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Immunity, ISSN 1074-7613, 10/2013, Volume 39, Issue 4, pp. 697 - 710
Macrophages possess numerous mechanisms to combat microbial invasion, including sequestration of essential nutrients, like zinc (Zn). The pleiotropic cytokine... 
ACTIVATION | HOMEOSTASIS | METALLOTHIONEIN | GROWTH | GENE-EXPRESSION | CALPROTECTIN | IMMUNOLOGY | PROTEINS | ZINC | HISTOPLASMA-CAPSULATUM | FAMILY | Phagosomes - microbiology | Zinc - metabolism | Golgi Apparatus - drug effects | Humans | STAT5 Transcription Factor - immunology | NADPH Oxidases - immunology | Histoplasma - drug effects | Histoplasmosis - microbiology | Superoxides - immunology | Histoplasmosis - immunology | STAT5 Transcription Factor - genetics | Phagosomes - immunology | Superoxides - metabolism | NADPH Oxidases - genetics | Zinc - immunology | Cation Transport Proteins - genetics | Golgi Apparatus - immunology | Macrophages, Peritoneal - drug effects | STAT3 Transcription Factor - genetics | Metallothionein - immunology | Phagosomes - drug effects | Signal Transduction | Gene Expression Regulation | Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology | Macrophages, Peritoneal - immunology | Mice, Transgenic | Macrophage Activation | Histoplasma - immunology | Host-Pathogen Interactions | Histoplasmosis - metabolism | Animals | Golgi Apparatus - microbiology | Macrophages, Peritoneal - microbiology | Metallothionein - genetics | Mice | STAT3 Transcription Factor - immunology | Cation Transport Proteins - immunology | Oxidases | Zinc compounds | Superoxide | Molecular genetics | Macrophages | Environmental health | Experiments | Exports | Proteomics | Streptococcus infections
Journal Article
Journal of Immunology, ISSN 0022-1767, 08/2014, Volume 193, Issue 4, pp. 1954 - 1965
Canonical neutrophil antimicrobial effector mechanisms, such as degranulation, production of reactive oxygen species, and release of neutrophil extracellular... 
MAMMALIAN TARGET | NADPH OXIDASE | NETTING NEUTROPHILS | SIGNALING PATHWAYS | RESPIRATORY BURST | SYNOVIAL-FLUID | SUPEROXIDE-PRODUCTION | IN-VIVO | IMMUNOLOGY | RECEPTOR-III | CELL-DEATH | Reactive Oxygen Species - metabolism | Nitriles - pharmacology | Humans | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - immunology | Macrophage-1 Antigen - immunology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Receptors, IgG - antagonists & inhibitors | Protein-Tyrosine Kinases - immunology | Lymphocyte Function-Associated Antigen-1 - immunology | Macrophage-1 Antigen - metabolism | Syk Kinase | CD11a Antigen - metabolism | Butadienes - pharmacology | Neutrophil Activation - immunology | GPI-Linked Proteins - immunology | Cell Degranulation | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | src-Family Kinases - antagonists & inhibitors | Autoimmune Diseases - immunology | Cells, Cultured | Neutrophils - immunology | Imidazoles - pharmacology | Inflammation - immunology | Antioxidants - pharmacology | Onium Compounds - pharmacology | Pyrimidines - pharmacology | Receptors, IgG - immunology | src-Family Kinases - immunology | CD18 Antigens - metabolism | Mesalamine - pharmacology | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Aminopyrine - pharmacology | Ascorbic Acid - pharmacology | Pyridines - pharmacology | Antigen-Antibody Complex - immunology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Protein-Tyrosine Kinases - antagonists & inhibitors
Journal Article
Journal Article
The Journal of Immunology, ISSN 0022-1767, 11/2007, Volume 179, Issue 10, pp. 6456 - 6467
Journal Article
Immunity, ISSN 1074-7613, 11/2015, Volume 43, Issue 5, pp. 974 - 986
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 2017, Volume 216, Issue 12, pp. 4073 - 4090
The antimicrobial defense activity of neutrophils partly depends on their ability to form neutrophil extracellular traps (NETs), but the underlying mechanism... 
