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1. Full Text Getting Syk: spleen tyrosine kinase as a therapeutic target
by Geahlen, Robert L
Trends in Pharmacological Sciences, ISSN 0165-6147, 2014, Volume 35, Issue 8, pp. 414 - 422
Highlights • Syk couples many immune recognition receptors to inflammatory responses. • Syk is a pro-survival factor for several hematological and... 
Advanced Basic Science | leukemia | protein kinase inhibitor | fostamatinib | tyrosine phosphorylation | allergic asthma | rheumatoid arthritis | RHEUMATOID-ARTHRITIS | COLLAGEN-INDUCED ARTHRITIS | SYSTEMIC-LUPUS-ERYTHEMATOSUS | FC-EPSILON-RI | MAST-CELLS | SIGNAL-TRANSDUCTION | BREAST-CANCER CELLS | IN-VIVO | CHRONIC LYMPHOCYTIC-LEUKEMIA | NON-HODGKIN-LYMPHOMA | PHARMACOLOGY & PHARMACY | Animals | Protein Kinase Inhibitors - therapeutic use | Protein-Tyrosine Kinases - metabolism | Humans | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - immunology | Intracellular Signaling Peptides and Proteins - metabolism | Protein Kinase Inhibitors - pharmacology | Molecular Targeted Therapy | Syk Kinase | Protein-Tyrosine Kinases - immunology | Protein-Tyrosine Kinases - antagonists & inhibitors | Tyrosine | Health aspects | tyrosine-phosphorylation
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2. Full Text An Oral Spleen Tyrosine Kinase (Syk) Inhibitor for Rheumatoid Arthritis
by Weinblatt, Michael E and Kavanaugh, Arthur and Genovese, Mark C and Musser, Theresa K and Grossbard, Elliott B and Magilavy, Daniel B
The New England Journal of Medicine, ISSN 0028-4793, 09/2010, Volume 363, Issue 14, pp. 1303 - 1312
Spleen tyrosine kinase (Syk) is an important modulator of immune signaling. In this randomized trial involving patients with active rheumatoid arthritis, there... 
TRIAL | VALIDATION | MEDICINE, GENERAL & INTERNAL | THERAPY | INFLAMMATION | Double-Blind Method | Humans | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Middle Aged | Male | Treatment Outcome | Methotrexate - therapeutic use | Protein Kinase Inhibitors - adverse effects | Oxazines - adverse effects | Pyridines - adverse effects | Arthritis, Rheumatoid - drug therapy | Oxazines - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Statistics, Nonparametric | Aged, 80 and over | Antirheumatic Agents - adverse effects | Adult | Female | Aged | Drug Therapy, Combination | Syk Kinase | Antirheumatic Agents - therapeutic use | Protein-Tyrosine Kinases - antagonists & inhibitors | Pyridines - therapeutic use | Spleen | Hypertension | Care and treatment | Rheumatoid arthritis | Physiological aspects | Health aspects | Risk factors | Tyrosine metabolism | Drug therapy | Drug dosages
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3. Full Text A reevaluation of the spleen tyrosine kinase (SYK) activation mechanism
by Mansueto, MS and Reens, A and Rakhilina, L and Chi, A and Pan, BS and Miller, JR
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 05/2019, Volume 294, Issue 19, pp. 7658 - 7668
Spleen tyrosine kinase (SYK) is a signaling node in many immune pathways and comprises two tandem Src homology (SH) 2 domains, an SH2-kinase linker, and a... 
