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Journal Article
Archives of Toxicology, ISSN 0340-5761, 3/2017, Volume 91, Issue 3, pp. 1319 - 1333
We investigated the responses of mice that are defective in the superoxide-scavenging enzyme SOD1 to thioacetamide (TAA)-induced hepatotoxicity. When a lethal... 
Biomedicine, general | Oxidative stress | Thioacetamide | Environmental Health | Biomedicine | Occupational Medicine/Industrial Medicine | ER stress | Superoxide | CYP | Pharmacology/Toxicology | Steatosis | RAT HEPATOCYTES | ENDOPLASMIC-RETICULUM STRESS | APO-B | IN-VITRO | LIPID DROPLET ACCUMULATION | HYDROGEN-PEROXIDE | MICE | TOXICOLOGY | PROTEINS | SUPEROXIDE-DISMUTASE | MONOOXYGENASE REACTIONS | Fatty Liver - pathology | Antioxidants - metabolism | Male | Superoxide Dismutase-1 - deficiency | Cytochrome P-450 CYP2E1 - genetics | Cytochrome P-450 CYP2E1 - metabolism | Fatty Liver - chemically induced | Cell Death - genetics | Inactivation, Metabolic - drug effects | Liver - drug effects | Superoxide Dismutase-1 - metabolism | Thioacetamide - administration & dosage | Cell Death - drug effects | Enzymes - metabolism | Endoplasmic Reticulum Stress - drug effects | Liver - metabolism | Mice, Inbred C57BL | Oxidative Stress - genetics | Mice, Knockout | Animals | Thioacetamide - toxicity | Lipid Metabolism - drug effects | Superoxide Dismutase-1 - genetics | Oxidative Stress - drug effects | Endoplasmic Reticulum Stress - physiology | Medical colleges | Liver diseases | Metabolites | Cell death | Liver | Cytochrome P-450 | Physiological aspects | Biochemistry | Adipocytes | Toxicity | Endoplasmic reticulum | Sulfide compounds | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, pp. e0175732 - e0175732
There is an emerging consensus that hyperhomocysteinemia is an independent risk factor for cerebral vascular disease and that homocysteine-lowering therapy... 
STROKE | HOMOCYSTEINE | ENDOTHELIAL DYSFUNCTION | MICE DEFICIENT | NITRIC-OXIDE SYNTHASE | MULTIDISCIPLINARY SCIENCES | PREVENTION | SMOOTH-MUSCLE-CELLS | B-VITAMINS | FOLIC-ACID | ARTERIOLES | Blood Pressure | Cerebrovascular Disorders - physiopathology | Hyperhomocysteinemia - pathology | Diet - adverse effects | Cerebral Arteries - physiopathology | Male | Superoxide Dismutase-1 - deficiency | Mice, 129 Strain | Cerebrovascular Disorders - etiology | Mice, Knockout | Hyperhomocysteinemia - physiopathology | Animals | Cerebral Arteries - pathology | Superoxide Dismutase-1 - genetics | Superoxides - metabolism | Female | Mice | Cerebrovascular Disorders - pathology | Hyperhomocysteinemia - complications | Disease Models, Animal | Hypertrophy | Superoxide | Hyperhomocysteinemia | Research | Health aspects | Risk factors | Endothelium | Brain | Cell culture | Ammonium | Arterioles | Lung | Smooth muscle | Fluorescent indicators | Glucose | Cerebrospinal fluid | pH effects | Blood | Folic acid | Vasodilation | Antioxidants | Alterations | Vitamin B | Inhibition | Deoxyribonucleic acid--DNA | Cadmium | Internal medicine | Breeding | Abnormalities | Calcium channels (voltage-gated) | Blood vessels | Liquid chromatography | Gene expression | Electron microscopy | Inhibitors | Diet | Nitric oxide | Electrochemistry | Adults | Aberration | Cardiovascular diseases | Circulation | Metabolic disorders | Cell proliferation | Drugs | Polyethylenes | Animal models | Hydrogen peroxide | Centrifugation | Fluorescence | Ethylenediaminetetraacetic acids | Polyethylene glycol | Rodents | Chemical bonds | Carotid artery | Heart diseases | Age | Hypertension | Stroke | Incubation | Health risks | Pharmacology | Functional analysis | Permeability | Computer programs | Medicine | Concentration (composition) | Skull | Homocysteine | Apoptosis | Plasmas (physics) | Veins & arteries | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Stem Cell Reviews and Reports, ISSN 1550-8943, 10/2017, Volume 13, Issue 5, pp. 686 - 698
Amyotrophic Lateral Sclerosis (ALS) is one of the most common adult-onset motor neuron disease causing a progressive, rapid and irreversible degeneration of... 
