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Journal of Biological Chemistry, ISSN 0021-9258, 02/2016, Volume 291, Issue 7, pp. 3508 - 3519
The suppressor of cytokine signaling (SOCS) proteins are negative regulators of the JAK/STAT pathway activated by proinflammatory cytokines, including the... 
PLASMA PCSK9 | tumor necrosis factor (TNF) | ACTIVATION | hepatocyte | proprotein convertase subtilisin | PROTEIN | insulin | CHOLESTEROL | BIOCHEMISTRY & MOLECULAR BIOLOGY | NECROSIS-FACTOR-ALPHA | APOLIPOPROTEIN-B | HUMAN ENDOTHELIAL-CELLS | INSULIN-RESISTANCE | stat-3 | HepG2 | kexin type 9 (PCSK9) | SMOOTH-MUSCLE-CELLS | MUTATIONS | suppressor of cytokine signaling 3 (SOCS3) | Proprotein Convertases - antagonists & inhibitors | Tumor Necrosis Factor-alpha - metabolism | Phosphorylation | Humans | STAT3 Transcription Factor - agonists | Tumor Necrosis Factor-alpha - genetics | Male | Janus Kinases - metabolism | Hepatocytes - metabolism | Proprotein Convertases - genetics | Recombinant Fusion Proteins - metabolism | RNA Interference | Serine Endopeptidases - genetics | Lipogenesis | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Recombinant Proteins - metabolism | Janus Kinases - chemistry | Signal Transduction | Mice, Inbred C57BL | Proprotein Convertases - metabolism | Insulin Resistance | Enzyme Induction | Suppressor of Cytokine Signaling Proteins - genetics | Serine Endopeptidases - chemistry | Proprotein Convertases - chemistry | Hep G2 Cells | Obesity - metabolism | Suppressor of Cytokine Signaling 3 Protein | Animals | Suppressor of Cytokine Signaling Proteins - antagonists & inhibitors | Suppressor of Cytokine Signaling Proteins - agonists | Obesity - enzymology | Protein Processing, Post-Translational | Serine Endopeptidases - metabolism | Mutation | Suppressor of Cytokine Signaling Proteins - metabolism | STAT3 Transcription Factor - antagonists & inhibitors | Hepatocytes - enzymology | Proprotein Convertase 9 | Index Medicus | Cell Biology
Journal Article
Science Signaling, ISSN 1945-0877, 05/2012, Volume 5, Issue 225, pp. ra38 - ra38
Interferon-beta (IFN-beta) is widely used to treat multiple sclerosis (MS), and its efficacy was demonstrated in the setting of experimental autoimmune... 
RESPONSES | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | ACTIVATION | MULTIPLE-SCLEROSIS | DENDRITIC CELLS | MECHANISM | CASPASE-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | CENTRAL-NERVOUS-SYSTEM | EXPRESSION | NALP3 INFLAMMASOME | CELL BIOLOGY | Recombinant Proteins - therapeutic use | Proto-Oncogene Proteins c-vav - antagonists & inhibitors | Reactive Oxygen Species - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Encephalomyelitis, Autoimmune, Experimental - immunology | Suppressor of Cytokine Signaling 1 Protein | Male | Receptor, Interferon alpha-beta - physiology | Interleukin-1beta - genetics | Neuropeptides - physiology | Proto-Oncogene Proteins c-vav - physiology | Cytoskeletal Proteins - deficiency | Interferon-beta - therapeutic use | rac GTP-Binding Proteins - antagonists & inhibitors | Interleukin-1beta - biosynthesis | Caspase 1 - physiology | rac GTP-Binding Proteins - physiology | Disease Models, Animal | Carrier Proteins - physiology | Macrophages - physiology | Encephalomyelitis, Autoimmune, Experimental - physiopathology | Receptor, Interferon alpha-beta - deficiency | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Mice, Inbred C57BL | Mice, Transgenic | Mice, Knockout | Gene Expression Regulation - drug effects | Carrier Proteins - genetics | Inflammasomes - physiology | Animals | Apoptosis Regulatory Proteins | Interferon beta-1b | CD4-Positive T-Lymphocytes - transplantation | CARD Signaling Adaptor Proteins | Suppressor of Cytokine Signaling Proteins - antagonists & inhibitors | Suppressor of Cytokine Signaling Proteins - physiology | Mice | Enzyme Activation | rac1 GTP-Binding Protein | Neuropeptides - antagonists & inhibitors | Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 07/2009, Volume 183, Issue 1, pp. 97 - 105
TGF-beta, together with IL-6 and IL-21, promotes Th17 cell development. IL-6 and IL-21 induce activation of STAT3, which is crucial for Th17 cell... 
