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1. Full Text Targeted Deletion of AIF Decreases Mitochondrial Oxidative Phosphorylation and Protects from Obesity and Diabetes
by Pospisilik, J. Andrew and Knauf, Claude and Joza, Nicholas and Benit, Paule and Orthofer, Michael and Cani, Patrice D and Ebersberger, Ingo and Nakashima, Tomoki and Sarao, Renu and Neely, Gregory and Esterbauer, Harald and Kozlov, Andrey and Kahn, C. Ronald and Kroemer, Guido and Rustin, Pierre and Burcelin, Remy and Penninger, Josef M
Cell (Cambridge), ISSN 0092-8674, 2007, Volume 131, Issue 3, pp. 476 - 491
CELLBIO | HUMDISEASE | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Mosaicism - drug effects | Organ Specificity - drug effects | Diabetes Mellitus - genetics | Diet - adverse effects | Apoptosis Inducing Factor - deficiency | Obesity - genetics | Oxidative Phosphorylation - drug effects | Liver - drug effects | Gene Deletion | Cell Respiration - drug effects | Muscles - metabolism | Gene Targeting | Insulin - pharmacology | Liver - metabolism | Diabetes Mellitus - metabolism | Mitochondria - metabolism | Mitochondria - drug effects | Apoptosis Inducing Factor - genetics | Mice, Knockout | Obesity - metabolism | Diabetes Mellitus - prevention & control | Phenotype | Animals | Substrate Specificity - drug effects | Muscles - drug effects | Obesity - prevention & control | Glucose - metabolism | Liver - cytology | Mice | Muscles - cytology | Index Medicus | Obesity | Apoptosis Inducing Factor | Liver | Oxidative Phosphorylation | Muscles | Substrate Specificity | Glucose | Organ Specificity | Diabetes Mellitus | Insulin | Mitochondria | Cell Respiration | Diet | Mosaicism
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2. Full Text Cdc25 Phosphatases:  Structure, Specificity, and Mechanism
by Rudolph, Johannes
Biochemistry (Easton), ISSN 0006-2960, 03/2007, Volume 46, Issue 12, pp. 3595 - 3604
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Protein Structure, Tertiary | Gene Expression Regulation, Enzymologic - drug effects | Protein Structure, Secondary | Neoplasm Proteins - biosynthesis | Humans | cdc25 Phosphatases - chemistry | Enzyme Inhibitors - pharmacology | Neoplasms - enzymology | Enzyme Inhibitors - therapeutic use | Neoplasms - drug therapy | Animals | Substrate Specificity - drug effects | cdc25 Phosphatases - antagonists & inhibitors | cdc25 Phosphatases - biosynthesis | Enzyme Inhibitors - chemistry | Gene Expression Regulation, Neoplastic - drug effects | Cell Cycle - drug effects | Neoplasms - pathology | Binding Sites | Proteins | Mechanical properties | Phosphatases | Research | Structure | Index Medicus
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3. Full Text Cholera toxin binds to lipid rafts but has a limited specificity for ganglioside GM1
by Blank, Norbert and Schiller, Martin and Krienke, Stefan and Wabnitz, Guido and Ho, Anthony D and Lorenz, Hanns‐Martin
Immunology and cell biology, ISSN 0818-9641, 07/2007, Volume 85, Issue 5, pp. 378 - 382
immunological synapse | T‐cell activation | lipid raft | activation marker | Activation marker | Lipid raft | Immunological synapse | T-cell activation | Immunology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Epitopes - metabolism | Leukocytes, Mononuclear - drug effects | Mitogens - pharmacology | Cholera Toxin - metabolism | Glucosidases - metabolism | Membrane Microdomains - metabolism | Endocytosis - drug effects | Humans | Trypsin - metabolism | Substrate Specificity - drug effects | Fluorescein-5-isothiocyanate | T-Lymphocytes - metabolism | Lymphocyte Activation - drug effects | Membrane Microdomains - drug effects | T-Lymphocytes - drug effects | Protein Binding - drug effects | Cell Proliferation - drug effects | G(M1) Ganglioside - metabolism | Trypsin, metabolism | Glucosidases, metabolism | Cholera Toxin, metabolism | Mitogens, pharmacology | Epitopes, metabolism | Cell Proliferation, drug effects | Protein Binding, drug effects | Substrate Specificity, drug effects | Endocytosis, drug effects | T-Lymphocytes, metabolism | Membrane Microdomains, metabolism | Lymphocyte Activation, drug effects | Membrane Microdomains, drug effects | Leukocytes, Mononuclear, drug effects | T-Lymphocytes, drug effects | G(M1) Ganglioside, metabolism | Index Medicus
