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JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 05/2019, Volume 294, Issue 19, pp. 7658 - 7668
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2013, Volume 56, Issue 4, pp. 1677 - 1692
Journal Article
Cancer Cell, ISSN 1535-6108, 07/2015, Volume 28, Issue 1, pp. 82 - 96
Journal Article
Journal Article
Circulation Research, ISSN 0009-7330, 01/2009, Volume 104, Issue 2, pp. 210 - 218
Oxidative modification of low-density lipoprotein (LDL) plays a causative role in the development of atherosclerosis. In this study, we demonstrate that... 
Reactive oxygen species | Minimally oxidized LDL | RANTES | Atherosclerosis | NADPH oxidase 2 | atherosclerosis | AORTIC ENDOTHELIAL-CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | SYK | SUPEROXIDE-PRODUCTION | minimally oxidized LDL | CUTTING EDGE | NOX FAMILY | reactive oxygen species | LIPOPOLYSACCHARIDE | PERIPHERAL VASCULAR DISEASE | MICE | HEMATOLOGY | NF-KAPPA-B | Phosphorylation | Reactive Oxygen Species - metabolism | Membrane Glycoproteins - metabolism | Muscle, Smooth, Vascular - metabolism | Protein-Tyrosine Kinases - metabolism | NADPH Oxidases - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Gene Knockdown Techniques | NADPH Oxidases - deficiency | Atherosclerosis - enzymology | Time Factors | Toll-Like Receptor 4 - deficiency | Interleukin-1beta - metabolism | Protein Kinase C - metabolism | Inflammation Mediators - metabolism | NADPH Oxidases - genetics | Chemokine CCL5 - metabolism | Lipoproteins, LDL - metabolism | Interleukin-6 - metabolism | Myocytes, Smooth Muscle - metabolism | Syk Kinase | Cell Line | Phospholipase C gamma - metabolism | Atherosclerosis - immunology | Signal Transduction | Macrophages, Peritoneal - enzymology | Myeloid Differentiation Factor 88 - genetics | Macrophages, Peritoneal - immunology | Toll-Like Receptor 4 - genetics | NADPH Oxidase 2 | Toll-Like Receptor 4 - metabolism | Membrane Glycoproteins - genetics | Mice, Knockout | Animals | Mice | Enzyme Activation | Myeloid Differentiation Factor 88 - metabolism | Membrane Glycoproteins - deficiency | Cell Movement
Journal Article
Blood, ISSN 0006-4971, 06/2010, Volume 115, Issue 22, pp. 4497 - 4506
The microenvironment provides essential growth and survival signals to chronic lymphocytic leukemia (CLL) cells and contributes to their resistance to... 
B-CELL RECEPTOR | MIGRATION | ALPHA-4-BETA-1 INTEGRIN | IN-VITRO | ACTIVATION | SYK | MCL-1 EXPRESSION | CD38 EXPRESSION | DRUG-RESISTANCE | HEMATOLOGY | GENE MUTATION STATUS | RNA, Small Interfering - genetics | Prognosis | Apoptosis - drug effects | Protein-Tyrosine Kinases - metabolism | Coculture Techniques | Humans | Middle Aged | Actins - metabolism | Male | Intracellular Signaling Peptides and Proteins - metabolism | Receptors, Antigen, B-Cell - metabolism | Integrins - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Protein-Tyrosine Kinases - genetics | Stromal Cells - drug effects | Female | Tumor Cells, Cultured | Proto-Oncogene Proteins c-akt - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Oxazines - pharmacology | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Stromal Cells - metabolism | Chemotaxis | Fibronectins - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Animals | Chemokine CXCL12 - metabolism | Integrin alpha4 - metabolism | Signal Transduction - drug effects | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Myeloid Cell Leukemia Sequence 1 Protein | Aged | Chemokines - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Vascular Cell Adhesion Molecule-1 - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2012, Volume 55, Issue 23, pp. 10414 - 10423
A novel approach to design selective spleen tyrosine kinase (Syk) inhibitors is described. Inhibition of spleen tyrosine kinase has attracted much attention as... 
RHEUMATOID-ARTHRITIS | RESPONSES | COMPLEX | CHEMISTRY, MEDICINAL | B-CELL | SYK | RECOGNITION | INFLAMMATION | INTEGRIN | DECTIN-2 | INDUCTION | Protein Kinase Inhibitors - chemistry | Spleen - enzymology | Humans | Drug Design | Models, Molecular | Protein Kinase Inhibitors - pharmacology | Protein-Tyrosine Kinases - antagonists & inhibitors
Journal Article
Cancer Research, ISSN 0008-5472, 07/2009, Volume 69, Issue 13, pp. 5424 - 5432
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 09/2019, Volume 294, Issue 36, pp. 13378 - 13395
Spleen tyrosine kinase (SYK) plays a major role in inflammation and in adaptive immune responses and could therefore contribute to the neuroinflammation... 
MAMMALIAN TARGET | tauopathy | autophagy | MICROGLIAL ACTIVATION | PROTEIN | Tau degradation | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MTOR PATHWAY | mammalian target of rapamycin (mTOR) | spleen tyrosine kinase (Syk) | S6K | Akt PKB | INSOLUBLE TAU | INHIBITION | Tau protein (Tau) | MOUSE MODEL | Tg Tau P301S | Alzheimer's disease | LC3 | STRESS GRANULES
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 12/2013, Volume 49, Issue 6, pp. 1085 - 1092
Journal Article
Gut, ISSN 0017-5749, 11/2013, Volume 62, Issue 11, pp. 1581 - 1590
Objective Intestinal inflammation resulting from manipulation-induced mast cell activation is a crucial mechanism in the pathophysiology of postoperative ileus... 
RHEUMATOID-ARTHRITIS | ACTIVATION | SYK | G-PROTEINS | RECEPTOR | Inflammation | Intestinal Motility | Macrophages | Abdominal Surgery | SUBSTANCE-P | KETOTIFEN | GASTROENTEROLOGY & HEPATOLOGY | MAST-CELL DEGRANULATION | EXPRESSION | Mast Cells | Phosphodiesterase Inhibitors - therapeutic use | Postoperative Complications - prevention & control | Thioxanthenes - therapeutic use | Substance P - pharmacology | Dose-Response Relationship, Drug | Ovalbumin - antagonists & inhibitors | Syk Kinase | Aniline Compounds - administration & dosage | Xanthones - therapeutic use | Drug Evaluation, Preclinical - methods | Substance P - antagonists & inhibitors | Aniline Compounds - pharmacology | Postoperative Complications - physiopathology | Pyrimidines - administration & dosage | Ileus - physiopathology | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Mice, Inbred C57BL | Cells, Cultured | Mast Cells - physiology | Gastrointestinal Transit - drug effects | Pyrimidines - pharmacology | Ovalbumin - pharmacology | Mast Cells - drug effects | Protein Kinase Inhibitors - administration & dosage | Animals | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Ileus - prevention & control | Mice | Protein Kinase Inhibitors - pharmacology | Aniline Compounds - therapeutic use | Macrophage Activation - drug effects | Cytokines - biosynthesis | Cell Degranulation - drug effects | Protein-Tyrosine Kinases - antagonists & inhibitors | Treatment outcome | Evaluation | Physiology, Pathological | Intestines | Obstructions | Care and treatment | Mast cells | Research | Abdominal surgery | Studies | Spleen | Phosphorylation | Cytokines | Surgery | Laboratory animals | Experiments | Abdomen
Journal Article