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Plos One, ISSN 1932-6203, 2015, Volume 10, Issue 10, pp. e0139853 - e0139853
INTRODUCTION: Sulf1 and Sulf2 are cell surface sulfatases, which remove specific 6-O-sulfate groups from heparan sulfate (HS) proteoglycans, resulting in... 
VENTRAL SPINAL-CORD | NERVOUS-SYSTEM | APOPTOSIS | 6-O-SULFATION | 6-O-ENDOSULFATASES | SONIC HEDGEHOG | MULTIDISCIPLINARY SCIENCES | NEUROGENESIS | FIBROBLAST-GROWTH-FACTOR | EXPRESSION | CELL-LINE | Sulfatases - genetics | Hedgehog Proteins - pharmacology | Neurites - physiology | Fibroblast Growth Factor 2 - pharmacology | Male | Sulfotransferases - deficiency | Glial Cell Line-Derived Neurotrophic Factor - pharmacology | Sulfatases - metabolism | Female | Sulfotransferases - metabolism | Neurons - metabolism | Neurites - drug effects | Sulfotransferases - genetics | Cell Survival - drug effects | Signal Transduction | Cerebellum - metabolism | Mice, Inbred C57BL | Cells, Cultured | Nerve Growth Factor - pharmacology | Sulfatases - deficiency | Mice, Knockout | Cell Movement - drug effects | Animals | Heparan Sulfate Proteoglycans - metabolism | Cerebellum - cytology | Mice | Nerve growth factor | Sulfates | Analysis | Antigenic determinants | Cerebellum | Neonates | Neuroprotection | Brain | Cell surface | Cell adhesion & migration | Signal transduction | Pathways | Precursors | Rodents | Localization | Heparan sulfate | Fibroblast growth factor 2 | Glial cell line-derived neurotrophic factor | Biochemical analysis | Cell survival | Proteoglycans | Neurons | Axonogenesis | Granule cells | Survival | Sulfation | Signaling | Molecular modelling | Hedgehog protein | Sulfate | Cell migration | Apoptosis | Index Medicus | Life Sciences | Development Biology | Neurons and Cognition | Embryology and Organogenesis | Neurobiology
Journal Article
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 05/2017, Volume 253, pp. 1 - 10
The lysosomal storage disorder (LSD) metachromatic leukodystrophy (MLD) is caused by a deficiency of the soluble, lysosomal hydrolase arylsulfatase A (ASA).... 
Metachromatic leukodystrophy | Polymeric nanoparticles | Blood-brain barrier | Lysosomal storage disease | Surfactant coating | Enzyme replacement therapy | IMMUNE-RESPONSE | ALBUMIN NANOPARTICLES | BIODEGRADABLE NANOPARTICLES | CHEMISTRY, MULTIDISCIPLINARY | PEPTIDE | ENZYME-REPLACEMENT THERAPY | TRANSPORT | POLY(BUTYL CYANOACRYLATE) NANOPARTICLES | POLY(LACTIC ACID) NANOPARTICLES | MOUSE MODEL | BODY DISTRIBUTION | PHARMACOLOGY & PHARMACY | Nanoparticles - chemistry | Polysorbates - chemistry | Cerebroside-Sulfatase - chemistry | Surface-Active Agents - pharmacokinetics | Brain - metabolism | Leukodystrophy, Metachromatic - metabolism | Polysorbates - administration & dosage | Avidin - chemistry | Female | Serum Albumin, Human - chemistry | Poloxamer - administration & dosage | Poloxamer - chemistry | Biotinylation | Lactic Acid - chemistry | Poloxamer - pharmacokinetics | Cerebroside-Sulfatase - pharmacokinetics | Polysorbates - pharmacokinetics | Mice, Knockout | Leukodystrophy, Metachromatic - drug therapy | Polyesters - chemistry | Animals | Surface-Active Agents - administration & dosage | Polyglycolic Acid - chemistry | Cerebroside-Sulfatase - administration & dosage | Nanoparticles - administration & dosage | Surface-Active Agents - chemistry | Cerebroside-Sulfatase - genetics | Nanoparticles | Enzymes | Surface active agents | Adsorption | Analysis | Index Medicus
Journal Article
Molecular Genetics and Metabolism, ISSN 1096-7192, 2007, Volume 90, Issue 3, pp. 329 - 337
To evaluate the safety and explore the efficacy of idursulfase (recombinant human iduronate-2-sulfatase) treatment for mucopolysaccharidosis II (MPS II).... 
