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Journal Article
PLoS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, p. e35429
A range of novel carboxamide fungicides, inhibitors of the succinate dehydrogenase enzyme (SDH, EC 1.3.5.1) is currently being introduced to the crop... 
UBIQUINONE-BINDING SITE | BOSCALID RESISTANCE | OXIDATIVE STRESS | CARBOXIN RESISTANCE | ELECTRON-TRANSFER | COMPLEX-II SUCCINATE | BOTRYTIS-CINEREA | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | OXIDOREDUCTASE | IRON-SULFUR SUBUNIT | Niacinamide - analogs & derivatives | Oxidative Stress | Molecular Sequence Data | Plant Diseases - microbiology | Ascomycota - drug effects | Fungal Proteins - antagonists & inhibitors | Norbornanes - pharmacology | Ascomycota - growth & development | Fungicides, Industrial - pharmacology | Biphenyl Compounds - pharmacology | Computer Simulation | Ascomycota - genetics | Conserved Sequence | Inhibitory Concentration 50 | Benzamides - pharmacology | Binding Sites | Triticum - microbiology | Pyrazoles - pharmacology | Amino Acid Sequence | Succinate Dehydrogenase - antagonists & inhibitors | Models, Molecular | Ascomycota - enzymology | Drug Resistance, Fungal - genetics | Fungal Proteins - genetics | Succinate Dehydrogenase - genetics | Mutagenesis | Protein Binding | Pyridines - pharmacology | Niacinamide - pharmacology | Carboxin - pharmacology | Drug resistance in microorganisms | Fungicides | Wheat | Analysis | Reactive oxygen species | Succinate dehydrogenase | Yeast | Dehydrogenases | Enzyme activity | Laboratories | Genes | Amino acids | Homology | Dehydrogenase | Proteins | Ubiquinone | E coli | Enzymatic activity | Docking | Physiology | Pharmaceutical sciences | Binding | Enzymes | Pathogens | Cell survival | Cloning | Pesticides | Pharmacology | Plant protection | Bacteriology | Chemistry | Inhibitors | Neural networks | In vivo methods and tests | Recombinants | Mutation | Binding sites | Fitness | Crop protection
Journal Article
Biological & pharmaceutical bulletin, ISSN 0918-6158, 2007, Volume 30, Issue 1, pp. 54 - 58
Solifenacin succinate [YM905; (3R)-1-azabicyclo[2.2.2]oct-3-yl(1S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate monosuccinate] is a new muscarinic... 
bladder capacity | solifenacin | urinary bladder | muscarinic receptor | Muscarinic receptor | Solifenacin | Urinary bladder | Bladder capacity | OVERACTIVE BLADDER SYNDROME | M-3 MUSCARINIC RECEPTORS | RAT | URINARY-BLADDER | DETRUSOR OVERACTIVITY | TOLTERODINE | SALIVARY-GLAND | IN-VITRO | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | MICE | Cricetulus | Rats, Wistar | Solifenacin Succinate | Benzofurans - pharmacology | Male | Phenylpropanolamine - pharmacology | Receptors, Muscarinic - metabolism | Muscarinic Antagonists - therapeutic use | Pyrrolidines - pharmacology | Dose-Response Relationship, Drug | Mandelic Acids - pharmacology | Muscle, Smooth - drug effects | Urinary Bladder, Overactive - drug therapy | Quinuclidines - therapeutic use | Receptors, Muscarinic - drug effects | Transfection | Muscarinic Antagonists - pharmacology | Tolterodine Tartrate | Urination - drug effects | Benzilates - pharmacology | Cholinergic Agonists - pharmacology | Cresols - pharmacology | CHO Cells | Muscarinic Antagonists - metabolism | Binding, Competitive | Tetrahydroisoquinolines - pharmacology | Cricetinae | Quinuclidines - pharmacology | Rats | Atropine - pharmacology | Tetrahydroisoquinolines - therapeutic use | Rats, Sprague-Dawley | Carbachol - pharmacology | Animals | Muscle Contraction - drug effects | Tetrahydroisoquinolines - metabolism | N-Methylscopolamine - metabolism | Urinary Bladder - drug effects | Benzhydryl Compounds - pharmacology | In Vitro Techniques | Quinuclidines - metabolism
Journal Article
Biomaterials, ISSN 0142-9612, 2014, Volume 35, Issue 37, pp. 9877 - 9887
Abstract P-glycoprotein (P-gp) mediated drug efflux has been recognized as a key factor contributing to the multidrug resistance (MDR) in tumor cells. To... 
