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British Journal of Dermatology, ISSN 0007-0963, 06/2018, Volume 178, Issue 6, pp. e450 - e450
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 06/2016, Volume 36, Issue 6, pp. 1247 - 1253
OBJECTIVE—Ischemic stroke, which is mainly caused by thromboembolic occlusion of brain arteries, is the second leading cause of death and disability worldwide... 
Syk kinase | thrombosis | mice | stroke | platelets | ACTIVATION | DISCOVERY | GLYCOPROTEIN VI | TRIAL | SPLEEN TYROSINE KINASE | ACUTE ISCHEMIC-STROKE | CHRONIC LYMPHOCYTIC-LEUKEMIA | PERIPHERAL VASCULAR DISEASE | SEPARATION | HEMATOLOGY | HEMOSTASIS | Arterial Occlusive Diseases - blood | Infarction, Middle Cerebral Artery - prevention & control | Brain - enzymology | Motor Activity - drug effects | Blood Platelets - enzymology | Syk Kinase - antagonists & inhibitors | Arterial Occlusive Diseases - genetics | Dose-Response Relationship, Drug | Time Factors | Syk Kinase - genetics | Infarction, Middle Cerebral Artery - genetics | Thrombosis - blood | Thrombosis - prevention & control | Blood Platelets - drug effects | Disease Models, Animal | Hemostasis - drug effects | Administration, Oral | Mice, Inbred C57BL | Thrombosis - enzymology | Genotype | Syk Kinase - deficiency | Arterial Occlusive Diseases - enzymology | Infarction, Middle Cerebral Artery - blood | Mice, Knockout | Brain - drug effects | Protein Kinase Inhibitors - administration & dosage | Phenotype | Animals | Signal Transduction - drug effects | Brain - pathology | Thrombosis - genetics | Fibrinolytic Agents - administration & dosage | Arterial Occlusive Diseases - prevention & control | Syk Kinase - blood | Infarction, Middle Cerebral Artery - enzymology
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 17, pp. 6410 - 6433
Journal Article
Immunity, ISSN 1074-7613, 04/2017, Volume 46, Issue 4, pp. 635 - 648
Mice carrying a hypomorphic point mutation in the gene ( mice) develop an inflammatory skin disease that resembles neutrophilic dermatosis in humans. Here, we... 
myeloid cells | SYK | RIPK3 | MLKL | autoinflammation | Ptpn6 | IL-1β | IL-1α | MyD88 | SHP1 | TAK1 | necrosis | RIPK1 | MOTH-EATEN MICE | SIGNALING PATHWAYS | STERILE INFLAMMATION | GENE | APOPTOTIC CELL-DEATH | PHOSPHATASE | IN-VIVO | IMMUNOLOGY | SHP-1 | NF-KAPPA-B | AUTOINFLAMMATORY DISEASE | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - immunology | Phosphorylation | Interleukin-1alpha - immunology | Skin Diseases - genetics | Humans | Immunoblotting | Interleukin-1alpha - metabolism | Syk Kinase - immunology | Signal Transduction - immunology | Inflammation - metabolism | Flow Cytometry | Syk Kinase - genetics | HEK293 Cells | Myeloid Differentiation Factor 88 - immunology | Interleukin-1alpha - genetics | Receptor-Interacting Protein Serine-Threonine Kinases - immunology | Skin Diseases - metabolism | MAP Kinase Kinase Kinases - genetics | Receptors, Interleukin-1 - immunology | Myeloid Differentiation Factor 88 - genetics | Skin Diseases - immunology | Inflammation - immunology | MAP Kinase Kinase Kinases - metabolism | Signal Transduction - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | MAP Kinase Kinase Kinases - immunology | Mice, Knockout | Receptors, Interleukin-1 - metabolism | Models, Immunological | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Syk Kinase - metabolism | Animals | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Inflammation - genetics | Mutation | Myeloid Differentiation Factor 88 - metabolism | Disease | SHP-1 protein | Crosstalk | Interleukin | Licenses | Interleukin 1 receptors | Kinases | Phosphatase | Inflammatory diseases | Proteins | Coding | Rodents | Interleukin 1 | Post-translation | Bone marrow | Skin diseases | Tumor necrosis factor-TNF | Protein-tyrosine kinase | Activation analysis | Immune system | Tyrosine | TAK1 protein | Neutrophils | Leukocytes (neutrophilic) | Inflammation | Roles | Scaffolding | Point mutation | MyD88 protein | Syk protein
Journal Article
Journal Article
Journal Article
Allergy, ISSN 0105-4538, 07/2017, Volume 72, Issue 7, pp. 1061 - 1072
Background Spleen tyrosine kinase (Syk) is an intracellular nonreceptor tyrosine kinase, which has been implicated as central immune modulator promoting... 
airway responsiveness | asthma | p38 MAPK | bronchoconstriction | airway remodeling | SYK KINASE | RHO-KINASE | ANGIOTENSIN-II | IMMUNOLOGY | INDUCED CONTRACTION | SPHINGOSINE 1-PHOSPHATE | MAPK ACTIVATION | ALLERGY | THERAPEUTIC TARGETS | SMOOTH-MUSCLE-CELLS | ENDOTHELIAL GROWTH-FACTOR | ACUTE SEVERE ASTHMA | Niacinamide - analogs & derivatives | Bronchial Hyperreactivity - drug therapy | Humans | Male | Th2 Cells - immunology | Syk Kinase - antagonists & inhibitors | Airway Remodeling - immunology | Allergens - immunology | Bronchoconstriction - drug effects | Syk Kinase - genetics | G-Protein-Coupled Receptor Kinase 1 - metabolism | Pyrrolidinones - pharmacology | Inflammation Mediators - metabolism | Bronchial Hyperreactivity - metabolism | Female | Lung - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Nitric Oxide Synthase Type III - metabolism | Protein Kinase C-alpha | Disease Models, Animal | Bronchial Hyperreactivity - etiology | Cell Proliferation - genetics | Gene Expression | Lung - pathology | Pyrimidines - pharmacology | Nitric Oxide Synthase Type III - genetics | Th2 Cells - metabolism | Bronchial Hyperreactivity - pathology | Syk Kinase - metabolism | Animals | Signal Transduction - drug effects | Lung - drug effects | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Airway Remodeling - drug effects | Niacinamide - pharmacology | Nitric Oxide - metabolism | Lung - immunology | Naphthyridines - pharmacology | Tyrosine | Allergens | Collagen | Analysis | Phenols | Inflammation | Asthma | Protein kinase C | Confocal microscopy | Smooth muscle | Lymphocytes T | Confocal | Remodeling | Contraction | Respiratory tract | Bronchoconstriction | Rodents | Constrictions | Bismuth | Attenuation | Respiratory tract diseases | Inhibition | Protein-tyrosine kinase | Deposition | Spleen | Bronchodilation | Immunomodulation | MAP kinase | Spectra | Muscle contraction | Rho-associated kinase | Allergies | Inhibitors | Microscopy | Lungs | Human performance | Syk protein | Mast cells | Intracellular
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 08/2017, Volume 23, Issue 15, pp. 4376 - 4387
Journal Article