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Human Molecular Genetics, ISSN 0964-6906, 2014, Volume 23, Issue 17, pp. 4491 - 4509
A novel mutation in the alpha-Synuclein (alpha-Syn) gene "G51D" was recently identified in two familial cases exhibiting features of Parkinson's disease (PD)... 
WILD-TYPE | INCLUSION FORMATION | OXIDATIVE STRESS | HUMAN PLASMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | RAT-BRAIN NEURONS | MONOCLONAL-ANTIBODY | SOLUTION NMR-SPECTROSCOPY | PULSED ESR MEASUREMENTS | TRANSGENIC MICE | PHOSPHOLIPID-BINDING | Neurons - pathology | Humans | alpha-Synuclein - ultrastructure | Saccharomyces cerevisiae - drug effects | Protein Transport - drug effects | Brain - metabolism | Saccharomyces cerevisiae - metabolism | Cell Nucleus - metabolism | Protein Binding - drug effects | Sodium Dodecyl Sulfate - pharmacology | Cell Membrane - metabolism | Neurons - metabolism | alpha-Synuclein - genetics | Phosphorylation - drug effects | Buffers | Inclusion Bodies - metabolism | Neurons - drug effects | Protein Aggregation, Pathological - genetics | Cell Membrane - drug effects | Neuroblastoma - pathology | Protein Aggregates - drug effects | Cell Line | Parkinson Disease - pathology | Protein Structure, Secondary | Subcellular Fractions - drug effects | Cells, Cultured | Inclusion Bodies - drug effects | Mitochondria - metabolism | alpha-Synuclein - secretion | Mitochondria - drug effects | Parkinson Disease - genetics | Mutation - genetics | Subcellular Fractions - metabolism | alpha-Synuclein - chemistry | Brain - drug effects | Unilamellar Liposomes - metabolism | Nuclear Envelope - metabolism | Nuclear Envelope - drug effects | Cell Differentiation - drug effects | Brain - pathology | Cell Nucleus - drug effects | Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 05/2010, Volume 30, Issue 20, pp. 6838 - 6851
alpha-Synuclein is central in Parkinson's disease pathogenesis. Although initially alpha-synuclein was considered a purely intracellular protein, recent data... 
PROTEIN | INHIBITION | MECHANISM | ACTIVATES MICROGLIA | PATHWAY | CONGO RED | MULTIVESICULAR BODY | RELEASE | ASSOCIATION | NEUROSCIENCES | PARKINSONS-DISEASE | Molecular Weight | Serum - metabolism | Calcium - metabolism | Microscopy, Electron, Transmission - methods | Humans | Culture Media, Conditioned - chemistry | Cell Survival - genetics | Brefeldin A - pharmacology | Neurons - ultrastructure | Piperidines - pharmacology | Neurons - metabolism | alpha-Synuclein - genetics | Protein Synthesis Inhibitors - pharmacology | Exosomes - ultrastructure | Cell Survival - drug effects | Calcium - pharmacology | Immunoprecipitation - methods | Multivesicular Bodies - pathology | Endocytosis - drug effects | Rats | Microscopy, Confocal - methods | Analysis of Variance | Cell Line, Tumor | beta-Galactosidase - genetics | Multivesicular Bodies - drug effects | Temperature | Chromatography, High Pressure Liquid - methods | Culture Media, Conditioned - pharmacology | Cerebral Cortex - cytology | Dose-Response Relationship, Drug | Subcellular Fractions - ultrastructure | Transfection | Exosomes - physiology | beta-Galactosidase - metabolism | Presenilin-1 - pharmacology | Cell Death - drug effects | Cytotoxicity Tests, Immunologic - methods | Gene Expression Regulation, Neoplastic - drug effects | Neurons - drug effects | Neuroblastoma - pathology | Pyrazoles - pharmacology | Subcellular Fractions - drug effects | Multivesicular Bodies - ultrastructure | Cells, Cultured | Hydrogen Peroxide - pharmacology | Receptors, Transferrin - metabolism | Subcellular Fractions - metabolism | Peptides - pharmacology | Nerve Tissue Proteins - metabolism | Animals | Neuroblastoma - ultrastructure | Cell Differentiation - drug effects | Cell Proliferation - drug effects | Mass Spectrometry - methods | alpha-Synuclein - metabolism | Index Medicus
Journal Article
Autophagy, ISSN 1554-8627, 09/2012, Volume 8, Issue 9, pp. 1333 - 1341
Photodynamic therapy (PDT) involves photosensitizing agents that, in the presence of oxygen and light, initiate formation of cytotoxic reactive oxygen species... 
