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Lancet, The, ISSN 0140-6736, 2012, Volume 380, Issue 9840, pp. 475 - 483
Summary Background Addition of a sulphonylurea to metformin improves glycaemic control in type 2 diabetes, but is associated with hypoglycaemia and weight... 
Internal Medicine | ALL-CAUSE MORTALITY | MEDICINE, GENERAL & INTERNAL | GLYCEMIC CONTROL | ADD-ON | METAANALYSIS | SULFONYLUREA | GLUCOSE CONTROL | CARDIOVASCULAR-DISEASE | RISK | COMPLICATIONS | MELLITUS | Metformin - therapeutic use | Dipeptidyl-Peptidase IV Inhibitors - therapeutic use | Glycated Hemoglobin A - metabolism | Humans | Middle Aged | Male | Purines - administration & dosage | Hypoglycemic Agents - administration & dosage | Treatment Failure | Adult | Female | Quinazolines - administration & dosage | Linagliptin | Purines - adverse effects | Purines - therapeutic use | Sulfonylurea Compounds - administration & dosage | Hypoglycemic Agents - therapeutic use | Double-Blind Method | Sulfonylurea Compounds - therapeutic use | Treatment Outcome | Sulfonylurea Compounds - adverse effects | Diabetes Mellitus, Type 2 - blood | Quinazolines - therapeutic use | Quinazolines - adverse effects | Aged | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Hypoglycemic Agents - adverse effects | Research Design | Type 2 diabetes | Complications and side effects | Dosage and administration | Metformin | Drug therapy | Hypoglycemic sulfonylureas | Sulfonylurea compounds | Glimepiride | Comparative analysis | Heart attacks | Diabetes | Pharmaceutical industry | Drug dosages | Drugs | Obesity | Body weight | Diabetes mellitus
Journal Article
Diabetes, ISSN 0012-1797, 06/2019, Volume 68, Issue Supplement 1, p. 111
Journal Article
Current Diabetes Reports, ISSN 1534-4827, 4/2014, Volume 14, Issue 4, pp. 1 - 8
Journal Article
Annals of Internal Medicine, ISSN 0003-4819, 11/2012, Volume 157, Issue 9, pp. 601 - 610
Journal Article
Diabetes care, ISSN 0149-5992, 09/2018, Volume 41, Issue 9, pp. 1844 - 1853
Journal Article
2015, Proposed Re-evaluation Decision, Volume PRVD2015-02.
Web Resource
PLoS ONE, ISSN 1932-6203, 10/2016, Volume 11, Issue 10, p. e0164785
Insulin secretagogues are used for treatment of type 2 diabetes. We attempted to discover novel small molecules to stimulate insulin secretion by using in... 
DRUG | GK RAT | METABOLISM | POTASSIUM CHANNELS | SENSITIVE K+ CHANNELS | GLUCOSE | MULTIDISCIPLINARY SCIENCES | PANCREATIC BETA-CELL | SULFONYLUREA RECEPTOR | SECRETION | SELECTIVITY | Islets of Langerhans - drug effects | Diabetes Mellitus, Experimental - drug therapy | Calcium - metabolism | Hypoglycemic Agents - metabolism | Half-Life | Male | Structure-Activity Relationship | Sulfonylurea Compounds - chemistry | Thiosemicarbazones - chemistry | Glyburide - pharmacology | Sulfonylurea Receptors - metabolism | Islets of Langerhans - metabolism | Sulfonylurea Compounds - metabolism | Sulfonylurea Compounds - pharmacology | Semicarbazides - pharmacology | KATP Channels - antagonists & inhibitors | Semicarbazides - chemistry | Glyburide - therapeutic use | Thiosemicarbazones - pharmacology | Insulin Secretion | Amino Acids, Cyclic - therapeutic use | Hypoglycemic Agents - therapeutic use | Membrane Potentials - drug effects | Cell Line | Glucose Tolerance Test | Amino Acids, Cyclic - pharmacology | Blood Glucose - analysis | Administration, Oral | Mice, Inbred C57BL | Semicarbazides - metabolism | Rats | Amino Acids, Cyclic - chemistry | Hypoglycemic Agents - chemistry | Semicarbazides - blood | Hypoglycemic Agents - pharmacology | KATP Channels - metabolism | Insulin - metabolism | Animals | Thiosemicarbazones - therapeutic use | Sulfonylurea Receptors - antagonists & inhibitors | Amino Acids, Cyclic - metabolism | Thiosemicarbazones - metabolism | Diabetes Mellitus, Experimental - pathology | Protein Binding | Mice | Type 2 diabetes | Blood sugar | Insulin | Analysis | Diabetes therapy
Journal Article
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 04/2016, Volume 18, Issue 4, pp. 333 - 347
Type 2 diabetes ( T2DM ) is a progressive disease, and pharmacotherapy with a single agent does not generally provide durable glycaemic control over the long... 
