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Cell (Cambridge), ISSN 0092-8674, 2007, Volume 131, Issue 3, pp. 476 - 491
CELLBIO | HUMDISEASE | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Mosaicism - drug effects | Organ Specificity - drug effects | Diabetes Mellitus - genetics | Diet - adverse effects | Apoptosis Inducing Factor - deficiency | Obesity - genetics | Oxidative Phosphorylation - drug effects | Liver - drug effects | Gene Deletion | Cell Respiration - drug effects | Muscles - metabolism | Gene Targeting | Insulin - pharmacology | Liver - metabolism | Diabetes Mellitus - metabolism | Mitochondria - metabolism | Mitochondria - drug effects | Apoptosis Inducing Factor - genetics | Mice, Knockout | Obesity - metabolism | Diabetes Mellitus - prevention & control | Phenotype | Animals | Substrate Specificity - drug effects | Muscles - drug effects | Obesity - prevention & control | Glucose - metabolism | Liver - cytology | Mice | Muscles - cytology | Index Medicus | Obesity | Apoptosis Inducing Factor | Liver | Oxidative Phosphorylation | Muscles | Substrate Specificity | Glucose | Organ Specificity | Diabetes Mellitus | Insulin | Mitochondria | Cell Respiration | Diet | Mosaicism
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Biochemistry (Easton), ISSN 0006-2960, 03/2007, Volume 46, Issue 12, pp. 3595 - 3604
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Protein Structure, Tertiary | Gene Expression Regulation, Enzymologic - drug effects | Protein Structure, Secondary | Neoplasm Proteins - biosynthesis | Humans | cdc25 Phosphatases - chemistry | Enzyme Inhibitors - pharmacology | Neoplasms - enzymology | Enzyme Inhibitors - therapeutic use | Neoplasms - drug therapy | Animals | Substrate Specificity - drug effects | cdc25 Phosphatases - antagonists & inhibitors | cdc25 Phosphatases - biosynthesis | Enzyme Inhibitors - chemistry | Gene Expression Regulation, Neoplastic - drug effects | Cell Cycle - drug effects | Neoplasms - pathology | Binding Sites | Proteins | Mechanical properties | Phosphatases | Research | Structure | Index Medicus
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Immunology and cell biology, ISSN 0818-9641, 07/2007, Volume 85, Issue 5, pp. 378 - 382
immunological synapse | T‐cell activation | lipid raft | activation marker | Activation marker | Lipid raft | Immunological synapse | T-cell activation | Immunology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Epitopes - metabolism | Leukocytes, Mononuclear - drug effects | Mitogens - pharmacology | Cholera Toxin - metabolism | Glucosidases - metabolism | Membrane Microdomains - metabolism | Endocytosis - drug effects | Humans | Trypsin - metabolism | Substrate Specificity - drug effects | Fluorescein-5-isothiocyanate | T-Lymphocytes - metabolism | Lymphocyte Activation - drug effects | Membrane Microdomains - drug effects | T-Lymphocytes - drug effects | Protein Binding - drug effects | Cell Proliferation - drug effects | G(M1) Ganglioside - metabolism | Trypsin, metabolism | Glucosidases, metabolism | Cholera Toxin, metabolism | Mitogens, pharmacology | Epitopes, metabolism | Cell Proliferation, drug effects | Protein Binding, drug effects | Substrate Specificity, drug effects | Endocytosis, drug effects | T-Lymphocytes, metabolism | Membrane Microdomains, metabolism | Lymphocyte Activation, drug effects | Membrane Microdomains, drug effects | Leukocytes, Mononuclear, drug effects | T-Lymphocytes, drug effects | G(M1) Ganglioside, metabolism | Index Medicus
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The Journal of biological chemistry, ISSN 0021-9258, 06/2011, Volume 286, Issue 25, pp. 22211 - 22218
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | HIV-1 - drug effects | Jurkat Cells | Humans | Histone Deacetylases - chemistry | HIV Long Terminal Repeat - genetics | Substrate Specificity | Histone Deacetylases - metabolism | Peptides, Cyclic - pharmacology | Phosphatidylinositol 3-Kinases - metabolism | HIV-1 - genetics | Valproic Acid - pharmacology | Virus Latency - drug effects | HIV-1 - physiology | Protein Isoforms - metabolism | Virus Activation - drug effects | Signal Transduction - drug effects | Protein Isoforms - chemistry | Adult | HIV-1 - enzymology | Histone Deacetylase Inhibitors - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Hydroxamic Acids - pharmacology | Protein Isoforms - antagonists & inhibitors | Index Medicus | Viral Transcription | Microbiology | HIV | Epigenetics | Antiviral Agents | HIV Latency | Histone Deacetylase
Journal Article
Nature (London), ISSN 0028-0836, 02/2016, Volume 530, Issue 7589, pp. 233 - 236
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Plasmodium falciparum - enzymology | Plasmodium - enzymology | Plasmodium chabaudi - enzymology | Species Specificity | Humans | Proteasome Inhibitors - chemistry | Plasmodium - drug effects | Plasmodium falciparum - drug effects | Protein Subunits - metabolism | Dose-Response Relationship, Drug | Artemisinins - pharmacology | Plasmodium chabaudi - physiology | Drug Design | Plasmodium - growth & development | Female | Drug Resistance | Antimalarials - adverse effects | Catalytic Domain | Proteasome Inhibitors - pharmacology | Models, Molecular | Proteasome Endopeptidase Complex - chemistry | Proteasome Inhibitors - toxicity | Proteasome Inhibitors - adverse effects | Antimalarials - pharmacology | Cryoelectron Microscopy | Drug Synergism | Animals | Substrate Specificity - drug effects | Proteasome Endopeptidase Complex - ultrastructure | Antimalarials - chemistry | Plasmodium chabaudi - drug effects | Mice | Mice, Inbred BALB C | Protein Subunits - antagonists & inhibitors | Protein Subunits - chemistry | Antimalarials - toxicity | Enzyme Activation | Plasmodium falciparum - growth & development | Proteasome Endopeptidase Complex - metabolism | Ubiquitin-proteasome system | Plasmodium | Health aspects | Proteins | Malaria | Protease inhibitors | Proteases | Erythrocytes | Ligands | Parasites | Drug dosages | Index Medicus