apoptosis | lysosomes | autophagy | subcellular localization | photodynamic therapy | Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Lysosomes | Photodynamic therapy | Autophagy | Subcellular localization | Apoptosis | CANCER-CELLS | ACTIVATION | AUTOPHAGIC RESPONSES | WST11 | CELL BIOLOGY | CYTOCHROME-C | BCL-2 | PHOTOSENSITIZER NPE6 | REACTIVE OXYGEN | MEMBRANE PERMEABILIZATION | Apoptosis - drug effects | Apoptosis - radiation effects | Microtubule-Associated Proteins - metabolism | Fluorescence | Phagosomes - radiation effects | Protein Transport - drug effects | Recombinant Fusion Proteins - metabolism | Vacuoles - drug effects | Cell Shape - radiation effects | Lysosomes - radiation effects | Photosensitizing Agents - pharmacology | Cell Nucleus - metabolism | Lysosomes - metabolism | Cell Nucleus - radiation effects | Light | Phagosomes - ultrastructure | Microtubule-Associated Proteins - deficiency | Phagosomes - drug effects | Lysosomes - drug effects | Cell Survival - drug effects | Green Fluorescent Proteins - metabolism | Permeability - drug effects | Subcellular Fractions - drug effects | Bacteriochlorophylls - pharmacology | Porphyrins - pharmacology | Cell Nucleus - ultrastructure | Amines - metabolism | Cell Survival - radiation effects | Subcellular Fractions - metabolism | Cell Shape - drug effects | Vacuoles - radiation effects | Autophagy-Related Protein 7 | Animals | Permeability - radiation effects | Protein Transport - radiation effects | Subcellular Fractions - radiation effects | Bacteriochlorophylls - chemistry | Cell Line, Tumor | Vacuoles - metabolism | Mice | Cell Nucleus - drug effects | Basic Research Paper
Journal Article
The Plant cell, ISSN 1532-298X, 2013, Volume 25, Issue 8, pp. 2925 - 2943
... activity. Reduction of pTAC5 expression by RNA interference led to similar phenotypic effects as observed in hsp21. HSP21 and pTAC5 formed a complex... 
Proteins | Heat stress disorders | Chloroplasts | RNA | RESEARCH ARTICLES | Genes | Promoter regions | Plants | Plastids | Seedlings | Plant cells | OXIDATIVE STRESS | ENCODED RNA-POLYMERASE | QUATERNARY DYNAMICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHLOROPHYLL BIOSYNTHESIS | DISULFIDE OXIDOREDUCTASE ACTIVITIES | DNA-BINDING PROTEIN | CHAPERONE FUNCTION | PLANT SCIENCES | CELL BIOLOGY | HIGHER-PLANTS | GENE-EXPRESSION | PHOTOSYSTEM-II | Heat-Shock Response - drug effects | Sequence Deletion | Arabidopsis - physiology | Protein Disulfide-Isomerases - metabolism | Protein Transport - drug effects | Heat-Shock Response - radiation effects | Seedlings - growth & development | Arabidopsis Proteins - metabolism | Arabidopsis - radiation effects | Light | Plants, Genetically Modified | Protein Binding - drug effects | Chloroplasts - radiation effects | Protein Binding - radiation effects | Carrier Proteins - chemistry | Chloroplasts - drug effects | Chloroplasts - genetics | Protein Structure, Tertiary | Gene Expression Regulation, Plant - radiation effects | Arabidopsis - drug effects | Subcellular Fractions - drug effects | Heat-Shock Proteins - metabolism | Seedlings - drug effects | Mutation - genetics | Subcellular Fractions - metabolism | Chloroplasts - metabolism | Heat-Shock Response - genetics | Arabidopsis - genetics | DNA, Chloroplast - metabolism | Gene Expression Regulation, Plant - drug effects | Phenotype | Carrier Proteins - metabolism | Arabidopsis Proteins - chemistry | Genes, Plant - genetics | Protein Transport - radiation effects | Subcellular Fractions - radiation effects | Zinc - pharmacology | Seedlings - radiation effects | Heat-Shock Proteins - chemistry | Seedlings - metabolism | Plant proteins | Arabidopsis thaliana | Physiological aspects | Heat shock proteins | Research | Protein-protein interactions
Journal Article
Plant physiology (Bethesda), ISSN 1532-2548, 2017, Volume 175, Issue 3, pp. 1321 - 1336
Long noncoding RNAs (lncRNAs) affect gene expression through a wide range of mechanisms and are considered as important regulators in many essential biological... 
