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1. Full Text An Oral Spleen Tyrosine Kinase (Syk) Inhibitor for Rheumatoid Arthritis
by Weinblatt, Michael E and Kavanaugh, Arthur and Genovese, Mark C and Musser, Theresa K and Grossbard, Elliott B and Magilavy, Daniel B
The New England journal of medicine, ISSN 0028-4793, 09/2010, Volume 363, Issue 14, pp. 1303 - 1312
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Inflammatory joint diseases | Biological and medical sciences | General aspects | Medical sciences | Diseases of the osteoarticular system | Double-Blind Method | Humans | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Middle Aged | Male | Treatment Outcome | Methotrexate - therapeutic use | Protein Kinase Inhibitors - adverse effects | Oxazines - adverse effects | Pyridines - adverse effects | Arthritis, Rheumatoid - drug therapy | Oxazines - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Statistics, Nonparametric | Aged, 80 and over | Antirheumatic Agents - adverse effects | Adult | Female | Aged | Drug Therapy, Combination | Syk Kinase | Antirheumatic Agents - therapeutic use | Protein-Tyrosine Kinases - antagonists & inhibitors | Pyridines - therapeutic use | Spleen | Hypertension | Care and treatment | Rheumatoid arthritis | Physiological aspects | Health aspects | Risk factors | Tyrosine metabolism | Drug therapy | Drug dosages | Index Medicus | Abridged Index Medicus
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2. Full Text Selective, novel spleen tyrosine kinase (Syk) inhibitors suppress chronic lymphocytic leukemia B-cell activation and migration
by Hoellenriegel, J and Coffey, G.P and Sinha, U and Pandey, A and Sivina, M and Ferrajoli, A and Ravandi, F and Wierda, W.G and O'Brien, S and Keating, M.J and Burger, J.A
Leukemia, ISSN 0887-6924, 2012, Volume 26, Issue 7, pp. 1576 - 1583
BCR | spleen tyrosine kinase (Syk) | chronic lymphyocytic leukemia (CLL) | Oncology | Life Sciences & Biomedicine | Hematology | Science & Technology | Hematologic and hematopoietic diseases | Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis | Biological and medical sciences | Medical sciences | Apoptosis - drug effects | Protein-Tyrosine Kinases - metabolism | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Flow Cytometry | Cyclohexylamines - pharmacology | Stromal Cells - drug effects | Phosphorylation - drug effects | Tumor Cells, Cultured | Syk Kinase | Enzyme-Linked Immunosorbent Assay | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Stromal Cells - metabolism | Pyrimidines - pharmacology | Cell Adhesion - drug effects | Chemotaxis | Blotting, Western | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Cell Movement - drug effects | Leukemia, Lymphocytic, Chronic, B-Cell - enzymology | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Stromal Cells - cytology | Protein-Tyrosine Kinases - antagonists & inhibitors | Tyrosine | Chronic lymphocytic leukemia | Care and treatment | Growth | Development and progression | Genetic aspects | B cells | Properties | Cell migration | Index Medicus
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3. Full Text Getting Syk: spleen tyrosine kinase as a therapeutic target
by Geahlen, Robert L
Trends in pharmacological sciences (Regular ed.), ISSN 0165-6147, 2014, Volume 35, Issue 8, pp. 414 - 422
Advanced Basic Science | leukemia | protein kinase inhibitor | fostamatinib | tyrosine phosphorylation | allergic asthma | rheumatoid arthritis | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Animals | Protein Kinase Inhibitors - therapeutic use | Protein-Tyrosine Kinases - metabolism | Humans | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - immunology | Intracellular Signaling Peptides and Proteins - metabolism | Protein Kinase Inhibitors - pharmacology | Molecular Targeted Therapy | Syk Kinase | Protein-Tyrosine Kinases - immunology | Protein-Tyrosine Kinases - antagonists & inhibitors | Tyrosine | Health aspects | Index Medicus | tyrosine-phosphorylation
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4. Full Text Macrophages Generate Reactive Oxygen Species in Response to Minimally Oxidized Low-Density Lipoprotein: Toll-Like Receptor 4– and Spleen Tyrosine Kinase–Dependent Activation of NADPH Oxidase 2
by Bae, Yun Soo and Lee, Jee Hyun and Choi, Soo Ho and Kim, Sunah and Almazan, Felicidad and Witztum, Joseph L and Miller, Yury I
Circulation research, ISSN 0009-7330, 01/2009, Volume 104, Issue 2, pp. 210 - 218
