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Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, ISSN 1672-7347, 10/2006, Volume 31, Issue 5, p. 687
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 2016, Volume 25, Issue 24, pp. 5365 - 5382
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause late-onset, autosomal dominant familial Parkinsons disease (PD) and variation at the LRRK2 locus... 
MICROTUBULE STABILITY | DOMAIN | AUTOSOMAL-DOMINANT PARKINSONISM | GENE | REPEAT KINASE 2 | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUTATION | GENETICS & HEREDITY | DOPAMINERGIC-NEURONS | ALPHA-SYNUCLEIN | GTP-BINDING | Phosphorylation | Proteome - genetics | Dopaminergic Neurons - pathology | Humans | Drosophila melanogaster - genetics | Drosophila Proteins - biosynthesis | Protein Interaction Maps | Brain - metabolism | Drosophila melanogaster - metabolism | Syntaxin 1 - genetics | Dopaminergic Neurons - metabolism | Phosphoric Monoester Hydrolases - biosynthesis | Nerve Tissue Proteins - biosynthesis | Parkinson Disease - metabolism | Syntaxin 1 - biosynthesis | Synaptic Vesicles - genetics | Disease Models, Animal | Parkinson Disease - pathology | Phosphoric Monoester Hydrolases - genetics | Synaptotagmin I - biosynthesis | Animals, Genetically Modified | Gene Expression Regulation | Parkinson Disease - genetics | Synaptotagmin I - genetics | Nerve Tissue Proteins - genetics | rab3 GTP-Binding Proteins - genetics | Animals | rab3 GTP-Binding Proteins - biosynthesis | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - biosynthesis | Brain - pathology | Drosophila Proteins - genetics | Mutation | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - genetics | Life Sciences | Human health and pathology
Journal Article
by Nalls, Michael A and Plagnol, Vincent and Hernandez, Dena G and Sharma, Manu and Sheerin, Una-Marie and Saad, Mohamad and Simon-Sanchez, Javier and Schulte, Claudia and Lesage, Suzanne and Sveinbjornsdottir, Sigurlaug and Arepalli, Sampath and Barker, Roger and Ben-Shlomo, Yoav and Berendse, Henk W and Berg, Daniela and Bhatia, Kailash and de Bie, Rob M. A and Biffi, Alessano and Bloem, Bas and Bochdanovits, Zoltan and Bonin, Michael and Bras, Jose M and Brockmann, Kathrin and Brooks, Janet and Burn, David J and Charlesworth, Gavin and Chen, Honglei and Chinnery, Patrick F and Chong, Sean and Clarke, Carl E and Cookson, Mark R and Cooper, J. Mark and Corvol, Jean Christophe and Counsell, Carl and Damier, Philippe and Dartigues, Jean-Francois and Deloukas, Panos and Deuschl, Guenther and Dexter, David T and van Dijk, Karin D and Dillman, Allissa and Durif, Frank and Duerr, Alexana and Edkins, Sarah and Evans, Jonathan R and Foltynie, Thomas and Gao, Jianjun and Gardner, Michelle and Gibbs, J. Raphael and Goate, Alison and Gray, Emma and Guerreiro, Rita and Gustafsson, Omar and Harris, Clare and van Hilten, Jacobus J and Hofman, Albert and Hollenbeck, Albert and Holton, Janice and Hu, Michele and Huang, Xuemei and Huber, Heiko and Hudson, Gavin and Hunt, Sarah E and Huttenlocher, Johanna and Illig, Thomas and Jonsson, Palmi V and Lambert, Jean-Charles and Langford, Cordelia and Lees, Anew and Lichtner, Peter and Limousin, Patricia and Lopez, Grisel and Lorenz, Delia and McNeill, Alisdair and Moorby, Catriona and Moore, Matthew and Morris, Huw R and Morrison, Karen E and Mudanohwo, Ese and O'Sullivan, Sean S and Pearson, Justin and Perlmutter, Joel S and Petursson, Hjoervar and Pollak, Pierre and Post, Bart and Potter, Simon and Ravina, Bernard and Revesz, Tamas and Riess, Olaf and Rivadeneira, Fernando and Rizzu, Patrizia and Ryten, Mina and Sawcer, Stephen and Schapira, Anthony and Scheffer, Hans and Shaw, Karen and Shoulson, Ira and Siansky, Ellen and Smith, Colin and Spencer, Chris C. A and ... and Wellcome Trust Case-Control Consor and Int Parkinson Dis Genomics Consort and International Parkinson Disease Genomics Consortium
Lancet, The, ISSN 0140-6736, 2011, Volume 377, Issue 9766, pp. 641 - 649
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 02/2017, Volume 37, Issue 8, pp. 2203 - 2215
Major signaling molecules initially characterized as key early developmental regulators are also essential for the plasticity of the nervous system.... 