Hunter syndrome | MPS II | Iduronate-2-sulfatase | Glycosaminoglycans | Enzyme replacement therapy | Idursulfase | Lysosomal storage disorder | Mucopolysaccharidosis II | glycosaminoglycans | idursulfase | MEDICINE, RESEARCH & EXPERIMENTAL | OBSTRUCTIVE SLEEP-APNEA | enzyme replacement therapy | 6-MINUTE WALK TEST | BONE-MARROW-TRANSPLANTATION | FABRY-DISEASE | N-ACETYLGALACTOSAMINE 4-SULFATASE | lysosomal storage disorder | DIMETHYLMETHYLENE BLUE | CHILDREN | iduronate-2-sulfatase | mucopolysaccharidosis II | ENDOCRINOLOGY & METABOLISM | GENETICS & HEREDITY | TERM-FOLLOW-UP | SCREENING-PROCEDURE | Recombinant Proteins - therapeutic use | Liver - pathology | Humans | Male | Spleen - drug effects | Recombinant Proteins - adverse effects | Joints - physiopathology | Mucopolysaccharidosis II - pathology | Iduronate Sulfatase - immunology | Immunoglobulin G - biosynthesis | Liver - drug effects | Mucopolysaccharidosis II - physiopathology | Adult | Iduronate Sulfatase - administration & dosage | Safety | Spleen - pathology | Child | Glycosaminoglycans - urine | Double-Blind Method | Joints - drug effects | Recombinant Proteins - administration & dosage | Recombinant Proteins - immunology | Mucopolysaccharidosis II - drug therapy | Adolescent | Infusions, Intravenous | Respiratory Function Tests | Iduronate Sulfatase - therapeutic use | Iduronate Sulfatase - adverse effects | Clinical trials | Product development | Biopharmaceutics | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2006, Volume 281, Issue 8, pp. 4969 - 4976
Journal Article
Science, ISSN 0036-8075, 8/2001, Volume 293, Issue 5535, pp. 1663 - 1666
The developmental signaling functions of cell surface heparan sulfate proteoglycans (HSPGs) are dependent on their sulfation states. Here, we report the... 
Cell lines | Stem cells | Antibodies | Reports | Physiological regulation | CHO cells | Sulfates | Embryos | Progenitor cells | Endothelial cells | Bleeding | ACTIVATION | PROTEOGLYCANS | GLYCOSAMINOGLYCANS | SONIC HEDGEHOG | MYOD | DOWNSTREAM | MULTIDISCIPLINARY SCIENCES | MUSCLE | ARYLSULFATASE-A | HEPARAN-SULFATE | INDUCTION | Sulfatases - genetics | Heparin - metabolism | MyoD Protein - genetics | Coculture Techniques | Quail - embryology | Embryo, Nonmammalian - metabolism | Molecular Sequence Data | Wnt Proteins | Stem Cells - metabolism | Heparitin Sulfate - metabolism | Recombinant Fusion Proteins - metabolism | Hedgehog Proteins | Transfection | Body Patterning | Cloning, Molecular | Sulfatases - metabolism | Trans-Activators - genetics | Sulfatases - chemistry | Cell Membrane - metabolism | Muscles - metabolism | Heparin - pharmacology | CHO Cells | Proto-Oncogene Proteins - metabolism | Somites - metabolism | Amino Acid Sequence | Cricetinae | Oligonucleotides, Antisense | Signal Transduction | Muscles - embryology | Cells, Cultured | Zebrafish Proteins | MyoD Protein - metabolism | Embryonic Development | Sequence Alignment | Animals | Heparan Sulfate Proteoglycans - metabolism | Trans-Activators - metabolism | Mutation | Muscles - cytology | Proteoglycans | Research | Human embryo | Cellular control mechanisms | Cellular biology | Cells | Index Medicus
Journal Article