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1. Full Text Coordinated regulation of hepatic phase I and II drug-metabolizing genes and transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-null mice
by Aleksunes, Lauren M and Klaassen, Curtis D
Drug metabolism and disposition, ISSN 0090-9556, 07/2012, Volume 40, Issue 7, pp. 1366 - 1379
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Inactivation, Metabolic | Receptors, Steroid - metabolism | Cytochrome P-450 Enzyme System - metabolism | Male | NAD(P)H Dehydrogenase (Quinone) - genetics | Organic Anion Transporters - metabolism | Glucuronosyltransferase - genetics | Organic Anion Transporters - genetics | Glutathione Transferase - genetics | Receptors, Aryl Hydrocarbon - metabolism | Female | NF-E2-Related Factor 2 - genetics | Sulfotransferases - metabolism | Aldehyde Dehydrogenase - metabolism | Sulfotransferases - genetics | Liver - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Receptors, Aryl Hydrocarbon - genetics | Glutathione Transferase - metabolism | Aldehyde Dehydrogenase - genetics | PPAR alpha - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Transcription Factors - genetics | Mice, Knockout | Gene Expression Regulation, Enzymologic | Transcription Factors - metabolism | Animals | Glucuronosyltransferase - metabolism | Receptors, Steroid - genetics | NF-E2-Related Factor 2 - metabolism | Cytochrome P-450 Enzyme System - genetics | NAD(P)H Dehydrogenase (Quinone) - metabolism | Mice | PPAR alpha - metabolism | Multidrug Resistance-Associated Proteins | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus
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2. Full Text A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors
by Park, Ryan J and Wang, Tim and Koundakjian, Dylan and Hultquist, Judd F and Lamothe-Molina, Pedro and Monel, Blandine and Schumann, Kathrin and Yu, Haiyan and Krupzcak, Kevin M and Garcia-Beltran, Wilfredo and Piechocka-Trocha, Alicja and Krogan, Nevan J and Marson, Alexander and Sabatini, David M and Lander, Eric S and Hacohen, Nir and Walker, Bruce D
Nature genetics, ISSN 1061-4036, 01/2017, Volume 49, Issue 2, pp. 193 - 203
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Sulfotransferases - genetics | Cell Line | HIV-1 - pathogenicity | Membrane Proteins - genetics | Virus Replication - genetics | HIV Infections - genetics | Humans | Genome - genetics | Receptors, CCR5 - genetics | Host-Pathogen Interactions - genetics | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | RNA Interference - physiology | Activated-Leukocyte Cell Adhesion Molecule - genetics | Innovations | Genotype | Genetic aspects | Genetic engineering | Virulence (Microbiology) | Host-virus relationships | HIV infection | Health aspects | Risk factors | Pathogens | Flow cytometry | Pandemics | Viruses | Infections | Identification | Genomes | Grants | Drug resistance | Proteins | Acquired immune deficiency syndrome--AIDS | Lymphocytes | Human immunodeficiency virus--HIV | Population | Gene therapy | Viral infections | Index Medicus
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3. Full Text Association of testicular germ cell tumor with polymorphisms in estrogen receptor and steroid metabolism genes
by Ferlin, Alberto and Ganz, Francesco and Pengo, Manuel and Selice, Riccardo and Frigo, Anna Chiara and Foresta, Carlo
Endocrine-related cancer, ISSN 1351-0088, 3/2010, Volume 17, Issue 1, pp. 17 - 25