MOLECULAR-MECHANISM | enzyme activation | BIOCHEMISTRY & MOLECULAR BIOLOGY | non-receptor tyrosine kinase (nRTK) | spleen tyrosine kinase (SYK) | immunity | conformational change | enzyme kinetics | ITAM (immune-receptor tyrosine activation motif) | autophosphorylation | STRUCTURAL BASIS | LOOP TYROSINES | cell signaling | ANTIGEN-RECEPTOR | IN-VIVO | SITES | phosphorylation | tonic signalling
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4. Full Text Pyrrolopyrazines as Selective Spleen Tyrosine Kinase Inhibitors
by Padilla, Fernando and Bhagirath, Niala and Chen, Shaoqing and Chiao, Eric and Goldstein, David M and Hermann, Johannes C and Hsu, Jonathan and Kennedy-Smith, Joshua J and Kuglstatter, Andreas and Liao, Cheng and Liu, Wenjian and Lowrie, Lee E and Luk, Kin Chun and Lynch, Stephen M and Menke, John and Niu, Linghao and Owens, Timothy D and O-Yang, Counde and Railkar, Aruna and Schoenfeld, Ryan C and Slade, Michelle and Steiner, Sandra and Tan, Yun-Chou and Villaseñor, Armando G and Wang, Ce and Wanner, Jutta and Xie, Wenwei and Xu, Daigen and Zhang, Xiaohu and Zhou, Mingyan and Lucas, Matthew C
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2013, Volume 56, Issue 4, pp. 1677 - 1692
We describe the discovery of several pyrrolopyrazines as potent and selective Syk inhibitors and the efforts that eventually led to the desired improvements in... 
AUTOIMMUNE | DESIGN | CHEMISTRY, MEDICINAL | SYK | INSIGHTS | B-Lymphocytes - enzymology | Humans | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Microsomes, Liver - metabolism | Models, Molecular | Crystallography, X-Ray | Structure-Activity Relationship | Blood Proteins - metabolism | Pyrazines - chemical synthesis | B-Lymphocytes - drug effects | Pyrroles - pharmacology | Animals | Pyrroles - chemical synthesis | Pyrazines - toxicity | Pyrroles - toxicity | Protein Binding | Mice | Molecular Structure | Pyrazines - pharmacology | Syk Kinase | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus
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5. Full Text An open-label phase 2 trial of entospletinib (GS-9973), a selective spleen tyrosine kinase inhibitor, in chronic lymphocytic leukemia
by Sharman, Jeff and Hawkins, Michael and Kolibaba, Kathryn and Boxer, Michael and Klein, Leonard and Wu, Meihua and Hu, Jing and Abella, Steve and Yasenchak, Chris
Blood, ISSN 0006-4971, 04/2015, Volume 125, Issue 15, pp. 2336 - 2343
Small-molecule inhibitors of kinases involved in B-cell receptor signaling are an important advance in managing lymphoid malignancies. Entospletinib (GS-9973)... 
B-CELLS | PHOSPHORYLATED ITAM PEPTIDE | SYK | IDELALISIB | CELL ANTIGEN RECEPTOR | IBRUTINIB | HEMATOLOGY | Humans | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Middle Aged | Male | Pyrazines - therapeutic use | Protein Kinase Inhibitors - adverse effects | Protein Kinase Inhibitors - blood | Disease-Free Survival | Indazoles - blood | Leukemia, Lymphocytic, Chronic, B-Cell - enzymology | Protein Kinase Inhibitors - therapeutic use | Pyrazines - adverse effects | Aged, 80 and over | Female | Aged | Indazoles - adverse effects | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Pyrazines - blood | Syk Kinase | Indazoles - therapeutic use | Protein-Tyrosine Kinases - antagonists & inhibitors | Clinical Trials and Observations
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6. Full Text Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules
by Yu, Yu and Gaillard, Stephanie and Phillip, Jude M and Huang, Tai-Chung and Pinto, Sneha M and Tessarollo, Nayara G and Zhang, Zhen and Pandey, Akhilesh and Wirtz, Denis and Ayhan, Ayse and Davidson, Ben and Wang, Tian-Li and Shih, Ie-Ming
Cancer Cell, ISSN 1535-6108, 07/2015, Volume 28, Issue 1, pp. 82 - 96
Resistance to chemotherapy represents a major obstacle for long-term remission, and effective strategies to overcome drug resistance would have significant... 
