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Nature, ISSN 0028-0836, 2013, Volume 500, Issue 7463, pp. 422 - 426
Journal Article
Nature Communications, ISSN 2041-1723, 01/2016, Volume 7, Issue 1, pp. 10242 - 10242
Metabolic syndrome (MetS) and Type 2 diabetes mellitus (T2DM) increase risk for Alzheimer's disease (AD). The molecular mechanism for this association remains... 
GLUTAMATE NEUROTOXICITY | METABOLIC SYNDROME | INSULIN-DEGRADING ENZYME | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | NITRIC-OXIDE | A-BETA | COGNITIVE IMPAIRMENT | SYNAPTIC PLASTICITY | NEURODEGENERATIVE DISEASES | MITOCHONDRIAL FISSION | Dynamins - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Cerebral Cortex - pathology | Immunoblotting | Male | Metabolic Syndrome - metabolism | Reactive Nitrogen Species | Diabetes Mellitus, Type 2 - metabolism | Cerebral Cortex - cytology | Case-Control Studies | Cerebral Cortex - metabolism | Alzheimer Disease - pathology | Brain - metabolism | Nitroso Compounds - metabolism | Synapses - metabolism | Mitochondrial Proteins - metabolism | Dendritic Spines | Amyloid beta-Peptides - metabolism | Aged, 80 and over | Adult | Female | Neurons - metabolism | Disease Models, Animal | Insulysin - metabolism | Brain - cytology | Memantine - pharmacology | Oxygen Consumption | Rats | Mice, Transgenic | Excitatory Amino Acid Antagonists - pharmacology | Hippocampus - pathology | Hippocampus - cytology | Hyperglycemia - metabolism | Hippocampus - metabolism | Insulin - metabolism | Animals | GTP Phosphohydrolases - metabolism | Alzheimer Disease - metabolism | Long-Term Potentiation | Brain - pathology | Glucose - metabolism | Aged | Mice | Nitric Oxide - metabolism | Induced Pluripotent Stem Cells | Index Medicus
Journal Article
Neuron, ISSN 0896-6273, 03/2012, Volume 73, Issue 6, pp. 1116 - 1126
The precise connectivity of inputs and outputs is critical for cerebral cortex function; however, the cellular mechanisms that establish these connections are... 
SYNAPTIC SPECIFICITY | ADULT BRAIN | SIGNALING PATHWAY | IN-VIVO | BOC | GROWTH | MECHANISMS | AXON-GUIDANCE | MEMBRANE-PROTEINS | NEUROSCIENCES | CEREBRAL-CORTEX | Silver Staining - methods | RNA, Small Interfering - genetics | Furans - metabolism | Electric Stimulation | gamma-Aminobutyric Acid - metabolism | Channelrhodopsins | Hedgehog Proteins - metabolism | Dendritic Spines - metabolism | Functional Laterality - genetics | Nerve Net - cytology | Synaptophysin - genetics | Neurons - ultrastructure | Neurons - metabolism | Repressor Proteins - metabolism | Gene Expression Regulation, Developmental - physiology | Synaptophysin - metabolism | Animals, Newborn | Fluorobenzenes - metabolism | Tumor Suppressor Proteins - metabolism | Matrix Attachment Region Binding Proteins - metabolism | Dendritic Spines - physiology | Mice, Transgenic | Synapses - ultrastructure | Electroporation - methods | Mutation - genetics | Corpus Callosum - cytology | Patch-Clamp Techniques | Immunoglobulin G - genetics | Cerebral Cortex - growth & development | Luminescent Proteins - genetics | Corpus Callosum - growth & development | Mice | Immunoglobulin G - metabolism | RNA, Small Interfering - metabolism | Receptors, Cell Surface - genetics | Membrane Potentials - genetics | Age Factors | Gene Expression Regulation, Developmental - genetics | Phosphopyruvate Hydratase - metabolism | Cerebral Cortex - cytology | DNA-Binding Proteins - metabolism | Synapses - metabolism | Hedgehog Proteins - genetics | Pyramidal Tracts - physiology | Stilbamidines - metabolism | Receptors, Cell Surface - metabolism | Nuclear Proteins - metabolism | Transcription Factors - metabolism | Animals | Nerve Net - metabolism | In Vitro Techniques | Luminescent Proteins - metabolism | Stem cell research | Neurosciences | Nervous system diseases | Neurons | Stem cells | Collateralized debt obligations | Physiological aspects | Cells | Proteins | Transcription factors | Software | Sucrose | Synaptogenesis | Circuits | Hedgehog protein | Neural networks | Pyramidal cells | Cortex | Synapses | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 507, Issue 7490, pp. 118 - 123
The recognition events that mediate adaptive cellular immunity and regulate antibody responses depend on intercellular contacts between T cells and... 
