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Journal Article
Journal Article
Toxicology and Industrial Health, ISSN 0748-2337, 12/2015, Volume 31, Issue 12, pp. 1325 - 1333
The present study is an unsubstantiated qualitative assessment of the abused drugs—tramadol and clonazepam. The aim of this study is to evaluate whether the... 
clonazepam | abuse | Tramadol | mitochondrial electron transport | TARGET | RESPIRATORY-CHAIN | METABOLITES | RISK | TOXICITY | 7-AMINOCLONAZEPAM | IDENTIFICATION | NEUROTOXICITY | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | URINE | TOXICOLOGY | DYSFUNCTION | Mitochondria - enzymology | Neurons - pathology | Electron Transport Complex III - metabolism | Electron Transport Complex IV - antagonists & inhibitors | Opioid-Related Disorders - pathology | Anticonvulsants - poisoning | Electron Transport Complex III - drug effects | Brain - enzymology | Substance-Related Disorders - pathology | Male | Substance-Related Disorders - enzymology | Weight Loss - drug effects | Electron Transport Complex I - metabolism | Electron Transport Complex IV - metabolism | Neurotoxicity Syndromes - pathology | Clonazepam - poisoning | Neurons - drug effects | Disease Models, Animal | Opioid-Related Disorders - enzymology | Electron Transport Complex I - antagonists & inhibitors | Analgesics, Opioid - poisoning | Rats | Mitochondria - drug effects | Random Allocation | Neurotoxicity Syndromes - complications | Electron Transport Complex I - drug effects | Nerve Tissue Proteins - drug effects | Substance-Related Disorders - complications | Brain - drug effects | Nerve Tissue Proteins - metabolism | Neurotoxicity Syndromes - enzymology | Animals | Electron Transport Complex III - antagonists & inhibitors | Electron Transport Complex II - metabolism | Tramadol - poisoning | Neurons - enzymology | Electron Transport Complex IV - drug effects | Brain - pathology | Qualitative Research | Electron Transport Complex II - drug effects | Opioid-Related Disorders - complications | Index Medicus
Journal Article
Drug and Alcohol Dependence, ISSN 0376-8716, 05/2018, Volume 186, pp. 159 - 166
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2016, Volume 11, Issue 12, p. e0167169
Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation and lung inflammation resulting in a progressive decline in lung... 
SMALL INTERFERING RNA | OXIDATIVE STRESS | NEUTROPHIL | EPITHELIAL-CELLS | MULTIDISCIPLINARY SCIENCES | DISEASE | EMPHYSEMA | EXACERBATIONS | PREVENTION | MECHANISMS | EXPRESSION | Respiratory System - pathology | Smoking - adverse effects | Epithelial Cells - metabolism | Humans | Middle Aged | Male | NF-kappa B - metabolism | Respiratory System - enzymology | RNA Interference | HEK293 Cells | Inflammation Mediators - metabolism | Aged, 80 and over | Adult | Female | Pulmonary Disease, Chronic Obstructive - metabolism | Pneumonia - genetics | Pulmonary Disease, Chronic Obstructive - genetics | Gene Expression | Pneumonia - etiology | Cytokines - metabolism | MAP Kinase Kinase Kinases - genetics | Pneumonia - enzymology | MAP Kinase Kinase Kinases - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Macrophages - enzymology | Pulmonary Disease, Chronic Obstructive - enzymology | Animals | Respiratory System - metabolism | Epithelial Cells - enzymology | Cell Line, Tumor | Aged | Mice | Mice, Inbred BALB C | Complications and side effects | Lung diseases, Obstructive | Analysis | Development and progression | Inflammation | Risk factors | Smoking | Oxidative stress | Animal models | Respiratory function | Transcription | Epithelial cells | Parenchyma | Viruses | Smoke | Kinases | Macrophages | Molecular weight | Osmotic stress | Respiratory tract | Chronic obstructive pulmonary disease | Inhibition | Alveoli | NF-κB protein | Tobacco smoke | Cytokines | Lung diseases | Neutrophils | Bronchus | Lamina propria | siRNA | Gene expression | Cigarettes | Epithelium | Patients | Disease control | Environmental stress | Air flow | Obstructive lung disease | Cell lines | Neutrophilia | Emphysema | Chemokines | Cigarette smoke
Journal Article
Toxicology Letters, ISSN 0378-4274, 09/2016, Volume 258, pp. 55 - 70
•Single enzyme incubations best suited for FMO3 substrate identification.•Integration of FMO3 in the relative activity factor (RAF) approach... 
FMO3 | Drugs of abuse | Relative activity factor approach | CYPs | Hepatic clearance | LC-MSN | HUMAN LIVER-MICROSOMES | DESIGNER DRUG | GC-MS | TOXICOLOGICAL DETECTION | METABOLISM | CYTOCHROME-P450 ENZYMES | HIGH-RESOLUTION MS | FLAVIN-CONTAINING MONOOXYGENASES | RAT URINE | TOXICOLOGY | Humans | Insecta | Microsomes, Liver - metabolism | Cytochrome P-450 Enzyme System - metabolism | Substance-Related Disorders - enzymology | Oxygenases - antagonists & inhibitors | Microsomes, Liver - drug effects | Oxygenases - metabolism | Antitussive Agents - metabolism | Microsomes, Liver - enzymology | Recombinant Proteins - metabolism | Cell Line | Substance-Related Disorders - etiology | Substance-Related Disorders - metabolism | Central Nervous System Agents - chemistry | Oxidation-Reduction | Enzyme Inhibitors - pharmacology | Recombinant Proteins - chemistry | Calibration | Hot Temperature | Antitussive Agents - chemistry | Cytochrome P-450 Enzyme Inhibitors - pharmacology | Cytochrome P-450 Enzyme System - chemistry | Animals | Models, Biological | Biotransformation - drug effects | Cytochrome P-450 Enzyme System - genetics | Central Nervous System Agents - metabolism | Kinetics | Oxygenases - genetics | Enzymes | Drug abuse | Therapeutics | Illegal drugs | Health aspects | Homeopathy | Materia medica and therapeutics | Biological products | Hydroxides | Liver | Cytochrome P-450 | Cytokinins | Metabolites | Analysis | Physiological aspects | Xenobiotics | Mass spectrometry | Index Medicus | Drugs | Mathematical analysis | Formations | Metabolism | Standards | Recombinant
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2012, Volume 7, Issue 6, p. e38909
Journal Article