PHOSPHOPROTEOMICS | ACTIVATION | SYK | ONCOLOGY | PHOSPHORYLATION | INTERACTS | GROWTH | RESISTANCE | ALPHA-TUBULIN | LEUKEMIA | ANTIGEN RECEPTOR | CELL BIOLOGY | Up-Regulation | Paclitaxel - pharmacology | Microtubule-Associated Proteins - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Ovarian Neoplasms - pathology | Intracellular Signaling Peptides and Proteins - metabolism | Gene Knockdown Techniques | Protein-Tyrosine Kinases - genetics | Tubulin - metabolism | Microtubules - drug effects | Female | Ovarian Neoplasms - metabolism | Oxazines - administration & dosage | Phosphorylation - drug effects | Paclitaxel - administration & dosage | Intracellular Signaling Peptides and Proteins - genetics | Ovarian Neoplasms - drug therapy | Syk Kinase | Oxazines - pharmacology | Pyridines - administration & dosage | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Drug Synergism | Xenograft Model Antitumor Assays | Cell Line, Tumor | Pyridines - pharmacology | Drug Resistance, Neoplasm - drug effects | Protein-Tyrosine Kinases - antagonists & inhibitors | Proteins | Tyrosine | Medical colleges | Chemotherapy | Analysis | Paclitaxel | Cancer cells | Phenols | Drug resistance | Ovarian cancer | Cancer | Prevention | Tubulins
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7. Full Text Discovery of GS-9973, a Selective and Orally Efficacious Inhibitor of Spleen Tyrosine Kinase
by Currie, Kevin S and Kropf, Jeffrey E and Lee, Tony and Blomgren, Peter and Xu, Jianjun and Zhao, Zhongdong and Gallion, Steve and Whitney, J. Andrew and Maclin, Deborah and Lansdon, Eric B and Maciejewski, Patricia and Rossi, Ann Marie and Rong, Hong and Macaluso, Jennifer and Barbosa, James and Di Paolo, Julie A and Mitchell, Scott A
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2014, Volume 57, Issue 9, pp. 3856 - 3873
Spleen tyrosine kinase (Syk) is an attractive drug target in autoimmune, inflammatory, and oncology disease indications. The most advanced Syk inhibitor, R406,... 
RHEUMATOID-ARTHRITIS | POTENT | ACTIVATION | CHEMISTRY, MEDICINAL | SYK | MODELS | INFLAMMATION | FOSTAMATINIB DISODIUM | DISEASE | NON-HODGKIN-LYMPHOMA | EXPRESSION | Indazoles - chemistry | Magnetic Resonance Spectroscopy | Administration, Oral | Humans | Pyrazines - administration & dosage | Cells, Cultured | Rats | Spleen - drug effects | Structure-Activity Relationship | Indazoles - administration & dosage | Drug Discovery | Indazoles - pharmacology | Protein Kinase Inhibitors - administration & dosage | Pyrazines - chemistry | Protein Kinase Inhibitors - chemistry | Animals | Spectrometry, Mass, Electrospray Ionization | Spleen - enzymology | Mice | Protein Kinase Inhibitors - pharmacology | Pyrazines - pharmacology | Protein-Tyrosine Kinases - antagonists & inhibitors
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8. Full Text Discovery and Development of Spleen Tyrosine Kinase (SYK) Inhibitors
by Singh, Rajinder and Masuda, Esteban S and Payan, Donald G
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2012, Volume 55, Issue 8, pp. 3614 - 3643
B-CELL DEVELOPMENT | RHEUMATOID-ARTHRITIS | SYSTEMIC-LUPUS-ERYTHEMATOSUS | AFFINITY IGE RECEPTOR | CHEMISTRY, MEDICINAL | FC-EPSILON-RI | IMMUNE THROMBOCYTOPENIC PURPURA | ACTIVATION MOTIF ITAM | NON-HODGKIN-LYMPHOMA | T-CELL | HUMAN MAST-CELLS | Protein-Tyrosine Kinases - metabolism | Humans | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Autoimmune Diseases - immunology | Hypersensitivity - immunology | Intracellular Signaling Peptides and Proteins - metabolism | Structure-Activity Relationship | Enzyme Inhibitors - chemical synthesis | Drug Discovery | Protein-Tyrosine Kinases - genetics | Animals | Enzyme Inhibitors - chemistry | ZAP-70 Protein-Tyrosine Kinase - antagonists & inhibitors | ZAP-70 Protein-Tyrosine Kinase - metabolism | Mice | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Protein-Tyrosine Kinases - antagonists & inhibitors
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9. Full Text Macrophages Generate Reactive Oxygen Species in Response to Minimally Oxidized Low-Density Lipoprotein: Toll-Like Receptor 4– and Spleen Tyrosine Kinase–Dependent Activation of NADPH Oxidase 2
by Bae, Yun Soo and Lee, Jee Hyun and Choi, Soo Ho and Kim, Sunah and Almazan, Felicidad and Witztum, Joseph L and Miller, Yury I
Circulation Research, ISSN 0009-7330, 01/2009, Volume 104, Issue 2, pp. 210 - 218
Oxidative modification of low-density lipoprotein (LDL) plays a causative role in the development of atherosclerosis. In this study, we demonstrate that... 
