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Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 06/2013, Volume 21, Issue 11, pp. 2925 - 2931
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2014, Volume 289, Issue 38, pp. 26481 - 26491
The B cell lymphoma-2 (BCL-2) family is the key mediator of cellular sensitivity to apoptosis during pharmacological interventions for numerous human... 
POTENT | OLIGOMERIZES BAK | CANCERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEATH | MITOCHONDRIAL-MEMBRANE | INHIBITORS | CYTOCHROME-C RELEASE | DISCOVERY | ADDICTION | MEMBRANE PERMEABILIZATION | bcl-2-Associated X Protein - chemistry | Nitriles - pharmacology | Apoptosis - drug effects | Mitochondria, Liver - metabolism | Humans | Unilamellar Liposomes - chemistry | bcl-2-Associated X Protein - physiology | Piperazines - chemistry | Proto-Oncogene Proteins - chemistry | Sulfones - pharmacology | Nitrophenols - chemistry | Benzopyrans - chemistry | bcl-X Protein - chemistry | Molecular Mimicry | Bcl-2-Like Protein 11 | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | Membrane Proteins - physiology | Sulfones - chemistry | BH3 Interacting Domain Death Agonist Protein - chemistry | Myeloid Cell Leukemia Sequence 1 Protein - chemistry | Benzamides - pharmacology | Protein Interaction Domains and Motifs | Biphenyl Compounds - chemistry | Benzopyrans - pharmacology | Benzamides - chemistry | Aniline Compounds - pharmacology | BH3 Interacting Domain Death Agonist Protein - physiology | Sulfonamides - chemistry | Apoptosis Regulatory Proteins - chemistry | Permeability | Sulfonamides - pharmacology | Piperazines - pharmacology | Mitochondrial Membranes - metabolism | Mitochondria, Liver - drug effects | Myeloid Cell Leukemia Sequence 1 Protein - physiology | Pyrroles - pharmacology | Animals | Membrane Proteins - chemistry | bcl-X Protein - physiology | Nitriles - chemistry | Proto-Oncogene Proteins - physiology | Pyrroles - chemistry | Apoptosis Regulatory Proteins - physiology | Mice | Aniline Compounds - chemistry | HeLa Cells | Index Medicus | BH3 Mimetics | MOMP | Mitochondria | Bcl-2 Proteins | Bax | Anticancer Drug | Cell Biology | Apoptosis
Journal Article
Science of the Total Environment, ISSN 0048-9697, 02/2014, Volume 472, pp. 800 - 808
Journal Article
Journal Article
Nature, ISSN 0028-0836, 07/2018, Volume 559, Issue 7712, pp. 83 - 88
Over the past three decades, considerable progress has been made in the development of methods to construct sp carbon-nitrogen (C-N) bonds using palladium,... 
Amines - chemistry | Copper - chemistry | Nitrogen - chemistry | Sulfonamides - chemistry | Carboxylic Acids - chemistry | Decarboxylation | Pharmaceutical Preparations - chemistry | Amides - chemistry | Aniline Compounds - chemistry | Catalysis | Carbon - chemistry | Photochemical Processes
Journal Article
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 01/2015, Volume 104, Issue 1, pp. 124 - 134
The primary aim of this research was to produce successfully taste masked formulations of Sildenafil Citrate (SC) using hot-melt extrusion (HME) technology.... 
