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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2012, Volume 109, Issue 13, pp. 4756 - 4761
Small molecules are important tools to measure and modulate intracellular signaling pathways. A longstanding limitation for using chemical compounds in complex... 
Molecules | Cell culture techniques | Neurons | Epithelial cells | Gap junctions | Cell lines | HeLa cells | Fluorescence | Esters | Kidney cells | Cellular imaging | Microscopy | Pharmacological agents | Enzyme substrates | Fluorophores | fluorophores | cellular imaging | NITROREDUCTASE | MULTIDISCIPLINARY SCIENCES | JUNCTIONAL INTERCELLULAR COMMUNICATION | enzyme substrates | pharmacological agents | DYE TRANSFER | CARBOXYLESTERASE | IN-VIVO | GENE-EXPRESSION | ABLATION | microscopy | ENDOPLASMIC-RETICULUM | PIG-LIVER ESTERASE | LIVING CELLS | Organ Specificity - drug effects | Gap Junctions - metabolism | Small Molecule Libraries - pharmacology | Hydrolysis - drug effects | Coculture Techniques | Humans | Fluorescent Dyes - metabolism | Esters - metabolism | Neurons - cytology | Biocatalysis - drug effects | Neurons - metabolism | Neurons - drug effects | Astrocytes - cytology | Astrocytes - drug effects | Cell Survival - drug effects | Cells - drug effects | Fluorescent Dyes - chemistry | Permeability - drug effects | Esterases - metabolism | Rats | Hippocampus - cytology | Animals | Cells - metabolism | Mice | HeLa Cells | Gap Junctions - drug effects | Microscopy, Fluorescence | Astrocytes - metabolism | Molecular dynamics | Biomolecules | Chemical properties | Research | Enzymes | Signal transduction | Tissue | Cells | Index Medicus | Biological Sciences | Physical Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2015, Volume 112, Issue 11, pp. 3511 - 3516
The incidence of multidrug-resistant bacterial infections is increasing globally and the need to understand the underlying mechanisms is paramount to discover... 
Efflux | Antimicrobial resistance | Whole genome sequencing | AcrB | MOLECULAR-DYNAMICS | ENTERICA SEROVAR TYPHIMURIUM | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | MULTIDRUG TRANSPORTER ACRB | efflux | CIPROFLOXACIN RESISTANCE | whole genome sequencing | EFFLUX PUMP | antimicrobial resistance | PSEUDOMONAS-AERUGINOSA | SALMONELLA-TYPHIMURIUM | STAPHYLOCOCCUS-AUREUS | MULTIPLE ANTIBIOTIC-RESISTANCE | Minocycline - pharmacology | Escherichia coli - drug effects | Humans | Salmonella enterica - genetics | Doxorubicin - chemistry | Microbial Sensitivity Tests | Salmonella enterica - drug effects | Membrane Transport Proteins - genetics | Water - chemistry | Salmonella enterica - isolation & purification | Membrane Transport Proteins - metabolism | Multidrug Resistance-Associated Proteins - genetics | Doxorubicin - metabolism | Binding Sites | Genome, Bacterial | Bacterial Proteins - genetics | Ciprofloxacin - pharmacology | Models, Molecular | Escherichia coli Proteins - metabolism | Mutation - genetics | Genetic Fitness | Substrate Specificity - drug effects | Escherichia coli - genetics | Escherichia coli - isolation & purification | Escherichia coli Proteins - genetics | Polymorphism, Single Nucleotide - genetics | Bacterial Proteins - metabolism | Anti-Bacterial Agents - pharmacology | Drug Resistance, Multiple, Bacterial - drug effects | Multidrug Resistance-Associated Proteins - metabolism | Amino Acid Substitution | Drug resistance in microorganisms | Usage | Gene mutations | Genetic aspects | Ciprofloxacin | Identification and classification | Health aspects | Multidrug resistant organisms | Genomes | Gram-negative bacteria | Mutation | Antibiotics | Drug resistance | Index Medicus | Biological Sciences
Journal Article
Cell, ISSN 0092-8674, 2007, Volume 131, Issue 3, pp. 476 - 491
Journal Article
Nature, ISSN 0028-0836, 02/2016, Volume 530, Issue 7589, pp. 233 - 236
The proteasome is a multi-component protease complex responsible for regulating key processes such as the cell cycle and antigen presentation(1). Compounds... 