Reactive oxygen species | Minimally oxidized LDL | RANTES | Atherosclerosis | NADPH oxidase 2 | atherosclerosis | AORTIC ENDOTHELIAL-CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | SYK | SUPEROXIDE-PRODUCTION | minimally oxidized LDL | CUTTING EDGE | NOX FAMILY | reactive oxygen species | LIPOPOLYSACCHARIDE | PERIPHERAL VASCULAR DISEASE | MICE | HEMATOLOGY | NF-KAPPA-B | Phosphorylation | Reactive Oxygen Species - metabolism | Membrane Glycoproteins - metabolism | Muscle, Smooth, Vascular - metabolism | Protein-Tyrosine Kinases - metabolism | NADPH Oxidases - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Gene Knockdown Techniques | NADPH Oxidases - deficiency | Atherosclerosis - enzymology | Time Factors | Toll-Like Receptor 4 - deficiency | Interleukin-1beta - metabolism | Protein Kinase C - metabolism | Inflammation Mediators - metabolism | NADPH Oxidases - genetics | Chemokine CCL5 - metabolism | Lipoproteins, LDL - metabolism | Interleukin-6 - metabolism | Myocytes, Smooth Muscle - metabolism | Syk Kinase | Cell Line | Phospholipase C gamma - metabolism | Atherosclerosis - immunology | Signal Transduction | Macrophages, Peritoneal - enzymology | Myeloid Differentiation Factor 88 - genetics | Macrophages, Peritoneal - immunology | Toll-Like Receptor 4 - genetics | NADPH Oxidase 2 | Toll-Like Receptor 4 - metabolism | Membrane Glycoproteins - genetics | Mice, Knockout | Animals | Mice | Enzyme Activation | Myeloid Differentiation Factor 88 - metabolism | Membrane Glycoproteins - deficiency | Cell Movement
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10. Full Text Spleen tyrosine kinase inhibition prevents chemokine- and integrin-mediated stromal protective effects in chronic lymphocytic leukemia
by Buchner, Maike and Baer, Constance and Prinz, Gabriele and Dierks, Christine and Burger, Meike and Zenz, Thorsten and Stilgenbauer, Stephan and Jumaa, Hassan and Veelken, Hendrik and Zirlik, Katja
Blood, ISSN 0006-4971, 06/2010, Volume 115, Issue 22, pp. 4497 - 4506
The microenvironment provides essential growth and survival signals to chronic lymphocytic leukemia (CLL) cells and contributes to their resistance to... 
B-CELL RECEPTOR | MIGRATION | ALPHA-4-BETA-1 INTEGRIN | IN-VITRO | ACTIVATION | SYK | MCL-1 EXPRESSION | CD38 EXPRESSION | DRUG-RESISTANCE | HEMATOLOGY | GENE MUTATION STATUS | RNA, Small Interfering - genetics | Prognosis | Apoptosis - drug effects | Protein-Tyrosine Kinases - metabolism | Coculture Techniques | Humans | Middle Aged | Actins - metabolism | Male | Intracellular Signaling Peptides and Proteins - metabolism | Receptors, Antigen, B-Cell - metabolism | Integrins - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Protein-Tyrosine Kinases - genetics | Stromal Cells - drug effects | Female | Tumor Cells, Cultured | Proto-Oncogene Proteins c-akt - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Oxazines - pharmacology | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Stromal Cells - metabolism | Chemotaxis | Fibronectins - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Animals | Chemokine CXCL12 - metabolism | Integrin alpha4 - metabolism | Signal Transduction - drug effects | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Myeloid Cell Leukemia Sequence 1 Protein | Aged | Chemokines - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Vascular Cell Adhesion Molecule-1 - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors
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11. Full Text Rational Design of Highly Selective Spleen Tyrosine Kinase Inhibitors
by Lucas, Matthew C and Goldstein, David M and Hermann, Johannes C and Kuglstatter, Andreas and Liu, Wenjian and Luk, Kin Chun and Padilla, Fernando and Slade, Michelle and Villaseñor, Armando G and Wanner, Jutta and Xie, Wenwei and Zhang, Xiaohu and Liao, Cheng
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2012, Volume 55, Issue 23, pp. 10414 - 10423
A novel approach to design selective spleen tyrosine kinase (Syk) inhibitors is described. Inhibition of spleen tyrosine kinase has attracted much attention as... 
