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Science, ISSN 0036-8075, 5/2012, Volume 336, Issue 6081, pp. 608 - 611
Phytoplankton blooms characterize temperate ocean margin zones in spring. We investigated the bacterioplankton response to a diatom bloom in the North Sea and... 
Phosphates | Metagenomics | Bacterioplankton | REPORTS | Gammaproteobacteria | Ecological succession | Bacteria | Phytoplankton | Bacteroidetes | Diatoms | Roseobacter | BACTERIAL COMMUNITY | TRANSPORT | CARBON | OCEAN | MULTIDISCIPLINARY SCIENCES | ORGANIC-MATTER | DYNAMICS | DEGRADATION | GAMMAPROTEOBACTERIUM | DIVERSITY | SP NOV | Sulfatases - genetics | Gammaproteobacteria - metabolism | Glycoside Hydrolases - genetics | North Sea | Bacteroidetes - enzymology | Alphaproteobacteria - growth & development | Diatoms - metabolism | Eutrophication | Alphaproteobacteria - enzymology | Phytoplankton - growth & development | Membrane Transport Proteins - genetics | Ecosystem | Phytoplankton - metabolism | Sulfatases - metabolism | Gammaproteobacteria - genetics | Membrane Transport Proteins - metabolism | Membrane Proteins - metabolism | Microbial Interactions | Gammaproteobacteria - enzymology | Seawater - microbiology | Membrane Proteins - genetics | Alphaproteobacteria - metabolism | Bacterial Proteins - genetics | Gammaproteobacteria - growth & development | Diatoms - growth & development | Phosphates - metabolism | Alphaproteobacteria - genetics | Bacteroidetes - metabolism | Bacterial Proteins - metabolism | Bacteroidetes - growth & development | Glycoside Hydrolases - metabolism | Bacteroidetes - genetics | Metagenome | Plankton | Phenetics | Physiological aspects | Environmental aspects | Genetic aspects | Biology | Research | Gene expression | Identification and classification | Marine biology | Microscopy | Algae | Index Medicus | Cycles | Uptakes | Scavengers | Marine | Coastal | Carbon | Transporter
Journal Article
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 06/2015, Volume 234, pp. 309 - 319
Estrogens have important roles in the pathogenesis of endometrial cancer. They can have carcinogenic effects through stimulation of cell proliferation or... 
Aromatase pathway | Sulfatase pathway | Phase I and phase II estrogen metabolism | Aldo–keto reductase 1C3 (AKR1C3) | 17β-Hydroxysteroid dehydrogenases (17β-HSDs, HSD17B) | Catechol-O-methyl transferase (COMT) | 17b-Hydroxysteroid dehydrogenases | (17b-HSDs HSD17B)Aldoketo reductase 1C3 (AKR1C3) | 17 beta-Hydroxysteroid dehydrogenases (17 beta-HSDs, HSD17B) | DEHYDROGENASES | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | PROGESTERONE ACTION | 17-BETA-ESTRADIOL | BETA | HYDROXYTAMOXIFEN | Aldo-keto reductase 1C3 (AKR1C3) | ENZYMES | PHARMACOLOGY & PHARMACY | TOXICOLOGY | PHASE-I | CARCINOMA | PRE-RECEPTOR REGULATION | Sulfatases - genetics | Progesterone Reductase - metabolism | Humans | Endometrial Neoplasms - metabolism | Aromatase - metabolism | Catechol O-Methyltransferase - genetics | Hydroxyprostaglandin Dehydrogenases - metabolism | Androstenedione - metabolism | Catechol O-Methyltransferase - metabolism | Aromatase - genetics | Endometrial Neoplasms - genetics | Sulfatases - metabolism | Estrogens - genetics | 3-Hydroxysteroid Dehydrogenases - metabolism | Female | Sulfotransferases - metabolism | Estrogens - metabolism | Quinones - pharmacology | Glutathione S-Transferase pi - genetics | Sulfotransferases - genetics | Estrone - genetics | Quinone Reductases - metabolism | Androstenedione - genetics | Glutathione S-Transferase pi - metabolism | Estrogens - biosynthesis | RNA, Messenger - genetics | Transcriptome - genetics | Progesterone Reductase - genetics | Arylsulfotransferase - genetics | Hydroxyprostaglandin Dehydrogenases - genetics | Estrone - analogs & derivatives | Aldo-Keto Reductase Family 1 Member C3 | Estrone - metabolism | Cell Line, Tumor | Quinone Reductases - genetics | 3-Hydroxysteroid Dehydrogenases - genetics | Arylsulfotransferase - metabolism | Physiological aspects | Endometrial cancer | Sulfates | Genes | Estrogen | Steroids | Index Medicus
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 06/2015, Volume 150, pp. 54 - 63
Epithelial ovarian cancer (EOC) accounts for about 90% of malignant ovarian tumors, and estrogen is often implicated in disease progression. We therefore... 