Advanced Basic Science | Dentistry | P-glycoprotein | pH-sensitive | Copolymer micelles | d-α-tocopheryl polyethylene glycol succinate | Hyaluronic acid | Multidrug resistance | D-α-tocopheryl polyethylene glycol succinate | PH-sensitive | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | SELF-ASSEMBLED NANOPARTICLES | D-alpha-tocopheryl polyethylene glycol succinate | DRUG-RESISTANCE | POLYMERIC MICELLES | CANCER | HYALURONIC-ACID | VITAMIN-E TPGS | IRON-OXIDE | IN-VITRO | INTRACELLULAR DELIVERY | TARGETED DELIVERY | Doxorubicin - therapeutic use | Histidine - pharmacology | Antibiotics, Antineoplastic - pharmacology | Drug Resistance, Multiple - drug effects | Humans | Vitamin E - analogs & derivatives | Delayed-Action Preparations - chemistry | Hyaluronic Acid - pharmacology | Polyethylene Glycols - chemistry | MCF-7 Cells | Delayed-Action Preparations - pharmacology | Micelles | Female | Vitamin E - chemistry | Doxorubicin - administration & dosage | Polyethylene Glycols - pharmacology | Hyaluronic Acid - chemistry | Breast Neoplasms - drug therapy | Antibiotics, Antineoplastic - administration & dosage | Animals | Antibiotics, Antineoplastic - therapeutic use | Mice, Nude | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Cell Line, Tumor | Mice, Inbred BALB C | Histidine - chemistry | Doxorubicin - pharmacology | Drug Resistance, Neoplasm - drug effects | Vitamin E - pharmacology | Drug resistance in microorganisms | Anthracyclines | Histidine | Hydrogen-ion concentration | Polyols | Polyethylene glycol
Journal Article
Clinical Pharmacokinetics, ISSN 0312-5963, 2009, Volume 48, Issue 4, pp. 211 - 241
... with New and Investigational Antiretrovirals Kevin C. Brown, Sunita Paul and Angela D.M. Kashuba School of Pharmacy, Center for AIDS Research Clinical Pharmacology... 
PHARMACOKINETIC INTERACTION | CCR5 ANTAGONIST | PROTEASE INHIBITOR | IN-VITRO | TREATMENT-NAIVE | IMMUNODEFICIENCY-VIRUS TYPE-1 | ANTIVIRAL ACTIVITY | PHARMACOLOGY & PHARMACY | CLINICAL PHARMACOKINETICS | NEGATIVE HEALTHY-VOLUNTEERS | HIGH GENETIC BARRIER | Anti-HIV Agents - pharmacology | HIV Integrase Inhibitors - pharmacology | Drugs, Investigational - pharmacology | Triterpenes - pharmacology | Humans | Drugs, Investigational - pharmacokinetics | Reverse Transcriptase Inhibitors - pharmacology | Succinates - pharmacokinetics | HIV Integrase Inhibitors - administration & dosage | Reverse Transcriptase Inhibitors - administration & dosage | Anti-HIV Agents - administration & dosage | HIV Protease Inhibitors - pharmacology | Reverse Transcriptase Inhibitors - pharmacokinetics | Succinates - administration & dosage | Drug Interactions | HIV Protease Inhibitors - pharmacokinetics | Molecular Structure | Receptors, Chemokine - antagonists & inhibitors | Drug Therapy, Combination | HIV Integrase Inhibitors - pharmacokinetics | HIV Protease Inhibitors - administration & dosage | Acquired Immunodeficiency Syndrome - drug therapy | Anti-HIV Agents - pharmacokinetics | Drugs, Investigational - administration & dosage | Triterpenes - pharmacokinetics | Succinates - pharmacology | Triterpenes - administration & dosage | Index Medicus
Journal Article
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, ISSN 0363-6119, 02/2009, Volume 296, Issue 2, pp. 289 - 298
Mitochondria affect cerebrovascular tone by activation of mitochondrial ATP-sensitive K+ (KATP) channels and generation of reactive oxygen species (ROS).... 
Depolarization | Zucker obese rats | Mitochondrial ATP-sensitive potassium channels | Diazoxide | PROTEIN-KINASE-C | METABOLIC SYNDROME | ACTIVATION | PHYSIOLOGY | mitochondrial ATP-sensitive potassium channels | DILATION | CALCIUM INFLUX | diazoxide | depolarization | ENDOTHELIAL-CELLS | NITRIC-OXIDE | DYSFUNCTION | POTASSIUM | CA2+ SPARKS | Free Radical Scavengers - pharmacology | Propionates - pharmacology | Mitochondria - enzymology | Diazoxide - pharmacology | Reactive Oxygen Species - metabolism | Muscle, Smooth, Vascular - metabolism | Endothelium, Vascular - drug effects | Male | Metalloporphyrins - pharmacology | Muscle, Smooth, Vascular - physiopathology | Cerebral Arteries - drug effects | Dose-Response Relationship, Drug | Potassium Channels - metabolism | Potassium Channels, Calcium-Activated - metabolism | Nitro Compounds - pharmacology | Nitric Oxide Synthase Type III - metabolism | Potassium Channel Blockers - pharmacology | Superoxide Dismutase - metabolism | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | NG-Nitroarginine Methyl Ester - pharmacology | Vasodilator Agents - pharmacology | Succinate Dehydrogenase - antagonists & inhibitors | Endothelium, Vascular - physiopathology | Enzyme Inhibitors - pharmacology | Insulin Resistance | Rats | Cerebral Arteries - physiopathology | Obesity - physiopathology | Mitochondria - metabolism | Mitochondria - drug effects | Indomethacin - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Nitric Oxide Synthase Type III - antagonists & inhibitors | Obesity - metabolism | Peptides - pharmacology | Rats, Zucker | Animals | Cerebral Arteries - metabolism | Endothelium, Vascular - metabolism | Succinate Dehydrogenase - metabolism | Vasodilation - drug effects | Nitric Oxide - metabolism | Neurohumoral Control of Cardiovascular Function
Journal Article
Nature, ISSN 0028-0836, 04/2000, Volume 404, Issue 6779, pp. 787 - 790
Diabetic hyperglycaemia causes a variety of pathological changes in small vessels, arteries and peripheral nerves. Vascular endothelial cells are an important... 
