0836, 10/2015, Volume 526, Issue 7572, pp. 224 - 229
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Protein Subunits - drug effects | Glycine - metabolism | Allosteric Regulation | Protein Conformation - drug effects | Receptors, Glycine - antagonists & inhibitors | Protein Subunits - metabolism | Ivermectin - metabolism | Strychnine - metabolism | Receptors, Glycine - agonists | Neurotransmitter Agents - pharmacology | Receptors, Glycine - metabolism | Binding Sites | Signal Transduction | Neurotransmitter Agents - metabolism | Models, Molecular | Zebrafish | Receptors, Glycine - ultrastructure | Strychnine - pharmacology | Ivermectin - pharmacology | Rotation | Cryoelectron Microscopy | Animals | Glycine - pharmacology | Protein Subunits - chemistry | Ion Channel Gating - drug effects | Biological research | Glycine receptors | Cryoelectron microscopy | Physiological aspects | Research | Molecular biology | Methods | Biology, Experimental | Signal transduction | Nervous system | Ligands | Neurotransmitters | Microscopy | Index Medicus
Journal Article
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Full Text
Oxime Ethers of (E)‑11-Isonitrosostrychnine as Highly Potent Glycine Receptor Antagonists
Journal of natural products (Washington, D.C.), ISSN 0163-3864, 12/2016, Volume 79, Issue 12, pp. 2997 - 3005
Binding, Competitive | Ethers - chemical synthesis | Glycine - metabolism | Strychnine - chemistry | Humans | Molecular Conformation | Crystallography, X-Ray | Ethers - chemistry | Structure-Activity Relationship | Strychnine - pharmacology | Receptors, Glycine - antagonists & inhibitors | Strychnine - analogs & derivatives | Ethers - pharmacology | Oximes - chemistry | Animals | Inhibitory Concentration 50 | Oximes - pharmacology | Ligands | Molecular Structure | Binding Sites | Glycine - analysis | Strychnine - chemical synthesis | Index Medicus
Journal Article