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DNA Repair, ISSN 1568-7864, 01/2017, Volume 49, pp. 51 - 59
Human PrimPol is a recently discovered bifunctional enzyme that displays DNA template-directed primase and polymerase activities. PrimPol has been implicated... 
Polymerase fidelity | DNA polymerase sugar selectivity | Enzyme regulation | Human PrimPol | Pre-steady-state kinetics | POLYMERIZATION | SULFOLOBUS-SOLFATARICUS P2 | GEMCITABINE | NUCLEOTIDE ANALOGS | REPLICATION | STRUCTURAL BASIS | GENETICS & HEREDITY | TOXICOLOGY | KINETIC BASIS | 1ST-LINE THERAPY | MITOCHONDRIAL-DNA POLYMERASE | MANGANESE MUTAGENESIS | Humans | Cytidine Triphosphate - metabolism | DNA Primase - metabolism | Antineoplastic Agents - therapeutic use | Lamivudine - analogs & derivatives | Antiviral Agents - metabolism | Multifunctional Enzymes - metabolism | Arabinofuranosylcytosine Triphosphate - therapeutic use | Antineoplastic Agents - metabolism | Coenzymes - metabolism | Cations, Divalent - metabolism | Dideoxynucleotides - metabolism | Lamivudine - therapeutic use | Emtricitabine - metabolism | Arabinofuranosylcytosine Triphosphate - metabolism | Emtricitabine - therapeutic use | Antiviral Agents - therapeutic use | Lamivudine - metabolism | DNA Replication | Magnesium - metabolism | Dideoxynucleotides - therapeutic use | DNA - metabolism | Emtricitabine - analogs & derivatives | Manganese - metabolism | Deoxyribonucleotides - metabolism | Cytidine Triphosphate - analogs & derivatives | DNA-Directed DNA Polymerase - metabolism | Kinetics | Cytidine Triphosphate - therapeutic use | Antiviral agents | Enzymes | DNA replication | Anisotropy | Analysis | DNA polymerases | Mitochondrial DNA
Journal Article
DNA Repair, ISSN 1568-7864, 11/2014, Volume 23, pp. 4 - 16
Poly(ADP-ribosyl)ation is a post-translational modification of proteins involved in regulation of many cellular pathways. Poly(ADP-ribose) (PAR) consists of... 
Macrodomain | PARP | PARG | DNA damage response | Poly(ADP-ribose) | MACRO DOMAINS | DNA-DAMAGE RESPONSE | CRYSTAL-STRUCTURE | SULFOLOBUS-SOLFATARICUS | MONO-ADP-RIBOSYLTRANSFERASE | FINGER ANTIVIRAL PROTEIN | STRUCTURAL BASIS | GENETICS & HEREDITY | VIRAL MESSENGER-RNAS | TOXICOLOGY | POLYMERASE-ACTIVITY | IONIZING-RADIATION | Viruses - genetics | Humans | Eukaryotic Cells - metabolism | Proto-Oncogene Proteins - chemistry | Phylogeny | Tankyrases - metabolism | Plant Proteins - chemistry | Fishes | DNA Repair Enzymes - metabolism | Archaeal Proteins - genetics | Plant Proteins - metabolism | Poly(ADP-ribose) Polymerases - chemistry | Insect Proteins - metabolism | DNA Repair Enzymes - chemistry | Archaeal Proteins - metabolism | Hydrolases - metabolism | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Catalytic Domain | Signal Transduction | Viruses - metabolism | Tankyrases - chemistry | Poly Adenosine Diphosphate Ribose - chemistry | Poly Adenosine Diphosphate Ribose - metabolism | Poly(ADP-ribose) Polymerases - metabolism | Animals | Prokaryotic Cells - metabolism | DNA Repair | Insect Proteins - chemistry | Hydrolases - chemistry | Evolution, Molecular | TARG1, terminal ADP-ribose protein glycohydrolase | ARH, ADP-ribosylhydrolase | PARG, poly(ADP-ribose) glycohydrolase | PAR, poly(ADP-ribose) | PARP, poly(ADP-ribose) polymerase | ADPr, ADP-ribose
Journal Article
Journal Article
Journal Article
The FEBS Journal, ISSN 1742-464X, 2013, Volume 280, Issue 18, pp. 4666 - 4680
Four enzymes of the gluconeogenic pathway in Sulfolobus solfataricus were purified and kinetically characterized. The enzymes were reconstituted in vitro to... 