SIGNALING AND RESPONSE | ARABIDOPSIS-THALIANA | ABIOTIC STRESS | SEED-GERMINATION | MESSENGER-RNA | PHOSPHATE HOMEOSTASIS | ANTISENSE RNA | ABSCISIC-ACID BIOSYNTHESIS | GENE FAMILY | GENOME-WIDE IDENTIFICATION | TRANSCRIPTION FACTOR | PLANT SCIENCES | Arabidopsis - physiology | Reactive Oxygen Species - metabolism | Genes, Plant | Proline - metabolism | Sodium Chloride - pharmacology | Seedlings - genetics | RNA, Messenger - metabolism | Salt-Tolerance - drug effects | Arabidopsis Proteins - metabolism | Cell Nucleus - metabolism | Droughts | Plants, Genetically Modified | Salt-Tolerance - genetics | Plant Leaves - drug effects | Stress, Physiological - drug effects | Arabidopsis Proteins - genetics | Arabidopsis - drug effects | Subcellular Fractions - drug effects | Stress, Physiological - genetics | RNA, Messenger - genetics | Up-Regulation - genetics | RNA, Long Noncoding - genetics | Seedlings - drug effects | Down-Regulation - drug effects | Mutation - genetics | Subcellular Fractions - metabolism | Down-Regulation - genetics | Arabidopsis - genetics | Up-Regulation - drug effects | Abscisic Acid - pharmacology | Gene Expression Regulation, Plant - drug effects | Plant Leaves - genetics | Cell Nucleus - drug effects | RNA, Long Noncoding - metabolism | Plant Leaves - physiology | Arabidopsis thaliana | RNA sequencing | Plant-soil relationships | Soils, Salts in | Genetic aspects | Health aspects | Methods | Signaling and Response
Journal Article
Nanomedicine: Nanotechnology, Biology, and Medicine, ISSN 1549-9634, 2010, Volume 6, Issue 3, pp. 427 - 441
Abstract Identification of pharmacological and toxicological profiles is of critical importance for the use of nanoparticles as drug carriers in nanomedicine and for the biosafety evaluation... 