Reactive oxygen species | Minimally oxidized LDL | RANTES | Atherosclerosis | NADPH oxidase 2 | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Fundamental and applied biological sciences. Psychology | Cardiology. Vascular system | Atherosclerosis (general aspects, experimental research) | Biological and medical sciences | Medical sciences | Vertebrates: cardiovascular system | Blood and lymphatic vessels | Phosphorylation | Reactive Oxygen Species - metabolism | Membrane Glycoproteins - metabolism | Muscle, Smooth, Vascular - metabolism | Protein-Tyrosine Kinases - metabolism | NADPH Oxidases - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Gene Knockdown Techniques | NADPH Oxidases - deficiency | Atherosclerosis - enzymology | Time Factors | Toll-Like Receptor 4 - deficiency | Interleukin-1beta - metabolism | Protein Kinase C - metabolism | Inflammation Mediators - metabolism | NADPH Oxidases - genetics | Chemokine CCL5 - metabolism | Lipoproteins, LDL - metabolism | Interleukin-6 - metabolism | Myocytes, Smooth Muscle - metabolism | Syk Kinase | Cell Line | Phospholipase C gamma - metabolism | Atherosclerosis - immunology | Signal Transduction | Macrophages, Peritoneal - enzymology | Myeloid Differentiation Factor 88 - genetics | Macrophages, Peritoneal - immunology | Toll-Like Receptor 4 - genetics | NADPH Oxidase 2 | Toll-Like Receptor 4 - metabolism | Membrane Glycoproteins - genetics | Mice, Knockout | Animals | Mice | Enzyme Activation | Myeloid Differentiation Factor 88 - metabolism | Membrane Glycoproteins - deficiency | Cell Movement | Index Medicus
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5. Full Text The oral Janus kinase/spleen tyrosine kinase inhibitor ASN002 demonstrates efficacy and improves associated systemic inflammation in patients with moderate‐to‐severe atopic dermatitis: results from a randomized double‐blind placebo‐controlled study
by Bissonnette, R and Maari, C and Forman, S and Bhatia, N and Lee, M and Fowler, J and Tyring, S and Pariser, D and Sofen, H and Dhawan, S and Zook, M and Zammit, D.J and Usansky, H and Denis, L and Rao, N and Song, T and Pavel, A.B and Guttman‐Yassky, E
British journal of dermatology (1951), ISSN 0007-0963, 10/2019, Volume 181, Issue 4, pp. 733 - 742
Life Sciences & Biomedicine | Dermatology | Science & Technology | Janus Kinase Inhibitors - pharmacokinetics | Humans | Middle Aged | E-Selectin - blood | Male | Janus Kinases - metabolism | Syk Kinase - antagonists & inhibitors | Acetonitriles - pharmacokinetics | Dermatitis, Atopic - diagnosis | Dose-Response Relationship, Drug | Young Adult | Signal Transduction - immunology | Acetonitriles - administration & dosage | Placebos - adverse effects | Dermatitis, Atopic - immunology | Pyridazines - administration & dosage | Adult | Female | Piperidines - pharmacokinetics | Placebos - administration & dosage | Pyridazines - adverse effects | Severity of Illness Index | Piperidines - administration & dosage | Double-Blind Method | Treatment Outcome | Biomarkers - blood | Acetonitriles - adverse effects | Down-Regulation - drug effects | Janus Kinases - antagonists & inhibitors | Janus Kinase Inhibitors - adverse effects | Syk Kinase - metabolism | Dermatitis, Atopic - drug therapy | Janus Kinase Inhibitors - administration & dosage | Signal Transduction - drug effects | Down-Regulation - immunology | Piperidines - adverse effects | Pyridazines - pharmacokinetics | Dermatitis, Atopic - blood | Tyrosine | Spleen | Helper cells | Lymphocytes T | Pruritus | Dermatitis | Atopic dermatitis | Arteriosclerosis | Eczema | Biomarkers | Janus kinase | Pharmacokinetics | Protein-tyrosine kinase | Index Medicus | Clinical Trial | Original
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6. Full Text Phosphorylation of spleen tyrosine kinase at tyrosine 348 (pSyk348 ) may be a marker of advanced phase of Chronic Myeloid Leukemia (CML)
by Bourgne, Céline and Janel, Alexandre and Berger, Juliette and Rapatel, Chantal and Tournilhac, Olivier and Hermet, Eric and Guerci, Agnès and Lioret, Frédérique and Briançon, Aurélie and Bamdad, Mahchid and Boiret-Dupré, Nathalie and Berger, Marc G
Leukemia research, ISSN 0145-2126, 2014, Volume 39, Issue 3, pp. 329 - 334
Hematology, Oncology and Palliative Medicine | Flow cytometry | Dasatinib | Chronic Myeloid Leukemia (CML) | Spleen tyrosine kinase (Syk) | pSyk348 | PSyk | Oncology | Life Sciences & Biomedicine | Hematology | Science & Technology | Phosphorylation | Prognosis | Follow-Up Studies | Protein-Tyrosine Kinases - metabolism | Humans | Middle Aged | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Male | Intracellular Signaling Peptides and Proteins - metabolism | Biomarkers, Tumor | Young Adult | Protein-Tyrosine Kinases - genetics | Flow Cytometry | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Aged, 80 and over | Adult | Female | Tumor Cells, Cultured | Blast Crisis | Child | Intracellular Signaling Peptides and Proteins - genetics | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - mortality | Real-Time Polymerase Chain Reaction | Syk Kinase | Oxazines - pharmacology | RNA, Messenger - genetics | Antineoplastic Combined Chemotherapy Protocols | Survival Rate | Pyrimidines - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Disease Progression | Adolescent | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Aged | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Thiazoles - pharmacology | Chronic Disease | Tyrosine | RNA | Index Medicus