Miniature EPSP | Wingless/Wnt | NMJ | Activity-dependent plasticity | Synaptic plasticity | GRASSHOPPER EMBRYOS | activity-dependent plasticity | ARP2/3 COMPLEX | ACTIN DYNAMICS | SPONTANEOUS NEUROTRANSMITTER RELEASE | NEUROSCIENCES | DROSOPHILA | MORPHOGENESIS | CELL-MIGRATION | GROWTH | DENDRITIC SPINE | miniature EPSP | synaptic plasticity | WNT | Wnt1 Protein - genetics | Neuromuscular Junction - drug effects | Neuronal Plasticity - drug effects | Male | Wnt1 Protein - metabolism | Drosophila Proteins - metabolism | Excitatory Postsynaptic Potentials - drug effects | Neuronal Plasticity - genetics | Neuronal Plasticity - physiology | Potassium Chloride - pharmacology | Tumor Suppressor Proteins - genetics | Female | RNA Interference - physiology | Excitatory Postsynaptic Potentials - genetics | Tumor Suppressor Proteins - metabolism | Presynaptic Terminals - drug effects | Animals, Genetically Modified | Gene Expression Regulation - genetics | Drosophila | Presynaptic Terminals - physiology | Signal Transduction - genetics | Cortactin - metabolism | Transcription Factors - genetics | Mutation - genetics | Synaptotagmin I - genetics | Gene Expression Regulation - drug effects | Transcription Factors - metabolism | Animals | Cortactin - genetics | Synaptotagmin I - metabolism | Horseradish Peroxidase - metabolism | Drosophila Proteins - genetics | Neuromuscular Junction - physiology | Wingless | Wnt
Journal Article
Journal Article
Nature Neuroscience, ISSN 1097-6256, 2014, Volume 17, Issue 5, pp. 670 - 677
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 04/2015, Volume 125, Issue 4, pp. 1670 - 1678
Journal Article
Biochemical Journal, ISSN 0264-6021, 06/2017, Volume 474, Issue 12, pp. 2039 - 2049
Misfolded alpha-synuclein (A-syn) is widely recognized as the primal cause of neurodegenerative diseases including Parkinson's disease and dementia with Lewy... 
MEMBRANE INTERACTIONS | SYNAPTIC VESICLES | IN-VITRO | NEUROTRANSMITTER RELEASE | LIPID VESICLES | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOPAMINE | PROTEINS | BINDING | LEWY BODIES | PARKINSONS-DISEASE | Synaptic Vesicles - metabolism | SNARE Proteins - genetics | Humans | Syntaxin 1 - metabolism | Vesicle-Associated Membrane Protein 2 - genetics | Recombinant Fusion Proteins - metabolism | Nerve Tissue Proteins - chemistry | SNARE Proteins - chemistry | Syntaxin 1 - genetics | Vesicle-Associated Membrane Protein 2 - chemistry | Micelles | Protein Interaction Domains and Motifs | Syntaxin 1 - chemistry | alpha-Synuclein - genetics | Peptide Fragments - genetics | Synaptosomal-Associated Protein 25 - genetics | Peptide Fragments - metabolism | Mutagenesis, Site-Directed | Membrane Fusion | Phosphatidylserines - metabolism | Rats | Synaptotagmin I - chemistry | Synaptosomal-Associated Protein 25 - chemistry | Recombinant Fusion Proteins - chemistry | Synaptotagmin I - genetics | Nerve Tissue Proteins - genetics | alpha-Synuclein - chemistry | Nerve Tissue Proteins - metabolism | Peptide Fragments - chemistry | Animals | Models, Biological | Synaptotagmin I - metabolism | Synaptosomal-Associated Protein 25 - metabolism | Liposomes | Mutation | Vesicle-Associated Membrane Protein 2 - metabolism | SNARE Proteins - metabolism | alpha-Synuclein - metabolism | Amino Acid Substitution
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 10/2010, Volume 30, Issue 40, pp. 13281 - 13290
Journal Article
eLife, ISSN 2050-084X, 2014, Volume 3, p. e03756
Previously we showed that fast Ca2+-triggered vesicle fusion with reconstituted neuronal SNAREs and synaptotagmin-1 begins from an initial hemifusion-free... 