Internal Medicine | Lysosomes | Mitochondria | Target treatment | Alzheimer disease | Single-walled carbon nanotubes | Organelles | MEDICINE, RESEARCH & EXPERIMENTAL | BIOCOMPATIBILITY | RATS | NANOSCIENCE & NANOTECHNOLOGY | MAMMALIAN-CELLS | DELIVERY | NANOPARTICLES | REACTIVE OXYGEN | IN-VIVO | HUMAN EPIDERMAL-KERATINOCYTES | CYTOTOXICITY | Memory - drug effects | Organ Specificity - drug effects | Drug Carriers - adverse effects | Intestinal Absorption - drug effects | Drug Carriers - toxicity | Mitochondria - ultrastructure | Autophagy - drug effects | Alzheimer Disease - pathology | Lysosomes - metabolism | Nanotubes, Carbon - toxicity | Brain - ultrastructure | Spectrum Analysis, Raman | Lysosomes - drug effects | Cell Survival - drug effects | Alzheimer Disease - physiopathology | Reproducibility of Results | Subcellular Fractions - drug effects | Acetylcholine - pharmacology | Alzheimer Disease - drug therapy | Nanotubes, Carbon - ultrastructure | Mitochondria - metabolism | Mitochondria - drug effects | Subcellular Fractions - metabolism | Brain - drug effects | Lysosomes - ultrastructure | Acetylcholine - administration & dosage | Animals | Nanomedicine - methods | Brain - pathology | Nanotubes, Carbon - adverse effects | Drug Carriers - pharmacokinetics | Mice | Health Status | Index Medicus
Journal Article
Plant physiology (Bethesda), ISSN 1532-2548, 2012, Volume 159, Issue 3, pp. 1159 - 1175
In the interaction between Arabidopsis (Arabidopsis thaliana) and the generalist herbivorous insect Spodoptera littoralis, little is known about early events... 
Leaves | Insect larvae | Calcium | Plant growth regulators | Genes | Gene expression regulation | Trichomes | Plants | Herbivores | Phytophagous insects | PLANTS INTERACTING WITH OTHER ORGANISMS | MOLECULAR-PATTERNS | DEFENSE RESPONSES | LIMA-BEAN LEAVES | METHYL JASMONATE | ORAL SECRETIONS | INDUCED RESISTANCE | GLUCOSINOLATE ACCUMULATION | AGROBACTERIUM-MEDIATED TRANSFORMATION | CALMODULIN-LIKE PROTEIN | ABSCISIC-ACID | PLANT SCIENCES | Arabidopsis - physiology | Intracellular Calcium-Sensing Proteins - genetics | Calcium - metabolism | Herbivory - physiology | Cytosol - drug effects | Glucosinolates - metabolism | Protein Transport - drug effects | RNA, Messenger - metabolism | Arabidopsis Proteins - metabolism | Cell Nucleus - metabolism | Spodoptera - drug effects | Stress, Physiological - drug effects | Arabidopsis Proteins - genetics | Arabidopsis - drug effects | Spodoptera - physiology | Subcellular Fractions - drug effects | RNA, Messenger - genetics | Signal Transduction - genetics | Cyclopentanes - pharmacology | Intracellular Calcium-Sensing Proteins - metabolism | Mutation - genetics | Herbivory - drug effects | Subcellular Fractions - metabolism | Arabidopsis - genetics | Oxylipins - metabolism | Gene Expression Regulation, Plant - drug effects | Animals | Signal Transduction - drug effects | Calcium Signaling - drug effects | Oxylipins - pharmacology | Arabidopsis - parasitology | Cyclopentanes - metabolism | Cytosol - metabolism | Cell Nucleus - drug effects | Arabidopsis thaliana | Arabidopsis | Plant genetics | Genetic aspects | Instrument industry | Chemical properties | Gene expression
Journal Article
Journal of experimental botany, ISSN 1460-2431, 2010, Volume 61, Issue 3, pp. 683 - 696
Osmotic stresses such as drought, salinity, and cold are major environmental factors that limit agricultural productivity worldwide. Protein... 