T(H)17 CELLS | ROR-GAMMA-T | IN-VIVO | STAT3 | HOST-DEFENSE | GENERATION | CYTOKINE | DIFFERENTIATION | IMMUNOLOGY | LINEAGE | FOXP3 | Protein-Serine-Threonine Kinases - deficiency | Intestinal Mucosa - metabolism | Receptors, Transforming Growth Factor beta - genetics | Interleukin-6 - antagonists & inhibitors | Transforming Growth Factor beta1 - antagonists & inhibitors | Interleukin-17 - physiology | Receptors, Transforming Growth Factor beta - physiology | Intestinal Mucosa - cytology | Cell Differentiation - genetics | Signal Transduction - immunology | Mucous Membrane - cytology | STAT3 Transcription Factor - physiology | Interleukins - physiology | Intestinal Mucosa - immunology | T-Lymphocytes, Helper-Inducer - immunology | Interleukin-6 - physiology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | T-Lymphocytes, Helper-Inducer - cytology | STAT3 Transcription Factor - metabolism | T-Lymphocytes, Helper-Inducer - metabolism | Protein-Serine-Threonine Kinases - physiology | Mice, Inbred C57BL | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Suppressor of Cytokine Signaling Proteins - genetics | Mice, Transgenic | Up-Regulation - genetics | Signal Transduction - genetics | Transforming Growth Factor beta1 - genetics | Interleukin-17 - biosynthesis | Transforming Growth Factor beta1 - physiology | Down-Regulation - genetics | Interleukins - antagonists & inhibitors | Mice, Knockout | Mucous Membrane - metabolism | Cell Differentiation - immunology | Suppressor of Cytokine Signaling 3 Protein | Animals | Receptors, Transforming Growth Factor beta - antagonists & inhibitors | Mucous Membrane - immunology | Up-Regulation - immunology | Down-Regulation - immunology | Suppressor of Cytokine Signaling Proteins - antagonists & inhibitors | Mice | Suppressor of Cytokine Signaling Proteins - biosynthesis | Receptors, Transforming Growth Factor beta - deficiency | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Circulation Research, ISSN 0009-7330, 03/2015, Volume 116, Issue 7, pp. 1170 - 1181
RATIONALE:Janus kinase/signal transducer and activator of transcription (JAK/STAT) signals and their endogenous inhibitor, suppressor of cytokine signaling 3... 
calpain | neovascularization, pathologic | signal transduction | vascular endothelial growth factor C | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | CRE RECOMBINASE | ATHEROSCLEROSIS | TUMOR ANGIOGENESIS | M-CALPAIN | IN-VITRO | SHEAR-STRESS | PERIPHERAL VASCULAR DISEASE | GROWTH-FACTOR | HEMATOLOGY | NF-KAPPA-B | TRANSGENIC MICE | Calpain - metabolism | Humans | Molecular Sequence Data | Male | Carcinoma, Lewis Lung - blood supply | Recombinant Fusion Proteins - metabolism | Cytokines - physiology | Retinopathy of Prematurity - physiopathology | STAT Transcription Factors - physiology | Janus Kinases - physiology | Aorta | Female | Neovascularization, Pathologic - physiopathology | Amino Acid Sequence | Mutagenesis, Site-Directed | Vascular Endothelial Growth Factor C - physiology | Endothelial Cells - metabolism | Mice, Inbred C57BL | Cells, Cultured | Suppressor of Cytokine Signaling Proteins - genetics | Mice, Transgenic | Neoplasms - blood supply | Adenocarcinoma - blood supply | Suppressor of Cytokine Signaling 3 Protein | Animals | Vascular Endothelial Growth Factor C - antagonists & inhibitors | Calcium-Binding Proteins - physiology | Suppressor of Cytokine Signaling Proteins - antagonists & inhibitors | Signal Transduction - physiology | Suppressor of Cytokine Signaling Proteins - physiology | Mice | Glioblastoma - blood supply | Calcium-Binding Proteins - genetics | Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2015, Volume 10, Issue 4, pp. e0123133 - e0123133
Suppressor of cytokine signaling (SOCS) family is an important negative regulator of cytokine signaling and deregulation of SOCS has been involved in many... 
