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syk kinase (513) 513
animals (495) 495
syk (400) 400
protein-tyrosine kinases - metabolism (368) 368
mice (345) 345
phosphorylation (328) 328
activation (313) 313
signal transduction (308) 308
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tyrosine (255) 255
cell biology (219) 219
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biochemistry & molecular biology (170) 170
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pharmacology & pharmacy (121) 121
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macrophages (118) 118
inhibition (116) 116
intracellular signaling peptides and proteins (115) 115
spleen tyrosine kinase (113) 113
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hematology (110) 110
receptor (106) 106
cell line, tumor (104) 104
analysis (103) 103
multidisciplinary sciences (101) 101
protein kinase inhibitors - pharmacology (101) 101
protein-tyrosine kinases - genetics (101) 101
oncology (98) 98
research article (97) 97
rats (96) 96
cytokines (94) 94
apoptosis (90) 90
spleen (89) 89
src-family kinases - metabolism (89) 89
research (88) 88
cancer (87) 87
intracellular signaling peptides and proteins - genetics (86) 86
cells (81) 81
syk kinase - metabolism (81) 81
medicine (76) 76
mice, knockout (74) 74
gene expression (73) 73
mast cells (73) 73
nf-kappa-b (72) 72
allergy (71) 71
enzyme precursors - metabolism (71) 71
chemistry, medicinal (70) 70
antigens (67) 67
degranulation (66) 66
hemic and immune systems (66) 66
hemic and lymphatic diseases (66) 66
mice, inbred balb c (66) 66
phosphorylation - drug effects (66) 66
immunoglobulin e (65) 65
signal-transduction (65) 65
health aspects (64) 64
rodents (64) 64
science (64) 64
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phagocytosis (61) 61
phenols (61) 61
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protein-tyrosine kinases - immunology (60) 60
dose-response relationship, drug (58) 58
physiological aspects (58) 58
rheumatoid-arthritis (58) 58
flow cytometry (57) 57
in-vitro (57) 57
mast cells - drug effects (56) 56
phosphotransferases (56) 56
cell activation (55) 55
leukemia (54) 54
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signal transduction - immunology (54) 54
protein binding (52) 52
tyrosine - metabolism (52) 52
in-vivo (51) 51
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Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 11/2011, Volume 68, Issue 22, pp. 3757 - 3770
The non-receptor tyrosine kinase Syk is a well-characterized hematopoietic signal transducer, which is also expressed in non-hematopoietic cells. In epithelial... 
Life Sciences | Biochemistry, general | DDR1 | Life Sciences, general | Syk | Epithelial cells | Migration | Biomedicine general | Cell Biology | Cancer | ACTIVATION | COLLAGEN | DISCOIDIN DOMAIN RECEPTOR-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-TYROSINE KINASE | CELL BIOLOGY | BREAST-CANCER CELLS | GROWTH | SUPPRESSES | EXPRESSION | PROGRESSION | MOTILITY | RNA, Small Interfering - genetics | Protein-Tyrosine Kinases - metabolism | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Recombinant Fusion Proteins - metabolism | Cell Movement - physiology | Breast Neoplasms - metabolism | Epithelial Cells - physiology | Protein-Tyrosine Kinases - genetics | Female | Epithelial Cells - cytology | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Cell Line | Mammary Glands, Animal - pathology | Discoidin Domain Receptor 1 | Receptor Protein-Tyrosine Kinases - metabolism | Gene Knock-In Techniques | Mammary Glands, Animal - cytology | Animals | Breast Neoplasms - genetics | Receptor Protein-Tyrosine Kinases - genetics | Breast Neoplasms - pathology | Recombinant Fusion Proteins - genetics | Mice | Mammary Glands, Animal - physiology | RNA, Small Interfering - metabolism | Tyrosine | Collagen | Oncology, Experimental | Skin | Research | Universities and colleges | Metastasis | Cellular biology | Kinases | Biological assays | Molecular biology
Journal Article
Nature Medicine, ISSN 1078-8956, 08/2016, Volume 22, Issue 8, pp. 915 - 923
Fungal infections claim an estimated 1.5 million lives each year. Mechanisms that protect from fungal infections are still elusive. Recognition of fungal... 