synaptic vesicle fusion | synaptotagmin | complexin | neurotransmitter release | membrane fusion | SNARE | MEMBRANE-FUSION | IN-VITRO | SNARE COMPLEX | EXOCYTOSIS | NEUROTRANSMITTER RELEASE | SYNAPTOTAGMIN | ESCHERICHIA-COLI | BIOLOGY | SWITCH | PROTEINS | BINDING | Synaptic Vesicles - metabolism | Calcium - metabolism | Adaptor Proteins, Vesicular Transport - genetics | Neurons - cytology | Syntaxin 1 - metabolism | Exocytosis | Vesicle-Associated Membrane Protein 2 - genetics | Adaptor Proteins, Vesicular Transport - metabolism | Calcium - chemistry | Nerve Tissue Proteins - chemistry | Syntaxin 1 - genetics | Biological Transport | Vesicle-Associated Membrane Protein 2 - chemistry | Escherichia coli - metabolism | Synaptic Vesicles - chemistry | Biological Assay | Adaptor Proteins, Vesicular Transport - chemistry | Neurons - metabolism | Syntaxin 1 - chemistry | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Synaptosomal-Associated Protein 25 - genetics | Gene Expression | Membrane Fusion | Neurons - chemistry | Protein Refolding | Rats | Recombinant Proteins - chemistry | Synaptotagmin I - chemistry | Recombinant Proteins - genetics | Synaptosomal-Associated Protein 25 - chemistry | Synaptotagmin I - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Animals | Escherichia coli - genetics | Models, Biological | Synaptotagmin I - metabolism | Protein Binding | Synaptosomal-Associated Protein 25 - metabolism | Mutation | Vesicle-Associated Membrane Protein 2 - metabolism | Proteins | Dyes | Insects | Calcium | Physiology | Titration | Synaptotagmin | Vesicle fusion | Diaphragm | Associations | Synchronization
Journal Article
Journal Article
eLife, ISSN 2050-084X, 12/2012, Volume 2012, Issue 1, p. e00109
The molecular underpinnings of synaptic vesicle fusion for fast neurotransmitter release are still unclear. Here, we used a single vesicle-vesicle system with... 
VESICLE FUSION | TRANSMITTER RELEASE | IN-VITRO | NEUROTRANSMITTER RELEASE | CRYOELECTRON MICROSCOPY | SYNAPTOTAGMIN | ESCHERICHIA-COLI | BIOLOGY | MEDIATED MEMBRANE-FUSION | SNARE COMPLEXES | SYNAPTOBREVIN C-TERMINUS | Synaptic Vesicles - metabolism | Calcium - metabolism | Proteolipids - metabolism | Adaptor Proteins, Vesicular Transport - genetics | Syntaxin 1 - metabolism | Vesicle-Associated Membrane Protein 2 - genetics | Adaptor Proteins, Vesicular Transport - metabolism | Proteolipids - ultrastructure | Synaptic Transmission | Action Potentials | Syntaxin 1 - genetics | Biological Transport | Time Factors | Recombinant Proteins - metabolism | Synaptosomal-Associated Protein 25 - genetics | Gene Expression | Calcium - pharmacology | Membrane Fusion | Synaptic Vesicles - ultrastructure | Rats | Recombinant Proteins - genetics | Synaptotagmin I - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Animals | Synaptotagmin I - metabolism | Synaptic Vesicles - drug effects | Synaptosomal-Associated Protein 25 - metabolism | Vesicle-Associated Membrane Protein 2 - metabolism | Membrane fusion | Neurotransmitter release | Calcium | Laboratories | Lipids | SNAP receptors | Biology | Injection | Vesicle fusion | Electron microscopy | Experiments | Intermediates | Proteins | Microscopy | Physiology | Synaptotagmin | Diaphragm
Journal Article