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Science, ISSN 0036-8075, 7/2009, Volume 325, Issue 5940, pp. 607 - 610
Epac2, a guanine nucleotide exchange factor for the small guanosine triphosphatase Rap1, is activated by adenosine 3′,5′-monophosphate. Fluorescence resonance... 
COS cells | Blood glucose | Medical research | Biomedical technology | Reports | Hypoglycemic agents | Diabetes | Sensors | Insulin | Insulin secretion | Vehicles | B-CELLS | ACTIVATION | STIMULATION | EXOCYTOSIS | K-ATP CHANNELS | GRANULE | MULTIDISCIPLINARY SCIENCES | INSULIN-SECRETION | PANCREATIC BETA-CELLS | RECEPTOR | MICE | Tolbutamide - pharmacology | Hypoglycemic Agents - metabolism | Cercopithecus aethiops | Insulin - blood | Sulfonylurea Compounds - chemistry | Glucose - administration & dosage | Glyburide - pharmacology | Guanine Nucleotide Exchange Factors - metabolism | Islets of Langerhans - metabolism | Sulfonylurea Compounds - metabolism | Sulfonylurea Compounds - pharmacology | Fluorescence Resonance Energy Transfer | Cyclic AMP - metabolism | Insulin Secretion | Tolbutamide - metabolism | Cell Line | rap1 GTP-Binding Proteins - metabolism | Guanine Nucleotide Exchange Factors - genetics | Blood Glucose - analysis | 8-Bromo Cyclic Adenosine Monophosphate - pharmacology | Mice, Inbred C57BL | Hypoglycemic Agents - chemistry | Glyburide - metabolism | Hypoglycemic Agents - pharmacology | Carrier Proteins - genetics | Insulin - metabolism | Animals | Carrier Proteins - metabolism | Mice | COS Cells | Properties | Cyclic adenylic acid | Prescription drugs | Rodents | Pharmacology | Glucose | Metabolism
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2016, Volume 11, Issue 10, p. e0164785
Insulin secretagogues are used for treatment of type 2 diabetes. We attempted to discover novel small molecules to stimulate insulin secretion by using in... 
DRUG | GK RAT | METABOLISM | POTASSIUM CHANNELS | SENSITIVE K+ CHANNELS | GLUCOSE | MULTIDISCIPLINARY SCIENCES | PANCREATIC BETA-CELL | SULFONYLUREA RECEPTOR | SECRETION | SELECTIVITY | Islets of Langerhans - drug effects | Diabetes Mellitus, Experimental - drug therapy | Calcium - metabolism | Hypoglycemic Agents - metabolism | Half-Life | Male | Structure-Activity Relationship | Sulfonylurea Compounds - chemistry | Thiosemicarbazones - chemistry | Glyburide - pharmacology | Sulfonylurea Receptors - metabolism | Islets of Langerhans - metabolism | Sulfonylurea Compounds - metabolism | Sulfonylurea Compounds - pharmacology | Semicarbazides - pharmacology | KATP Channels - antagonists & inhibitors | Semicarbazides - chemistry | Glyburide - therapeutic use | Thiosemicarbazones - pharmacology | Insulin Secretion | Amino Acids, Cyclic - therapeutic use | Hypoglycemic Agents - therapeutic use | Membrane Potentials - drug effects | Cell Line | Glucose Tolerance Test | Amino Acids, Cyclic - pharmacology | Blood Glucose - analysis | Administration, Oral | Mice, Inbred C57BL | Semicarbazides - metabolism | Rats | Amino Acids, Cyclic - chemistry | Hypoglycemic Agents - chemistry | Semicarbazides - blood | Hypoglycemic Agents - pharmacology | KATP Channels - metabolism | Insulin - metabolism | Animals | Thiosemicarbazones - therapeutic use | Sulfonylurea Receptors - antagonists & inhibitors | Amino Acids, Cyclic - metabolism | Thiosemicarbazones - metabolism | Diabetes Mellitus, Experimental - pathology | Protein Binding | Mice | Type 2 diabetes | Blood sugar | Insulin | Analysis | Diabetes therapy
Journal Article
Journal Article
Diabetes, ISSN 0012-1797, 12/2002, Volume 51, Issue 3, pp. S368 - S376
Sulfonylureas are widely used to treat type 2 diabetes because they stimulate insulin secretion from pancreatic beta-cells. They primarily act by binding to... 
SENSITIVE POTASSIUM CHANNELS | KIR6.2 | SMOOTH-MUSCLE | K-ATP CHANNELS | GLIBENCLAMIDE BINDING | ENDOCRINOLOGY & METABOLISM | HIGH-AFFINITY | PANCREATIC BETA-CELLS | RECEPTOR SUR2B | N-TERMINUS | TOLBUTAMIDE
Journal Article
Applied and Environmental Microbiology, ISSN 0099-2240, 03/2012, Volume 78, Issue 6, pp. 1962 - 1968
Journal Article
Journal Article
Journal of the Science of Food and Agriculture, ISSN 0022-5142, 09/2018, Volume 98, Issue 12, pp. 4501 - 4508
BACKGROUND To resist plant diseases, boscalid and triflumizole have been applied to cucumbers frequently. However, the residue and dietary risk assessment of... 
dietary risk assessment | metabolite | dissipation kinetics | triflumizole | cucumber | boscalid | MULTIRESIDUE PESTICIDE ANALYSIS | HONEY | SULFONYLUREA HERBICIDES | CHINA | FOOD SCIENCE & TECHNOLOGY | TANDEM MASS-SPECTROMETRY | LC-MS/MS | AGRICULTURE, MULTIDISCIPLINARY | SOIL | CHEMISTRY, APPLIED | WATER SAMPLES | RESIDUES | SOLID-PHASE EXTRACTION | Niacinamide - analogs & derivatives | Pesticide Residues - metabolism | Chromatography, High Pressure Liquid - methods | Fungicides, Industrial - isolation & purification | Niacinamide - metabolism | Risk Assessment | Biphenyl Compounds - isolation & purification | Imidazoles - chemistry | Imidazoles - isolation & purification | Biphenyl Compounds - analysis | Biphenyl Compounds - metabolism | Fungicides, Industrial - chemistry | Fungicides, Industrial - metabolism | Pesticide Residues - chemistry | Niacinamide - isolation & purification | China | Kinetics | Niacinamide - analysis | Pesticide Residues - isolation & purification | Tandem Mass Spectrometry - methods | Cucumis sativus - chemistry | Cucumis sativus - metabolism | Imidazoles - metabolism | Fungicides | Metabolites | Mass spectrometry | Risk assessment | Methods | High performance liquid chromatography | Pesticides | Mass spectroscopy | Liquid chromatography | Dosage | High-performance liquid chromatography | Organic chemistry | Plant diseases | Diet | Dissipation | Field tests | Food safety | Product safety | Cucumbers
Journal Article
Biochemistry, ISSN 0006-2960, 02/2005, Volume 44, Issue 7, pp. 2330 - 2338
Journal Article
Journal Article