Salt tolerance | Fluorescence | Amino acids | Cell membranes | Plants | Drought | Dehydration | Gene expression | Transgenic plants | RESEARCH PAPER | Seedlings | Morphological character | Stress responses | Abiotic stress | Physiological trait | HYPEROSMOTIC STRESS | CHLOROPHYLL FLUORESCENCE | BIOCHEMICAL-CHARACTERIZATION | physiological trait | morphological character | stress responses | SALT TOLERANCE | STOMATAL CLOSURE | PLANT SCIENCES | ACID SIGNAL-TRANSDUCTION | LEAF WATER-LOSS | RESPONSIVE GENE-EXPRESSION | ABSCISIC-ACID | BARLEY ALEURONE LAYERS | Arabidopsis - growth & development | Sodium Chloride - pharmacology | Adaptation, Physiological - drug effects | Molecular Sequence Data | Gene Expression Profiling | Protein Transport - drug effects | Phylogeny | Freezing | Droughts | Plant Proteins - chemistry | Plants, Genetically Modified | Plant Proteins - metabolism | Stress, Physiological - drug effects | Triticum - enzymology | Cell Membrane - drug effects | Protein-Serine-Threonine Kinases - metabolism | Amino Acid Sequence | Arabidopsis - drug effects | Subcellular Fractions - drug effects | Arabidopsis - cytology | Gene Expression Regulation, Developmental - drug effects | Protein-Serine-Threonine Kinases - genetics | Water - metabolism | Osmosis - drug effects | Arabidopsis - genetics | Triticum - genetics | Plant Proteins - genetics | Gene Expression Regulation, Plant - drug effects | Sequence Alignment | Photosynthesis - drug effects | Protein-Serine-Threonine Kinases - chemistry | Subcellular Fractions - enzymology | Triticum - drug effects | Research Papers
Journal Article
The Plant cell, ISSN 1532-298X, 2010, Volume 22, Issue 5, pp. 1633 - 1646
Long-distance transport of nitrate requires xylem loading and unloading, a successive process that determines nitrate distribution and subsequent assimilation... 
Cadmium | Xylem | Reverse transcriptase polymerase chain reaction | Epidermal cells | Plant roots | Parenchyma | Nitrates | Plants | Oocytes | Plant cells | ENCODES | ROOT | PHYTOCHELATINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SHOOT | PLANT SCIENCES | CELL BIOLOGY | HIGHER-PLANTS | CHL1 | GENE-EXPRESSION | ACCUMULATION | LONG-DISTANCE TRANSPORT | THIOL-PEPTIDES | Arabidopsis - enzymology | Xylem - enzymology | Adaptation, Physiological - drug effects | Xylem - drug effects | Gene Expression Profiling | Protein Transport - drug effects | Xylem - genetics | Arabidopsis Proteins - metabolism | Xylem - cytology | Adaptation, Physiological - genetics | Hydrogen-Ion Concentration - drug effects | Stress, Physiological - drug effects | Cell Membrane - drug effects | Arabidopsis Proteins - genetics | Arabidopsis - drug effects | Cadmium - toxicity | Subcellular Fractions - drug effects | Stress, Physiological - genetics | Arabidopsis - cytology | Plant Exudates - metabolism | Mutation - genetics | Anion Transport Proteins - metabolism | Arabidopsis - genetics | Up-Regulation - drug effects | Cell Membrane - enzymology | Nitrates - metabolism | Gene Expression Regulation, Plant - drug effects | Plant Exudates - genetics | Subcellular Fractions - enzymology | Anion Transport Proteins - genetics | Arabidopsis thaliana | Biological transport | Genetic aspects | Health aspects
Journal Article
Molecular Endocrinology, ISSN 1944-9917, 2009, Volume 23, Issue 6, pp. 893 - 900
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2013, Volume 110, Issue 9, pp. 3621 - 3626
The maintenance of functional chloroplasts in photosynthetic eukaryotes requires real-time coordination of the nuclear and plastid genomes. Tetrapyrroles play... 