Hot Melt Extrusion | Crystalline Solid Dispersion | Disintegrating Tablets | Bitter API | Chemical Imaging | Screw Configuration | Taste Masking | Crystalline solid dispersion | Taste masking | Hot melt extrusion | Disintegrating tablets | Chemical imaging | Screw configuration | CHEMISTRY, MEDICINAL | PHARMACOLOGY & PHARMACY | CHEMISTRY, MULTIDISCIPLINARY | EXTRUSION | Phosphodiesterase 5 Inhibitors - chemistry | Piperazines - administration & dosage | Drug Carriers - adverse effects | Tablets | Phosphodiesterase 5 Inhibitors - adverse effects | Humans | Drug Carriers - administration & dosage | Acetates - chemistry | Piperazines - chemistry | Povidone - analogs & derivatives | Purines - administration & dosage | Saliva - chemistry | Equipment Design | Gastric Juice - chemistry | Drug Carriers - chemistry | Sildenafil Citrate | Cellulose - chemistry | Excipients - chemistry | Surface Properties | Purines - adverse effects | Cellulose - analogs & derivatives | Sulfonamides - chemistry | Phosphodiesterase 5 Inhibitors - administration & dosage | Solubility | Hot Temperature | Piperazines - adverse effects | Drug Compounding - instrumentation | Povidone - chemistry | Purines - chemistry | Models, Biological | Sulfonamides - adverse effects | Polymers - chemistry | Vasodilator Agents - chemistry | Taste | Vasodilator Agents - adverse effects | Vasodilator Agents - administration & dosage | Sulfonamides - administration & dosage | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 06/2017, Volume 474, Issue 11, pp. 1867 - 1877
Until recently, one of the major limitations of hydrogen/deuterium exchange mass spectrometry (HDX-MS) was the peptide-level resolution afforded by proteolytic... 
ACTIVATION | AMIDE HYDROGENS | PROTEIN | HDX-MS | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTRAMOLECULAR MIGRATION | KINASE | IDENTIFICATION | CAPTURE DISSOCIATION | BINDING | Oligonucleotides - genetics | Oligonucleotides - chemistry | Class Ia Phosphatidylinositol 3-Kinase - metabolism | Electron Transport | Molecular Weight | Humans | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Enzyme Inhibitors - chemistry | Oligonucleotides - antagonists & inhibitors | Signal Processing, Computer-Assisted | Binding Sites | Peptide Fragments - genetics | Drug Evaluation, Preclinical - methods | Triazines - metabolism | Triazines - pharmacology | Indazoles - chemistry | Enzyme Inhibitors - metabolism | Purines - metabolism | Enzyme Inhibitors - pharmacology | Models, Molecular | Indazoles - metabolism | Recombinant Fusion Proteins - chemistry | Sulfonamides - pharmacology | Class Ia Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Indazoles - pharmacology | Oligonucleotides - metabolism | Peptide Fragments - chemistry | Class I Phosphatidylinositol 3-Kinases | Purines - chemistry | Peptide Fragments - antagonists & inhibitors | Protein Conformation | Quinazolinones - chemistry | Quinazolinones - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Recombinant Fusion Proteins - metabolism | Quinolines - pharmacology | Antineoplastic Agents - metabolism | Tandem Mass Spectrometry | Class Ia Phosphatidylinositol 3-Kinase - chemistry | Deuterium Exchange Measurement | Triazines - chemistry | Antineoplastic Agents - pharmacology | Class Ia Phosphatidylinositol 3-Kinase - genetics | Quinazolinones - pharmacology | Peptide Fragments - metabolism | Reproducibility of Results | Sulfonamides - chemistry | Purines - pharmacology | Quinolines - chemistry | Phosphatidylinositol 3-Kinases - chemistry | Antineoplastic Agents - chemistry | Phosphatidylinositol 3-Kinases - genetics | Quinolines - metabolism | Sulfonamides - metabolism | Index Medicus | 1 | s | 4 | ETD | PI3K | 39 | MS | 8 | 10
Journal Article
PLoS Pathogens, ISSN 1553-7366, 07/2012, Volume 8, Issue 7, pp. 22 - e1002832
Hepatitis C virus (HCV) infects over 170 million people worldwide and is the leading cause of chronic liver diseases, including cirrhosis, liver failure, and... 
WILD-TYPE | RAPID VIRAL RESPONSE | ENZYMATIC-ACTIVITIES | PRECLINICAL PROFILE | MICROBIOLOGY | HCV INFECTION | INTERFERON-ALPHA | VIROLOGY | IN-VIVO | GENOTYPE 1 INFECTION | ANTIVIRAL EFFICACY |