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Journal Article
Journal of Immunotherapy, ISSN 1524-9557, 06/2010, Volume 33, Issue 5, pp. 492 - 499
Antibody-targeted superantigens have a potential to become useful drugs for tumor therapy. However, clinical practice has identified several issues that need... 
Superantigen | Protein engineering | Antibody | Cancer | MEDICINE, RESEARCH & EXPERIMENTAL | TUMOR-THERAPY | antibody | MONOCLONAL-ANTIBODY | IMMUNOLOGY | superantigen | RENAL-CELL CARCINOMA | CANCER-THERAPY | LUNG-CANCER | protein engineering | ONCOLOGY | PHASE-I TRIAL | TARGETED SUPERANTIGENS | IMMUNOTHERAPY | STAPHYLOCOCCAL-ENTEROTOXIN-A | cancer | 5T4 ONCOFETAL ANTIGEN | Neoplasm Transplantation | Superantigens - administration & dosage | Membrane Glycoproteins - metabolism | Humans | Macaca fascicularis | Recombinant Fusion Proteins - metabolism | Carcinoma, Renal Cell - immunology | Superantigens - metabolism | Point Mutation - genetics | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Protein Engineering | Antigens, Neoplasm - metabolism | Membrane Glycoproteins - immunology | T-Lymphocytes - pathology | Carcinoma, Renal Cell - drug therapy | Cytotoxicity, Immunologic - drug effects | Recombinant Fusion Proteins - administration & dosage | Antigens, Neoplasm - genetics | Antigens, Neoplasm - immunology | Carcinoma, Renal Cell - pathology | Mice, SCID | Membrane Glycoproteins - genetics | Enterotoxins - administration & dosage | Antibodies, Monoclonal - genetics | Enterotoxins - genetics | Animals | Immunoconjugates | Immunotoxins - therapeutic use | Antibodies, Monoclonal - administration & dosage | Superantigens - genetics | Cell Line, Tumor | Enterotoxins - metabolism | Recombinant Fusion Proteins - genetics | T-Lymphocytes - immunology | Cell Proliferation - drug effects | Mice | Antibodies, Monoclonal - metabolism | Index Medicus | Antigens | Toxicity | Tumor cells | Immunodeficiency | Antibodies | Clinical trials | Lymphocytes T | Epitopes | Major histocompatibility complex | Antigenicity | Lymphocytes | Immunotherapy | Superantigens | Antitumor activity | Solid tumors | Fusion protein | Tumors
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 01/2014, Volume 274, Issue 2, pp. 240 - 248
Menstrual toxic shock syndrome (mTSS) is a rare, recognizable, and treatable disease that has been associated with tampon use epidemiologically. It involves a... 
Vagina | Temperature | Toxic shock syndrome toxin-1 (TSST-1) | Permeability | Surfactant | Endotoxin | PENETRATION | PERMEABILITY CHARACTERISTICS | IDENTIFICATION | SUPERANTIGEN | FUNCTIONAL-PROPERTIES | TRANSMISSION | INFLAMMATION | PHARMACOLOGY & PHARMACY | STAPHYLOCOCCUS-AUREUS | TOXICOLOGY | SKIN | BENZALKONIUM CHLORIDE | Superantigens - toxicity | Epithelial Cells - metabolism | Enterotoxins - toxicity | Vagina - drug effects | Epithelial Cells - drug effects | Bacterial Toxins - toxicity | Lipopolysaccharides - metabolism | Salmonella typhimurium - metabolism | Swine | Hemolysin Proteins - toxicity | Female | Mucous Membrane - drug effects | Staphylococcus aureus | Vagina - pathology | Virulence Factors - toxicity | Shock, Septic - pathology | Risk Factors | Shock, Septic - microbiology | Surface-Active Agents - pharmacology | Mucous Membrane - pathology | Animals | Cell Membrane Permeability - drug effects | Lipopolysaccharides - isolation & purification | In Vitro Techniques | Environmental aspects | Usage | Surface active agents | Analysis | Toxic shock syndrome | Index Medicus | GLYCEROL | PERMEABILITY | TOXINS | TOXICITY | SULFURIC ACID ESTERS | 60 APPLIED LIFE SCIENCES | ENVIRONMENTAL EFFECTS | STAPHYLOCOCCUS | ENVIRONMENTAL SCIENCES | FEMALE GENITALS | DISEASES | RISK ASSESSMENT | TRITIUM | TRITIUM OXIDES | ECOSYSTEMS | MUCOUS MEMBRANES
Journal Article
Journal Article
Toxins, ISSN 2072-6651, 2014, Volume 6, Issue 6, pp. 1724 - 1741
Toxic shock syndrome (TSS) results from the host's overwhelming inflammatory response and cytokine storm mainly due to superantigens (SAgs). There is no... 
