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Biochemical journal, ISSN 0264-6021, 2000, Volume 351, Issue 1, pp. 95 - 105
Journal Article
Drug metabolism and disposition, ISSN 1521-009X, 2012, Volume 40, Issue 9, pp. 1744 - 1756
Interindividual variability in activity of uptake transporters is evident in vivo, yet limited data exist in vitro, confounding in vitro-in vivo extrapolation.... 
DRUG TRANSPORTERS | IN-VITRO CLEARANCE | CRYOPRESERVED HUMAN HEPATOCYTES | HMG-COA REDUCTASE | PHARMACOLOGY & PHARMACY | ANION TRANSPORTING POLYPEPTIDES | HEPATIC-UPTAKE | HEALTHY-VOLUNTEERS | METABOLIC ENZYMES | RECEPTOR ANTAGONIST | PREDICTION | Antihypertensive Agents - pharmacology | Tetrazoles - pharmacology | Species Specificity | Valsartan | Hypoglycemic Agents - metabolism | Benzoates - metabolism | Humans | Antihypertensive Agents - metabolism | Hepatocytes - metabolism | Angiotensin II Type 1 Receptor Blockers - pharmacology | Angiotensin II Type 1 Receptor Blockers - metabolism | Organic Anion Transporters - metabolism | Pyrimidines - metabolism | Quinolines - pharmacology | Tetrazoles - metabolism | Carbamates - metabolism | Dose-Response Relationship, Drug | Fluorobenzenes - pharmacology | Drug Interactions | Hydroxymethylglutaryl-CoA Reductase Inhibitors - metabolism | Biological Transport | Piperidines - pharmacology | Hepatocytes - drug effects | Carbamates - pharmacology | Pravastatin - pharmacology | Fluorobenzenes - metabolism | Piperidines - metabolism | Pravastatin - metabolism | Valine - analogs & derivatives | Rats | Rosuvastatin Calcium | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Hypoglycemic Agents - pharmacology | Quinolines - metabolism | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Valine - metabolism | Models, Biological | Benzimidazoles - metabolism | Sulfonamides - metabolism | Benzoates - pharmacology | Benzimidazoles - pharmacology | Kinetics | Valine - pharmacology | Organic Anion Transporters - drug effects
Journal Article
Nature communications, ISSN 2041-1723, 2014, Volume 5, Issue 1, p. 5712
Increased expression of the Microphthalmia-associated transcription factor (MITF) contributes to melanoma progression and resistance to BRAF pathway... 
BRAF INHIBITION | TYROSINE KINASE AXL | RAF INHIBITION | CELLS | BREAST-CANCER METASTASIS | MULTIDISCIPLINARY SCIENCES | ACQUIRED-RESISTANCE | IMPROVED SURVIVAL | MEK INHIBITORS | UP-REGULATION | CONFERS RESISTANCE | Prognosis | Skin Neoplasms - drug therapy | Humans | Gene Expression Regulation, Neoplastic | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Melanoma - genetics | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Indoles - pharmacology | Pyrimidinones - pharmacology | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Proto-Oncogene Proteins B-raf - metabolism | Melanoma - metabolism | Proto-Oncogene Proteins - metabolism | Skin Neoplasms - pathology | Proto-Oncogene Proteins - antagonists & inhibitors | Microphthalmia-Associated Transcription Factor - metabolism | Signal Transduction | Proto-Oncogene Proteins - genetics | Imidazoles - pharmacology | Melanoma - pathology | Pyrimidines - pharmacology | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Skin Neoplasms - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Receptor Protein-Tyrosine Kinases - genetics | Proto-Oncogene Proteins B-raf - genetics | Aminopyridines - pharmacology | Melanoma - drug therapy | Skin Neoplasms - genetics | Cell Line, Tumor | Oximes - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | Microphthalmia-Associated Transcription Factor - genetics | Pyridones - pharmacology
Journal Article
Behavioural Pharmacology, ISSN 0955-8810, 10/2015, Volume 26, Issue 7 - Special Issue Pharmacological Approaches To The Study Of Social Behaviour - Part 2: Social Modulation Of Drug Effects, pp. 681 - 690
Journal Article
Psychopharmacology, ISSN 0033-3158, 1/2014, Volume 231, Issue 1, pp. 269 - 281
Journal Article
The Journal of physiology, ISSN 0022-3751, 2010, Volume 588, Issue 14, pp. 2605 - 2619
In vertebrate retina, melatonin regulates various physiological functions. In this work we investigated the mechanisms underlying melatonin‐induced... 
