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PLoS ONE, ISSN 1932-6203, 10/2016, Volume 11, Issue 10, pp. e0164732 - e0164732
Journal Article
Immunity, ISSN 1074-7613, 09/2017, Volume 47, Issue 3, pp. 566 - 581.e9
Microglia play a pivotal role in the maintenance of brain homeostasis but lose homeostatic function during neurodegenerative disorders. We identified a... 
Alzheimer’s disease | multiple sclerosis | transcriptional regulation | neurodegeneration | TREM2 | APOE | amyotrophic lateral sclerosis | microglia | Alzheimer's disease | GENE-EXPRESSION SIGNATURE | ACTIVATION | MULTIPLE-SCLEROSIS | ALZHEIMERS-DISEASE | MOUSE MODEL | MACROPHAGE | MICE | IMMUNOLOGY | DEFICIENCY | APOLIPOPROTEIN-E | CELL-DEATH | Microglia - metabolism | Apolipoproteins E - deficiency | Membrane Glycoproteins - metabolism | Humans | Cerebral Cortex - pathology | Transcriptome | Apoptosis - genetics | Monocytes - metabolism | Gene Expression Profiling | Monocytes - immunology | Phagocytosis - genetics | Neurodegenerative Diseases - immunology | Apolipoproteins E - metabolism | Cerebral Cortex - metabolism | Alzheimer Disease - pathology | Microglia - immunology | Superoxide Dismutase-1 - metabolism | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Female | Neurons - metabolism | Disease Models, Animal | Gene Targeting | Plaque, Amyloid - pathology | Signal Transduction | Gene Expression Regulation | Phagocytosis - immunology | Immune Tolerance | Mice, Transgenic | Neurodegenerative Diseases - genetics | Neurodegenerative Diseases - metabolism | Mice, Knockout | Encephalomyelitis, Autoimmune, Experimental | Phenotype | Animals | Apoptosis - immunology | Apolipoproteins E - genetics | Alzheimer Disease - metabolism | Superoxide Dismutase-1 - genetics | Plaque, Amyloid - metabolism | Mice | Alzheimer Disease - genetics | Transforming Growth Factor beta - metabolism | Receptors, Immunologic - metabolism | Cluster Analysis | Nervous system diseases | Multiple sclerosis | Neurons | Analysis | Amyotrophic lateral sclerosis | Genetic aspects | Genetic transcription | Apolipoproteins | Brain | Animal models | Disease | Transcription | Genes | Homeostasis | Sclerosis | Proteins | Restoration | Neurodegeneration | Apolipoprotein E | Rodents | Plaques | Myeloid cells | Neurodegenerative diseases | Microglia | Neurological diseases | Molecular modelling | β-Amyloid | Phagocytosis | Apoptosis | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 05/2018, Volume 475, Issue 10, pp. 1701 - 1719
Misfolding and aggregation of Cu, Zn Superoxide dismutase (SOD1) is involved in the neurodegenerative disease, amyotrophic lateral sclerosis. Many studies have... 
Protein Structure, Secondary | Trifluoroethanol - pharmacology | Humans | Superoxide Dismutase-1 - metabolism | Enzyme Stability | Superoxide Dismutase-1 - genetics | Mutation | Molecular Dynamics Simulation | Protein Folding | Superoxide Dismutase-1 - chemistry | Index Medicus
Journal Article
Nordic Journal of Psychiatry, ISSN 0803-9488, 11/2017, Volume 71, Issue 8, pp. 570 - 573
Journal Article
Cell Reports, ISSN 2211-1247, 10/2017, Volume 21, Issue 1, pp. 1 - 9
Reactive oxygen species (ROS) are continuously produced as a by-product of mitochondrial metabolism and eliminated via antioxidant systems. Regulation of... 