Estrogen sulfotransferase | Ovarian surface epithelium | Steroid sulfatase | Epithelial ovarian cancer | Estrogen | SURFACE EPITHELIUM | ER-BETA | PROGESTERONE-RECEPTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-LINES | RECEPTOR-ALPHA | ENDOMETRIAL CANCER | STEROID SULFATASE INHIBITORS | BREAST-CANCER | BETA MESSENGER-RNAS | ENDOCRINOLOGY & METABOLISM | AROMATASE EXPRESSION | Epithelial Cells - metabolism | Epithelial Cells - drug effects | Humans | Ovarian Neoplasms - pathology | Neoplasms, Glandular and Epithelial - metabolism | Tritium | RNA, Messenger - metabolism | Hydroxyprostaglandin Dehydrogenases - metabolism | Ovarian Neoplasms - genetics | Neoplasms, Glandular and Epithelial - genetics | Sulfotransferases - antagonists & inhibitors | Biotransformation | 3-Hydroxysteroid Dehydrogenases - metabolism | Female | Ovary - drug effects | Steryl-Sulfatase - metabolism | Sulfotransferases - metabolism | Ovarian Neoplasms - metabolism | Estrogens - metabolism | Ovary - metabolism | Steryl-Sulfatase - genetics | Sulfotransferases - genetics | Neoplasms, Glandular and Epithelial - pathology | Ovary - pathology | RNA, Messenger - genetics | Gene Expression Regulation | Epithelial Cells - pathology | Hydroxyprostaglandin Dehydrogenases - genetics | Aldo-Keto Reductase Family 1 Member C3 | Estradiol Dehydrogenases - genetics | Estradiol Dehydrogenases - metabolism | Carcinoma, Ovarian Epithelial | Cell Line, Tumor | 3-Hydroxysteroid Dehydrogenases - genetics | Interleukin-1alpha - pharmacology | Physiological aspects | Ovarian cancer | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2010, Volume 107, Issue 22, pp. 10202 - 10207
The balance between anabolic and catabolic signaling pathways is critical in maintaining cartilage homeostasis and its disturbance contributes to joint... 
Cartilage | Knee joint | Phosphorylation | Receptors | Articular cartilage | Chondrocytes | Small interfering RNA | Fibroblast growth factors | Gene expression regulation | Osteoarthritis | Heparan sulfate | Smad | Erk | osteoarthritis | MULTIDISCIPLINARY SCIENCES | FIBROBLAST-GROWTH-FACTOR | HUMAN ARTICULAR CHONDROCYTES | NOGGIN | heparan sulfate | INTERVERTEBRAL DISC | HEPARAN-SULFATE | MICE | BONE MORPHOGENETIC PROTEIN-4 | EXPRESSION | SPEMANN ORGANIZER | RNA, Small Interfering - genetics | Sulfatases - genetics | Humans | Homeostasis | Extracellular Signal-Regulated MAP Kinases - metabolism | RNA, Messenger - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Sulfotransferases - deficiency | Fibroblast Growth Factors - metabolism | Bone Morphogenetic Proteins - metabolism | Cartilage, Articular - metabolism | Sulfatases - metabolism | Fibroblast Growth Factor 2 - metabolism | Sulfotransferases - metabolism | Osteoarthritis - pathology | Chondrocytes - metabolism | Sulfatases - antagonists & inhibitors | Sulfotransferases - genetics | ADAMTS5 Protein | Signal Transduction | Matrix Metalloproteinase 13 - genetics | Mice, Inbred C57BL | RNA, Messenger - genetics | Cells, Cultured | Osteoarthritis - metabolism | Smad Proteins - genetics | Sulfatases - deficiency | Osteoarthritis - genetics | Mice, Knockout | Carrier Proteins - genetics | Cartilage, Articular - pathology | Animals | Bone Morphogenetic Protein 7 - metabolism | Mice | ADAM Proteins - genetics | Osteoarthritis - etiology | Smad Proteins - metabolism | Extracellular signal-regulated kinases | Bone morphogenetic proteins | Genetic aspects | Cellular signal transduction | Properties | Observations | Methods | Studies | Proteins | Rodents | Arthritis | Gene expression | Index Medicus | Biological Sciences
Journal Article
Science, ISSN 0036-8075, 8/2001, Volume 293, Issue 5535, pp. 1663 - 1666
The developmental signaling functions of cell surface heparan sulfate proteoglycans (HSPGs) are dependent on their sulfation states. Here, we report the... 
