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Journal of sexual medicine, ISSN 1743-6095, 12/2012, Volume 9, Issue 12, pp. 3028 - 3040
Journal Article
Journal of sexual medicine, ISSN 1743-6095, 04/2013, Volume 10, Issue 4, pp. 960 - 971
Prevalence of erectile dysfunction (ED) increases progressively with aging, but the ED pathophysiology at its early stages is still poorly investigated. This... 
Erectile Dysfunction | Antioxidant Therapy | Oxidative Stress | Corpus Cavernosum | Apocynin | Superoxide Dismutase | STIMULATOR BAY 41-2272 | HUMAN CORPUS CAVERNOSUM | RELAXATION | DIABETIC-RATS | PHOSPHODIESTERASE TYPE-5 INHIBITORS | SOLUBLE GUANYLATE-CYCLASE | SMOOTH-MUSCLE | CARDIOVASCULAR-DISEASE | UROLOGY & NEPHROLOGY | ENDOGENOUS NITRIC-OXIDE | Blood Pressure | Free Radical Scavengers - pharmacology | Cyclic GMP - pharmacology | Up-Regulation | Electric Stimulation | Membrane Glycoproteins - metabolism | NADPH Oxidases - metabolism | Male | Nitroprusside - pharmacology | RNA, Messenger - metabolism | Sulfones - pharmacology | Penile Erection | Sildenafil Citrate | Cyclic GMP - analogs & derivatives | Acetophenones - pharmacology | NADPH Oxidases - genetics | Phosphodiesterase 5 Inhibitors - pharmacology | Superoxide Dismutase - metabolism | Pyrazoles - pharmacology | Superoxide Dismutase - pharmacology | Vasodilator Agents - pharmacology | Acetylcholine - pharmacology | Purines - pharmacology | Down-Regulation | Enzyme Inhibitors - pharmacology | Rats | Muscle Relaxation | NADPH Oxidase 2 | Piperazines - pharmacology | Erectile Dysfunction - metabolism | Membrane Glycoproteins - genetics | Animals | Aging - physiology | Cyclic GMP - metabolism | Endothelium, Vascular - metabolism | Nitric Oxide Synthase - metabolism | Pyridines - pharmacology | Superoxide Dismutase-1 | Prevention | Oxidases | Antioxidants | Impotence | Nitric oxide | Sodium nitroferricyanide | Superoxide
Journal Article
Journal Article
Respiratory Research, ISSN 1465-9921, 12/2011, Volume 12, Issue 1, pp. 1 - 8
The development of bronchial hyperreactivity (BHR) subsequent to precapillary pulmonary hypertension (PHT) was prevented by acting on the major signalling... 
Medicine & Public Health | Pneumology/Respiratory System | PARENCHYMAL MECHANICS | LUNG | METHACHOLINE-INDUCED BRONCHOCONSTRICTION | AIRWAY | THERAPY | VASOACTIVE-INTESTINAL-PEPTIDE | RESPIRATORY SYSTEM | ARTERIAL-HYPERTENSION | INHALATION | NITRIC-OXIDE | VIP | Antihypertensive Agents - pharmacology | Tetrazoles - pharmacology | Airway Resistance - drug effects | Iloprost - pharmacology | Bronchial Provocation Tests | Antihypertensive Agents - administration & dosage | Hypertension, Pulmonary - physiopathology | Male | Endothelins - metabolism | Sulfones - pharmacology | Lung Volume Measurements | Sildenafil Citrate | Time Factors | Vasoactive Intestinal Peptide - pharmacology | Bronchoconstriction - drug effects | Bronchial Hyperreactivity - physiopathology | Bronchial Hyperreactivity - metabolism | Blood Pressure - drug effects | Hypertension, Pulmonary - drug therapy | Lung - metabolism | Phosphodiesterase 5 Inhibitors - pharmacology | Endothelin Receptor Antagonists | Disease Models, Animal | Bronchial Hyperreactivity - etiology | Prostaglandins I - metabolism | Bronchial Hyperreactivity - therapy | Infusion Pumps, Implantable | Vasodilator Agents - pharmacology | Administration, Oral | Purines - pharmacology | Receptors, Endothelin - metabolism | Infusions, Parenteral | Rats | Hypertension, Pulmonary - metabolism | Lung - physiopathology | Piperazines - pharmacology | Rats, Sprague-Dawley | Animals | Analysis of Variance | Signal Transduction - drug effects | Lung - drug effects | Pyridines - pharmacology | Lung - blood supply | Nitric Oxide - metabolism | Vasodilator Agents - administration & dosage | Hypertension, Pulmonary - complications | Bronchi | Physiological aspects | Development and progression | Respiratory agents | Research | Drug therapy | Health aspects | Pulmonary hypertension | Prevention | Nitric oxide
Journal Article
Journal Article
Journal of molecular and cellular cardiology, ISSN 0022-2828, 2014, Volume 72, pp. 85 - 94
Abstract Tumor necrosis factor-α (TNF-α) is an established pro-atherosclerotic factor, but the mechanism is not completely understood. We explored whether... 
