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1. Full Text Hepatitis B virus X protein impairs α‐interferon signaling via up‐regulation of suppressor of cytokine signaling 3 and protein phosphatase 2A
by Tsunematsu, Seiji and Suda, Goki and Yamasaki, Kazushi and Kimura, Megumi and Izumi, Takaaki and Umemura, Machiko and Ito, Jun and Sato, Fumiyuki and Nakai, Masato and Sho, Takuya and Morikawa, Kenichi and Ogawa, Koji and Tanaka, Yasuhito and Watashi, Koichi and Wakita, Takaji and Sakamoto, Naoya
Journal of medical virology, ISSN 0146-6615, 02/2017, Volume 89, Issue 2, pp. 267 - 275
biopsy | hepatitis B virus X protein | cytokine signaling 3 | interferon signaling | protein phosphatase 2A | Host-Pathogen Interactions | Up-Regulation | Immune Evasion | Signal Transduction | Humans | Interferon-alpha - antagonists & inhibitors | Protein Phosphatase 2 - metabolism | Trans-Activators - metabolism | Hepatitis B virus - physiology | Suppressor of Cytokine Signaling 3 Protein - metabolism | Hep G2 Cells | Index Medicus
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2. Full Text The PPE18 protein of Mycobacterium tuberculosis inhibits NF-κB/rel - Mediated proinflammatory cytokine production by upregulating and phosphorylating suppressor of cytokine signaling 3 protein
by Nair, Shiny and Pandey, Akhilesh Datt and Mukhopadhyay, Sangita
The Journal of immunology (1950), ISSN 0022-1767, 05/2011, Volume 186, Issue 9, pp. 5413 - 5424
Life Sciences & Biomedicine | Immunology | Science & Technology | Up-Regulation | Phosphorylation | Immunoprecipitation | Humans | Antigens, Bacterial - immunology | Mycobacterium tuberculosis - immunology | NF-kappa B - immunology | NF-kappa B - metabolism | Signal Transduction - immunology | Flow Cytometry | Transfection | Transcription Factor RelA - immunology | Bacterial Proteins - immunology | Electrophoretic Mobility Shift Assay | Tuberculosis - metabolism | Macrophages - immunology | Macrophages - microbiology | Cell Line | Cell Separation | Suppressor of Cytokine Signaling Proteins - immunology | Inflammation - immunology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Tuberculosis - immunology | Suppressor of Cytokine Signaling 3 Protein | Transcription Factor RelA - metabolism | Bacterial Proteins - metabolism | RNA, Small Interfering | Antigens, Bacterial - metabolism | Suppressor of Cytokine Signaling Proteins - biosynthesis | Cytokines - biosynthesis | Index Medicus | Abridged Index Medicus
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3. Full Text The molecular basis of JAK/STAT inhibition by SOCS1
by Liau, Nicholas P. D and Laktyushin, Artem and Lucet, Isabelle S and Murphy, James M and Yao, Shenggen and Whitlock, Eden and Callaghan, Kimberley and Nicola, Nicos A and Kershaw, Nadia J and Babon, Jeffrey J
Nature communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1558 - 14
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Phosphorylation | Humans | STAT Transcription Factors - metabolism | Suppressor of Cytokine Signaling 3 Protein - chemistry | Crystallography, X-Ray | Interferon-gamma - metabolism | Janus Kinase 1 - metabolism | Janus Kinase 2 - chemistry | Janus Kinase 1 - genetics | Janus Kinase 2 - metabolism | Cullin Proteins - metabolism | Protein Domains | Suppressor of Cytokine Signaling 1 Protein - chemistry | Interferon-gamma - genetics | Binding Sites | Suppressor of Cytokine Signaling 1 Protein - genetics | Signal Transduction | Janus Kinase 2 - genetics | Janus Kinase Inhibitors - chemistry | Models, Molecular | Suppressor of Cytokine Signaling 1 Protein - metabolism | Suppressor of Cytokine Signaling 3 Protein - genetics | Janus Kinase 1 - chemistry | Cullin Proteins - genetics | STAT Transcription Factors - genetics | Janus Kinase Inhibitors - metabolism | Suppressor of Cytokine Signaling 3 Protein - metabolism | Ubiquitin | Cytokines | Catalytic activity | Inflammation | Proteins | Signal transduction | Signaling | Inhibitors | γ-Interferon | Interferon | Catalysis | Inhibition | Index Medicus
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4. Full Text Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability
