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Cell, ISSN 0092-8674, 2011, Volume 145, Issue 6, pp. 863 - 874
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 06/2017, Volume 37, Issue 8, pp. 1503 - 1512
OBJECTIVE—Phosphatidylserine exposure mediates platelet procoagulant function and regulates platelet life span. Apoptotic, necrotic, and integrin-mediated... 
phosphatidylserine | blood platelet | cell death | cytosol | mitochondrial membrane | PERMEABILITY TRANSITION PORE | ACTIVATION | BLOOD-COAGULATION | INTEGRIN ALPHA(IIB)BETA | PROCOAGULANT PLATELETS | CELL-DEATH | THROMBUS GROWTH | CALCIUM | SURFACE | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | EXPOSURE | Crotalid Venoms - pharmacology | Apoptosis - drug effects | Venous Thrombosis - blood | bcl-2 Homologous Antagonist-Killer Protein - genetics | Mitochondria - ultrastructure | Necrosis | Mitochondrial Membranes - drug effects | Cytochromes c - blood | Thrombin - pharmacology | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | bcl-2 Homologous Antagonist-Killer Protein - blood | Platelet Aggregation - drug effects | Blood Platelets - drug effects | Integrins - blood | bcl-2-Associated X Protein - blood | bcl-2-Associated X Protein - genetics | Disease Models, Animal | Cyclophilins - blood | Signal Transduction | Lectins, C-Type | Genotype | Cyclophilins - genetics | Mitochondria - metabolism | Mitochondria - drug effects | Sulfonamides - pharmacology | Piperazines - pharmacology | Mice, Knockout | Mitochondrial Membranes - metabolism | Phenotype | Animals | Blood Coagulation - drug effects | Blood Platelets - metabolism | Blood Platelets - ultrastructure | Venous Thrombosis - genetics | Caspases - blood | Kinetics | Venous Thrombosis - pathology | Phosphatidylserines - blood | Index Medicus | platelet | inner mitochondrial membrane
Journal Article
Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 12/2007, Volume 5, Issue 12, pp. 2376 - 2385
Background:  Selective inhibitors of cyclooxygenase‐2 (COX‐2) called coxibs, are effective anti‐inflammatory and analgesic drugs. Recently, these drugs were... 
thromboxane | coxibs | thrombin generation | prostacyclin | NSAID | platelet activation | Thrombin generation | Prostacyclin | Platelet activation | Thromboxane | Coxibs | MASS-SPECTROMETRY | CYCLOOXYGENASES | ANTIPLATELET | THROMBOMODULIN | CLOPIDOGREL | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | EXPRESSION | IONIZATION | TISSUE FACTOR | Humans | Naproxen - pharmacology | Sulfones - adverse effects | Male | Reference Values | Blood Platelets - enzymology | Sulfones - pharmacology | Prostaglandins - blood | Lactones - pharmacology | Phospholipases A - blood | Cyclooxygenase 2 Inhibitors - adverse effects | Sulfonamides - blood | Lactones - blood | Cyclooxygenase 2 - blood | Time Factors | Prostaglandins - urine | Pyrazoles - blood | Antigens, Neoplasm - blood | Adult | Platelet Aggregation - drug effects | Cyclooxygenase 2 Inhibitors - blood | Blood Platelets - drug effects | Sulfones - blood | Pyrazoles - adverse effects | Pyrazoles - pharmacology | Thrombomodulin - blood | Naproxen - adverse effects | Cyclic AMP - blood | Cyclooxygenase 2 Inhibitors - pharmacology | Double-Blind Method | Celecoxib | Lactones - adverse effects | Cell Adhesion - drug effects | Naproxen - blood | Sulfonamides - pharmacology | Thromboxanes - blood | Thromboxanes - urine | Blood Platelets - metabolism | Fibrinogen - metabolism | P-Selectin - blood | Sulfonamides - adverse effects | Leukocytes - drug effects | Platelet Activation - drug effects | Thrombin - metabolism | Platelet Membrane Glycoprotein IIb - blood | Physiological aspects | Prothrombin | COX-2 inhibitors | Thrombin | Analysis | Index Medicus
Journal Article
Molecular Pharmaceutics, ISSN 1543-8384, 08/2012, Volume 9, Issue 8, pp. 2358 - 2363
The aims of this work were to study pharmacokinetics of randomly selected drugs in plasma and saliva samples in healthy human volunteers, and to introduce a... 
