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Drug Metabolism and Disposition, ISSN 0090-9556, 07/2012, Volume 40, Issue 7, pp. 1366 - 1379
The transcription factors aryl hydrocarbon receptor (AhR), constitutive androstane receptor (CAR), pregnane X receptor (PXR), peroxisome proliferator-activated... 
TRANSCRIPTION FACTORS | PRIMARY HUMAN HEPATOCYTES | ANTIOXIDANT RESPONSE ELEMENT | MESSENGER-RNA EXPRESSION | CONSTITUTIVE ANDROSTANE RECEPTOR | BILIARY-EXCRETION | PROLIFERATOR-ACTIVATED RECEPTOR | MOUSE-LIVER | PHARMACOLOGY & PHARMACY | MICROSOMAL-ENZYME INDUCERS | PREGNANE-X-RECEPTOR | Inactivation, Metabolic | Receptors, Steroid - metabolism | Cytochrome P-450 Enzyme System - metabolism | Male | NAD(P)H Dehydrogenase (Quinone) - genetics | Organic Anion Transporters - metabolism | Glucuronosyltransferase - genetics | Organic Anion Transporters - genetics | Glutathione Transferase - genetics | Receptors, Aryl Hydrocarbon - metabolism | Female | NF-E2-Related Factor 2 - genetics | Sulfotransferases - metabolism | Aldehyde Dehydrogenase - metabolism | Sulfotransferases - genetics | Liver - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Receptors, Aryl Hydrocarbon - genetics | Glutathione Transferase - metabolism | Aldehyde Dehydrogenase - genetics | PPAR alpha - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Transcription Factors - genetics | Mice, Knockout | Gene Expression Regulation, Enzymologic | Transcription Factors - metabolism | Animals | Glucuronosyltransferase - metabolism | Receptors, Steroid - genetics | NF-E2-Related Factor 2 - metabolism | Cytochrome P-450 Enzyme System - genetics | NAD(P)H Dehydrogenase (Quinone) - metabolism | Mice | PPAR alpha - metabolism | Multidrug Resistance-Associated Proteins | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus
Journal Article
Journal of the Science of Food and Agriculture, ISSN 0022-5142, 10/2016, Volume 96, Issue 13, pp. 4329 - 4336
BACKGROUND: Cytochrome P450 79F1 (CYP79F1), cytochrome P450 83A1 (CYP83A1), UDP-glucosyltransferase 74B1 (UGT74B1), sulfotransferase 18 (ST5b) and... 
broccoli sprouts | sulforaphane | gene expression | jasmonic acid | glucoraphanin | Broccoli sprouts | Gene expression | Glucoraphanin | Sulforaphane | Jasmonic acid | ISOTHIOCYANATES | ARABIDOPSIS-THALIANA | SIGNALING PATHWAYS | FOOD SCIENCE & TECHNOLOGY | HYDROLYSIS | HEALTH-PROMOTING COMPOUNDS | IDENTIFICATION | BIOSYNTHESIS | AGRICULTURE, MULTIDISCIPLINARY | BRASSICA-OLERACEA | CHEMISTRY, APPLIED | MYROSINASE | Molecular Weight | Seedlings - chemistry | Glycoside Hydrolases - genetics | Cytochrome P-450 Enzyme System - metabolism | Glucosinolates - metabolism | Isoenzymes - chemistry | Anticarcinogenic Agents - metabolism | Seedlings - enzymology | Functional Food - analysis | Seedlings - growth & development | Isothiocyanates - metabolism | Glucosyltransferases - metabolism | Isoenzymes - metabolism | Oxygenases - metabolism | Plant Proteins - chemistry | China | Cloning, Molecular | Gene Expression Regulation, Plant | Sulfotransferases - metabolism | Plant Proteins - metabolism | Brassica - chemistry | Glucosyltransferases - genetics | Recombinant Proteins - metabolism | Sulfotransferases - genetics | Brassica - growth & development | Brassica - metabolism | Isoenzymes - genetics | Enzyme Induction | Recombinant Proteins - chemistry | Oxygenases - chemistry | Oxylipins - metabolism | Plant Proteins - genetics | Cytochrome P-450 Enzyme System - chemistry | Glucosyltransferases - chemistry | Cytochrome P-450 Enzyme System - genetics | Cyclopentanes - metabolism | Glycoside Hydrolases - metabolism | Oxygenases - genetics | Plant Growth Regulators - metabolism | Brassica - enzymology | Sulfotransferases - chemistry | Seedlings - metabolism | Chemical industry | Herbicides | Pesticides industry | Enzymes | Cloning | Genes | Genetic research | Physiological aspects | Index Medicus | Broccoli | Glucosinolates | Formations | Aliphatic compounds | Cytochromes P450
Journal Article
Nature Neuroscience, ISSN 1097-6256, 03/2012, Volume 15, Issue 3, pp. 414 - 422
Cortical plasticity is most evident during a critical period in early life, but the mechanisms that restrict plasticity after the critical period are poorly... 
