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Nature cell biology, ISSN 1476-4679, 2009, Volume 11, Issue 8, pp. 973 - 979
... signalling, usually associated with senescence, not after transient DNA damage responses (DDRs). Initiation and maintenance of this cytokine response required the DDR proteins ATM, NBS1 and CHK2, but not the cell-cycle arrest enforcers p53 and pRb... 
ROLES | HUMAN-CELLS | BARRIER | HUMAN FIBROBLASTS | GROWTH-FACTOR | ONCOGENE-INDUCED SENESCENCE | CELLULAR SENESCENCE | CANCER | TUMORIGENESIS | P53 | CELL BIOLOGY | RNA, Small Interfering - genetics | Humans | Male | Green Fluorescent Proteins - genetics | Tumor Suppressor Protein p53 - genetics | DNA-Binding Proteins - metabolism | Telomerase - genetics | Transfection | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Telomerase - metabolism | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Fibroblasts - metabolism | Telomere - genetics | Cell Line | Green Fluorescent Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Enzyme-Linked Immunosorbent Assay | Cell Cycle Proteins - metabolism | Cells, Cultured | Cytokines - secretion | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | Cellular Senescence - physiology | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Nuclear Proteins - metabolism | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Interleukin-6 - secretion | Blotting, Western | Fibroblasts - radiation effects | Checkpoint Kinase 2 | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Signal Transduction - physiology | Fibroblasts - cytology | DNA Damage | Microscopy, Fluorescence | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Cytokines | DNA damage
Journal Article
Nature communications, ISSN 2041-1723, 2015, Volume 6, Issue 1, p. 6118
Journal Article
Nature immunology, ISSN 1529-2916, 2006, Volume 7, Issue 2, pp. 148 - 155
.... The adaptor protein Mal is specifically involved in signaling via TLR2 and TLR4. We demonstrate here that after TLR2 and TLR4 stimulation Mal becomes phosphorylated by Bruton's tyrosine kinase (Btk... 
BRUTONS TYROSINE KINASE | INDUCED STAT INHIBITOR | ACTIVATION | SOCS PROTEINS | PHOSPHORYLATION | LIPOPOLYSACCHARIDE | TRANSDUCTION | BOX | IMMUNOLOGY | NF-KAPPA-B | TLR4 | Phosphorylation | Humans | Proteolipids - metabolism | Transcriptional Activation | Ubiquitin - metabolism | Suppressor of Cytokine Signaling 1 Protein | Suppressor of Cytokine Signaling Proteins - deficiency | Transcription Factor RelA - genetics | Proteolipids - immunology | Myelin and Lymphocyte-Associated Proteolipid Proteins | Mice, Inbred CBA | Myelin Proteins - immunology | Membrane Transport Proteins - metabolism | Toll-Like Receptors - metabolism | Carrier Proteins - immunology | Repressor Proteins - metabolism | Cell Line | Signal Transduction | Suppressor of Cytokine Signaling Proteins - immunology | Repressor Proteins - genetics | Suppressor of Cytokine Signaling Proteins - genetics | Toll-Like Receptor 2 - metabolism | Immunity, Innate | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Carrier Proteins - genetics | Tyrosine - metabolism | Animals | Carrier Proteins - metabolism | Transcription Factor RelA - metabolism | Repressor Proteins - immunology | Mice | Suppressor of Cytokine Signaling Proteins - metabolism | Membrane Transport Proteins - immunology | Myelin Proteins - metabolism
Journal Article
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 2010, Volume 185, Issue 10, pp. 6226 - 6233
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2012, Volume 36, Issue 2, pp. 239 - 250
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 9, p. e75317
Sustained hedgehog (Hh) signaling mediated by the GLI transcription factors is implicated in many types of cancer... 