Regular papers | Oncology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Cytochrome P-450 CYP1A1 - genetics | Humans | Male | Neoplasms, Germ Cell and Embryonal - genetics | Catechol O-Methyltransferase - genetics | Seminoma - metabolism | Young Adult | Aromatase - genetics | Estrogen Receptor beta - genetics | Cytochrome P-450 CYP1A2 - genetics | Adult | Hydro-Lyases - genetics | Estrogens - metabolism | Neoplasm Proteins - genetics | Seminoma - genetics | Sulfotransferases - genetics | Genetic Predisposition to Disease | Testicular Neoplasms - genetics | Genetic Association Studies | Testicular Neoplasms - metabolism | Genotype | Neoplasms, Germ Cell and Embryonal - metabolism | Arylsulfotransferase - genetics | Peroxisomal Multifunctional Protein-2 | Estrogen Receptor alpha - genetics | Estradiol Dehydrogenases - genetics | 17-Hydroxysteroid Dehydrogenases - genetics | Cytochrome P-450 CYP1B1 | Cytochrome P-450 Enzyme System - genetics | Polymorphism, Single Nucleotide | Aryl Hydrocarbon Hydroxylases | Cryptorchidism - genetics | Index Medicus
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4. Full Text A Shared Genetic Basis for Self-Limited Delayed Puberty and Idiopathic Hypogonadotropic Hypogonadism
by Zhu, Jia and Choa, Ruth E.-Y and Guo, Michael H and Plummer, Lacey and Buck, Cassandra and Palmert, Mark R and Hirschhorn, Joel N and Seminara, Stephanie B and Chan, Yee-Ming
The journal of clinical endocrinology and metabolism, ISSN 0021-972X, 04/2015, Volume 100, Issue 4, pp. E646 - E654
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Receptors, Tachykinin - genetics | Sulfotransferases - genetics | Puberty, Delayed - genetics | Extracellular Matrix Proteins - genetics | Humans | Male | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Nerve Tissue Proteins - genetics | Receptors, Peptide - genetics | Hypogonadism - genetics | Tachykinins - genetics | DNA Mutational Analysis | Pedigree | Adolescent | Female | Receptors, G-Protein-Coupled - genetics | Retrospective Studies | Index Medicus | Abridged Index Medicus | Advances in Genetics | JCEM Online
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5. Full Text The endometrial cancer cell lines Ishikawa and HEC-1A, and the control cell line HIEEC, differ in expression of estrogen biosynthetic and metabolic genes, and in androstenedione and estrone-sulfate metabolism
by Hevir-Kene, Neli and Rižner, Tea Lanišnik
Chemico-biological interactions, ISSN 0009-2797, 06/2015, Volume 234, pp. 309 - 319
Aromatase pathway | Sulfatase pathway | Phase I and phase II estrogen metabolism | Aldo–keto reductase 1C3 (AKR1C3) | 17β-Hydroxysteroid dehydrogenases (17β-HSDs, HSD17B) | Catechol-O-methyl transferase (COMT) | 17b-Hydroxysteroid dehydrogenases | (17b-HSDs HSD17B)Aldoketo reductase 1C3 (AKR1C3) | Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Toxicology | Life Sciences & Biomedicine | Science & Technology | Sulfatases - genetics | Progesterone Reductase - metabolism | Humans | Endometrial Neoplasms - metabolism | Aromatase - metabolism | Catechol O-Methyltransferase - genetics | Hydroxyprostaglandin Dehydrogenases - metabolism | Androstenedione - metabolism | Catechol O-Methyltransferase - metabolism | Aromatase - genetics | Endometrial Neoplasms - genetics | Sulfatases - metabolism | Estrogens - genetics | 3-Hydroxysteroid Dehydrogenases - metabolism | Female | Sulfotransferases - metabolism | Estrogens - metabolism | Quinones - pharmacology | Glutathione S-Transferase pi - genetics | Sulfotransferases - genetics | Estrone - genetics | Quinone Reductases - metabolism | Androstenedione - genetics | Glutathione S-Transferase pi - metabolism | Estrogens - biosynthesis | RNA, Messenger - genetics | Transcriptome - genetics | Progesterone Reductase - genetics | Arylsulfotransferase - genetics | Hydroxyprostaglandin Dehydrogenases - genetics | Estrone - analogs & derivatives | Aldo-Keto Reductase Family 1 Member C3 | Estrone - metabolism | Cell Line, Tumor | Quinone Reductases - genetics | 3-Hydroxysteroid Dehydrogenases - genetics | Arylsulfotransferase - metabolism | Physiological aspects | Endometrial cancer | Sulfates | Genes | Estrogen | Steroids | Index Medicus