SUPRAMOLECULAR ACTIVATION CLUSTER | ADHESION | COMPLEX | PROTEIN | MULTIDISCIPLINARY SCIENCES | DYNAMICS | PROLIFERATION | MICROSCOPY | CLASS-II | ELECTRON TOMOGRAPHY | MOLECULES | Cell Polarity | Virus Release | Antigen-Presenting Cells - cytology | Vesicular Transport Proteins - metabolism | Humans | Secretory Vesicles - metabolism | Male | Receptors, Antigen, T-Cell - ultrastructure | Immunological Synapses - metabolism | CD4-Positive T-Lymphocytes - immunology | DNA-Binding Proteins - metabolism | Histocompatibility Antigens Class I - metabolism | gag Gene Products, Human Immunodeficiency Virus - metabolism | Female | HIV - metabolism | Receptors, Antigen, T-Cell - immunology | CD4-Positive T-Lymphocytes - virology | B-Lymphocytes - metabolism | Antigen-Presenting Cells - metabolism | B-Lymphocytes - cytology | Immunological Synapses - ultrastructure | Receptors, Antigen, T-Cell - metabolism | Signal Transduction | Lymphocyte Activation | CD4-Positive T-Lymphocytes - metabolism | Endosomal Sorting Complexes Required for Transport - metabolism | Histocompatibility Antigens Class I - immunology | Immunological Synapses - secretion | Antigen-Presenting Cells - immunology | Protein Transport | Transcription Factors - metabolism | Secretory Vesicles - secretion | Intercellular Adhesion Molecule-1 - metabolism | Animals | B-Lymphocytes - immunology | CD4-Positive T-Lymphocytes - secretion | Protein Binding | Mice | Medicine | Plasma | Medical imaging | Microscopy | Lymphocytes | Rheumatology | Tomography | T cell receptors | Biology | Cytoplasm | Index Medicus
Journal Article
FEBS Journal, ISSN 1742-464X, 07/2010, Volume 277, Issue 14, pp. 3051 - 3067
The cognitive impairment in patients with Alzheimer's disease is closely associated with synaptic loss in the neocortex and limbic system. Although the... 
amyloid | PSD95 | Shank | Alzheimer's disease | oligomers | BIOCHEMISTRY & MOLECULAR BIOLOGY | COGNITIVE IMPAIRMENT | DELETION SYNDROME | DENDRITIC SPINES | GLUTAMATE RECEPTORS | POSTSYNAPTIC DENSITY PROTEINS | SOLUBLE BETA-AMYLOID(1-40) | A-BETA | LONG-TERM POTENTIATION | NMDA RECEPTOR SUBUNITS | SECRETED OLIGOMERS | Disks Large Homolog 4 Protein | Amyloid beta-Peptides - pharmacology | Humans | Cerebral Cortex - pathology | Male | Dendritic Spines - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Cerebral Cortex - metabolism | Alzheimer Disease - pathology | Alzheimer Disease - diagnosis | Brain - metabolism | Dementia - metabolism | Synapses - metabolism | Protein Multimerization - physiology | Amyloid beta-Peptides - metabolism | Aged, 80 and over | Female | Mice, Inbred DBA | Cell Membrane - metabolism | Membrane Proteins - metabolism | Neurons - metabolism | Neurons - drug effects | Peptide Fragments - genetics | Mice, Inbred C57BL | Cells, Cultured | Mice, Transgenic | Nerve Tissue Proteins - metabolism | Amyloid beta-Protein Precursor - genetics | Animals | Carrier Proteins - metabolism | Guanylate Kinases | Qa-SNARE Proteins - metabolism | Alzheimer Disease - metabolism | Brain - pathology | Cytosol - metabolism | Aged | Mice | Synaptosomal-Associated Protein 25 - metabolism | Vesicle-Associated Membrane Protein 2 - metabolism | Protein Binding - physiology | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 08/2011, Volume 108, Issue 31, pp. E392 - E401
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 04/2013, Volume 33, Issue 16, pp. 6964 - 6978
Excitatory synapses are polarized structures that primarily reside on dendritic spines in the brain. The small GTPase Rac1 regulates the development and... 