CIRCADIAN CLOCK | PROTEIN-KINASE-C | ACTIVATION | PHYSIOLOGY | PHOSPHOLIPASE-C | VISUAL PATHWAY | FUNCTIONAL-ROLE | RECEPTOR | MT2 MELATONIN | EXPRESSION | NEUROSCIENCES | MODULATION | Cyclic GMP - pharmacology | Receptor, Melatonin, MT2 - antagonists & inhibitors | Tetradecanoylphorbol Acetate - pharmacology | Maleimides - pharmacology | Male | Calcium - analysis | Melatonin - physiology | Type C Phospholipases - antagonists & inhibitors | Cyclic GMP-Dependent Protein Kinases - antagonists & inhibitors | Cyclic GMP-Dependent Protein Kinases - physiology | Isoquinolines - pharmacology | Cyclic GMP - analogs & derivatives | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Bridged-Ring Compounds - pharmacology | Egtazic Acid - analogs & derivatives | Indoles - pharmacology | Guanosine Diphosphate - pharmacology | Pertussis Toxin - pharmacology | Retinal Ganglion Cells - physiology | Protein Kinase C - physiology | Retinal Ganglion Cells - enzymology | 8-Bromo Cyclic Adenosine Monophosphate - pharmacology | Rats | Protein Kinase C - antagonists & inhibitors | Receptor, Melatonin, MT2 - physiology | Sulfonamides - pharmacology | Rats, Sprague-Dawley | Animals | Egtazic Acid - pharmacology | Glycine - physiology | Guanosine Diphosphate - analogs & derivatives | Signal Transduction - drug effects | Tetrahydronaphthalenes - pharmacology | Thiones - pharmacology | Carbazoles - pharmacology | Type C Phospholipases - physiology | Melatonin | Phospholipids | Glycine | Ganglion | Gross domestic product | Protein kinases | Kinases | Retina | Physiology | Neuroscience
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2012, Volume 287, Issue 15, pp. 11810 - 11819
gamma-Secretase-mediated cleavage of amyloid precursor protein (APP) results in the production of Alzheimer disease-related amyloid-beta (A beta) peptides. The... 
TARGET | PROTEIN | PATTERN | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSMEMBRANE DOMAIN | INHIBITORS | BINDING-SITES | EXPRESSION | FAILURE | PRESENILIN-1 | Pyridines - chemistry | Receptors, Notch - metabolism | Humans | Receptor, EphA4 - metabolism | Pyrimidines - chemistry | Brain - metabolism | Alanine - analogs & derivatives | Dibenzazepines - pharmacology | Drug Interactions | Azepines - chemistry | Piperidines - pharmacology | Protein Processing, Post-Translational - drug effects | Pyrans - chemistry | Amyloid beta-Protein Precursor - metabolism | HEK293 Cells | Female | Pyrans - pharmacology | Alanine - pharmacology | Carbamates - pharmacology | Binding, Competitive | Guinea Pigs | Amyloid beta-Peptides - biosynthesis | Dipeptides - pharmacology | Mice, Inbred C57BL | Rats | Imidazoles - pharmacology | Pyrimidines - pharmacology | Receptor, EphB2 - metabolism | Sulfonamides - pharmacology | Azepines - pharmacology | Brain - drug effects | Sulindac - analogs & derivatives | Amyloid Precursor Protein Secretases - metabolism | Animals | Cell-Free System | Protein Binding | Mice | Pyridines - pharmacology | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Flurbiprofen - pharmacology | Sulindac - pharmacology | Neurodegenerative Diseases | Secretases | Neurobiology | Intramembrane Proteolysis | Amyloid | Pharmacology | Alzheimer Disease
Journal Article
PloS one, ISSN 1932-6203, 2019, Volume 14, Issue 1, pp. e0210608 - e0210608
Standard treatment, unfortunately, yields a poor prognosis for patients with primary or metastatic cancers in the central nervous system, indicating a... 