Continual stimulation | Rabbit animal model | TNF-alpha | Postexposure treatment | IL-2 | Toxic shock syndrome toxin-1 | Neutralizing antibody | postexposure treatment | MUTANT | BACTERIAL SUPERANTIGENS | VACCINE | neutralizing antibody | MESSENGER-RNA STABILITY | SEPSIS | PROTECTS | continual stimulation | STAPHYLOCOCCAL-ENTEROTOXIN-B | rabbit animal model | T-CELL-ACTIVATION | AUREUS | TOXICOLOGY | toxic shock syndrome toxin-1 | EXPRESSION | Superantigens - toxicity | Tumor Necrosis Factor-alpha - metabolism | Leukocytes, Mononuclear - metabolism | Shock, Septic - etiology | Enterotoxins - toxicity | Humans | Bacterial Toxins - toxicity | Male | Shock, Septic - immunology | Shock, Septic - metabolism | Superantigens - metabolism | Bacterial Toxins - antagonists & inhibitors | Antitoxins - therapeutic use | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Antibodies, Neutralizing - therapeutic use | Leukocytes, Mononuclear - immunology | Shock, Septic - drug therapy | Mutant Proteins - toxicity | Bacterial Toxins - genetics | Female | Mutant Proteins - antagonists & inhibitors | Disease Models, Animal | Interleukin-2 - metabolism | Recombinant Proteins - metabolism | Rabbits | Leukocytes, Mononuclear - drug effects | Cells, Cultured | Recombinant Proteins - chemistry | Antibodies, Neutralizing - pharmacology | Mutant Proteins - metabolism | Gene Expression Regulation - drug effects | Toxicokinetics | Interleukin-2 - genetics | Bacterial Toxins - metabolism | Enterotoxins - genetics | Animals | Lymphocyte Activation - drug effects | Antitoxins - pharmacology | Superantigens - genetics | Survival Analysis | Enterotoxins - antagonists & inhibitors | Enterotoxins - metabolism | Recombinant Proteins - toxicity | Leukocytes, Mononuclear - cytology | T-Lymphocytes - immunology | Cell Proliferation - drug effects
Journal Article
Biochemistry, ISSN 0006-2960, 12/2008, Volume 47, Issue 49, pp. 12995 - 13003
Journal Article
PLoS Biology, ISSN 1544-9173, 06/2017, Volume 15, Issue 6, p. e2001930
Superantigens (SAgs) are potent exotoxins secreted by Staphylococcus aureus and Streptococcus pyogenes. They target a large fraction of T cell pools to set in... 
NKT CELLS | INVARIANT T-CELLS | GAMMA PRODUCTION | STAPHYLOCOCCAL-ENTEROTOXIN-B | ALPHA-CHAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGY | TOXIC-SHOCK-SYNDROME | BINDING | MR1 | MHC CLASS-II | CD1D-INDEPENDENT ACTIVATION | Superantigens - toxicity | Leukocytes, Mononuclear - metabolism | Enterotoxins - secretion | Enterotoxins - toxicity | Transplantation Chimera - immunology | Humans | Superantigens - metabolism | Mucosal-Associated Invariant T Cells - immunology | Mucosal-Associated Invariant T Cells - metabolism | Clonal Anergy - drug effects | Bone Marrow Cells - immunology | Leukocytes, Mononuclear - immunology | Bone Marrow Cells - drug effects | Female | Mucosal-Associated Invariant T Cells - cytology | Antigens, Bacterial - toxicity | Staphylococcus aureus - metabolism | Cell Line | Mucosal-Associated Invariant T Cells - drug effects | Leukocytes, Mononuclear - drug effects | Specific Pathogen-Free Organisms | Bone Marrow Cells - cytology | Streptococcus pyogenes - immunology | Cells, Cultured | Mice, Transgenic | Streptococcus pyogenes - metabolism | Immunity, Innate | Mice, SCID | Mice, Knockout | Transplantation Chimera - metabolism | Models, Immunological | Animals | Transplantation Chimera - blood | Lymphocyte Activation - drug effects | Hybridomas | Leukocytes, Mononuclear - cytology | Mice, Inbred NOD | Staphylococcus aureus - immunology | Mice | Antigens, Bacterial - metabolism | Bone Marrow Cells - metabolism | Crosses, Genetic | Klebsiella | Anergy | Mucosa | Colleges & universities | Antiinfectives and antibacterials | Invariants | Proteins | T-cell receptor | Genotype & phenotype | Signal transduction | Cell activation | Illnesses | Surgery | Bone marrow | Medical research | Cytokines | Enterotoxin B | Interleukin 12 | T cell receptors | Roles | Pools | Gene expression | Interleukin 18 | Immunosuppression | Major histocompatibility complex | Sag | Sepsis | Affinity | Animal models | Pneumonia | Interleukin | Editing | Lymphocytes T | Infections | Activation | CD223 antigen | Kinases | Immunology | E coli | Lymphocytes | Bacteria | Tumor necrosis factor-TNF | Chimeras | Bacterial infections | Transgenic mice | Inflammation | Streptococcus | Exotoxins | Cell death | Exhaustion | Writing | Interferon | Histocompatibility antigen HLA | Apoptosis
Journal Article
Particle and Fibre Toxicology, ISSN 1743-8977, 08/2014, Volume 11, Issue 1, pp. 38 - 38
Journal Article