by Williams, Jamie J.L and Alotaiq, Nasser and Mullen, William and Burchmore, Richard and Liu, Libin and Baillie, George S and Schaper, Fred and Pilch, Paul F and Palmer, Timothy M
Nature communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 168 - 17
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | RNA-Binding Proteins - genetics | Janus Kinases - genetics | Membrane Proteins - genetics | Humans | Gene Expression Regulation | STAT Transcription Factors - metabolism | Janus Kinases - metabolism | Suppressor of Cytokine Signaling 3 Protein - genetics | Caveolae - physiology | STAT Transcription Factors - genetics | Animals | Gene Deletion | HEK293 Cells | Protein Binding | Membrane Proteins - metabolism | Mice | Suppressor of Cytokine Signaling 3 Protein - metabolism | RNA-Binding Proteins - metabolism | Caveolin-1 | Phosphorylation | Cytokines | Caveolae | Caveolin | Stat3 protein | Cyclic AMP | Cytokine receptors | Endothelial cells | Interleukin 6 | Proteins | Signaling | Receptors | SOCS-3 protein | Clonal deletion | Inhibition | Localization | Index Medicus
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5. Full Text Neuronal Suppressor of Cytokine Signaling 3 Role in Modulating Chronic Metabolic and Cardiovascular Effects of Leptin
by do Carmo, Jussara M and da Silva, Alexandre A and Freeman, John Nathan and Wang, Zhen and Moak, Sydney P and Hankins, Michael W and Drummond, Heather A and Hall, John E
Hypertension (Dallas, Tex. 1979), ISSN 0194-911X, 06/2018, Volume 71, Issue 6, pp. 1248 - 1257
Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Body Weight | Signal Transduction | Male | Metabolic Syndrome - metabolism | Metabolic Syndrome - drug therapy | Oxygen Consumption - physiology | Animals | Metabolic Syndrome - physiopathology | Female | Blood Pressure - physiology | Leptin - pharmacology | Mice | Neurons - metabolism | Suppressor of Cytokine Signaling 3 Protein - metabolism | Disease Models, Animal | Hypertension | Obesity | Complications and side effects | Control | Cytokines | Leptin | Blood pressure | Research | Health aspects | Risk factors | Index Medicus | blood pressure | heart rate | glucose | Food intake | liver steatosis | energy expenditure | hypertension | obesity
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6. Full Text Suppressor of cytokine signaling 3 (SOCS3) is related to pro-inflammatory cytokine production and triglyceride deposition in turbot (Scophthalmus maximus)
by Tan, Peng and Peng, Mo and Liu, Dongwu and Guo, Huarong and Mai, Kangsen and Nian, Rui and Macq, Benoit and Ai, Qinghui
Fish & shellfish immunology, ISSN 1050-4648, 11/2017, Volume 70, pp. 381 - 390
High-lipid diet | Suppressor of cytokine signaling 3 | Toll-like receptor-nuclear transcription factor kappa-B | Triglyceride | Mature sterol regulatory element binding protein 1 | Veterinary Sciences | Fisheries | Immunology | Life Sciences & Biomedicine | Marine & Freshwater Biology | Science & Technology | Amino Acid Sequence | Cytokines - metabolism | Fish Proteins - chemistry | Fish Proteins - immunology | Gene Expression Regulation - immunology | Flatfishes - immunology | Immunity, Innate - genetics | Suppressor of Cytokine Signaling 3 Protein - chemistry | Suppressor of Cytokine Signaling 3 Protein - genetics | Flatfishes - genetics | Phylogeny | Random Allocation | Sequence Alignment - veterinary | Triglycerides - metabolism | Fish Proteins - genetics | Gene Expression Profiling - veterinary | Animals | Base Sequence | Fish Diseases - immunology | Suppressor of Cytokine Signaling 3 Protein - immunology | Physiological aspects | Monounsaturated fatty acids | Triglycerides | Cytokines | Fishes | Protein binding | Liver | Index Medicus
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7. Full Text SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition
by Kershaw, Nadia J and Murphy, James M and Liau, Nicholas P.D and Varghese, Leila N and Laktyushin, Artem and Whitlock, Eden L and Lucet, Isabelle S and Nicola, Nicos A and Babon, Jeffrey J
Nature structural & molecular biology, ISSN 1545-9993, 05/2013, Volume 20, Issue 4, pp. 469 - 476
Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Amino Acid Sequence | Cytokines - metabolism | Signal Transduction | Humans | Models, Molecular | Molecular Sequence Data | Sequence Homology, Amino Acid | Suppressor of Cytokine Signaling 3 Protein | Janus Kinase 2 - chemistry | Janus Kinase 2 - metabolism | Protein Binding | Suppressor of Cytokine Signaling Proteins - metabolism | Suppressor of Cytokine Signaling Proteins - chemistry | Binding Sites | Janus Kinase 2 - antagonists & inhibitors | Physiological aspects | Protein tyrosine kinase | Cellular signal transduction | Research | Cytokines | Structure | Signal transduction | Biochemistry | Kinases | Molecular biology | Crystal structure | Index Medicus
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8. Full Text Molecular characterization and expression of suppressor of cytokine signaling (SOCS) 1, 2 and 3 under acute hypoxia and reoxygenation in pufferfish, Takifugu fasciatus
by Wang, Dan and Wen, Xin and Zhang, Xinyu and Hu, Yadong and Li, Xinru and Zhu, Wenxu and Wang, Tao and Yin, Shaowu
Genes & genomics, ISSN 1976-9571, 11/2018, Volume 40, Issue 11, pp. 1225 - 1235
Takifugu fasciatus | Hypoxia | SOCS | Reoxygenation | Biochemistry & Molecular Biology | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Suppressor of Cytokine Signaling 1 Protein - classification | Suppressor of Cytokine Signaling 3 Protein - chemistry | Phylogeny | RNA, Messenger - metabolism | Hypoxia - metabolism | Tissue Distribution | Fish Proteins - genetics | Suppressor of Cytokine Signaling 1 Protein - chemistry | Suppressor of Cytokine Signaling Proteins - chemistry | Suppressor of Cytokine Signaling 1 Protein - genetics | Fish Proteins - chemistry | Takifugu - metabolism | Fish Proteins - metabolism | Suppressor of Cytokine Signaling Proteins - genetics | Suppressor of Cytokine Signaling 1 Protein - metabolism | Suppressor of Cytokine Signaling 3 Protein - genetics | Fish Proteins - classification | Takifugu - genetics | Hypoxia - genetics | Animals | Suppressor of Cytokine Signaling 3 Protein - classification | Suppressor of Cytokine Signaling Proteins - classification | Suppressor of Cytokine Signaling Proteins - metabolism | Suppressor of Cytokine Signaling 3 Protein - metabolism | Hypoxia - veterinary | Genetic research | Cytokines | RNA | Analysis | Liver | Marine sciences | mRNA | Inflammation | SOCS-1 protein | Immune system | Index Medicus | 생물학
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9. Full Text Suppression of Cytokine Signaling by SOCS3: Characterization of the Mode of Inhibition and the Basis of Its Specificity
by Babon, Jeffrey J and Kershaw, Nadia J and Murphy, James M and Varghese, Leila N and Laktyushin, Artem and Young, Samuel N and Lucet, Isabelle S and Norton, Raymond S and Nicola, Nicos A
Immunity (Cambridge, Mass.), ISSN 1074-7613, 02/2012, Volume 36, Issue 2, pp. 239 - 250
Life Sciences & Biomedicine | Immunology | Science & Technology | Humans | Molecular Sequence Data | Suppressor of Cytokine Signaling 1 Protein | Janus Kinases - metabolism | Recombinant Fusion Proteins - metabolism | Conserved Sequence | Nuclear Magnetic Resonance, Biomolecular | Suppressor of Cytokine Signaling Proteins - chemistry | Interleukin-6 - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | Janus Kinases - chemistry | Mutagenesis, Site-Directed | Cytokines - metabolism | Janus Kinases - genetics | Signal Transduction | Models, Molecular | Suppressor of Cytokine Signaling Proteins - genetics | Binding Sites - genetics | Recombinant Fusion Proteins - chemistry | Amino Acid Motifs | Janus Kinases - antagonists & inhibitors | Sequence Homology, Amino Acid | Suppressor of Cytokine Signaling 3 Protein | Animals | Recombinant Fusion Proteins - genetics | Suppressor of Cytokine Signaling Proteins - metabolism | Chemical properties | Research | Cytokines | Phosphotransferases | Oncology, Experimental | Cancer | Proteins | Enzymes | Phosphorylation | Peptides | Councils | Rodents | Kinases | Conserved sequence | Index Medicus
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