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1. Full Text Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages
by Mills, Evanna L and Kelly, Beth and Logan, Angela and Costa, Ana S.H and Varma, Mukund and Bryant, Clare E and Tourlomousis, Panagiotis and Däbritz, J. Henry M and Gottlieb, Eyal and Latorre, Isabel and Corr, Sinéad C and McManus, Gavin and Ryan, Dylan and Jacobs, Howard T and Szibor, Marten and Xavier, Ramnik J and Braun, Thomas and Frezza, Christian and Murphy, Michael P and O’Neill, Luke A
Cell (Cambridge), ISSN 0092-8674, 10/2016, Volume 167, Issue 2, pp. 457 - 470.e13
succinate | reverse electron transport | toll-like receptors | innate immunity | immunometabolism | macrophage | succinate dehydrogenase | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Mitochondria - enzymology | Reactive Oxygen Species - metabolism | Transcriptome | Malonates - pharmacology | Lipopolysaccharides - immunology | Oxidative Phosphorylation - drug effects | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Mitochondrial Proteins - metabolism | Adenosine Triphosphate - metabolism | Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology | Membrane Potential, Mitochondrial | Oxidation-Reduction - drug effects | Interleukin-10 - metabolism | Plant Proteins - metabolism | Macrophages - immunology | Oxidoreductases - metabolism | Mice, Inbred C57BL | Inflammation - immunology | Mitochondria - drug effects | Citric Acid Cycle | Macrophage Activation | Macrophages - metabolism | Succinate Dehydrogenase - genetics | Animals | Sequence Analysis, RNA | Succinic Acid - metabolism | Glycolysis | Inflammation - genetics | Succinate Dehydrogenase - metabolism | Mice | Oxidases | RNA sequencing | Glucose metabolism | Medical colleges | RNA | Gastrointestinal diseases | Genes | Research institutes | Macrophages | Gene expression | Mitogens | Index Medicus
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2. Full Text Interplay between oxidant species and energy metabolism
by Quijano, Celia and Trujillo, Madia and Castro, Laura and Trostchansky, Andrés
Redox biology, ISSN 2213-2317, 08/2016, Volume 8, Issue C, pp. 28 - 42
Energy metabolism | Mitochondria | Reactive oxygen species | Reactive nitrogen species | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Inactivation, Metabolic | Reactive Oxygen Species - metabolism | Oxidation-Reduction | Oxidative Stress | Purines - metabolism | Antioxidants - metabolism | Humans | Oxidants - metabolism | Mitochondria - metabolism | Adenosine Triphosphate - biosynthesis | PPAR gamma - metabolism | Citric Acid Cycle | Animals | Energy Metabolism | Metabolic Networks and Pathways | Electron Transport Chain Complex Proteins - metabolism | Fatty Acids - metabolism | Index Medicus
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3. Full Text Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation
by Lampropoulou, Vicky and Sergushichev, Alexey and Bambouskova, Monika and Nair, Sharmila and Vincent, Emma E and Loginicheva, Ekaterina and Cervantes-Barragan, Luisa and Ma, Xiucui and Huang, Stanley Ching-Cheng and Griss, Takla and Weinheimer, Carla J and Khader, Shabaana and Randolph, Gwendalyn J and Pearce, Edward J and Jones, Russell G and Diwan, Abhinav and Diamond, Michael S and Artyomov, Maxim N
Cell metabolism, ISSN 1550-4131, 07/2016, Volume 24, Issue 1, pp. 158 - 166
Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Inflammation - pathology | Reactive Oxygen Species - metabolism | Macrophages - pathology | Reperfusion Injury - pathology | Reperfusion Injury - enzymology | Succinate Dehydrogenase - antagonists & inhibitors | Mice, Inbred C57BL | Mitochondria - metabolism | Mitochondria - drug effects | Macrophages - enzymology | Macrophages - metabolism | Animals | Succinic Acid - metabolism | Cell Respiration - drug effects | Lipopolysaccharides - pharmacology | Female | Macrophages - drug effects | Succinate Dehydrogenase - metabolism | Macrophage Activation - drug effects | Inflammation - enzymology | Succinates - pharmacology | Medical colleges | Inflammation | Metabolites | Macrophages | Index Medicus
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4. Full Text Immunoresponsive gene 1 and itaconate inhibit succinate dehydrogenase to modulate intracellular succinate levels
by Cordes, Thekla and Wallace, Martina and Michelucci, Alessandro and Divakaruni, Ajit S and Sapcariu, Sean C and Sousa, Carole and Koseki, Haruhiko and Cabrales, Pedro and Murphy, Anne N and Hiller, Karsten and Metallo, Christian M
The Journal of biological chemistry, ISSN 0021-9258, 07/2016, Volume 291, Issue 27, pp. 14274 - 14284
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cell Line | Macrophages - metabolism | Animals | Succinate Dehydrogenase - antagonists & inhibitors | Succinic Acid - metabolism | Lipopolysaccharides - pharmacology | Macrophages - drug effects | Mice | Succinates - pharmacology | Hydro-Lyases - physiology | Index Medicus | succinate | mitochondrial respiratory chain complex | immunoresponsive gene 1 (Irg1) | itaconate | inflammation | succinate dehydrogenase (SDH) | macrophage | Metabolism | metabolic regulation | mitochondrial metabolism
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5. Full Text Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism
by Lussey-Lepoutre, Charlotte and Hollinshead, Kate E. R and Ludwig, Christian and Menara, Mélanie and Morin, Aurélie and Castro-Vega, Luis-Jaime and Parker, Seth J and Janin, Maxime and Martinelli, Cosimo and Ottolenghi, Chris and Metallo, Christian and Gimenez-Roqueplo, Anne-Paule and Favier, Judith and Tennant, Daniel A