linagliptin | glyburide | incretin | saxagliptin | diabetes mellitus | GLP | omarigliptin | anagliptin | gliclazide | glimepiride | sitagliptin | vildagliptin | gemigliptin | alogliptin | antidiabetic drug | glipizide | glycaemic control | trelagliptin | glibenclamide | evogliptin | teneligliptin | Glimepiride | Incretin | GLP-1 | Trelagliptin | Diabetes mellitus | Sitagliptin | Glipizide | Evogliptin | Anagliptin | Glyburide | Antidiabetic drug | Omarigliptin | Gliclazide | Alogliptin | Linagliptin | Vildagliptin | Gemigliptin | Glibenclamide | Glycaemic control | Teneligliptin | Saxagliptin | SEVERE HYPOGLYCEMIA | IV INHIBITOR | ENDOCRINOLOGY & METABOLISM | TYPE-2 DIABETES-MELLITUS | INSULIN SECRETAGOGUES | GLYCEMIC CONTROL | CARDIOVASCULAR EVENTS | DPP-4 INHIBITOR | DOUBLE-BLIND | METFORMIN THERAPY | SAVOR-TIMI 53 | Glycated Hemoglobin A - analysis | Hypoglycemia - epidemiology | Dipeptidyl-Peptidase IV Inhibitors - adverse effects | Cardiovascular Diseases - prevention & control | Dipeptidyl-Peptidase IV Inhibitors - therapeutic use | Humans | Risk | Hypoglycemia - prevention & control | Cardiovascular Diseases - complications | Hypoglycemic Agents - administration & dosage | Cardiovascular Diseases - epidemiology | Diabetic Cardiomyopathies - prevention & control | Weight Gain - drug effects | Sulfonylurea Compounds - administration & dosage | Diabetic Angiopathies - prevention & control | Sulfonylurea Compounds - pharmacokinetics | Hypoglycemia - chemically induced | Diabetes Mellitus, Type 2 - complications | Hypoglycemic Agents - therapeutic use | Hyperglycemia - prevention & control | Hypoglycemic Agents - pharmacokinetics | Administration, Oral | Sulfonylurea Compounds - therapeutic use | Sulfonylurea Compounds - adverse effects | Dipeptidyl-Peptidase IV Inhibitors - administration & dosage | Diabetes Mellitus, Type 2 - blood | Dipeptidyl-Peptidase IV Inhibitors - pharmacokinetics | Diabetic Cardiomyopathies - epidemiology | Diabetic Angiopathies - epidemiology | Diabetes Mellitus, Type 2 - drug therapy | Hypoglycemic Agents - adverse effects | Prescription drugs | Insulin | Side effects | Peptidase | Clinical trials | Metformin | Hypoglycemia | Cardiovascular diseases | Diabetes mellitus (non-insulin dependent) | Patients
Journal Article
Diabetes Care, ISSN 0149-5992, 04/2018, Volume 41, Issue 4, pp. 713 - 722
Journal Article