GLI1 EXPRESSION | STEM-CELLS | JAK/STAT PATHWAY | INTERFERON-GAMMA | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | PANCREATIC BETA-CELLS | HUMAN-MELANOMA | HUMAN KERATINOCYTES | HUMAN HOMOLOG | TRANSGENIC MICE | Humans | Zinc Finger Protein Gli2 | Hedgehog Proteins - metabolism | Suppressor of Cytokine Signaling 1 Protein | Interferon-gamma - metabolism | Neoplasm Proteins - metabolism | Phosphorylation - genetics | Hedgehog Proteins - genetics | Kruppel-Like Transcription Factors - metabolism | Medulloblastoma - pathology | Response Elements - genetics | Interferon-gamma - genetics | Medulloblastoma - genetics | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Signal Transduction | Suppressor of Cytokine Signaling Proteins - genetics | Nuclear Proteins - metabolism | Medulloblastoma - metabolism | Transcription Factors - genetics | Transcription Factors - metabolism | Keratinocytes - pathology | Keratinocytes - metabolism | Cell Line, Tumor | Zinc Finger Protein GLI1 | Suppressor of Cytokine Signaling Proteins - metabolism | Kruppel-Like Transcription Factors - genetics | Chromatin | Genes | Development and progression | Genetic aspects | Interferon | DNA binding proteins | Genetic transcription | Biological response modifiers | Tumors | Phosphorylation | Transcription factors | Immunoprecipitation | Target recognition | Kinases | Immunity | Proteins | Signal transduction | Cell growth | Rodents | Cell cycle | Tumorigenesis | Stat1 protein | Cytokines | Tumor cells | Melanoma | Keratinocytes | SOCS-1 protein | Gene expression | Signaling | Hospitals | Hedgehog protein | Medulloblastoma | γ-Interferon | Mutation | Molecular biology | Binding sites | Cancer | Apoptosis
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 10/2009, Volume 86, Issue 4, pp. 863 - 875
.... Endotoxin tolerance reprograms cell responses to LPS by repressing expression of proinflammatory cytokines, while not inhibiting production of anti... 
monocytes/macrophages | lipopolysaccharide | signal transduction | suppression/anergy | cell activation | Lipopolysaccharide | Signal transduction | Cell activation | Monocytes/macrophages | Suppression/anergy | STRANDED-RNA | ACTIVATION | DOWN-REGULATION | NECROSIS-FACTOR-ALPHA | BACTERIAL FLAGELLIN | IMMUNOLOGY | CUTTING EDGE | CELL BIOLOGY | RECEPTOR-ASSOCIATED KINASE | TOLL-LIKE RECEPTORS | HEMATOLOGY | NF-KAPPA-B | INNATE IMMUNITY | Protein Kinase C - genetics | Cytoskeletal Proteins - genetics | Humans | Adaptor Proteins, Vesicular Transport - genetics | Suppressor of Cytokine Signaling 1 Protein | Monocytes - metabolism | Monocytes - immunology | Armadillo Domain Proteins - genetics | Adaptor Proteins, Vesicular Transport - metabolism | Interferon Regulatory Factor-3 - genetics | Lipopolysaccharides - immunology | Signal Transduction - immunology | Protein Kinase C - metabolism | Myeloid Differentiation Factor 88 - immunology | Cytoskeletal Proteins - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Cytokines - genetics | Protein-Serine-Threonine Kinases - metabolism | Cytokines - immunology | Interferon Regulatory Factor-3 - immunology | Cell Line | Cytokines - metabolism | Gene Expression Regulation - immunology | Suppressor of Cytokine Signaling Proteins - immunology | Myeloid Differentiation Factor 88 - genetics | Protein-Serine-Threonine Kinases - genetics | Suppressor of Cytokine Signaling Proteins - genetics | Toll-Like Receptor 4 - genetics | p38 Mitogen-Activated Protein Kinases - genetics | Protein Kinase C - immunology | Toll-Like Receptor 4 - immunology | p38 Mitogen-Activated Protein Kinases - immunology | Adaptor Proteins, Vesicular Transport - immunology | Armadillo Domain Proteins - immunology | Toll-Like Receptor 4 - metabolism | Gene Expression Regulation - drug effects | Cytoskeletal Proteins - immunology | Signal Transduction - drug effects | Armadillo Domain Proteins - metabolism | Lipopolysaccharides - pharmacology | Interferon Regulatory Factor-3 - metabolism | Protein-Serine-Threonine Kinases - immunology | Suppressor of Cytokine Signaling Proteins - metabolism | Myeloid Differentiation Factor 88 - metabolism | monocytes | macrophages | suppression | Receptors, Signal Transduction, & Genes | anergy
Journal Article