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Nature cell biology, ISSN 1476-4679, 07/2009, Volume 11, Issue 8, pp. 973 - 979
... signalling, usually associated with senescence, not after transient DNA damage responses (DDRs). Initiation and maintenance of this cytokine response required the DDR proteins ATM, NBS1 and CHK2, but not the cell-cycle arrest enforcers p53 and pRb... 
Life Sciences & Biomedicine | Science & Technology | Cell Biology | RNA, Small Interfering - genetics | Humans | Male | Green Fluorescent Proteins - genetics | Tumor Suppressor Protein p53 - genetics | DNA-Binding Proteins - metabolism | Telomerase - genetics | Transfection | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Telomerase - metabolism | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Fibroblasts - metabolism | Telomere - genetics | Cell Line | Green Fluorescent Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Enzyme-Linked Immunosorbent Assay | Cell Cycle Proteins - metabolism | Cells, Cultured | Cytokines - secretion | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | Cellular Senescence - physiology | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Nuclear Proteins - metabolism | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Interleukin-6 - secretion | Blotting, Western | Fibroblasts - radiation effects | Checkpoint Kinase 2 | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Signal Transduction - physiology | Fibroblasts - cytology | DNA Damage | Microscopy, Fluorescence | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Cytokines | DNA damage | Index Medicus
Journal Article
Nature communications, ISSN 2041-1723, 2015, Volume 6, Issue 1, pp. 6118 - 6118
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 02/2012, Volume 36, Issue 2, pp. 239 - 250
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 6/2011, Volume 108, Issue 23, pp. 9554 - 9559
.... Here we interrogated signal transducer and activator of transcription 1 (STAT1) regulation by GC and its consequences for cytokine production during activation of macrophages with TLR-specific ligands... 
Phosphorylation | Cytokines | Glucocorticoids | Secretion | Interferons | Ligands | Mice | Physiological regulation | Pretreatment | Macrophages | JAK | Knockout mice | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Suppressor of Cytokine Signaling 1 Protein | Mice, 129 Strain | STAT1 Transcription Factor - metabolism | Dexamethasone - pharmacology | Janus Kinase 2 - metabolism | Phosphorylation - drug effects | Toll-Like Receptors - metabolism | Interleukin-6 - metabolism | Interferon-alpha - metabolism | Interleukin-12 Subunit p40 - metabolism | Poly I-C - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Suppressor of Cytokine Signaling Proteins - genetics | Macrophages - cytology | STAT1 Transcription Factor - genetics | Blotting, Western | Mice, Knockout | Receptors, Interferon - metabolism | Macrophages - metabolism | Animals | Interferon-beta - pharmacology | Lipopolysaccharides - pharmacology | Glucocorticoids - pharmacology | Interferon Regulatory Factor-3 - metabolism | Macrophages - drug effects | Suppressor of Cytokine Signaling Proteins - metabolism | Signal transduction | T cell receptors | Effects | Rodents | Index Medicus | Cell activation | Transcription | Toll-like receptors | Data processing | Inflammation | Interferon | SOCS-1 protein | Stat1 protein | TLR3 protein | Biological Sciences | knockout mice
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 10/2009, Volume 86, Issue 4, pp. 863 - 875
.... Endotoxin tolerance reprograms cell responses to LPS by repressing expression of proinflammatory cytokines, while not inhibiting production of anti... 
monocytes/macrophages | lipopolysaccharide | signal transduction | suppression/anergy | cell activation | Lipopolysaccharide | Signal transduction | Cell activation | Monocytes/macrophages | Suppression/anergy | Immunology | Life Sciences & Biomedicine | Hematology | Science & Technology | Cell Biology | Protein Kinase C - genetics | Cytoskeletal Proteins - genetics | Humans | Adaptor Proteins, Vesicular Transport - genetics | Suppressor of Cytokine Signaling 1 Protein | Monocytes - metabolism | Monocytes - immunology | Armadillo Domain Proteins - genetics | Adaptor Proteins, Vesicular Transport - metabolism | Interferon Regulatory Factor-3 - genetics | Lipopolysaccharides - immunology | Signal Transduction - immunology | Protein Kinase C - metabolism | Myeloid Differentiation Factor 88 - immunology | Cytoskeletal Proteins - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Cytokines - genetics | Protein-Serine-Threonine Kinases - metabolism | Cytokines - immunology | Interferon Regulatory Factor-3 - immunology | Cell Line | Cytokines - metabolism | Gene Expression Regulation - immunology | Suppressor of Cytokine Signaling Proteins - immunology | Myeloid Differentiation Factor 88 - genetics | Protein-Serine-Threonine Kinases - genetics | Suppressor of Cytokine Signaling Proteins - genetics | Toll-Like Receptor 4 - genetics | p38 Mitogen-Activated Protein Kinases - genetics | Protein Kinase C - immunology | Toll-Like Receptor 4 - immunology | p38 Mitogen-Activated Protein Kinases - immunology | Adaptor Proteins, Vesicular Transport - immunology | Armadillo Domain Proteins - immunology | Toll-Like Receptor 4 - metabolism | Gene Expression Regulation - drug effects | Cytoskeletal Proteins - immunology | Signal Transduction - drug effects | Armadillo Domain Proteins - metabolism | Lipopolysaccharides - pharmacology | Interferon Regulatory Factor-3 - metabolism | Protein-Serine-Threonine Kinases - immunology | Suppressor of Cytokine Signaling Proteins - metabolism | Myeloid Differentiation Factor 88 - metabolism | Index Medicus | monocytes | macrophages | suppression | Receptors, Signal Transduction, & Genes | anergy
Journal Article
Journal Article
Nature structural & molecular biology, ISSN 1545-9985, 03/2013, Volume 20, Issue 4, pp. 469 - 476
The inhibitory protein SOCS3 plays a key part in the immune and hematopoietic systems by regulating signaling induced by specific cytokines... 
Biochemistry & Molecular Biology |