DENDRITIC SPINE MORPHOGENESIS | NMDA RECEPTOR | EMERGING ROLES | ANGIOGENESIS INHIBITOR-1 BAI1 | MENTAL-RETARDATION | PROTEIN-COUPLED RECEPTOR | APOPTOTIC CELLS | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | ALPHA(V)BETA INTEGRIN | CELL POLARITY | Disks Large Homolog 4 Protein | Angiogenic Proteins - genetics | Electric Stimulation | Cadherins - metabolism | Embryo, Mammalian | Microtubule-Associated Proteins - metabolism | Humans | Rats, Long-Evans | Actins - metabolism | Green Fluorescent Proteins - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Nerve Growth Factors - metabolism | Neoplasm Proteins - metabolism | Brain - metabolism | Synapses - metabolism | Transfection | Guanine Nucleotide Exchange Factors - metabolism | Brain - ultrastructure | Neurons - physiology | Membrane Proteins - metabolism | Imaging, Three-Dimensional | T-Lymphoma Invasion and Metastasis-inducing Protein 1 | Excitatory Postsynaptic Potentials - genetics | Vesicular Glutamate Transport Protein 1 - metabolism | Cells, Cultured | Rats | Electroporation | Hippocampus - cytology | Mutation - genetics | Cell Adhesion Molecules - metabolism | Cell Polarity - genetics | Microscopy, Confocal | Patch-Clamp Techniques | Animals | Carrier Proteins - metabolism | Analysis of Variance | Angiogenic Proteins - metabolism | rac1 GTP-Binding Protein - metabolism | RNA, Small Interfering - metabolism | Index Medicus
Journal Article
Cerebral cortex (New York, N.Y. : 1991), ISSN 1047-3211, 2014, Volume 24, Issue 10, pp. 2784 - 2795
Journal Article
Journal Article
Journal of Comparative Neurology, ISSN 0021-9967, 03/2010, Volume 518, Issue 5, pp. 687 - 698
Transient receptor potential ankyrin 1 (TRPA1), responding to noxious cold and pungent compounds, is implicated in the mediation of nociception, but little is... 
synapse | TRPA1 | trigeminal | primary afferent | Synapse | Primary afferent | Trigeminal | TRPA 1 | CORD | A-DELTA-FIBERS | ION-CHANNEL TRPA1 | NOCICEPTIVE RESPONSES | NEUROSCIENCES | PAIN | ZOOLOGY | SUBNUCLEUS INTERPOLARIS | COLD HYPERSENSITIVITY | SUBSTANTIA-GELATINOSA | NEURONS | NEUROPATHIC RATS | Immunohistochemistry | Trigeminal Nerve - metabolism | Posterior Horn Cells - metabolism | Synaptic Vesicles - metabolism | Calcium Channels - metabolism | Trigeminal Caudal Nucleus - metabolism | Dendrites - ultrastructure | Nerve Fibers, Unmyelinated - ultrastructure | Presynaptic Terminals - ultrastructure | Pain - metabolism | Microscopy, Immunoelectron | Posterior Horn Cells - cytology | Trigeminal Caudal Nucleus - cytology | Axons - ultrastructure | Sensory Receptor Cells - metabolism | Trigeminal Nuclei - metabolism | Afferent Pathways - metabolism | Biomarkers - metabolism | Dendrites - metabolism | Trigeminal Ganglion - cytology | Trigeminal Nuclei - cytology | Synaptic Vesicles - ultrastructure | TRPC Cation Channels | Axons - metabolism | Rats | Trigeminal Ganglion - metabolism | Nociceptors - cytology | Afferent Pathways - cytology | Rats, Sprague-Dawley | Animals | Sensory Receptor Cells - cytology | Nerve Fibers, Unmyelinated - metabolism | Pain - physiopathology | TRPA1 Cation Channel | Brain Mapping | Presynaptic Terminals - metabolism | Ankyrins | Substance P - metabolism | Nociceptors - metabolism | Rhizotomy | Plant Lectins - metabolism | Trigeminal Nerve - cytology | Index Medicus
Journal Article