OVEREXPRESSION | IN-VITRO | ACTIVATION | PROTEIN | RAT | BOVINE ENDOTHELIAL-CELLS | MULTIDISCIPLINARY SCIENCES | ADVANCED GLYCATION ENDPRODUCTS | KAPPA-B | EXPRESSION | ALDOSE REDUCTASE | Electron Transport | Reactive Oxygen Species - metabolism | Uncoupling Agents - pharmacology | Ion Channels | Multienzyme Complexes - metabolism | Endothelium, Vascular - drug effects | NF-kappa B - metabolism | Membrane Proteins - pharmacology | Mitochondrial Proteins | Electron Transport Complex II | Sorbitol - metabolism | Cattle | Protein Kinase C - metabolism | Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology | Carrier Proteins - pharmacology | Hyperglycemia - pathology | Malates - metabolism | Rotenone - pharmacology | Superoxide Dismutase - metabolism | Superoxide Dismutase - pharmacology | Oxidoreductases - metabolism | Thenoyltrifluoroacetone - analogs & derivatives | Mitochondria - metabolism | Hyperglycemia - metabolism | Animals | Thenoyltrifluoroacetone - pharmacology | Endothelium, Vascular - metabolism | Glycation End Products, Advanced - metabolism | Aspartic Acid - metabolism | Endothelium, Vascular - pathology | Succinate Dehydrogenase - metabolism | Hyperglycemia - etiology | Enzyme Activation | Uncoupling Protein 1 | Blood Glucose - metabolism | Oxidation | Pharmacology | Glucose | Diabetes | Metabolism | Cells | Electrons
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 2004, Volume 4, Issue 10, pp. 1059 - 1077
Journal Article
Brain Research, ISSN 0006-8993, 2006, Volume 1133, Issue 1, pp. 186 - 192
Abstract Matrix metalloproteinase inhibitors (MMPIs) reduce blood–brain barrier (BBB) disruption and prevent cell death. Animal models of multiple sclerosis,... 
Neurology | Matrix metalloproteinase inhibitor | Rat | Lipopolysaccharide | Neuroinflammation | Mice | Matrix metalloproteinase | Blood brain barrier | MINOCYCLINE | rat | CNS | matrix metalloproteinase inhibitor | mice | NEUROSCIENCES | blood brain barrier | STROKE | MULTIPLE-SCLEROSIS | neuroinflammation | MOUSE MODEL | INTRACEREBRAL HEMORRHAGE | matrix metalloproteinase | DIMETHYL-SULFOXIDE | RAT-BRAIN | lipopolysaccharide | INFLAMMATORY RESPONSE | Phenylalanine - analogs & derivatives | Species Specificity | Phenylalanine - pharmacology | Blood-Brain Barrier - physiopathology | Rats, Inbred WKY | Dimethyl Sulfoxide - pharmacology | Sulfones - pharmacology | Solvents - pharmacology | Dexamethasone - pharmacology | Encephalitis - physiopathology | Genetic Variation - drug effects | Heterocyclic Compounds, 1-Ring - pharmacology | Inflammation Mediators - pharmacology | Pentoxifylline - pharmacology | Disease Models, Animal | Drug Evaluation, Preclinical - methods | Encephalitis - enzymology | Benzyl Compounds | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Rats | Thiophenes - pharmacology | Blood-Brain Barrier - drug effects | Animals | Blood-Brain Barrier - enzymology | Succinates | Lipopolysaccharides - pharmacology | Matrix Metalloproteinase Inhibitors | Genetic Variation - genetics | Encephalitis - chemically induced | Matrix Metalloproteinases - metabolism | Endothelial Cells - enzymology | Drug Combinations | Endothelial Cells - drug effects
Journal Article
International Journal of Pharmaceutics, ISSN 0378-5173, 09/2014, Volume 472, Issue 1-2, pp. 56 - 64
Journal Article