mathematical model | thermal instability | carbon loss | thermophile | HYPERTHERMOPHILIC ARCHAEA | ENTNER-DOUDOROFF PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | METHANOTHERMUS-FERVIDUS | FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE/PHOSPHATASE | THERMOPROTEUS-TENAX | PYROCOCCUS-WOESEI | PHOSPHORYLATING GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE | CENTRAL CARBOHYDRATE-METABOLISM | DNA MICROARRAY ANALYSIS | GLUCOSE-DEHYDROGENASE | Dihydroxyacetone Phosphate - metabolism | Diphosphoglyceric Acids - metabolism | Sulfolobus solfataricus - genetics | Half-Life | Triose-Phosphate Isomerase - genetics | Thermodynamics | Escherichia coli - metabolism | Triose-Phosphate Isomerase - metabolism | Archaeal Proteins - genetics | Fructose-Bisphosphate Aldolase - metabolism | Phosphoglycerate Kinase - genetics | Archaeal Proteins - metabolism | Glyceraldehyde 3-Phosphate - metabolism | Recombinant Proteins - metabolism | Enzyme Stability | Glyceraldehyde-3-Phosphate Dehydrogenases - genetics | Recombinant Proteins - genetics | Sulfolobus solfataricus - chemistry | Hot Temperature | Models, Statistical | Sulfolobus solfataricus - enzymology | Glyceric Acids - metabolism | Gluconeogenesis - genetics | Escherichia coli - genetics | Fructose-Bisphosphate Aldolase - genetics | Glyceraldehyde-3-Phosphate Dehydrogenases - metabolism | Kinetics | Fructosephosphates - biosynthesis | Phosphoglycerate Kinase - metabolism | Phosphates | Glucose metabolism | Enzymes | Metabolites | Analysis | Glucose | Fructose | Dextrose | Mathematical models | Dehydrogenases | High temperature | Efficiency | Data bases
Journal Article
Marine Drugs, ISSN 1660-3397, 02/2017, Volume 15, Issue 2, pp. 37 - 37
Recently, we identified an alginate-assimilating gene cluster in the genome of Flavobacterium sp. strain UMI-01, a member of Bacteroidetes. Alginate lyase... 
2-keto-3-deoxy-D-gluconate (KDG) kinase/2-keto-3-deoxy-6-phosphogluconate (KDPG) aldolase | 4-deoxy-L-erythro-5-hexoseulose uronic acid (DEH) metabolism | Proteobacteria | Flavobacterium | Alginate-derived products | Bacteroidetes | Alginate degradation | alginate-derived products | CHEMISTRY, MEDICINAL | alginate degradation | ENTNER-DOUDOROFF PATHWAY | APLYSIA-KURODAI | 2-keto-3-deoxy-D-gluconate (KDG) kinase | ESCHERICHIA-COLI | SULFOLOBUS-SOLFATARICUS | SACCHAROPHAGUS-DEGRADANS 2-40 | 4-DEOXY-L-ERYTHRO-5-HEXOSEULOSE URONIC-ACID | 2-keto-3deoxy-6-phosphogluconate (KDPG) aldolase | HALIOTIS-DISCUS-HANNAI | 2-KETO-3-DEOXYGLUCONATE KINASE | 2-KETO-3-DEOXY-6-PHOSPHOGLUCONATE KDPG ALDOLASE | OLIGOALGINATE LYASE | Amino Acid Sequence | Proteobacteria - metabolism | Oxidoreductases - metabolism | Glucuronic Acid - metabolism | Phylogeny | Uronic Acids - metabolism | Alginates - metabolism | Gluconates - metabolism | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Sequence Alignment | Bacteroidetes - metabolism | Escherichia coli - metabolism | Aldehyde-Lyases - metabolism | Hexuronic Acids - metabolism | Flavobacterium - metabolism | 4-deoxy | l-erythro-5-hexoseulose uronic acid (DEH) metabolism">">l-erythro-5-hexoseulose uronic acid (DEH) metabolism | d-gluconate (KDG) kinase">">d-gluconate (KDG) kinase | 2-keto-3-deoxy | 2-keto-3-deoxy-6-phosphogluconate (KDPG) aldolase
Journal Article