Salivary Excretion Classification System | effective permeability | pharmacokinetics | protein binding | bioequivalence | SimCYP | MEDICINE, RESEARCH & EXPERIMENTAL | RELATIVE BIOAVAILABILITY | PERMEABILITY | CLINICAL PHARMACOKINETICS | BIOLOGICAL FLUID | DRUGS | PHARMACOLOGY & PHARMACY | Quinolines - blood | Acetates - blood | Fluorobenzenes - pharmacokinetics | Hydrochlorothiazide - pharmacokinetics | Triazoles - blood | Piroxicam - blood | Azithromycin - blood | Humans | Losartan - blood | Saliva - secretion | Male | Naphthalenes - blood | Benzhydryl Compounds - blood | Fluorobenzenes - pharmacology | Quinolines - pharmacokinetics | Sulfonamides - blood | Azithromycin - pharmacokinetics | Tolterodine Tartrate | Female | Triazoles - pharmacokinetics | Naphthalenes - pharmacokinetics | Piroxicam - analogs & derivatives | Sitagliptin Phosphate | Hydrochlorothiazide - blood | Losartan - pharmacokinetics | Benzhydryl Compounds - pharmacokinetics | Metformin - blood | Cresols - blood | Phenylpropanolamine - blood | Metformin - pharmacokinetics | Rosuvastatin Calcium | Cloxacillin - pharmacokinetics | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Sulfonamides - pharmacokinetics | Cinacalcet Hydrochloride | Cloxacillin - blood | Saliva - metabolism | Pyrazines - pharmacokinetics | Piroxicam - pharmacokinetics | Pyrimidines - pharmacokinetics | Cresols - pharmacokinetics | Anthraquinones - blood | Anthraquinones - pharmacokinetics | Phenylpropanolamine - pharmacokinetics | Pyrazines - blood | Acetates - pharmacokinetics | Index Medicus
Journal Article
FASEB Journal, ISSN 0892-6638, 03/2006, Volume 20, Issue 3, pp. 542 - 544
It is widely believed that the potencies of nonsteroid anti-inflammatory drugs ( NSAIDs) as inhibitors of cyclooxygenase ( COX) are influenced by protein... 
SITE | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | nonsteroid anti-inflammatory drugs | coxibs | PROSTAGLANDIN H-2 SYNTHASE | CELL BIOLOGY | CYCLO-OXYGENASE-2 | THERAPY | FLUID | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | BIOLOGY | prostaglandins | SELECTIVITY | Organic Chemicals - cerebrospinal fluid | Humans | Naproxen - pharmacology | Synovial Fluid - metabolism | Pyrazoles - cerebrospinal fluid | Sodium Salicylate - pharmacology | Lactones - pharmacology | Aspirin - cerebrospinal fluid | Cell Line - drug effects | Calcium - physiology | Pyrazoles - blood | Organic Chemicals - pharmacology | Dinoprostone - cerebrospinal fluid | Diclofenac - cerebrospinal fluid | Aspirin - pharmacology | Sulfones - cerebrospinal fluid | Aspirin - blood | Thiazines - blood | Sulfonamides - pharmacology | Indomethacin - cerebrospinal fluid | Indomethacin - pharmacology | Cyclooxygenase 1 - drug effects | Cyclooxygenase Inhibitors - adverse effects | Cyclooxygenase Inhibitors - blood | Diclofenac - pharmacology | Thiazoles - blood | Thromboxane A2 - blood | Cerebrospinal Fluid Proteins - pharmacology | Dinoprostone - biosynthesis | Lactones - cerebrospinal fluid | Blood Platelets - enzymology | Cyclooxygenase 2 Inhibitors - cerebrospinal fluid | Sodium Salicylate - cerebrospinal fluid | Sulfones - pharmacology | Blood Proteins - pharmacology | Cyclooxygenase 2 Inhibitors - adverse effects | Sulfonamides - blood | Lactones - blood | Naproxen - cerebrospinal fluid | Sodium Salicylate - blood | Thiazines - pharmacology | Cyclooxygenase 2 Inhibitors - blood | Cyclooxygenase Inhibitors - cerebrospinal fluid | Blood Platelets - drug effects | Sulfones - blood | Organic Chemicals - blood | Ionophores - pharmacology | Pyrazoles - pharmacology | Sulfonamides - cerebrospinal fluid | Cyclooxygenase 2 Inhibitors - pharmacology | Thiazoles - cerebrospinal fluid | Celecoxib | Diclofenac - blood | Dinoprostone - blood | Naproxen - blood | Organ Specificity | Calcimycin - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Indomethacin - blood | Protein Binding | Thiazines - cerebrospinal fluid | Thiazoles - pharmacology | Index Medicus
Journal Article
Blood, ISSN 0006-4971, 04/2013, Volume 121, Issue 15, pp. 3023 - 3032
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 168 - 176
This study investigated the role of a multispecific organic anion transporter, Oatp1a4/ Slco1a4 , in drug transport across the blood-brain barrier. In vitro... 