VISUALIZATION | FALCIPARUM MALARIA | MECHANISM | SPECIFICITY | ARTEMISININ RESISTANCE | MULTIDISCIPLINARY SCIENCES | VALIDATION | ELECTRON-MICROSCOPY | IDENTIFICATION | PARASITE | HUMAN 20S PROTEASOME | Plasmodium falciparum - enzymology | Plasmodium - enzymology | Plasmodium chabaudi - enzymology | Species Specificity | Humans | Proteasome Inhibitors - chemistry | Plasmodium - drug effects | Plasmodium falciparum - drug effects | Protein Subunits - metabolism | Dose-Response Relationship, Drug | Artemisinins - pharmacology | Plasmodium chabaudi - physiology | Drug Design | Plasmodium - growth & development | Female | Drug Resistance | Antimalarials - adverse effects | Catalytic Domain | Proteasome Inhibitors - pharmacology | Models, Molecular | Proteasome Endopeptidase Complex - chemistry | Proteasome Inhibitors - toxicity | Proteasome Inhibitors - adverse effects | Antimalarials - pharmacology | Cryoelectron Microscopy | Drug Synergism | Animals | Substrate Specificity - drug effects | Proteasome Endopeptidase Complex - ultrastructure | Antimalarials - chemistry | Plasmodium chabaudi - drug effects | Mice | Mice, Inbred BALB C | Protein Subunits - antagonists & inhibitors | Protein Subunits - chemistry | Antimalarials - toxicity | Enzyme Activation | Plasmodium falciparum - growth & development | Proteasome Endopeptidase Complex - metabolism | Ubiquitin-proteasome system | Plasmodium | Health aspects | Proteins | Malaria | Protease inhibitors | Proteases | Erythrocytes | Ligands | Parasites | Drug dosages | Index Medicus
Journal Article
PLoS Biology, ISSN 1544-9173, 01/2012, Volume 10, Issue 1, pp. e1001242 - e1001242
Journal Article
Cell Metabolism, ISSN 1550-4131, 07/2016, Volume 24, Issue 1, pp. 63 - 74
The gut microbiota has been implicated in obesity and cardiometabolic diseases, although evidence in humans is scarce. We investigated how gut microbiota... 
BODY-WEIGHT | NORFLOXACIN | VANCOMYCIN | CHAIN FATTY-ACIDS | INSULIN-RESISTANCE | ENDOCRINOLOGY & METABOLISM | SENSITIVITY | CHROMATOGRAPHY-MASS SPECTROMETRY | SECRETION | GLUCOSE-TOLERANCE | MODULATION | CELL BIOLOGY | Organ Specificity - drug effects | Inflammation - pathology | Humans | Middle Aged | Male | Adipocytes - drug effects | Obesity - genetics | Obesity - microbiology | Vancomycin - pharmacology | Placebos | Adult | Butyric Acid - blood | Biomarkers - metabolism | Insulin - pharmacology | Double-Blind Method | Permeability | Adipocytes - pathology | Obesity - metabolism | Cell Shape - drug effects | Gene Expression Regulation - drug effects | Feces - chemistry | Gastrointestinal Microbiome - drug effects | Substrate Specificity - drug effects | Amoxicillin - pharmacology | Adipocytes - metabolism | Aged | Anti-Bacterial Agents - pharmacology | Energy Metabolism - drug effects | Obesity | Metabolites | Microbiota (Symbiotic organisms) | Physiological aspects | Clinical trials | Electric power production | Gene expression | Fatty acids | Antibacterial agents | Prediabetic state | Deoxycholic acid | Index Medicus | Nutrition, Metabolism and Genomics | Microbiologie | Microbiology | Chair Nutrition Metabolism and Genomics | HNE Voeding, Metabolisme en Genomics | VLAG | Voeding, Metabolisme en Genomica | Laboratorium voor Microbiologie | Microbiological Laboratory | HNE Nutrition, Metabolism and Genomics | WIMEK
Journal Article
Nature Cell Biology, ISSN 1465-7392, 02/2015, Volume 17, Issue 2, pp. 160 - 169
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