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4. Full Text Inhibitors of histone deacetylases: Correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells
by Huber, Kelly and Doyon, Geneviève and Plaks, Joseph and Fyne, Elizabeth and Mellors, John W and Sluis-Cremer, Nicolas
The Journal of biological chemistry, ISSN 0021-9258, 06/2011, Volume 286, Issue 25, pp. 22211 - 22218
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | HIV-1 - drug effects | Jurkat Cells | Humans | Histone Deacetylases - chemistry | HIV Long Terminal Repeat - genetics | Substrate Specificity | Histone Deacetylases - metabolism | Peptides, Cyclic - pharmacology | Phosphatidylinositol 3-Kinases - metabolism | HIV-1 - genetics | Valproic Acid - pharmacology | Virus Latency - drug effects | HIV-1 - physiology | Protein Isoforms - metabolism | Virus Activation - drug effects | Signal Transduction - drug effects | Protein Isoforms - chemistry | Adult | HIV-1 - enzymology | Histone Deacetylase Inhibitors - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Hydroxamic Acids - pharmacology | Protein Isoforms - antagonists & inhibitors | Index Medicus | Viral Transcription | Microbiology | HIV | Epigenetics | Antiviral Agents | HIV Latency | Histone Deacetylase
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5. Full Text Structure-and function-based design of Plasmodium-selective proteasome inhibitors
by Li, Hao and O'Donoghue, Anthony J and Van Der Linden, Wouter A and Xie, Stanley C and Yoo, Euna and Foe, Ian T and Tilley, Leann and Craik, Charles S and Da Fonseca, Paula C. A and Bogyo, Matthew
Nature (London), ISSN 0028-0836, 02/2016, Volume 530, Issue 7589, pp. 233 - 236
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Plasmodium falciparum - enzymology | Plasmodium - enzymology | Plasmodium chabaudi - enzymology | Species Specificity | Humans | Proteasome Inhibitors - chemistry | Plasmodium - drug effects | Plasmodium falciparum - drug effects | Protein Subunits - metabolism | Dose-Response Relationship, Drug | Artemisinins - pharmacology | Plasmodium chabaudi - physiology | Drug Design | Plasmodium - growth & development | Female | Drug Resistance | Antimalarials - adverse effects | Catalytic Domain | Proteasome Inhibitors - pharmacology | Models, Molecular | Proteasome Endopeptidase Complex - chemistry | Proteasome Inhibitors - toxicity | Proteasome Inhibitors - adverse effects | Antimalarials - pharmacology | Cryoelectron Microscopy | Drug Synergism | Animals | Substrate Specificity - drug effects | Proteasome Endopeptidase Complex - ultrastructure | Antimalarials - chemistry | Plasmodium chabaudi - drug effects | Mice | Mice, Inbred BALB C | Protein Subunits - antagonists & inhibitors | Protein Subunits - chemistry | Antimalarials - toxicity | Enzyme Activation | Plasmodium falciparum - growth & development | Proteasome Endopeptidase Complex - metabolism | Ubiquitin-proteasome system | Plasmodium | Health aspects | Proteins | Malaria | Protease inhibitors | Proteases | Erythrocytes | Ligands | Parasites | Drug dosages | Index Medicus
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6. Full Text Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase
by Smith, Blake E and Wang, Stephen L and Jaime-Figueroa, Saul and Harbin, Alicia and Wang, Jing and Hamman, Brian D and Crews, Craig M
Nature communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 131 - 131
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Small Molecule Libraries - pharmacology | Humans | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Substrate Specificity | Ubiquitin-Protein Ligases - chemistry | Proteolysis - drug effects | Small Molecule Libraries - chemistry | Ubiquitination - drug effects | Protein Domains | Von Hippel-Lindau Tumor Suppressor Protein - chemistry | Molecular Structure | p38 Mitogen-Activated Protein Kinases - metabolism | p38 Mitogen-Activated Protein Kinases - chemistry | Von Hippel-Lindau Tumor Suppressor Protein - metabolism | Ubiquitin | Complex formation | MAP kinase | Selectivity | Substrates | Recruitment | Proteins | Degradation | Ubiquitination | Proteolysis | Substrate specificity | VHL protein | Chimeras | Neoplasia | Protein families | Ubiquitin-protein ligase | Index Medicus
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7. Full Text A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells
by Shibuya, Norihiro and Koike, Shin and Tanaka, Makiko and Ishigami-Yuasa, Mari and Kimura, Yuka and Ogasawara, Yuki and Fukui, Kiyoshi and Nagahara, Noriyuki and Kimura, Hideo
Nature communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, pp. 1366 - 1366
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Hydrogen Sulfide - metabolism | Organ Specificity - drug effects | Neurons - pathology | Kidney - blood supply | Kidney - pathology | Brain - enzymology | Male | Cysteine - administration & dosage | Cysteine - pharmacology | Cytoprotection - drug effects | Cysteine - metabolism | D-Amino-Acid Oxidase - metabolism | Neurons - drug effects | Mammals - metabolism | Kidney - drug effects | Reperfusion Injury - pathology | Mice, Inbred C57BL | Cells, Cultured | Brain - drug effects | Animals | Biosynthetic Pathways - drug effects | Substrate Specificity - drug effects | Mice | Oxidative Stress - drug effects | Sulfurtransferases - metabolism | Index Medicus
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8. Full Text Large-scale prediction and testing of drug activity on side-effect targets
by Lounkine, Eugen and Keiser, Michael J and Whitebread, Steven and Mikhailov, Dmitri and Hamon, Jacques and Jenkins, Jeremy L and Lavan, Paul and Weber, Eckhard and Doak, Allison K and Côté, Serge and Shoichet, Brian K and Urban, Laszlo
Nature (London), ISSN 0028-0836, 06/2012, Volume 486, Issue 7403, pp. 361 - 367
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Biological and medical sciences | Infectious diseases | Medical sciences | Animal viral diseases | Viral diseases | Drug Evaluation, Preclinical - methods | Molecular Targeted Therapy - adverse effects | Reproducibility of Results | Humans | Substrate Specificity | Forecasting | Cyclooxygenase Inhibitors - pharmacology | Models, Biological | Drug-Related Side Effects and Adverse Reactions | Chlorotrianisene - pharmacology | Chlorotrianisene - chemistry | Toxicity Tests - methods | Chlorotrianisene - adverse effects | Platelet Aggregation - drug effects | Cyclooxygenase 1 - metabolism | Estrogens, Non-Steroidal - adverse effects | Estrogens, Non-Steroidal - pharmacology | Blood Platelets - drug effects | Cyclooxygenase Inhibitors - adverse effects | Databases, Factual | Drugs | Adverse and side effects | Drug targeting | Diagnosis | Methods | Risk factors | Hypothesis testing | Ligands | Databases | Proprietary | Pharmaceutical industry | Index Medicus
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9. Full Text The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors
by Medzhitov, Ruslan and Flavell, Richard A and Horng, Tiffany and Barton, Gregory M
Nature (London), ISSN 0028-0836, 11/2002, Volume 420, Issue 6913, pp. 329 - 333
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Signal transduction | Intermolecular phenomena | Interactions. Associations | Molecular biophysics | Biological and medical sciences | Cell physiology | Molecular and cellular biology | Toll-Like Receptor 1 | Toll-Like Receptor 2 | Toll-Like Receptor 4 | Membrane Glycoproteins - metabolism | Receptors, Interleukin-1 - genetics | Substrate Specificity | Male | NF-kappa B - metabolism | Spleen - drug effects | Toll-Like Receptor 5 | Toll-Like Receptor 7 | Toll-Like Receptors | Receptors, Interleukin-1 - deficiency | Antigens, Differentiation - metabolism | Dendritic Cells - drug effects | Female | Drosophila Proteins | Mice, Inbred C57BL | Cells, Cultured | Receptors, Cell Surface - metabolism | Spleen - cytology | Myeloid Differentiation Factor 88 | Immunity, Innate | Cell Division - drug effects | Interleukin-1 - pharmacology | Macrophages - enzymology | Mice, Knockout | Receptors, Interleukin-1 - metabolism | Adaptor Proteins, Signal Transducing | Macrophages - metabolism | Animals | Signal Transduction - drug effects | Spleen - metabolism | Cell Differentiation - drug effects | Lipopolysaccharides - pharmacology | Macrophages - drug effects | Antigens, Differentiation - genetics | Dendritic Cells - cytology | Interleukin-18 - pharmacology | Mice | Receptors, Immunologic - genetics | Cytokines - biosynthesis | Receptors, Immunologic - metabolism | Mitogen-Activated Protein Kinases - metabolism | Molecules | Immunology | Cytokines | Immune system | Index Medicus
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