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Journal Article
International Journal of Cancer, ISSN 0020-7136, 07/2018, Volume 143, Issue 2, pp. 419 - 429
Aneustat (OMN54) is a multivalent, botanical anticancer candidate therapeutic. A recent Phase‐I clinical trial has indicated that it is well tolerated by... 
immunomodulation | first‐generation PDX model | Aneustat | aerobic glycolysis | lactic acid secretion | first-generation PDX model | LACTIC-ACID | TARGET | PROGNOSIS | BALANCE | NK CELLS | GENE | ONCOLOGY | IMMUNE SURVEILLANCE | MICE | SUPPRESSOR-CELLS | T-CELLS | Small Molecule Libraries - pharmacology | Aerobiosis | Small Molecule Libraries - administration & dosage | Humans | Lactic Acid - metabolism | Immunologic Factors - administration & dosage | Male | Macrophages - cytology | Glycolysis - drug effects | Prostatic Neoplasms - immunology | Xenograft Model Antitumor Assays | Animals | Prostatic Neoplasms - genetics | Cell Differentiation - drug effects | Cell Line, Tumor | Macrophages - drug effects | RAW 264.7 Cells | Cell Proliferation - drug effects | Mice | Gene Expression Regulation, Neoplastic - drug effects | Immunologic Factors - pharmacology | Prostatic Neoplasms - drug therapy | Glucose metabolism | Killer cells | Immune response | Analysis | Immunotherapy | Lactic acid | Diagnosis | Macrophages | Gene expression | Prostate cancer | Cancer | Cell proliferation | Animal models | Phenotypes | Immunomodulation | Secretion | CD8 antigen | Xenotransplantation | Acidification | Cytotoxicity | Lymphocytes T | Patients | Immunosuppression | Rodents | Xenografts | Glycolysis | In vivo methods and tests | Differentiation | Prostate | Immune system | Cancer Therapy and Prevention
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2006, Volume 116, Issue 10, pp. 2777 - 2790
Active suppression of tumor-specific T lymphocytes can limit the efficacy of immune surveillance and immunotherapy. While tumor-recruited CD11b(+) myeloid... 
MEDICINE, RESEARCH & EXPERIMENTAL | MYELOID SUPPRESSOR-CELLS | RESPONSES | GROWTH-FACTOR-BETA | COLONY-STIMULATING FACTOR | MECHANISM | MACROPHAGES | RECEPTOR EXPRESSION | IMMUNE DYSFUNCTION | NITRIC-OXIDE | CANCER | Neoplasms - metabolism | Spleen - immunology | Gene Expression - genetics | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Receptors, Cell Surface - analysis | Arginase - metabolism | Monocytes - metabolism | Monocytes - immunology | Interferon-gamma - metabolism | Lymphocyte Activation - immunology | CD11b Antigen - analysis | Myeloid Cells - immunology | CD8-Positive T-Lymphocytes - metabolism | Myeloid Cells - drug effects | Interferon-gamma - genetics | Interleukin-4 - genetics | T-Lymphocytes, Cytotoxic - immunology | Interleukin-4 - metabolism | Mice, Inbred C57BL | Receptors, Cell Surface - metabolism | Mice, Transgenic | Arginase - genetics | Spleen - cytology | Interleukin-13 - metabolism | Interleukin-13 - pharmacology | Granulocyte-Macrophage Colony-Stimulating Factor - genetics | Mice, Knockout | Monocytes - drug effects | Immunity, Cellular - immunology | Models, Immunological | Animals | Nitric Oxide Synthase Type II - genetics | T-Lymphocytes, Cytotoxic - metabolism | Neoplasms - immunology | Cell Line, Tumor | Myeloid Cells - metabolism | Mice | Mice, Inbred BALB C | CD8-Positive T-Lymphocytes - immunology | Neoplasms - pathology | Interferon-gamma - pharmacology | Nitric Oxide Synthase Type II - metabolism | Receptors, Cell Surface - genetics | Medicine, Experimental | Medical research | Care and treatment | Research | T cells | Tumors
Journal Article
Nature, ISSN 0028-0836, 08/2016, Volume 537, Issue 7618, pp. 63 - 68
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 12/2016, Volume 375, Issue 26, pp. 2550 - 2560
Journal Article
Journal Article
Journal Article
Nature Cell Biology, ISSN 1465-7392, 08/2017, Volume 19, Issue 8, pp. 962 - 973
Journal Article