Cardiovascular | NF-κB | TNF-α | LDL | PPAR-γ | Atherosclerosis | APOPTOSIS | CARDIAC & CARDIOVASCULAR SYSTEMS | ANTAGONIST | TNF-alpha | LOW-DENSITY-LIPOPROTEIN | PPAR-gamma | CELL BIOLOGY | TUMOR-NECROSIS-FACTOR | TRANSPORT | NF-kappa B | INHIBITION | INFLAMMATION | ACTIVATED-RECEPTOR-GAMMA | EXPRESSION | CAVEOLIN-1 | Tumor Necrosis Factor-alpha - metabolism | RNA, Small Interfering - genetics | Human Umbilical Vein Endothelial Cells - metabolism | Nitriles - pharmacology | Atherosclerosis - genetics | Humans | NF-kappa B - metabolism | Filipin - pharmacology | PPAR gamma - metabolism | Sulfones - pharmacology | Caveolin 2 - antagonists & inhibitors | Thiocarbamates - pharmacology | Human Umbilical Vein Endothelial Cells - cytology | Proline - pharmacology | Benzamides - pharmacology | Lipoproteins, LDL - metabolism | PPAR gamma - genetics | Caveolin 1 - antagonists & inhibitors | Receptors, LDL - genetics | Atherosclerosis - pathology | NF-kappa B - antagonists & inhibitors | Human Umbilical Vein Endothelial Cells - drug effects | Proline - analogs & derivatives | Signal Transduction | Atherosclerosis - chemically induced | Receptors, LDL - antagonists & inhibitors | Gene Expression Regulation | Caveolin 1 - genetics | Receptors, LDL - metabolism | Mice, Knockout | Caveolin 1 - metabolism | Caveolin 2 - metabolism | Cinchona Alkaloids - pharmacology | Tumor Necrosis Factor-alpha - pharmacology | Animals | PPAR gamma - antagonists & inhibitors | Lipoproteins, LDL - antagonists & inhibitors | NF-kappa B - genetics | Anilides - pharmacology | Mice | Pyridines - pharmacology | Transcytosis - drug effects | Caveolin 2 - genetics | Atherosclerosis - prevention & control | RNA, Small Interfering - metabolism
Journal Article
The Journal of pharmacology and experimental therapeutics, ISSN 0022-3565, 12/2013, Volume 347, Issue 3, pp. 626 - 634
Journal Article
Molecular cancer therapeutics, ISSN 1538-8514, 2007, Volume 6, Issue 7, pp. 2012 - 2021
With the development of targeted therapeutics, especially for small-molecule inhibitors, it is important to understand whether the observed in vivo efficacy... 
kinase inhibitor | Pharmacodynamics | pazopanib | angiogenesis | VEGF | TARGET | CELLS | ONCOLOGY | RECEPTORS | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | Pyrimidines - blood | Humans | Fibroblast Growth Factor 2 - pharmacology | Antineoplastic Agents - administration & dosage | Indazoles - administration & dosage | Sulfones - pharmacology | Neovascularization, Pathologic - pathology | Phosphotyrosine - metabolism | Dose-Response Relationship, Drug | Sulfonamides - blood | Inhibitory Concentration 50 | Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Cornea - pathology | Phosphorylation - drug effects | Sulfones - blood | Vascular Endothelial Growth Factor A - pharmacology | Protein Kinase Inhibitors - pharmacokinetics | Pyrimidines - administration & dosage | Pyrimidines - pharmacology | Sulfones - pharmacokinetics | Sulfonamides - pharmacology | Protein Kinase Inhibitors - blood | Sulfonamides - pharmacokinetics | Indazoles - pharmacology | Protein Kinase Inhibitors - administration & dosage | Indazoles - blood | Animals | Indazoles - pharmacokinetics | Cell-Free System | Mice, Nude | Antineoplastic Agents - blood | Cell Line, Tumor | Pyrimidines - pharmacokinetics | Mice | Protein Kinase Inhibitors - pharmacology | Sulfonamides - administration & dosage | Sulfones - administration & dosage
Journal Article
Neuroscience, ISSN 0306-4522, 2014, Volume 268, pp. 236 - 246
Highlights • l -NAME, aminoguanidine and sildenafil prevent LPS-induced depressive-like behavior. • l -Arginine, a NO precursor, did not prevent LPS-induced... 