Nature communications, ISSN 2041-1723, 11/2015, Volume 6, Issue 1, pp. 8784 - 8784
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Paraganglioma - enzymology | Electron Transport Complex II - genetics | Membrane Proteins - genetics | Neuroendocrine Tumors - metabolism | Paraganglioma - genetics | Humans | Oxidative Phosphorylation | Neuroendocrine Tumors - enzymology | Mice, Knockout | Neuroendocrine Tumors - genetics | Succinate Dehydrogenase - genetics | Animals | Electron Transport Complex II - metabolism | Paraganglioma - metabolism | Pyruvic Acid - metabolism | Aspartic Acid - metabolism | Succinate Dehydrogenase - metabolism | Membrane Proteins - metabolism | Mice | Cell proliferation | Tricarboxylic acid cycle | Phosphorylation | Phenotypes | Succinate dehydrogenase | Dehydrogenases | Homeostasis | Paraganglioma | Pyruvic acid | Amino acids | Metabolism | Dehydrogenase | Pyruvate carboxylase | Substrates | Cell growth | Oxidative phosphorylation | Dependence | Carboxylation | Metabolic pathways | Mutation | Tumors | Index Medicus
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6. Full Text SDH5, a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma
by Huai-Xiang Hao and Oleh Khalimonchuk and Margit Schraders and Noah Dephoure and Jean-Pierre Bayley and Henricus Kunst and Peter Devilee and Cor W. R. J. Cremers and Joshua D. Schiffman and Brandon G. Bentz and Steven P. Gygi and Dennis R. Winge and Hannie Kremer and Jared Rutter
Science (American Association for the Advancement of Science), ISSN 0036-8075, 8/2009, Volume 325, Issue 5944, pp. 1139 - 1142
Yeasts | Mitochondria | Nervous system diseases | Dehydrogenases | Plasmids | Genes | Fluorescence | Antibodies | Reports | Genetic mutation | Tumors | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Neurology | Biological and medical sciences | Medical sciences | Tumors of the nervous system. Phacomatoses | Haplotypes | Saccharomyces cerevisiae - genetics | Humans | Molecular Sequence Data | Male | Mitochondrial Proteins - genetics | Protein Subunits - metabolism | Inheritance Patterns | Saccharomyces cerevisiae - metabolism | Flavin-Adenine Dinucleotide - metabolism | Mitochondrial Proteins - metabolism | Germ-Line Mutation | Female | Amino Acid Sequence | Cell Line | Flavoproteins - metabolism | Paraganglioma - genetics | Oxygen Consumption | Mitochondria - metabolism | Saccharomyces cerevisiae Proteins - genetics | Pedigree | Mitochondrial Proteins - chemistry | Proteomics | Saccharomyces cerevisiae Proteins - metabolism | Cell Line, Tumor | Succinate Dehydrogenase - metabolism | Saccharomyces cerevisiae - growth & development | Saccharomyces cerevisiae Proteins - chemistry | Succinate dehydrogenase complex | Genetic aspects | Gliomas | Health aspects | Adenine | Index Medicus
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7. Full Text SDHAF4 Promotes Mitochondrial Succinate Dehydrogenase Activity and Prevents Neurodegeneration
by Van Vranken, Jonathan G and Bricker, Daniel K and Dephoure, Noah and Gygi, Steven P and Cox, James E and Thummel, Carl S and Rutter, Jared
Cell metabolism, ISSN 1550-4131, 08/2014, Volume 20, Issue 2, pp. 241 - 252
Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Mitochondria - enzymology | Neurodegenerative Diseases - pathology | Oxidative Stress | Saccharomyces cerevisiae Proteins - antagonists & inhibitors | Mitochondrial Proteins - antagonists & inhibitors | Male | Mitochondrial Proteins - genetics | Neurodegenerative Diseases - metabolism | Saccharomyces cerevisiae Proteins - genetics | Drosophila Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Animals | RNA Interference | Electron Transport Complex II - metabolism | Mitochondrial Proteins - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Succinate Dehydrogenase - metabolism | Mice | Drosophila - metabolism | Drosophila Proteins - genetics | Drosophila Proteins - antagonists & inhibitors | RNA, Small Interfering - metabolism | Cells | Medical colleges | Index Medicus | electron transport chain | metabolism | neurodegenerative disease | mitochondria | succinate dehydrogenase
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8. Full Text Succinate dehydrogenase deficient gastrointestinal stromal tumors (GISTs) – A review
by Miettinen, Markku and Lasota, Jerzy
The international journal of biochemistry & cell biology, ISSN 1357-2725, 08/2014, Volume 53, pp. 514 - 519
SDH-complex | GIST | SDHA | SDHB | Gastrointestinal stromal tumor | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Gastrointestinal Stromal Tumors - enzymology | Genetic Predisposition to Disease | Electron Transport Complex II - genetics | Gastrointestinal Stromal Tumors - epidemiology | Membrane Proteins - genetics | Humans | DNA Methylation - genetics | Succinate Dehydrogenase - deficiency | Membrane Proteins - deficiency | Succinate Dehydrogenase - genetics | Gastrointestinal Stromal Tumors - pathology | Electron Transport Complex II - deficiency | Mutation | Energy Metabolism - genetics | Gastrointestinal Stromal Tumors - genetics | Somatomedins - metabolism | Proteins | Immunohistochemistry | Epigenetic inheritance | Analysis | Physiological aspects | Methylation | Tumors | Index Medicus | mutation | pseudohypoxia | SDHC | SDHD
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