METHYLATION | JAK/STAT PATHWAY | MULTIDISCIPLINARY SCIENCES | GROWTH | HUMAN HEPATOCELLULAR-CARCINOMA | EXPRESSION | STRATEGIES | RNA, Small Interfering - genetics | Cervix Uteri - metabolism | Humans | Gene Expression Regulation, Neoplastic | Uterine Cervical Neoplasms - pathology | Promoter Regions, Genetic - genetics | Immunoenzyme Techniques | DNA Methylation | RNA Interference | Uterine Cervical Neoplasms - metabolism | Female | Acetylation | Real-Time Polymerase Chain Reaction | Uterine Cervical Neoplasms - radiotherapy | Cytokines - metabolism | Down-Regulation | RNA, Messenger - genetics | Cells, Cultured | Radiation Tolerance - genetics | Suppressor of Cytokine Signaling Proteins - genetics | Signal Transduction - genetics | Radiotherapy | Reverse Transcriptase Polymerase Chain Reaction | Uterine Cervical Neoplasms - genetics | Blotting, Western | Transcription Factors - metabolism | Suppressor of Cytokine Signaling Proteins - antagonists & inhibitors | Histones - metabolism | Suppressor of Cytokine Signaling Proteins - metabolism | Proteins | Immunohistochemistry | Ionizing radiation | Cytokines | Genes | DNA | Genetic aspects | Genetic engineering | Methylation | Cervical cancer | Cancer | Biotechnology | Deregulation | Radiation | Radioresistance | Radiation therapy | SOCS-1 protein | Tumor cell lines | Cervix | Gene expression | Gene silencing | Signaling | Deacetylation | Cell lines | Regulatory mechanisms (biology) | DNA methylation | Deoxyribonucleic acid--DNA | Index Medicus | Deoxyribonucleic acid
Journal Article
Journal Article
The Journal of Immunology, ISSN 0022-1767, 05/2008, Volume 180, Issue 9, pp. 6270 - 6278
Journal Article
Journal of Endocrinology, ISSN 0022-0795, 12/2010, Volume 207, Issue 3, pp. 343 - 353
Visceral adipocytes and associated macrophages produce and release excessive amounts of biologically active inflammatory cytokines via the portal and systemic... 
TOLL-LIKE RECEPTOR-3 | SKELETAL-MUSCLE | NONCANONICAL WNT5A | TYROSINE PHOSPHORYLATION | ENDOCRINOLOGY & METABOLISM | NECROSIS-FACTOR-ALPHA | TNF-ALPHA | SATURATED FATTY-ACIDS | SERINE PHOSPHORYLATION | INSULIN-RECEPTOR SUBSTRATE-1 | ADIPOSE-TISSUE | Leptin - antagonists & inhibitors | Interleukin-6 - antagonists & inhibitors | Adipocytes - drug effects | Lipopolysaccharides - antagonists & inhibitors | Nitric Oxide Synthase Type II - antagonists & inhibitors | Palmitates - pharmacology | Inflammation Mediators - antagonists & inhibitors | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Methimazole - analogs & derivatives | Interleukin-1beta - antagonists & inhibitors | Insulin Receptor Substrate Proteins - analysis | NF-kappa B - antagonists & inhibitors | Methimazole - pharmacology | Insulin Resistance | Chemokine CXCL10 - antagonists & inhibitors | 3T3-L1 Cells | Interferon-beta - antagonists & inhibitors | Up-Regulation - drug effects | Suppressor of Cytokine Signaling 3 Protein | Insulin - metabolism | Macrophages - metabolism | Animals | Adipocytes - metabolism | Suppressor of Cytokine Signaling Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - analysis | Macrophages - drug effects | Mice | Palmitates - metabolism | Thiones - pharmacology | AKT protein | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 02/2017, Volume 77, Issue 4, pp. 1021 - 1034
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, pp. e108410 - e108410
Journal Article
Journal Article