RHEUMATOID-ARTHRITIS | RESPONSES | COMPLEX | CHEMISTRY, MEDICINAL | B-CELL | SYK | RECOGNITION | INFLAMMATION | INTEGRIN | DECTIN-2 | INDUCTION | Protein Kinase Inhibitors - chemistry | Spleen - enzymology | Humans | Drug Design | Models, Molecular | Protein Kinase Inhibitors - pharmacology | Protein-Tyrosine Kinases - antagonists & inhibitors
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12. Full Text Spleen tyrosine kinase is overexpressed and represents a potential therapeutic target in chronic lymphocytic leukemia
by Buchner, Maike and Fuchs, Simon and Prinz, Gabriele and Pfeifer, Dietmar and Bartholomé, Kilian and Burger, Meike and Chevalier, Nina and Vallat, Laurent and Timmer, Jens and Gribben, John G and Jumaa, Hassan and Veelken, Hendrik and Dierks, Christine and Zirlik, Katja
Cancer Research, ISSN 0008-5472, 07/2009, Volume 69, Issue 13, pp. 5424 - 5432
B-cell receptor signaling contributes to apoptosis resistance in chronic lymphocytic leukemia (CLL), limiting the efficacy of current therapeutic approaches.... 
B-CELL RECEPTOR | ZAP-70 | APOPTOSIS | ACTIVATION | CLL | SYK | ONCOLOGY | LYMPHOMA | CD38 EXPRESSION | ANTIGEN RECEPTOR | GENE MUTATION STATUS | Phosphorylation | Prognosis | Protein-Tyrosine Kinases - metabolism | Humans | Intracellular Signaling Peptides and Proteins - drug effects | Caspase 3 - metabolism | Antineoplastic Agents - therapeutic use | Gene Expression Profiling | Intracellular Signaling Peptides and Proteins - metabolism | Protein-Tyrosine Kinases - genetics | Protein-Tyrosine Kinases - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Pyridines - therapeutic use | B-Lymphocytes - enzymology | Curcumin - therapeutic use | Vidarabine - analogs & derivatives | Vidarabine - therapeutic use | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Leukemia, Lymphocytic, Chronic, B-Cell - enzymology | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Oxazines - therapeutic use | Cell Line, Tumor | Immunoglobulin Variable Region - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Mutation | Neoplasm Staging | Apoptosis
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13. Full Text Spleen tyrosine kinase (SYK) blocks autophagic Tau degradation in vitro and in vivo
by Schweig, JE and Yao, HL and Coppola, K and Jin, C and Crawford, F and Mullan, M and Paris, D
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 09/2019, Volume 294, Issue 36, pp. 13378 - 13395
Spleen tyrosine kinase (SYK) plays a major role in inflammation and in adaptive immune responses and could therefore contribute to the neuroinflammation... 
MAMMALIAN TARGET | tauopathy | autophagy | MICROGLIAL ACTIVATION | PROTEIN | Tau degradation | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MTOR PATHWAY | mammalian target of rapamycin (mTOR) | spleen tyrosine kinase (Syk) | S6K | Akt PKB | INSOLUBLE TAU | INHIBITION | Tau protein (Tau) | MOUSE MODEL | Tg Tau P301S | Alzheimer's disease | LC3 | STRESS GRANULES
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14. Full Text Inhibition of Spleen tyrosine kinase attenuates allergen-mediated airway constriction
by Moy, Lily Y and Jia, Yanlin and Caniga, Michael and Lieber, Gissela and Gil, Malgorzata and Fernandez, Xiomara and Sirkowski, Erich and Miller, Richard and Alexander, Jessica P and Lee, Hyun-Hee and Shin, John D and Ellis, J. Michael and Chen, Hongmin and Wilhelm, Alan and Yu, Hongshi and Vincent, Stella and Chapman, Richard W and Kelly, Nancy and Hickey, Emily and Abraham, William M and Northrup, Alan and Miller, Thomas and Houshyar, Hani and Crackower, Michael A
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 12/2013, Volume 49, Issue 6, pp. 1085 - 1092
Spleen tyrosine kinase (SYK) is a key activator of signaling pathways downstream of multiple surface receptors implicated in asthma. SYK function has been... 
