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Science, ISSN 0036-8075, 3/2012, Volume 335, Issue 6074, pp. 1355 - 1359
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 2011, Volume 18, Issue 5, pp. 542 - 549
Journal Article
Biochemical Journal, ISSN 0264-6021, 06/2017, Volume 474, Issue 12, pp. 2039 - 2049
Misfolded alpha-synuclein (A-syn) is widely recognized as the primal cause of neurodegenerative diseases including Parkinson's disease and dementia with Lewy... 
MEMBRANE INTERACTIONS | SYNAPTIC VESICLES | IN-VITRO | NEUROTRANSMITTER RELEASE | LIPID VESICLES | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOPAMINE | PROTEINS | BINDING | LEWY BODIES | PARKINSONS-DISEASE | Synaptic Vesicles - metabolism | SNARE Proteins - genetics | Humans | Syntaxin 1 - metabolism | Vesicle-Associated Membrane Protein 2 - genetics | Recombinant Fusion Proteins - metabolism | Nerve Tissue Proteins - chemistry | SNARE Proteins - chemistry | Syntaxin 1 - genetics | Vesicle-Associated Membrane Protein 2 - chemistry | Micelles | Protein Interaction Domains and Motifs | Syntaxin 1 - chemistry | alpha-Synuclein - genetics | Peptide Fragments - genetics | Synaptosomal-Associated Protein 25 - genetics | Peptide Fragments - metabolism | Mutagenesis, Site-Directed | Membrane Fusion | Phosphatidylserines - metabolism | Rats | Synaptotagmin I - chemistry | Synaptosomal-Associated Protein 25 - chemistry | Recombinant Fusion Proteins - chemistry | Synaptotagmin I - genetics | Nerve Tissue Proteins - genetics | alpha-Synuclein - chemistry | Nerve Tissue Proteins - metabolism | Peptide Fragments - chemistry | Animals | Models, Biological | Synaptotagmin I - metabolism | Synaptosomal-Associated Protein 25 - metabolism | Liposomes | Mutation | Vesicle-Associated Membrane Protein 2 - metabolism | SNARE Proteins - metabolism | alpha-Synuclein - metabolism | Amino Acid Substitution
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 29, pp. 12165 - 12177
Journal Article
eLife, ISSN 2050-084X, 2014, Volume 3, p. e03756
Previously we showed that fast Ca2+-triggered vesicle fusion with reconstituted neuronal SNAREs and synaptotagmin-1 begins from an initial hemifusion-free... 
synaptic vesicle fusion | synaptotagmin | complexin | neurotransmitter release | membrane fusion | SNARE | MEMBRANE-FUSION | IN-VITRO | SNARE COMPLEX | EXOCYTOSIS | NEUROTRANSMITTER RELEASE | SYNAPTOTAGMIN | ESCHERICHIA-COLI | BIOLOGY | SWITCH | PROTEINS | BINDING | Synaptic Vesicles - metabolism | Calcium - metabolism | Adaptor Proteins, Vesicular Transport - genetics | Neurons - cytology | Syntaxin 1 - metabolism | Exocytosis | Vesicle-Associated Membrane Protein 2 - genetics | Adaptor Proteins, Vesicular Transport - metabolism | Calcium - chemistry | Nerve Tissue Proteins - chemistry | Syntaxin 1 - genetics | Biological Transport | Vesicle-Associated Membrane Protein 2 - chemistry | Escherichia coli - metabolism | Synaptic Vesicles - chemistry | Biological Assay | Adaptor Proteins, Vesicular Transport - chemistry | Neurons - metabolism | Syntaxin 1 - chemistry | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Synaptosomal-Associated Protein 25 - genetics | Gene Expression | Membrane Fusion | Neurons - chemistry | Protein Refolding | Rats | Recombinant Proteins - chemistry | Synaptotagmin I - chemistry | Recombinant Proteins - genetics | Synaptosomal-Associated Protein 25 - chemistry | Synaptotagmin I - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Animals | Escherichia coli - genetics | Models, Biological | Synaptotagmin I - metabolism | Protein Binding | Synaptosomal-Associated Protein 25 - metabolism | Mutation | Vesicle-Associated Membrane Protein 2 - metabolism | Proteins | Dyes | Insects | Calcium | Physiology | Titration | Synaptotagmin | Vesicle fusion | Diaphragm | Associations | Synchronization
Journal Article
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 08/2011, Volume 18, Issue 8, pp. 941 - 946
The core mechanism of intracellular vesicle fusion consists of SNAREpin zippering between vesicular and target membranes. Recent studies indicate that the same... 
BIOPHYSICS | FORCE | NEUROTRANSMITTER RELEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISTINCT DOMAINS | SWITCH | BINDING | CELL BIOLOGY | Adaptor Proteins, Signal Transducing - chemistry | Humans | Vesicle-Associated Membrane Protein 2 - physiology | Syntaxin 1 - metabolism | Adaptor Proteins, Vesicular Transport - metabolism | Nerve Tissue Proteins - chemistry | SNARE Proteins - chemistry | Vesicle-Associated Membrane Protein 2 - chemistry | Adaptor Proteins, Vesicular Transport - chemistry | Syntaxin 1 - chemistry | Binding Sites | Protein Structure, Tertiary | Nerve Tissue Proteins - physiology | Adaptor Proteins, Vesicular Transport - physiology | SNARE Proteins - physiology | Models, Molecular | Rats | Synaptosomal-Associated Protein 25 - chemistry | Nerve Tissue Proteins - metabolism | Adaptor Proteins, Signal Transducing - physiology | Animals | Synaptosomal-Associated Protein 25 - physiology | Mice | Synaptosomal-Associated Protein 25 - metabolism | Lipid Bilayers - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Membrane Fusion - physiology | Vesicle-Associated Membrane Protein 2 - metabolism | SNARE Proteins - metabolism | Syntaxin 1 - physiology | Cell hybridization | Physiological aspects | Research | Exocytosis | Membrane proteins | Proteins | Neurotransmitters | Membranes | Molecular biology | Vesicle-Associated Membrane Protein 2 | Membrane Fusion | Biochemistry, Molecular Biology | Nerve Tissue Proteins | Biophysics | Cellular Biology | Adaptor Proteins, Vesicular Transport | Life Sciences | Adaptor Proteins, Signal Transducing | Lipid Bilayers | Syntaxin 1 | Synaptosomal-Associated Protein 25 | SNARE Proteins
Journal Article
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 08/2011, Volume 18, Issue 8, pp. 934 - 940
Journal Article
Physical Review Letters, ISSN 0031-9007, 05/2007, Volume 98, Issue 21, p. 218103
We report the breaking of the diffraction resolution barrier in far-field fluorescence microscopy by transiently shelving the fluorophore in a metastable dark... 
RHODAMINE 6G | POLY(VINYL ALCOHOL) | RESOLUTION LIMIT | PHYSICS, MULTIDISCIPLINARY | TRIPLET | Cell Line | Fluorescent Dyes - chemistry | Synaptosomal-Associated Protein 25 - chemistry | Microscopy, Fluorescence - methods | Optics and Photonics | Humans
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2017, Volume 114, Issue 27, pp. E5343 - E5351
Membrane fusion is essential in a myriad of eukaryotic cell biological processes, including the synaptic transmission. Rabphilin-3A is a membrane trafficking... 
X-ray crystallography | Membrane fusion | Rabphilin-3A | C2 domains |