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6. Full Text Identification of Targets of Twist1 Transcription Factor in Thyroid Cancer Cells
by Di Maro, Gennaro and Orlandella, Francesca Maria and Bencivenga, Tammaro Claudio and Salerno, Paolo and Ugolini, Clara and Basolo, Fulvio and Maestro, Roberta and Salvatore, Giuliana
The journal of clinical endocrinology and metabolism, ISSN 0021-972X, 09/2014, Volume 99, Issue 9, pp. E1617 - E1626
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | RNA, Small Interfering - genetics | Carcinoma, Papillary - genetics | Humans | Gene Expression Regulation, Neoplastic | Cell Survival - genetics | Inhibitor of Differentiation Proteins - genetics | Promoter Regions, Genetic - genetics | Carcinoma, Papillary - metabolism | Thyroid Hormone Receptors alpha - genetics | rhoB GTP-Binding Protein - genetics | Carcinoma - pathology | Nuclear Proteins - genetics | Sulfotransferases - genetics | Basic Helix-Loop-Helix Transcription Factors - genetics | Membrane Proteins - genetics | Nuclear Proteins - metabolism | Carcinoma, Papillary - pathology | Thyroid Cancer, Papillary | Thyroid Neoplasms - genetics | Twist-Related Protein 1 - genetics | Cell Line, Tumor | Carcinoma - genetics | Carcinoma - metabolism | Twist-Related Protein 1 - metabolism | Thyroid Neoplasms - metabolism | Thyroid Neoplasms - pathology | Index Medicus | Abridged Index Medicus
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7. Full Text Hypoxia-induced p53 modulates both apoptosis and radiosensitivity via AKT
by Leszczynska, K.B and Foskolou, I.P and Abraham, A.G and Anbalagan, S and Tellier, C and Haider, S and Span, P.N and O'Neill, E.E and Buffa, F.M and Hammond, E.M
The Journal of clinical investigation, ISSN 0021-9738, 2015, Volume 125, Issue 6, pp. 2385 - 2398
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Neoplasms - metabolism | Humans | Radiation Tolerance | Inositol Polyphosphate 5-Phosphatases | Proto-Oncogene Proteins c-akt - genetics | Tumor Suppressor Protein p53 - genetics | Immediate-Early Proteins - metabolism | Neoplasms - genetics | Tumor Suppressor Proteins - genetics | Sulfotransferases - metabolism | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Sulfotransferases - genetics | Phosphoric Monoester Hydrolases - genetics | Tumor Suppressor Proteins - metabolism | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | Carrier Proteins - genetics | Carrier Proteins - metabolism | Immediate-Early Proteins - genetics | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Adaptor Proteins, Signal Transducing - metabolism | Cell Hypoxia - genetics | Neoplasms - pathology | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases | Phosphoric Monoester Hydrolases - metabolism | Apoptosis | Studies | Breast cancer | Mutation | Rodents | DNA damage | Index Medicus | Abridged Index Medicus | Oncology
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8. Full Text Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes
by Teumer, Alexander and Tin, Aienne and Sorice, Rossella and Gorski, Mathias and Yeo, Nan Cher and Chu, Auey Y and Li, Man and Li, Yong and Mijatovic, Vladan and Ko, Yi-An and Taliun, Daniel and Luciani, Alessano and Chen, Ming-Huei and Yang, Qiong and Foster, Meredith C and Olden, Matthias and Hiraki, Linda T and Tayo, Bamidele O and Fuchsberger, Christian and Dieffenbach, Aida Karina and Shuldiner, Alan R and Smith, Albert V and Zappa, Allison M and Lupo, Antonio and Kollerits, Barbara and Ponte, Belen and Stengel, Bénédicte and Krämer, Bernhard K and Paulweber, Bernhard and Mitchell, Braxton D and Hayward, Caroline and Helmer, Catherine and Meisinger, Christa and Gieger, Christian and Shaffer, Christian M and Müller, Christian and Langenberg, Claudia and Ackermann, Daniel and Siscovick, David and Boerwinkle, Eric and Kronenberg, Florian and Ehret, Georg B and Homuth, Georg and Waeber, Gerard and Navis, Gerjan and Mateo Leach, I and Hillege, Hans L and Verweij, Niek and van der Harst, Pim and Gansevoort, Ron T and DCCT EDIC and DCCT/EDIC
Diabetes (New York, N.Y.), ISSN 0012-1797, 03/2016, Volume 65, Issue 3, pp. 803 - 817
KIDNEY-DISEASE | MORTALITY | GLOMERULAR-FILTRATION-RATE | MODULATES PROTEINURIA | RAB38 | RISK POPULATION COHORTS | COLLABORATIVE METAANALYSIS | EXPRESSION | HERITABILITY | INSIGHTS | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Diabetic Nephropathies - etiology | Diabetes Mellitus, Type 2 - genetics | Humans | Middle Aged | Male | rab GTP-Binding Proteins - genetics | Kidney - metabolism | Diabetes Mellitus, Experimental | Adult | Female | Kidney Tubules - metabolism | Diabetes Mellitus, Type 2 - complications | Sulfotransferases - genetics | rab GTP-Binding Proteins - metabolism | Genetic Predisposition to Disease | Genome-Wide Association Study | Albuminuria - etiology | Cathepsin C - genetics | Rats | Diabetic Nephropathies - genetics | Gene Knockout Techniques | Albuminuria - genetics | Animals | Aged | Polymorphism, Single Nucleotide | Receptors, Cell Surface - genetics | Urine | Cardiovascular disease | Genomes | Gene loci | Diabetes | Kidney diseases | Index Medicus | Abridged Index Medicus | Metabolomics | Genetics | Proteomics
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9. Full Text Genetic heterogeneity and clinical variability in musculocontractural ehlers-danlos syndrome caused by impaired dermatan sulfate biosynthesis
by Syx, Delfien and Van Damme, Tim and Symoens, Sofie and Maiburg, Merel C and van de Laar, Ingrid and Morton, Jenny and Suri, Mohnish and Del campo, Miguel and Hausser, Ingrid and Hermanns-Lê, Trinh and De Paepe, Anne and Malfait, Fransiska
Human mutation, ISSN 1059-7794, 05/2015, Volume 36, Issue 5, pp. 535 - 547
Ehlers-Danlos syndrome | Dermatan sulfate epimerase-1 | Genetics(clinical) | Dermatan 4-O-sulfotransferase-1 | Review | Journal Article | Case Reports | EDS | Research Support, Non-U.S. Gov't | DSE | Genetics | Medicine(all) | CHST14 | dermatan 4‐O‐sulfotransferase‐1 | Ehlers–Danlos syndrome | dermatan sulfate epimerase‐1 | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Exons | Humans | Extracellular Matrix - metabolism | Molecular Sequence Data | Dermatan Sulfate - biosynthesis | Male | Neoplasm Proteins - metabolism | RNA, Messenger - metabolism | DNA-Binding Proteins - metabolism | Young Adult | Ehlers-Danlos Syndrome - genetics | Facies | Antigens, Neoplasm - metabolism | Adult | Female | Sulfotransferases - metabolism | Neoplasm Proteins - genetics | Child | Skin - pathology | Sulfotransferases - genetics | Amino Acid Sequence | Antigens, Neoplasm - genetics | RNA, Messenger - genetics | DNA-Binding Proteins - genetics | Fibronectins - metabolism | Genetic Heterogeneity | Collagen - metabolism | Phenotype | Sequence Alignment | Ehlers-Danlos Syndrome - metabolism | Biopsy | Pedigree | Adolescent | Skin - ultrastructure | Ehlers-Danlos Syndrome - diagnosis | Mutation | Sulfotransferases - chemistry | Fibronectins | Glycosaminoglycans | Collagen | Physiological aspects | Genetic research | Family | Biosynthesis | Sulfates | Cell differentiation | Genetic disorders | Cell adhesion & migration | Index Medicus
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