Allergy | Inflammation | Spleen tyrosine kinase | Asthma | ACTIVATION | FC-EPSILON-RI | spleen tyrosine kinase | SYK | BIOCHEMISTRY & MOLECULAR BIOLOGY | MAST-CELLS | INHALATION | allergy | asthma | HYPERRESPONSIVENESS | CELL BIOLOGY | inflammation | DISODIUM-CROMOGLYCATE | RESPIRATORY SYSTEM | INDIVIDUAL AIRWAYS | Asthma - prevention & control | Ovalbumin - immunology | Humans | Macaca fascicularis | Male | Protein-Tyrosine Kinases - physiology | Allergens - administration & dosage | Rats, Inbred BN | Ascaris suum - immunology | Bronchoconstriction - drug effects | Bronchoconstriction - immunology | Asthma - etiology | Syk Kinase | Disease Models, Animal | Bronchoconstriction - physiology | Mast Cells - immunology | Asthma - physiopathology | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Rats | Mast Cells - drug effects | Rats, Sprague-Dawley | Animals | Signal Transduction - drug effects | Sheep | Protein Kinase Inhibitors - pharmacology | Intracellular Signaling Peptides and Proteins - physiology | Cell Degranulation - drug effects | Protein-Tyrosine Kinases - antagonists & inhibitors
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15. Full Text Inhibition of spleen tyrosine kinase as treatment of postoperative ileus
by van Bree, Sjoerd H W and Gomez-Pinilla, Pedro Julian and van de Bovenkamp, Fleur Suzanne and Di Giovangiulio, Martina and Farro, Giovanna and Nemethova, Andrea and Cailotto, Cathy and de Jonge, Wouter J and Lee, Kevin and Ramirez-Molina, Cesar and Lugo, Dave and Skynner, Michael J and Boeckxstaens, Guy E E and Matteoli, Gianluca
Gut, ISSN 0017-5749, 11/2013, Volume 62, Issue 11, pp. 1581 - 1590
Objective Intestinal inflammation resulting from manipulation-induced mast cell activation is a crucial mechanism in the pathophysiology of postoperative ileus... 
RHEUMATOID-ARTHRITIS | ACTIVATION | SYK | G-PROTEINS | RECEPTOR | Inflammation | Intestinal Motility | Macrophages | Abdominal Surgery | SUBSTANCE-P | KETOTIFEN | GASTROENTEROLOGY & HEPATOLOGY | MAST-CELL DEGRANULATION | EXPRESSION | Mast Cells | Phosphodiesterase Inhibitors - therapeutic use | Postoperative Complications - prevention & control | Thioxanthenes - therapeutic use | Substance P - pharmacology | Dose-Response Relationship, Drug | Ovalbumin - antagonists & inhibitors | Syk Kinase | Aniline Compounds - administration & dosage | Xanthones - therapeutic use | Drug Evaluation, Preclinical - methods | Substance P - antagonists & inhibitors | Aniline Compounds - pharmacology | Postoperative Complications - physiopathology | Pyrimidines - administration & dosage | Ileus - physiopathology | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Mice, Inbred C57BL | Cells, Cultured | Mast Cells - physiology | Gastrointestinal Transit - drug effects | Pyrimidines - pharmacology | Ovalbumin - pharmacology | Mast Cells - drug effects | Protein Kinase Inhibitors - administration & dosage | Animals | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Ileus - prevention & control | Mice | Protein Kinase Inhibitors - pharmacology | Aniline Compounds - therapeutic use | Macrophage Activation - drug effects | Cytokines - biosynthesis | Cell Degranulation - drug effects | Protein-Tyrosine Kinases - antagonists & inhibitors | Treatment outcome | Evaluation | Physiology, Pathological | Intestines | Obstructions | Care and treatment | Mast cells | Research | Abdominal surgery | Studies | Spleen | Phosphorylation | Cytokines | Surgery | Laboratory animals | Experiments | Abdomen
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