Life Sciences | Stem Cells | Biomedical Engineering | Motor neurons | Regenerative Medicine/Tissue Engineering | IPSCs | Pericytes | Mesenchymal stromal cells | Amyotrophic lateral sclerosis | SOD1 mice | Cell Biology | MOTOR-NEURONS | MEDICINE, RESEARCH & EXPERIMENTAL | REGRESSION-MODELS | SPINAL-CORD | AMYOTROPHIC-LATERAL-SCLEROSIS | MESENCHYMAL STEM-CELLS | CELL & TISSUE ENGINEERING | CELL BIOLOGY | SKELETAL-MUSCLE | INFLAMMATION | MOUSE MODEL | DISEASE | CENTRAL-NERVOUS-SYSTEM | Spinal Cord - metabolism | Humans | Pericytes - cytology | Brain Stem - metabolism | Cerebral Cortex - pathology | Adipose Tissue - cytology | Male | Superoxide Dismutase-1 - deficiency | Cerebral Cortex - metabolism | Motor Neurons - pathology | Adipose Tissue - metabolism | Brain Stem - pathology | Spinal Cord - pathology | Mesenchymal Stem Cells - cytology | Pericytes - transplantation | Female | Mesenchymal Stem Cells - metabolism | Disease Models, Animal | Induced Pluripotent Stem Cells - metabolism | Induced Pluripotent Stem Cells - pathology | Gene Expression | Amyotrophic Lateral Sclerosis - therapy | Catalase - genetics | Amyotrophic Lateral Sclerosis - genetics | Pericytes - metabolism | RNA-Binding Protein FUS - genetics | Mice, Transgenic | RNA-Binding Protein FUS - metabolism | Amyotrophic Lateral Sclerosis - mortality | Blood-Brain Barrier - metabolism | Catalase - metabolism | Motor Neurons - metabolism | Blood-Brain Barrier - pathology | Amyotrophic Lateral Sclerosis - pathology | Animals | Superoxide Dismutase-1 - genetics | Survival Analysis | Mice | Mutation | Antioxidants | Enzymes | Nervous system diseases | Neurons | Analysis | Stem cells | Transplantation | Gene expression | Adipose tissues | Spinal cord | Animal models | Adipose tissue | Mesenchyme | Brain stem | Central nervous system | Medical services | Motor neuron disease | Clinical trials | Superoxide dismutase | In vitro testing | Cortex (motor) | Males | Sclerosis | FUS protein | Blood-brain barrier | Neurodegeneration | Degeneration | Medical research | Neurodegenerative diseases | Patients | Survival | Neurological diseases | Stromal cells | Females | Inhibitory postsynaptic potentials | Index Medicus
Journal Article
Bioscience, Biotechnology, and Biochemistry, ISSN 0916-8451, 08/2017, Volume 81, Issue 8, pp. 1586 - 1590
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2017, Volume 12, Issue 5, pp. e0177649 - e0177649
Journal Article
CELL DEATH & DISEASE, ISSN 2041-4889, 02/2018, Volume 9, Issue 2, pp. 250 - 16
Microglia activation is a commonly pathological hallmark of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), a devastating disorder... 