NADPH OXIDASE | PRIMARY GRANULE EXOCYTOSIS | REVERSIBLE S-GLUTATHIONYLATION | NEURITE OUTGROWTH | CHRONIC GRANULOMATOUS-DISEASE | SUPEROXIDE GENERATION | NET FORMATION | MITOCHONDRIAL-DNA | ALDRICH-SYNDROME PROTEIN | F-ACTIN DYNAMICS | CELL BIOLOGY
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 10/2009, Volume 86, Issue 4, pp. 981 - 988
Mammalian STC1 decreases the mobility of macrophages and diminishes their response to chemokines. In the current experiments, we sought to determine the impact... 
Uncoupling proteins | Lipopolysaccharide | Monocytes | Free radicals | Gene regulation | Apoptosis | STANNIUS | monocytes | CELLS | free radicals | PERITONEAL | apoptosis | IMMUNOLOGY | uncoupling proteins | CELL BIOLOGY | TRANSPORT | MESSENGER-RNA | gene regulation | GENE-EXPRESSION | CORPUSCLES | lipopolysaccharide | HEMATOLOGY | TRANSGENIC MICE | Ion Channels - immunology | Electron Transport - immunology | Macrophages, Peritoneal - pathology | Ion Channels - genetics | NADPH Oxidases - immunology | Adenosine Triphosphate - genetics | Apoptosis - genetics | Mitochondria - immunology | Mitochondrial Proteins - genetics | Superoxides - immunology | Cell Movement - genetics | Necrosis - immunology | Cell Movement - immunology | Protein Transport - immunology | Mitochondria - genetics | Time Factors | NADPH Oxidases - genetics | G1 Phase - genetics | Membrane Glycoproteins - immunology | Glycoproteins - genetics | Cell Line | G1 Phase - immunology | Gene Expression Regulation - genetics | Gene Expression Regulation - immunology | Macrophages, Peritoneal - immunology | Adenosine Triphosphate - immunology | NADPH Oxidase 2 | Protein Transport - genetics | Membrane Glycoproteins - genetics | Mice, Knockout | Glycoproteins - immunology | Animals | Apoptosis - immunology | Mice | Necrosis - genetics | Uncoupling Protein 2 | Mitochondrial Proteins - immunology
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2013, Volume 8, Issue 7, p. e68871
Background: Previous studies by us and other have provided evidence that leukocytes play a critical role in the development of diabetic retinopathy, suggesting... 
PATHOGENESIS | CAPILLARIES | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | TACTILE ALLODYNIA | RETINOPATHY | DEGENERATION | Leukostasis - immunology | Retina - metabolism | Capillary Permeability - immunology | Retina - immunology | Superoxides - immunology | Leukocytes - immunology | Interleukin-1beta - metabolism | Bone Marrow Cells - immunology | Myeloid Differentiation Factor 88 - immunology | Superoxides - metabolism | Chemokine CXCL1 - metabolism | Diabetes Mellitus, Experimental - metabolism | Interleukin-6 - metabolism | Diabetic Retinopathy - immunology | Signal Transduction | Endothelial Cells - metabolism | Intercellular Adhesion Molecule-1 - immunology | Mice, Inbred C57BL | Interleukin-1beta - immunology | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Diabetic Retinopathy - metabolism | Diabetes Mellitus, Experimental - immunology | Endothelial Cells - immunology | Chemokine CXCL1 - immunology | Intercellular Adhesion Molecule-1 - metabolism | Leukostasis - metabolism | Animals | Interleukin-6 - immunology | Toll-Like Receptor 2 - immunology | Mice | Leukocytes - metabolism | Myeloid Differentiation Factor 88 - metabolism | Bone Marrow Cells - metabolism | Diabetic retinopathy | Development and progression | Interleukins | Streptozocin | Endothelium | Transcription factors | Retinopathy | Pathogenesis | Interleukin | Erythrocytes | Retina | Leukocytes | Interleukin 6 | Proteins | Signal transduction | Receptors | Hyperglycemia | Histopathology | Pathways | Rodents | Toll-like receptors | Bone marrow | Physiology | Inhibition | Immune system | Killing | Pathogens | Intercellular adhesion molecule 1 | Incubation | Complications | Abnormalities | Diabetes mellitus | Blood cells | Superoxide | Inflammation | Insulin | Endothelial cells | Medicine | White blood cells | Signaling | TLR2 protein | MyD88 protein | Diabetes | Laboratory animals
Journal Article
Journal of interferon & cytokine research, ISSN 1079-9907, 01/2013, Volume 33, Issue 1, pp. 1 - 8
In view of well-established immunomodulatory properties of Lactobacillus , present investigation was carried out to evaluate antioxidant and anti-inflammatory... 