ADULT VISUAL-CORTEX | PARVALBUMIN | EXPERIENCE-DEPENDENT PLASTICITY | INHIBITORY NEURONS | RAT FRONTAL-CORTEX | SULFATE | CRITICAL PERIOD | CENTRAL-NERVOUS-SYSTEM | PERINEURONAL NETS | NEUROSCIENCES | OCULAR DOMINANCE PLASTICITY | Action Potentials - genetics | Chondroitin Sulfates - genetics | Chondroitin Sulfates - metabolism | Age Factors | Amphetamines - pharmacology | Humans | Visual Pathways - metabolism | Cercopithecus aethiops | Gene Expression Regulation, Developmental - genetics | Otx Transcription Factors - metabolism | Parvalbumins - metabolism | Receptors, N-Acetylglucosamine - metabolism | Visual Cortex - physiology | Neuronal Plasticity - genetics | Neuronal Plasticity - physiology | Time Factors | Up-Regulation - physiology | Functional Laterality - physiology | Action Potentials - drug effects | Gene Expression Regulation, Developmental - physiology | Animals, Newborn | Sulfotransferases - genetics | Visual Cortex - cytology | Vesicular Glutamate Transport Protein 2 - metabolism | Bacterial Proteins - genetics | Cells, Cultured | Chondroitin Sulfate Proteoglycans - metabolism | Mice, Transgenic | Up-Regulation - genetics | Aggrecans - metabolism | Electroporation - methods | Nerve Tissue Proteins - metabolism | Sensory Deprivation - physiology | Patch-Clamp Techniques | Animals | Bacterial Proteins - metabolism | Luminescent Proteins - genetics | Mice | Visual Cortex - drug effects | In Vitro Techniques | Plant Lectins - metabolism | Astrocytes - metabolism | Luminescent Proteins - metabolism | Physiological aspects | Cerebral cortex | Research | Sulfates | Chondroitin | Index Medicus
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 06/2015, Volume 234, pp. 309 - 319
Estrogens have important roles in the pathogenesis of endometrial cancer. They can have carcinogenic effects through stimulation of cell proliferation or... 