MEDICINE, RESEARCH & EXPERIMENTAL | ASPERGILLUS-FUMIGATUS | C-TYPE LECTIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | INNATE IMMUNE-RESPONSE | CHRONIC MUCOCUTANEOUS CANDIDIASIS | FUNGAL-INFECTIONS | CELL BIOLOGY | GENETIC SUSCEPTIBILITY | CELL ANTIGEN RECEPTOR | NEGATIVE REGULATION | HOST-DEFENSE | SYK TYROSINE 317 | Candida albicans | Caspase 8 | Immunoprecipitation | Dendritic Cells - immunology | Monocytes - immunology | Phagocytosis - genetics | Kidney | Lectins, C-Type - metabolism | Ubiquitination | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Reactive Oxygen Species - immunology | Polymerase Chain Reaction | Adaptor Proteins, Signal Transducing - immunology | Dendritic Cells - drug effects | Macrophages - immunology | Cytokines - immunology | Lectins, C-Type - drug effects | Proto-Oncogene Proteins c-cbl - genetics | Phagocytosis - drug effects | Sepsis - immunology | Enzyme-Linked Immunosorbent Assay | Neutrophils - drug effects | Neutrophils - immunology | Phagocytosis - immunology | Blotting, Western | Mice, Knockout | Peptides - pharmacology | Monocytes - drug effects | Animals | Candidiasis, Invasive - immunology | Adaptor Proteins, Signal Transducing - genetics | Proto-Oncogene Proteins c-cbl - antagonists & inhibitors | Macrophages - drug effects | Mice | Proto-Oncogene Proteins c-cbl - immunology | Prevention | Candidiasis | Immune response | Ligases | Sepsis | Genetic aspects | Health aspects | Fungi | Pathogens | Infections
Journal Article
Cancer Cell, ISSN 1535-6108, 07/2015, Volume 28, Issue 1, pp. 82 - 96
Journal Article
Journal Article
Journal Article
Arthritis Research & Therapy, ISSN 1478-6354, 2015, Volume 17, Issue 1, pp. 356 - 356
INTRODUCTION: Despite the broad spectrum of antirheumatic drugs, RA is still not well controlled in up to 30-50 % of patients. Inhibition of JAK kinases by... 
Memory cells | Anti-TNF therapy | SYK | JAK | Osteoclasts | Arthritis | Fibroblast-like synoviocytes | Small molecule inhibitors | COLLAGEN-INDUCED ARTHRITIS | CONTROLLED-TRIAL | IMMUNE-RESPONSE | ACTIVE RHEUMATOID-ARTHRITIS | DEFECTIVE LYMPHOID DEVELOPMENT | NECROSIS-FACTOR-ALPHA | RHEUMATOLOGY | TOFACITINIB CP-690,550 | RECEPTOR-GAMMA-CHAIN | RECEIVING METHOTREXATE | SPLEEN TYROSINE KINASE | Piperidines - administration & dosage | Enzyme-Linked Immunosorbent Assay | Antirheumatic Agents - administration & dosage | Pyrimidines - administration & dosage | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Immunophenotyping | Male | Arthritis, Experimental - immunology | Arthritis, Rheumatoid - pathology | Arthritis, Experimental - pathology | Janus Kinases - antagonists & inhibitors | Protein Kinase Inhibitors - administration & dosage | Cyclohexylamines - administration & dosage | Drug Therapy, Combination - methods | Animals | Flow Cytometry | Pyrroles - administration & dosage | Mice, Inbred DBA | Mice | Mice, Inbred BALB C | Arthritis, Rheumatoid - immunology | Syk Kinase | Disease Models, Animal | Protein-Tyrosine Kinases - antagonists & inhibitors | Killer cells | Antirheumatic agents | Cytokines | Memory (Computers) | Analysis | Disease susceptibility | Phosphotransferases | Index Medicus
Journal Article
Journal Article
British Journal of Cancer, ISSN 0007-0920, 07/2010, Volume 103, Issue 3, pp. 401 - 410
Journal Article