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7. Full Text Spleen Tyrosine Kinase-Mediated Autophagy Is Required for Epithelial-Mesenchymal Plasticity and Metastasis in Breast Cancer
by Shinde, Aparna and Hardy, Shana D and Kim, Dongwook and Akhand, Saeed Salehin and Jolly, Mohit Kumar and Wang, Wen-Hung and Anderson, Joshua C and Khodadadi, Ryan B and Brown, Wells S and George, Jason T and Liu, Sheng and Wan, Jun and Levine, Herbert and Willey, Christopher D and Krusemark, Casey J and Geahlen, Robert L and Wendt, Michael K
Cancer research (Chicago, Ill.), ISSN 0008-5472, 04/2019, Volume 79, Issue 8, pp. 1831 - 1843
Life Sciences & Biomedicine | Oncology | Science & Technology | Breast Neoplasms - genetics | Syk Kinase - genetics | Autophagy | Humans | Transforming Growth Factor beta | Epithelial-Mesenchymal Transition | Index Medicus
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8. Full Text Imidazotriazines: Spleen Tyrosine Kinase (Syk) Inhibitors Identified by Free‐Energy Perturbation (FEP)
by Lovering, Frank and Aevazelis, Cristina and Chang, Jeanne and Dehnhardt, Christoph and Fitz, Lori and Han, Seungil and Janz, Kristin and Lee, Julie and Kaila, Neelu and McDonald, Joseph and Moore, William and Moretto, Alessandro and Papaioannou, Nikolaos and Richard, David and Ryan, Mark S and Wan, Zhao‐Kui and Thorarensen, Atli
ChemMedChem, ISSN 1860-7179, 01/2016, Volume 11, Issue 2, pp. 217 - 233
imidazotriazines | drug discovery | spleen tyrosine kinase | free-energy perturbation | molecular modeling | Protein Kinase Inhibitors - chemical synthesis | Triazines - pharmacology | Protein-Tyrosine Kinases - metabolism | Humans | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Imidazoles - chemistry | Models, Molecular | Imidazoles - pharmacology | Intracellular Signaling Peptides and Proteins - metabolism | Structure-Activity Relationship | Dose-Response Relationship, Drug | Thermodynamics | Protein Kinase Inhibitors - chemistry | Triazines - chemical synthesis | Triazines - chemistry | Molecular Structure | Protein Kinase Inhibitors - pharmacology | Imidazoles - chemical synthesis | Syk Kinase | Protein-Tyrosine Kinases - antagonists & inhibitors | Autoimmunity | Tyrosine | Phenols | Analysis | Spleen | Index Medicus
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9. Full Text Autoantibodies to IgE and FcεRI and the natural variability of spleen tyrosine kinase expression in basophils
by MacGlashan, Donald
Journal of allergy and clinical immunology, ISSN 0091-6749, 03/2019, Volume 143, Issue 3, pp. 1100 - 1107.e11
Human | Fc receptors | allergy | basophil | Allergy | Immunology | Life Sciences & Biomedicine | Science & Technology | Autoantibodies - immunology | Immunoglobulin E - immunology | Humans | Basophils - immunology | Cells, Cultured | Receptors, IgE - immunology | Urticaria - immunology | Chronic Disease | Syk Kinase - immunology | Tyrosine | Spleen | CD34 antigen | Immunoglobulins | Autoantibodies | Urticaria | Secretion | Variability | Antibodies | Immunoglobulin E | Kinases | Patients | Asthma | Hemopoiesis | Histamine | Hypotheses | Algorithms | Peripheral blood | Syk protein | Mast cells | Leukocytes (basophilic) | Protein-tyrosine kinase | Index Medicus | Abridged Index Medicus
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10. Full Text A reevaluation of the spleen tyrosine kinase (SYK) activation mechanism
by Mansueto, My S and Reens, Abigail and Rakhilina, Larissa and Chi, An and Pan, Bo-Sheng and Miller, J. Richard
The Journal of biological chemistry, ISSN 0021-9258, 05/2019, Volume 294, Issue 19, pp. 7658 - 7668
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Phosphorylation | Syk Kinase - metabolism | Models, Chemical | Humans | src-Family Kinases - metabolism | Enzyme Activation | src-Family Kinases - chemistry | Amino Acid Motifs | Syk Kinase - chemistry | src Homology Domains | Index Medicus | ITAM (immune-receptor tyrosine activation motif) | enzyme activation | autophosphorylation | non-receptor tyrosine kinase (nRTK) | cell signaling | spleen tyrosine kinase (SYK) | immunity | Enzymology | conformational change | phosphorylation | enzyme kinetics | tonic signalling
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