Aromatase pathway | Sulfatase pathway | Phase I and phase II estrogen metabolism | Aldo–keto reductase 1C3 (AKR1C3) | 17β-Hydroxysteroid dehydrogenases (17β-HSDs, HSD17B) | Catechol-O-methyl transferase (COMT) | 17b-Hydroxysteroid dehydrogenases | (17b-HSDs HSD17B)Aldoketo reductase 1C3 (AKR1C3) | 17 beta-Hydroxysteroid dehydrogenases (17 beta-HSDs, HSD17B) | DEHYDROGENASES | QUINONES | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROGESTERONE ACTION | 17-BETA-ESTRADIOL | CARCINOGENESIS | OVARIAN ENDOMETRIOSIS | Aldo-keto reductase 1C3 (AKR1C3) | ENZYMES | PHARMACOLOGY & PHARMACY | TOXICOLOGY | PHASE-I | CARCINOMA | PRE-RECEPTOR REGULATION | Sulfatases - genetics | Progesterone Reductase - metabolism | Humans | Endometrial Neoplasms - metabolism | Aromatase - metabolism | Catechol O-Methyltransferase - genetics | Hydroxyprostaglandin Dehydrogenases - metabolism | Androstenedione - metabolism | Catechol O-Methyltransferase - metabolism | Aromatase - genetics | Endometrial Neoplasms - genetics | Sulfatases - metabolism | Estrogens - genetics | 3-Hydroxysteroid Dehydrogenases - metabolism | Female | Sulfotransferases - metabolism | Estrogens - metabolism | Quinones - pharmacology | Glutathione S-Transferase pi - genetics | Sulfotransferases - genetics | Estrone - genetics | Quinone Reductases - metabolism | Androstenedione - genetics | Glutathione S-Transferase pi - metabolism | Estrogens - biosynthesis | RNA, Messenger - genetics | Transcriptome - genetics | Progesterone Reductase - genetics | Arylsulfotransferase - genetics | Hydroxyprostaglandin Dehydrogenases - genetics | Estrone - analogs & derivatives | Aldo-Keto Reductase Family 1 Member C3 | Estrone - metabolism | Cell Line, Tumor | Quinone Reductases - genetics | 3-Hydroxysteroid Dehydrogenases - genetics | Arylsulfotransferase - metabolism | Physiological aspects | Endometrial cancer | Sulfates | Genes | Estrogen | Steroids | Index Medicus
Journal Article
P L o S Genetics (Print), ISSN 1553-7390, 04/2011, Volume 7, Issue 4, pp. e1002025 - e1002025
textabstractDehydroepiandrosterone sulphate (DHEAS) is the most abundant circulating steroid secreted by adrenal glands-yet its function is unknown. Its serum... 
POLYCYSTIC-OVARY-SYNDROME | DEHYDROEPIANDROSTERONE-SULFATE LEVELS | RISK LOCI | BONE-MINERAL DENSITY | XENOBIOTIC METABOLISM | INSULIN-RESISTANCE | ACID-METABOLISM | GENETICS & HEREDITY | SUSCEPTIBILITY LOCI | CARDIOVASCULAR-DISEASE | GENOME-WIDE ASSOCIATION | Cytochrome P-450 CYP2C9 | Homeodomain Proteins - metabolism | Humans | Middle Aged | Aryl Hydrocarbon Hydroxylases - genetics | Actin-Related Protein 2-3 Complex - genetics | Male | Young Adult | Actin-Related Protein 2-3 Complex - metabolism | Aging - genetics | Bcl-2-Like Protein 11 | Kruppel-Like Transcription Factors - metabolism | Apoptosis Regulatory Proteins - genetics | Adult | Female | Sulfotransferases - metabolism | Membrane Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Sulfotransferases - genetics | European Continental Ancestry Group - genetics | Gene Expression | Genome-Wide Association Study | Membrane Proteins - genetics | Liver - metabolism | Proto-Oncogene Proteins - genetics | Transcription Factors - genetics | Dehydroepiandrosterone Sulfate - blood | Homeodomain Proteins - genetics | Apoptosis Regulatory Proteins - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | Linkage Disequilibrium | Aging - blood | Transcription Factors - metabolism | Adaptor Proteins, Signal Transducing - genetics | Aged | Polymorphism, Single Nucleotide | Adaptor Proteins, Signal Transducing - metabolism | Kruppel-Like Transcription Factors - genetics | Physiological aspects | Aging | Dehydroepiandrosterone | Research | Single nucleotide polymorphisms | Gene expression | Index Medicus | Medical and Health Sciences | Medicin och hälsovetenskap | Mens health | Womens health | Mortality | Men | Technological change | Genomes | Lymphomas | Diabetes | Metabolism | Age
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 06/2015, Volume 150, pp. 54 - 63
Epithelial ovarian cancer (EOC) accounts for about 90% of malignant ovarian tumors, and estrogen is often implicated in disease progression. We therefore... 