Neurology | nitric oxide | depressive-like behavior | neuroinflammation | BDNF | LPS | oxidative stress | Depressive-like behavior | Oxidative stress | Neuroinflammation | Nitric oxide | ACTIVATION | GUANOSINE-MONOPHOSPHATE PATHWAY | PREPULSE INHIBITION | NITROSATIVE STRESS | MAJOR DEPRESSION | KAPPA-B | NEUROSCIENCES | L-TRYPTOPHAN | ANIMAL-MODEL | ACOUSTIC STARTLE | PITUITARY-ADRENAL AXIS | Oxidative Stress - physiology | Nitric Oxide Synthase - antagonists & inhibitors | Depressive Disorder - drug therapy | Guanidines - pharmacology | Male | Sulfones - pharmacology | Lipopolysaccharides | Brain - metabolism | Sildenafil Citrate | Interleukin-1beta - metabolism | Behavior, Animal - drug effects | Antidepressive Agents - pharmacology | Brain-Derived Neurotrophic Factor - metabolism | Disease Models, Animal | NG-Nitroarginine Methyl Ester - pharmacology | Purines - pharmacology | Enzyme Inhibitors - pharmacology | Behavior, Animal - physiology | Depressive Disorder - metabolism | Piperazines - pharmacology | Brain - drug effects | Animals | Cyclic GMP - metabolism | Signal Transduction - drug effects | Arginine - pharmacology | Depressive Disorder - prevention & control | Signal Transduction - physiology | Mice | Nitric Oxide Synthase - metabolism | Oxidative Stress - drug effects | Imipramine - pharmacology | Nitric Oxide - metabolism | Antidepressants | Mitogens | Depression, Mental | Index Medicus
Journal Article
European journal of pain, ISSN 1090-3801, 2013, Volume 17, Issue 4, pp. 469 - 479
Background Injection of nerve growth factor (NGF) produces mechanical and thermal hypersensitivity in rodents and humans. Treatment with sequestering... 
ANTI-NGF | SODIUM-CHANNELS | ALLODYNIA | DIFFERENTIAL REGULATION | NEUROSCIENCES | CLINICAL NEUROLOGY | MUSCLE SENSITIZATION | PAIN | INTRAPLANTAR INJECTION | ANESTHESIOLOGY | HYPERALGESIA | PRIMARY SENSORY NEURONS | RECEPTORS | Hyperalgesia - chemically induced | Analgesics - pharmacology | Diclofenac - pharmacology | Pain Threshold - physiology | Sulfones - therapeutic use | Thiophenes - therapeutic use | Pyrazoles - therapeutic use | Male | Sulfones - pharmacology | Nerve Growth Factor | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Dose-Response Relationship, Drug | TRPV Cation Channels - antagonists & inhibitors | Amines - therapeutic use | Pain Threshold - drug effects | Behavior, Animal - drug effects | gamma-Aminobutyric Acid - therapeutic use | Pyrazoles - pharmacology | Pyridines - therapeutic use | Physical Stimulation | Analgesics - therapeutic use | Cyclohexanecarboxylic Acids - therapeutic use | Diclofenac - therapeutic use | Rats | Thiophenes - pharmacology | gamma-Aminobutyric Acid - pharmacology | Behavior, Animal - physiology | Celecoxib | Sulfonamides - pharmacology | Rats, Sprague-Dawley | Hyperalgesia - physiopathology | Animals | Hyperalgesia - drug therapy | Sulfonamides - therapeutic use | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Cyclohexanecarboxylic Acids - pharmacology | Duloxetine Hydrochloride | Pyridines - pharmacology | Amines - pharmacology
Journal Article