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Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase
Nature communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 131 - 131
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Small Molecule Libraries - pharmacology | Humans | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Substrate Specificity | Ubiquitin-Protein Ligases - chemistry | Proteolysis - drug effects | Small Molecule Libraries - chemistry | Ubiquitination - drug effects | Protein Domains | Von Hippel-Lindau Tumor Suppressor Protein - chemistry | Molecular Structure | p38 Mitogen-Activated Protein Kinases - metabolism | p38 Mitogen-Activated Protein Kinases - chemistry | Von Hippel-Lindau Tumor Suppressor Protein - metabolism | Ubiquitin | Complex formation | MAP kinase | Selectivity | Substrates | Recruitment | Proteins | Degradation | Ubiquitination | Proteolysis | Substrate specificity | VHL protein | Chimeras | Neoplasia | Protein families | Ubiquitin-protein ligase | Index Medicus
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A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells
Nature communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, pp. 1366 - 1366
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Hydrogen Sulfide - metabolism | Organ Specificity - drug effects | Neurons - pathology | Kidney - blood supply | Kidney - pathology | Brain - enzymology | Male | Cysteine - administration & dosage | Cysteine - pharmacology | Cytoprotection - drug effects | Cysteine - metabolism | D-Amino-Acid Oxidase - metabolism | Neurons - drug effects | Mammals - metabolism | Kidney - drug effects | Reperfusion Injury - pathology | Mice, Inbred C57BL | Cells, Cultured | Brain - drug effects | Animals | Biosynthetic Pathways - drug effects | Substrate Specificity - drug effects | Mice | Oxidative Stress - drug effects | Sulfurtransferases - metabolism | Index Medicus
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Nature (London), ISSN 0028-0836, 06/2012, Volume 486, Issue 7403, pp. 361 - 367
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Biological and medical sciences | Infectious diseases | Medical sciences | Animal viral diseases | Viral diseases | Drug Evaluation, Preclinical - methods | Molecular Targeted Therapy - adverse effects | Reproducibility of Results | Humans | Substrate Specificity | Forecasting | Cyclooxygenase Inhibitors - pharmacology | Models, Biological | Drug-Related Side Effects and Adverse Reactions | Chlorotrianisene - pharmacology | Chlorotrianisene - chemistry | Toxicity Tests - methods | Chlorotrianisene - adverse effects | Platelet Aggregation - drug effects | Cyclooxygenase 1 - metabolism | Estrogens, Non-Steroidal - adverse effects | Estrogens, Non-Steroidal - pharmacology | Blood Platelets - drug effects | Cyclooxygenase Inhibitors - adverse effects | Databases, Factual | Drugs | Adverse and side effects | Drug targeting | Diagnosis | Methods | Risk factors | Hypothesis testing | Ligands | Databases | Proprietary | Pharmaceutical industry | Index Medicus
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Nature (London), ISSN 0028-0836, 11/2002, Volume 420, Issue 6913, pp. 329 - 333
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Signal transduction | Intermolecular phenomena | Interactions. Associations | Molecular biophysics | Biological and medical sciences | Cell physiology | Molecular and cellular biology | Toll-Like Receptor 1 | Toll-Like Receptor 2 | Toll-Like Receptor 4 | Membrane Glycoproteins - metabolism | Receptors, Interleukin-1 - genetics | Substrate Specificity | Male | NF-kappa B - metabolism | Spleen - drug effects | Toll-Like Receptor 5 | Toll-Like Receptor 7 | Toll-Like Receptors | Receptors, Interleukin-1 - deficiency | Antigens, Differentiation - metabolism | Dendritic Cells - drug effects | Female | Drosophila Proteins | Mice, Inbred C57BL | Cells, Cultured | Receptors, Cell Surface - metabolism | Spleen - cytology | Myeloid Differentiation Factor 88 | Immunity, Innate | Cell Division - drug effects | Interleukin-1 - pharmacology | Macrophages - enzymology | Mice, Knockout | Receptors, Interleukin-1 - metabolism | Adaptor Proteins, Signal Transducing | Macrophages - metabolism | Animals | Signal Transduction - drug effects | Spleen - metabolism | Cell Differentiation - drug effects | Lipopolysaccharides - pharmacology | Macrophages - drug effects | Antigens, Differentiation - genetics | Dendritic Cells - cytology | Interleukin-18 - pharmacology | Mice | Receptors, Immunologic - genetics | Cytokines - biosynthesis | Receptors, Immunologic - metabolism | Mitogen-Activated Protein Kinases - metabolism | Molecules | Immunology | Cytokines | Immune system | Index Medicus
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