Estrogen sulfotransferase | Ovarian surface epithelium | Steroid sulfatase | Epithelial ovarian cancer | Estrogen | SURFACE EPITHELIUM | ER-BETA | PROGESTERONE-RECEPTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-LINES | RECEPTOR-ALPHA | ENDOMETRIAL CANCER | STEROID SULFATASE INHIBITORS | BREAST-CANCER | BETA MESSENGER-RNAS | ENDOCRINOLOGY & METABOLISM | AROMATASE EXPRESSION | Epithelial Cells - metabolism | Epithelial Cells - drug effects | Humans | Ovarian Neoplasms - pathology | Neoplasms, Glandular and Epithelial - metabolism | Tritium | RNA, Messenger - metabolism | Hydroxyprostaglandin Dehydrogenases - metabolism | Ovarian Neoplasms - genetics | Neoplasms, Glandular and Epithelial - genetics | Sulfotransferases - antagonists & inhibitors | Biotransformation | 3-Hydroxysteroid Dehydrogenases - metabolism | Female | Ovary - drug effects | Steryl-Sulfatase - metabolism | Sulfotransferases - metabolism | Ovarian Neoplasms - metabolism | Estrogens - metabolism | Ovary - metabolism | Steryl-Sulfatase - genetics | Sulfotransferases - genetics | Neoplasms, Glandular and Epithelial - pathology | Ovary - pathology | RNA, Messenger - genetics | Gene Expression Regulation | Epithelial Cells - pathology | Hydroxyprostaglandin Dehydrogenases - genetics | Aldo-Keto Reductase Family 1 Member C3 | Estradiol Dehydrogenases - genetics | Estradiol Dehydrogenases - metabolism | Carcinoma, Ovarian Epithelial | Cell Line, Tumor | 3-Hydroxysteroid Dehydrogenases - genetics | Interleukin-1alpha - pharmacology | Physiological aspects | Ovarian cancer | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 12/2011, Volume 71, Issue 24, pp. 7683 - 7693
The glycome acts as an essential interface between cells and the surrounding microenvironment. However, changes in glycosylation occur in nearly all breast... 
ONCOLOGY | INFLAMMATION | PROSTATE-CANCER | BONE-MARROW | P-SELECTIN | CARBOHYDRATE ANTIGENS | CELL-ADHESION | O-GLYCANS | GLYCOSYLATION | EXPRESSION | CARCINOMA | Neoplasms, Hormone-Dependent - metabolism | Receptors, Estrogen - metabolism | Human Umbilical Vein Endothelial Cells - metabolism | Lewis X Antigen - genetics | Oligonucleotide Array Sequence Analysis | Humans | Gene Expression Regulation, Neoplastic | N-Acetylglucosaminyltransferases - genetics | Gene Expression Profiling | Lewis X Antigen - metabolism | Heparitin Sulfate - metabolism | Breast Neoplasms - metabolism | Neoplasms, Hormone-Dependent - genetics | Neoplasm Metastasis | E-Selectin - genetics | Human Umbilical Vein Endothelial Cells - cytology | Female | Sulfotransferases - metabolism | Sulfotransferases - genetics | Cell Line | Fucosyltransferases - genetics | Glycomics - methods | Sialyltransferases - genetics | E-Selectin - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Sialyltransferases - metabolism | Cell Adhesion | Blotting, Western | N-Acetylglucosaminyltransferases - metabolism | Fucosyltransferases - metabolism | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Neoplasms, Hormone-Dependent - pathology | Cell Line, Tumor | Index Medicus | sialyl-Lewis x | heparan sulfate | selectin | estrogen receptor | breast cancer metastasis
Journal Article
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 1292 - 11
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2009, Volume 106, Issue 34, pp. 14728 - 14733
We provide a demonstration in humans of the principle of pharmacometabonomics by showing a dear connection between an individual's metabolic phenotype, in the... 