LOCALIZATION | INVOLVEMENT | POLYPEPTIDE-2 | PENETRATION | PHARMACOLOGY & PHARMACY | RAT-BRAIN | OATP2 | BCRP/ABCG2 | 17-BETA-ESTRADIOL-D-17-BETA-GLUCURONIDE | CANCER RESISTANCE PROTEIN | P-GLYCOPROTEIN | Fluorobenzenes - pharmacokinetics | Gene Expression - genetics | Pyrimidines - blood | Humans | Ion Pumps - genetics | Fluorobenzenes - administration & dosage | Quinolines - administration & dosage | Pyrimidines - metabolism | Brain - metabolism | Quinolines - pharmacokinetics | Choroid Plexus - blood supply | ATP-Binding Cassette Transporters - genetics | Ochratoxins - administration & dosage | Cell Membrane - metabolism | Cerebral Cortex - drug effects | Capillaries - metabolism | Fluorobenzenes - metabolism | Tetrahydroisoquinolines - pharmacology | Organic Cation Transport Proteins - metabolism | Pravastatin - metabolism | Liver - metabolism | Rosuvastatin Calcium | Sulfonamides - pharmacokinetics | Blood-Brain Barrier - metabolism | Mice, Knockout | Brain - drug effects | Taurocholic Acid - administration & dosage | Pravastatin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - administration & dosage | Pyrimidines - pharmacokinetics | Mice | Kinetics | Organic Cation Transport Proteins - genetics | Pravastatin - pharmacokinetics | Sulfonamides - administration & dosage | Quinolines - blood | Digoxin - metabolism | Taurocholic Acid - metabolism | Choroid Plexus - metabolism | Taurocholic Acid - blood | Ochratoxins - pharmacokinetics | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Ochratoxins - metabolism | Cerebral Cortex - metabolism | Organic Anion Transporters - metabolism | Brain - blood supply | Sulfonamides - blood | Organic Anion Transporters - genetics | Transfection | Fluorobenzenes - blood | Enkephalin, D-Penicillamine (2,5)- - pharmacokinetics | Recombinant Proteins - metabolism | Cell Line | Pyrimidines - administration & dosage | Mice, Inbred C57BL | Recombinant Proteins - genetics | Blood-Brain Barrier - drug effects | Digoxin - pharmacokinetics | Quinolines - metabolism | Taurocholic Acid - pharmacokinetics | Liver - blood supply | Pharmaceutical Preparations - metabolism | Animals | Digoxin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - metabolism | Acridines - pharmacology | Sulfonamides - metabolism | Index Medicus
Journal Article
Circulation Research, ISSN 0009-7330, 07/2014, Volume 115, Issue 3, pp. 388 - 399
Journal Article
Clinica Chimica Acta, ISSN 0009-8981, 07/2017, Volume 470, pp. 8 - 13
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2018, Volume 13, Issue 10, pp. e0205600 - e0205600
Aims Liver injury can occur during antiviral therapies with direct-acting antivirals (DAAs), potentially necessitating discontinuation of the therapies, with... 
HEPATOCELLULAR-CARCINOMA | POSITIVE MAC-2-BINDING PROTEIN | ANTIVIRAL THERAPY | SAFETY | COMBINATION THERAPY | MULTIDISCIPLINARY SCIENCES | ALANINE AMINOTRANSFERASE ELEVATION | 1B INFECTION | JAPANESE PATIENTS | DRUG-DRUG INTERACTIONS | NS5A INHIBITORS | Isoquinolines - adverse effects | Humans | Middle Aged | Hepacivirus - genetics | Hepatitis C, Chronic - virology | Male | Protein Isoforms - blood | Young Adult | Sulfonamides - blood | Drug Therapy, Combination - adverse effects | Antigens, Neoplasm - blood | Protease Inhibitors - adverse effects | Adult | Female | Retrospective Studies | Imidazoles - therapeutic use | Protease Inhibitors - therapeutic use | Liver Cirrhosis - etiology | Antiviral Agents - blood | Antiviral Agents - therapeutic use | Imidazoles - adverse effects | Membrane Glycoproteins - blood | Isoquinolines - blood | Liver Cirrhosis - blood | Biomarkers - blood | Hepatitis C, Chronic - drug therapy | Imidazoles - blood | Sulfonamides - therapeutic use | Antiviral Agents - adverse effects | Isoquinolines - therapeutic use | Protease Inhibitors - blood | Sulfonamides - adverse effects | Aged | Antiviral agents | Complications and side effects | Usage | Care and treatment | Genetic aspects | Research | Hepatitis C virus | Liver cirrhosis | Risk factors | Protein binding | Therapy | Correlation | Hemodialysis | Liver | Transaminase | Viruses | Proteins | Confidence intervals | Hepatitis | Liver cancer | Genotype & phenotype | Elevation | Consent | Hepatology | Gastroenterology | Drug dosages | Injuries | Genotypes | Statistical analysis | Glycosylation | Serum albumin | Regression analysis | Patients | Medicine | Fibrosis | Interferon | Hepatitis C | Platelets | Index Medicus
Journal Article