Research Reports | RHEUMATOID-ARTHRITIS | ADJUVANT-INDUCED ARTHRITIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYTOKINE | IMMUNOLOGY | INTERLEUKIN-6 | CELL BIOLOGY | PATHOGENESIS | REACTIVE OXYGEN | ARTICULAR-CARTILAGE | MICE | NF-KAPPA-B | EXPRESSION | Probiotics - administration & dosage | Rats, Wistar | Glutathione - metabolism | Antioxidants - metabolism | Tumor Necrosis Factor-alpha - blood | Interleukin-17 - immunology | Oxidative Stress - immunology | Interleukin-10 - blood | Male | Arthritis, Experimental - microbiology | Host-Pathogen Interactions - immunology | Interleukin-1beta - blood | Signal Transduction - immunology | Time Factors | Interleukin-6 - blood | Arthritis, Experimental - prevention & control | Lipid Peroxidation - drug effects | Tumor Necrosis Factor-alpha - immunology | Lactobacillus acidophilus - immunology | Lactobacillus casei - physiology | Superoxide Dismutase - metabolism | Interleukin-17 - blood | Glutathione Peroxidase - metabolism | Inflammation - microbiology | Catalase - immunology | Lactobacillus acidophilus - physiology | Interleukin-1beta - immunology | Rats | Arthritis, Experimental - immunology | Inflammation - immunology | Probiotics - pharmacology | Lactobacillus casei - immunology | Catalase - metabolism | Glutathione - immunology | Interleukin-4 - immunology | Superoxide Dismutase - immunology | Interleukin-4 - blood | Animals | Signal Transduction - drug effects | Glutathione Peroxidase - immunology | Interleukin-6 - immunology | Oxidative Stress - drug effects | Interleukin-10 - immunology | Lipid Peroxidation - immunology
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2009, Volume 284, Issue 6, pp. 3691 - 3699
Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease, in which activated microglia overexpressing ALS-linked SOD1 mutants (mSOD1) are... 
NADPH OXIDASE | CELLS | OXIDATIVE STRESS | ACTIVATION | TOLL-LIKE RECEPTOR-4 | MOTOR-NEURON DEGENERATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE MODEL | DISMUTASE | NECROSIS-FACTOR-ALPHA | EXTEND SURVIVAL | ADAM17 Protein | Tumor Necrosis Factor-alpha - metabolism | Amyloid Precursor Protein Secretases - genetics | Amyloid Precursor Protein Secretases - immunology | ADAM Proteins - immunology | Superoxide Dismutase - genetics | Reactive Oxygen Species - metabolism | Toll-Like Receptor 2 - genetics | Humans | Tumor Necrosis Factor-alpha - genetics | Amino Acid Substitution - immunology | Cell Death - immunology | Immunity, Innate - genetics | NADPH Oxidases - metabolism | NADPH Oxidases - immunology | Microglia - immunology | Reactive Oxygen Species - immunology | Tumor Necrosis Factor-alpha - immunology | NADPH Oxidases - genetics | Membrane Proteins - metabolism | Superoxide Dismutase - metabolism | Amyotrophic Lateral Sclerosis - immunology | Cell Line | Membrane Proteins - genetics | Amyotrophic Lateral Sclerosis - genetics | Neurons - immunology | ADAM10 Protein | Microglia - enzymology | Toll-Like Receptor 4 - genetics | Membrane Proteins - immunology | Inflammation - immunology | Toll-Like Receptor 4 - immunology | Amyotrophic Lateral Sclerosis - ethnology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Superoxide Dismutase - immunology | ADAM Proteins - metabolism | Amyloid Precursor Protein Secretases - metabolism | Neurons - enzymology | Inflammation - genetics | Toll-Like Receptor 2 - immunology | Mutation, Missense - immunology | Superoxide Dismutase-1 | ADAM Proteins - genetics | Inflammation - enzymology | Index Medicus
Journal Article