Urine | Metabolomics | Excretion | Pharmacogenetics | Metabolites | Metabolic diseases | Bacteria | Glucuronides | Sulfates | Metabolism | Sulfate | Acetaminophen | p-cresol | Glucuronide | DNA-ADDUCTS | sulfate | QUINONE METHIDE | bacteria | MULTIDISCIPLINARY SCIENCES | ACETAMINOPHEN HEPATOTOXICITY | MYELIN BASIC-PROTEIN | acetaminophen | AUTISTIC-CHILDREN | GUT MICROFLORA | glucuronide | LOW-DOSE PARACETAMOL | PHARMACOGENOMICS | P-CRESOL SULFATE | HUMAN SULFOTRANSFERASES | Acetaminophen - metabolism | Analgesics, Non-Narcotic - pharmacokinetics | Humans | Middle Aged | Male | Sulfuric Acid Esters - metabolism | Young Adult | Bacteria - growth & development | Cresols - urine | Adult | Bacteria - metabolism | Acetaminophen - analogs & derivatives | Sulfates - metabolism | Magnetic Resonance Spectroscopy | Administration, Oral | Gastrointestinal Tract - microbiology | Acetaminophen - urine | Analgesics, Non-Narcotic - administration & dosage | Analgesics, Non-Narcotic - metabolism | Cresols - metabolism | Gastrointestinal Tract - metabolism | Host-Pathogen Interactions | Sulfuric Acid Esters - urine | Adolescent | Acetaminophen - pharmacokinetics | Host-bacteria relationships | Drug metabolism | Metabonomic analysis | Research | Drugs | Health care | Biomarkers | Genotype & phenotype | Nuclear magnetic resonance--NMR | Competition | biomarkers | Cresol | Magnetic resonance spectroscopy | p-Cresol | Analgesics | Sulfonation | Xenobiotics | Digestive tract | Pharmaceuticals | Index Medicus | Biological Sciences
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2004, Volume 279, Issue 41, pp. 42732 - 42741
Using a high throughput heparan sulfate (HS) isolation and characterization protocol, we have analyzed HS structure in several tissues from mice/mouse embryos... 
SYNDECAN-1 | DEACETYLASE/N-SULFOTRANSFERASE ISOZYMES | TARGETED DISRUPTION | NEONATAL LETHALITY | LIGAND-BINDING | FINE-STRUCTURE | IDURONIC ACID | BIOCHEMISTRY & MOLECULAR BIOLOGY | MAST-CELLS | DOMAIN-STRUCTURE | FIBROBLAST-GROWTH-FACTOR | Heparitin Sulfate - biosynthesis | Membrane Glycoproteins - metabolism | Models, Chemical | Chromatography, High Pressure Liquid | Disaccharides - chemistry | Glycosaminoglycans - chemistry | Tissue Distribution | Kidney - metabolism | Membrane Glycoproteins - physiology | Time Factors | Swine | Oligosaccharides - chemistry | Sulfotransferases - metabolism | Sulfotransferases - physiology | Amidohydrolases - metabolism | Sulfotransferases - genetics | Syndecans | Glycosaminoglycans - metabolism | Mice, Inbred C57BL | Proteoglycans - metabolism | Genotype | Mice, Transgenic | Carbohydrate Epimerases - chemistry | Membrane Glycoproteins - genetics | Animals | Heparitin Sulfate - chemistry | Proteoglycans - physiology | Syndecan-1 | Mice | Proteoglycans - genetics | Sulfotransferases - chemistry | Index Medicus | Models; Chemical | Mice; Transgenic | Glycosaminoglycans/chemistry/metabolism | Oligosaccharides/chemistry | Proteoglycans/genetics/metabolism/physiology | Heparitin Sulfate/biosynthesis/chemistry | Chromatography; High Pressure Liquid | Kidney/metabolism | Mice; Inbred C57BL | Disaccharides/chemistry | Carbohydrate Epimerases/chemistry | Sulfotransferases/chemistry/genetics/metabolism/physiology | Research Support; Non-U.S. Gov't | Amidohydrolases/metabolism | Membrane Glycoproteins/genetics/metabolism/physiology
Journal Article
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