Cell lines | Stem cells | Antibodies | Reports | Physiological regulation | CHO cells | Sulfates | Embryos | Progenitor cells | Endothelial cells | Bleeding | ACTIVATION | PROTEOGLYCANS | GLYCOSAMINOGLYCANS | SONIC HEDGEHOG | MYOD | DOWNSTREAM | MULTIDISCIPLINARY SCIENCES | MUSCLE | ARYLSULFATASE-A | HEPARAN-SULFATE | INDUCTION | Sulfatases - genetics | Heparin - metabolism | MyoD Protein - genetics | Coculture Techniques | Quail - embryology | Embryo, Nonmammalian - metabolism | Molecular Sequence Data | Wnt Proteins | Stem Cells - metabolism | Heparitin Sulfate - metabolism | Recombinant Fusion Proteins - metabolism | Hedgehog Proteins | Transfection | Body Patterning | Cloning, Molecular | Sulfatases - metabolism | Trans-Activators - genetics | Sulfatases - chemistry | Cell Membrane - metabolism | Muscles - metabolism | Heparin - pharmacology | CHO Cells | Proto-Oncogene Proteins - metabolism | Somites - metabolism | Amino Acid Sequence | Cricetinae | Oligonucleotides, Antisense | Signal Transduction | Muscles - embryology | Cells, Cultured | Zebrafish Proteins | MyoD Protein - metabolism | Embryonic Development | Sequence Alignment | Animals | Heparan Sulfate Proteoglycans - metabolism | Trans-Activators - metabolism | Mutation | Muscles - cytology | Proteoglycans | Research | Human embryo | Cellular control mechanisms | Cellular biology | Cells | Index Medicus
Journal Article
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 09/2017, Volume 102, Issue 12, pp. 4588 - 4595
Journal Article
Medicine, ISSN 0025-7974, 09/2018, Volume 97, Issue 38, pp. e12393 - e12393
Rationale: Mucopolysaccharidosis IVA (Morquio A) is a catabolic mucopolysaccharide disorder caused by galactose-6-sulfate sulfatase deficiency. It is an... 
GALNS | DIAGNOSIS | MEDICINE, GENERAL & INTERNAL | galactose-6-sulfate sulfatase | MORQUIO | hormone level. mucopolysaccharidosis IVA | MUTATIONS | Gene mutations | Genetics | Mucopolysaccharidosis | Research | Diagnosis | Risk factors | Endocrinology | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Journal of Molecular Cell Biology, ISSN 1674-2788, 2015, Volume 7, Issue 6, pp. 568 - 579
17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) type 1 is known as a critical target to block the final step of estrogen production in estrogen-dependent... 
17β-hydroxysteroid dehydrogenase type 7 | Steroid enzyme inhibition | Breast cancer | Xenograft tumor | ANDROGEN RECEPTOR | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE-1 | 3-KETOSTEROID REDUCTASE | steroid enzyme inhibition | breast cancer | ENDOCRINE THERAPY | CELL-PROLIFERATION | CELL BIOLOGY | 17 beta-hydroxysteroid dehydrogenase type 7 | xenograft tumor | ESTRADIOL | AROMATASE INHIBITORS | EXPRESSION | RECEPTOR-ASSOCIATED PROTEIN | SULFATASE | Estradiol - blood | Cyclin D1 - metabolism | Multifunctional Enzymes - chemistry | Humans | Resting Phase, Cell Cycle | Multifunctional Enzymes - metabolism | Estrogens - blood | Breast Neoplasms - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Breast Neoplasms - enzymology | MCF-7 Cells | Androgens - blood | Dihydrotestosterone - blood | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Dihydrotestosterone - pharmacology | Female | Membrane Proteins - metabolism | Estrogens - metabolism | Estradiol Dehydrogenases - chemistry | Dihydrotestosterone - metabolism | Estradiol - metabolism | 17-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Cholesterol - metabolism | Multifunctional Enzymes - antagonists & inhibitors | Apoptosis Regulatory Proteins - metabolism | Cell Cycle Checkpoints | G1 Phase | Androgens - pharmacology | 17-Hydroxysteroid Dehydrogenases - genetics | Estrone - metabolism | Cell Proliferation - drug effects | Androgens - metabolism | 17-Hydroxysteroid Dehydrogenases - metabolism | Apoptosis | Index Medicus
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 04/2012, Volume 97, Issue 4, pp. E591 - E601
Journal Article