NERVOUS-SYSTEM | ADULT-MOUSE BRAIN | MOTOR-NEURON DEGENERATION | MULTIPLE-SCLEROSIS | INTERFERON-GAMMA | SPINAL-CORD | MUTANT SUPEROXIDE-DISMUTASE | DEPENDENT MECHANISM | ALTERNATIVE ACTIVATION | MACROPHAGE ACTIVATION | CELL BIOLOGY | Microglia - metabolism | Spinal Cord - metabolism | Transcriptome | Superoxide Dismutase-1 - deficiency | Green Fluorescent Proteins - genetics | Transplantation, Homologous | Spinal Cord - pathology | Bone Marrow Transplantation | Microglia - pathology | Interleukin-4 - genetics | Genes, Reporter | Disease Models, Animal | Green Fluorescent Proteins - metabolism | Signal Transduction | Amyotrophic Lateral Sclerosis - therapy | Amyotrophic Lateral Sclerosis - genetics | Interleukin-4 - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Mice, Transgenic | Nerve Tissue Proteins - genetics | Disease Progression | Nerve Tissue Proteins - metabolism | Amyotrophic Lateral Sclerosis - pathology | Phenotype | Animals | Interleukin-4 - administration & dosage | Amyotrophic Lateral Sclerosis - metabolism | Superoxide Dismutase-1 - genetics | Mice | Primary Cell Culture | Homeostasis - genetics | Genetic Therapy - methods | Motor neurons | Phenotypes | Cell survival | Neurodegenerative diseases | Central nervous system | Homeostasis | Amyotrophic lateral sclerosis | Gene expression | Sclerosis | Microglia | Embryogenesis | Interleukin 4 | Neurodegeneration | Rodents | Gene therapy | Index Medicus
Journal Article
Regulatory Toxicology and Pharmacology, ISSN 0273-2300, 08/2016, Volume 79, pp. 83 - 90
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2017, Volume 12, Issue 5, pp. e0176800 - e0176800
Iron regulatory protein 1 (IRP1) is a cytosolic bifunctional [4Fe-4S] protein which exhibits aconitase activity or binds iron responsive elements (IREs) in... 
OVEREXPRESSION | ACTIVATION | PROTECTION | METABOLISM | ACONITASE | ERYTHROPOIESIS | MULTIDISCIPLINARY SCIENCES | CELLULAR IRON HOMEOSTASIS | DISMUTASE | PROTEIN-1 GENE-EXPRESSION | MODULATION | Superoxide Dismutase-1 - deficiency | RNA, Messenger - metabolism | Dose-Response Relationship, Drug | Kidney - metabolism | Liver - drug effects | Tumor Suppressor Proteins - deficiency | Receptors, LDL - deficiency | Superoxides - metabolism | Paraquat - pharmacology | Iron Regulatory Protein 1 - genetics | Tumor Suppressor Proteins - metabolism | Kidney - drug effects | Liver - metabolism | RNA, Messenger - genetics | Receptors, LDL - metabolism | Apoferritins - genetics | Macrophages - cytology | Down-Regulation - drug effects | Gene Expression Regulation - drug effects | Macrophages - metabolism | Animals | Iron Regulatory Protein 1 - metabolism | Macrophages - drug effects | RAW 264.7 Cells | Mice | Oxidative Stress - drug effects | Herbicides | Oxidative stress | Analysis | Physiological aspects | Superoxide dismutase | Chemical properties | Macrophages | Health aspects | Cell culture | Liver | Escherichia coli | Biochemistry | Electron spin | Blood | Proteins | Degradation | Animal breeding | Clusters | Bone marrow | Hydroxyl radicals | Biocompatibility | Genetics | Copper | Deoxyribonucleic acid--DNA | Binding | Enzymes | Paramagnetic resonance | Fluctuations | Breeding | Developmental biology | Fetuses | Cultures | Gene expression | Metabolism | Embryos | Stem cells | Affinity | Residues | Hydrogen peroxide | Arches | Toxicity | Leukemia | Gene regulation | Homeostasis | Viruses | Iron | Biology | Neurotoxicity | Allosteric properties | Ethylenediaminetetraacetic acids | Clonal deletion | Uterus | Rodents | Biodegradation | Oxygen | Amyotrophic lateral sclerosis | Pharmacology | Biophysics | Ribonucleic acid--RNA | Citric acid | Cell death | In vivo methods and tests | Molecular biology | Females | Tumors | Peritoneum | Cancer | Index Medicus | Stresses | Ribonucleic acids | Deoxyribonucleic acid | DNA
Journal Article
Journal Article
American Journal of Pathology, ISSN 0002-9440, 05/2012, Volume 180, Issue 5, pp. 1879 - 1896
Journal Article
Journal Article