senescence | mitochondria | ROS | AMPK | PGC-1α | ULK1 | LKB1 | oxidative stress | nutrient signaling energy stress | CANCER-CELLS | SURVIVAL | COMPLEX-III | ENERGY STRESS | ACTIVATED PROTEIN-KINASE | GROWTH | NEURODEGENERATION | HYDROGEN-PEROXIDE | DIRECT PHOSPHORYLATION | CELL BIOLOGY | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics | Superoxide Dismutase - genetics | Reactive Oxygen Species - metabolism | Uncoupling Protein 3 - genetics | Humans | Autophagy-Related Protein-1 Homolog - metabolism | AMP-Activated Protein Kinases - deficiency | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - deficiency | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Superoxide Dismutase-1 - metabolism | HEK293 Cells | Protein Stability | Superoxide Dismutase - metabolism | Fibroblasts - metabolism | Cellular Senescence - genetics | Glutathione Peroxidase - metabolism | Uncoupling Protein 3 - metabolism | Signal Transduction | Uncoupling Protein 2 - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Gene Expression Regulation | Mice, Transgenic | Mitochondria - metabolism | Glutathione Peroxidase - genetics | Uncoupling Protein 2 - genetics | Metabolic Networks and Pathways - genetics | Animals | Superoxide Dismutase-1 - genetics | Fibroblasts - cytology | Mice | Primary Cell Culture | Autophagy-Related Protein-1 Homolog - genetics | AMP-Activated Protein Kinases - genetics | Homeostasis - genetics | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 06/2017, Volume 114, Issue 23, pp. E4556 - E4563
How proteins sense and navigate the cellular interior to find their functional partners remains poorly understood. An intriguing aspect of this search is that... 
Protein surface properties | Intracellular diffusion | In-cell NMR | MAGNETIC-RESONANCE RELAXATION | STABILITY | MULTIDISCIPLINARY SCIENCES | in-cell NMR | EUKARYOTIC CELLS | intracellular diffusion | protein surface properties | MODEL-FREE APPROACH | FOLDING KINETICS | RESIDUE LEVEL | TEST-TUBE | SUPEROXIDE-DISMUTASE | LIVING CELLS | Recombinant Proteins - metabolism | Biophysical Phenomena | Mutagenesis, Site-Directed | Humans | Models, Molecular | Recombinant Proteins - chemistry | Escherichia coli Proteins - metabolism | Recombinant Proteins - genetics | Static Electricity | Metallochaperones - genetics | Metallochaperones - chemistry | Protein Transport | Superoxide Dismutase-1 - chemistry | Escherichia coli - genetics | Superoxide Dismutase-1 - metabolism | Escherichia coli - metabolism | Superoxide Dismutase-1 - genetics | Escherichia coli Proteins - genetics | Hydrophobic and Hydrophilic Interactions | Nuclear Magnetic Resonance, Biomolecular | Protein Interaction Domains and Motifs | Metallochaperones - metabolism | Escherichia coli Proteins - chemistry | Amino Acid Substitution | Surface charge | Nuclear magnetic resonance--NMR | Biological control | Escherichia coli | Electric dipoles | Hydrophobicity | Cells | Optimization | Proteins | Charge density | Chemistry | E coli | Bacteria | Dipole moments | Mutation | Diffusion | Protein interaction | Cytoplasm | Index Medicus | Biological Sciences | PNAS Plus | Naturvetenskap | Biologiska vetenskaper | Natural Sciences
Journal Article
Journal Article
Journal of Cell Science, ISSN 0021-9533, 2016, Volume 129, Issue 21, pp. 4118 - 4129
Journal Article
The Journal of Physiology, ISSN 0022-3751, 09/2016, Volume 594, Issue 18, pp. 5195 - 5207
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2016, Volume 126, Issue 6, pp. 2249 - 2253
Amyotrophic lateral sclerosis (ALS) is an adult-onset degeneration of motor neurons that is commonly caused by mutations in the gene encoding superoxide... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | MODELS | INCLUSIONS | GENE |