Chloroplasts | Genes | Cell lines | Genomes | Bile pigments | Plants | Gene expression | Plastids | Chlorophylls | Plant cells | Iron homeostasis | Oxidative stress | RNA-Seq analysis | Biliverdin | Heme oxygenase | heme oxygenase | iron homeostasis | PHYTOCHROME CHROMOPHORE BIOSYNTHESIS | MULTIDISCIPLINARY SCIENCES | STRESS-RESPONSE | LIGHT | REINHARDTII | NUCLEAR GENE-EXPRESSION | HEME OXYGENASES | GENOME REVEALS | biliverdin | SINGLET OXYGEN | MG-PROTOPORPHYRIN IX | oxidative stress | BILIVERDIN REDUCTASE | Chloroplasts - enzymology | Heme - metabolism | Gene Expression Profiling | Gene Regulatory Networks - drug effects | Biliverdine - pharmacology | Pigmentation - radiation effects | Chlamydomonas reinhardtii - genetics | Chlamydomonas reinhardtii - physiology | Pigmentation - genetics | Biocatalysis - drug effects | Light | Plants, Genetically Modified | Chloroplasts - radiation effects | Phycocyanin - biosynthesis | Signal Transduction - radiation effects | Chloroplasts - drug effects | Heme Oxygenase (Decyclizing) - metabolism | Iron - pharmacology | Heme Oxygenase (Decyclizing) - genetics | Biocatalysis - radiation effects | Phototrophic Processes - drug effects | Chlamydomonas reinhardtii - cytology | Gene Expression Regulation, Plant - radiation effects | Pigmentation - drug effects | Oxidoreductases - metabolism | Subcellular Fractions - drug effects | Oxidoreductases - genetics | Phycobilins - biosynthesis | Signal Transduction - genetics | Chlorophyll - metabolism | Mutation - genetics | Subcellular Fractions - metabolism | Bile Pigments - metabolism | Gene Expression Regulation, Plant - drug effects | Phenotype | Signal Transduction - drug effects | Genes, Plant - genetics | Phototrophic Processes - genetics | Chlamydomonas reinhardtii - enzymology | Subcellular Fractions - radiation effects | Gene Regulatory Networks - radiation effects | Physiological aspects | Research | Photosynthesis | Chlamydomonas | Pyrrole | Biological Sciences
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 4, p. e62087
Silica nanoparticles have become promising carriers for drug delivery or gene therapy... 
PATHWAYS | MAINTENANCE | AIR-POLLUTION | OXIDATIVE STRESS | CHK1 | PARTICLES | MULTIDISCIPLINARY SCIENCES | DISEASE | MITOCHONDRIA | SIZE-DEPENDENT CYTOTOXICITY | CANCER | Protein Kinases - metabolism | Reactive Oxygen Species - metabolism | Nanoparticles - chemistry | Apoptosis - drug effects | Humans | Membrane Potential, Mitochondrial - drug effects | Necrosis | Flow Cytometry | G2 Phase Cell Cycle Checkpoints - drug effects | Human Umbilical Vein Endothelial Cells - drug effects | Intracellular Space - drug effects | Subcellular Fractions - drug effects | Endocytosis - drug effects | Nanoparticles - ultrastructure | Hydrodynamics | Static Electricity | Comet Assay | Nanoparticles - toxicity | Subcellular Fractions - metabolism | Particle Size | Human Umbilical Vein Endothelial Cells - enzymology | Silicon Dioxide - toxicity | Intracellular Space - metabolism | Checkpoint Kinase 1 | Human Umbilical Vein Endothelial Cells - pathology | DNA Damage | Oxidative Stress - drug effects | Drugs | Nanoparticles | Drug delivery systems | DNA | DNA damage | Superoxide | Radiation, Background | DNA repair | Silica | Vehicles | Endothelium | Cdc2 protein | Reactive oxygen species | Intravenous administration | Toxicity | Cytology | Cytotoxicity | Superoxide dismutase | Drug delivery | Kinases | Cyclin B1 | Silicon dioxide | Signal transduction | Mitochondria | Peroxidase | Membrane potential | Damage | Heart diseases | Deoxyribonucleic acid--DNA | Glutathione | Glutathione peroxidase | Outdoor air quality | Oxygen | CHK1 protein | Lactate dehydrogenase | Exposure | Hazards | Malondialdehyde | L-Lactate dehydrogenase | Endothelial cells | Signaling | Lactic acid | Mutation | Gene therapy | Cardiovascular diseases | Apoptosis | Deoxyribonucleic acid
Journal Article
Journal Article