CELLS | APOPTOSIS | ACTIVATION | MELANOMA | BEVACIZUMAB | MULTIDISCIPLINARY SCIENCES | IMMUNOTOXIN THERAPY | PROTEOGLYCAN | INHIBITOR | PROMOTES | EXPRESSION | Thiophenes - therapeutic use | Humans | Antineoplastic Agents - therapeutic use | Furin - pharmacology | Immunotoxins - pharmacology | Biphenyl Compounds - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Proto-Oncogene Proteins c-bcl-2 - metabolism | Brain Neoplasms - secondary | Isoquinolines - pharmacology | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | Time Factors | Nitrophenols - therapeutic use | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Cell Death - drug effects | Benzothiazoles - pharmacology | Endocytosis - drug effects | Chondroitin Sulfate Proteoglycans - metabolism | Thiophenes - pharmacology | Exotoxins - pharmacology | Piperazines - therapeutic use | Pyrimidines - pharmacology | Brain Neoplasms - drug therapy | Sulfonamides - pharmacology | Piperazines - pharmacology | Drug Synergism | Xenograft Model Antitumor Assays | Animals | Immunotoxins - therapeutic use | Signal Transduction - drug effects | Sulfonamides - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mice, Nude | Models, Biological | Pyrimidines - therapeutic use | Survival Analysis | Cell Line, Tumor | Isoquinolines - therapeutic use | Benzothiazoles - therapeutic use | Care and treatment | Prognosis | Brain tumors | Central nervous system diseases | Research | Antibody-toxin conjugates | Health aspects | Brain | Animal models | Bcl-2 protein | Laboratories | Toxicity | Brain cancer | Xenotransplantation | Lung cancer | Central nervous system | Glioblastoma | Cytotoxicity | Metastasis | Neurosurgery | Kinases | Cancer therapies | Anticancer properties | Metastases | Proteins | Xenografts | Antigens | Proteoglycans | Melanoma | Poly(ADP-ribose) polymerase | Breast cancer | Pharmacology | Tumor cell lines | Patients | Chemical compounds | Immunotoxins | Pathology | Chemotherapy | Pancreatic cancer | Antitumor activity | Sensitivity enhancement | Chondroitin sulfate | Synergistic effect | Apoptosis | Tumors | Index Medicus
Journal Article
Circulation Research: Journal of the American Heart Association, ISSN 0009-7330, 08/2003, Volume 93, Issue 4, pp. 311 - 320
ABSTRACT—Homocysteine (Hcy) is an independent risk factor for cardiovascular disease. Monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) are... 
Monocyte chemoattractant protein-1 | Monocytes | Homocysteine | Interleukin-8 | Atherosclerosis | homocysteine | atherosclerosis | monocytes | ENDOTHELIAL-CELL INJURY | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | OXIDANT STRESS | monocyte chemoattractant protein-1 | RISK FACTOR | PLASMA HOMOCYST(E)INE | interleukin-8 | VASCULAR-DISEASE | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | ATHEROMATOUS PLAQUES | HEMATOLOGY | NF-KAPPA-B | T-LYMPHOCYTES | Interleukin-8 - genetics | Reactive Oxygen Species - metabolism | Chemokine CCL2 - secretion | Monocytes - cytology | Humans | Dimethyl Sulfoxide - pharmacology | Monocytes - metabolism | RNA, Messenger - metabolism | Pyrrolidines - pharmacology | Dose-Response Relationship, Drug | Thiocarbamates - pharmacology | Chromans - pharmacology | Time Factors | Homocysteine - pharmacology | Indoles - pharmacology | Interleukin-8 - secretion | Flavonoids - pharmacology | RNA, Messenger - drug effects | RNA, Messenger - genetics | Cells, Cultured | Enzyme Inhibitors - pharmacology | Chemokine CCL2 - genetics | Imidazoles - pharmacology | Tyrphostins - pharmacology | Antioxidants - pharmacology | Onium Compounds - pharmacology | Sulfonamides - pharmacology | Naphthalenes - pharmacology | Gene Expression Regulation - drug effects | Monocytes - drug effects | Genistein - pharmacology | Pyridines - pharmacology | Thiazoles - pharmacology | Thiazolidinediones
Journal Article