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syncytin-1 (50) 50
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1. Full Text Cytotoxic stress induces transfer of mitochondria-associated human endogenous retroviral rna and proteins between cancer cells
by Díaz-Carballo, David and Klein, Jacqueline and Acikelli, Ali H and Wilk, Camilla and Saka, Sahitya and Jastrow, Holger and Wennemuth, Gunther and Dammann, Phillip and Giger-Pabst, Urs and Khosrawipour, Veria and Rassow, Joachim and Nienen, Mikalai and Strumberg, Dirk
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 56, pp. 95945 - 95964
About 8 % of the human genome consists of human endogenous retroviruses (HERVs), which are relicts of ancient exogenous retroviral infections incurred during... 
Mitochondria | Human endogenous retroviruses (HERVs) | Intercellular mitochondrial transfer | Syncytin-1/2 receptors | FUSION | intercellular mitochondrial transfer | mitochondria | PLACENTA | PROLIFERATION | MESENCHYMAL STEM-CELLS | CELL BIOLOGY | ROLES | syncytin-1/2 receptors | RESPIRATION | ENVELOPE | SYNCYTIN | DIFFERENTIATION | human endogenous retroviruses (HERVs) | EXPRESSION
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2. Full Text The aliens inside us: HERV-W endogenous retroviruses and multiple sclerosis
by Dolei, Antonina
Multiple Sclerosis Journal, ISSN 1352-4585, 1/2018, Volume 24, Issue 1, pp. 42 - 47
Two human endogenous retroviruses of the HERV-W family are proposed as multiple sclerosis (MS) co-factors: MS-associated retrovirus (MSRV) and ERVWE1, whose... 
MS pathogenesis | dual virus hypothesis | MS therapy | biomarker | HERV-W/MSRV/Syncytin-1 human endogenous retroviruses | PROTEIN | HERV-W | PARTICLES | DEATH | NEUROSCIENCES | MSRV | CLINICAL NEUROLOGY | Syncytin-1 human endogenous retroviruses | FAMILY | THERAPY | DISEASE | COHORT | EXPRESSION | MS PATIENTS | MODULATION | Endogenous Retroviruses | Epstein-Barr Virus Infections | Humans | Multiple Sclerosis - virology | Herpesvirus 4, Human | Multiple sclerosis | Animal models | Mononucleosis | Neuropathology | Immunoglobulin G | Clinical trials | Remission | Infectious mononucleosis | Plaques | Syncytin
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3. Full Text Regulation of the human endogenous retroviral Syncytin-1 and cell-cell fusion by the nuclear hormone receptors PPARIγ/RXRα in placentogenesis
by Ruebner, Matthias and Langbein, Manuela and Strissel, Pamela L and Henke, Christine and Schmidt, Doreen and Goecke, Tamme W and Faschingbauer, Florian and Schild, Ralf L and Beckmann, Matthias W and Strick, Reiner
Journal of Cellular Biochemistry, ISSN 0730-2312, 07/2012, Volume 113, Issue 7, pp. 2383 - 2396
HERV | LEPTIN | placental syndromes | PPARIγ | Placenta | RXRα | cell fusion | SYNCYTIN-1 | preeclampsia | trophoblast
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4. Full Text Expression of Human Endogenous Retroviruses in Peripheral Leukocytes During the Menstrual Cycle Suggests Coordinated Hormonal Regulation
by Mueller, Olivia and Moore, Doris W and Giovannucci, Joseph and Etter, Andrea R and Peterson, Emily M and Mudge, Aaron and Liu, Yingguang
AIDS Research and Human Retroviruses, ISSN 0889-2229, 11/2018, Volume 34, Issue 11, pp. 909 - 911
HERV | syncytin-1 | estrogen | endogenous retrovirus | Estradiol | progesterone | INFECTIOUS DISEASES | VIROLOGY | IMMUNOLOGY | estradiol | White blood cells | Endogenous retroviruses | Menstruation | Leukocytes | Menstrual cycle
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5. Full Text Natalizumab inhibits the expression of human endogenous retroviruses of the W family in multiple sclerosis patients: a longitudinal cohort study
by Arru, Giannina and Leoni, Stefania and Pugliatti, Maura and Mei, Alessandra and Serra, Caterina and Delogu, Lucia Gemma and Manetti, Roberto and Dolei, Antonina and Sotgiu, Stefano and Mameli, Giuseppe
Multiple Sclerosis Journal, ISSN 1352-4585, 2/2014, Volume 20, Issue 2, pp. 174 - 182
Background: Several viruses were reported as co-factors triggering the pathogenesis of multiple sclerosis (MS), including the endogenous retroviruses of the... 
Multiple sclerosis | MSRV/syncytin-1/HERV-W | natalizumab | HERV-W | EFFICACY | NEUROSCIENCES | MSRV | CLINICAL NEUROLOGY | B-CELLS | PATHOGENESIS | syncytin-1 | DISABILITY | MODULATION | PCR | Antibodies, Monoclonal, Humanized - therapeutic use | Natalizumab | Multiple Sclerosis, Relapsing-Remitting - drug therapy | Humans | Middle Aged | Male | Endogenous Retroviruses - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Leukocytes, Mononuclear - virology | Young Adult | Flow Cytometry | Adult | Female | Longitudinal Studies | Multiple Sclerosis, Relapsing-Remitting - virology | Real-Time Polymerase Chain Reaction | Gene Products, env - analysis | Cohort Studies | Pregnancy Proteins - analysis
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6. Full Text Identification of a post-transcriptional regulatory element in the human endogenous retroviral syncytin-1
by Kitao, Koichi and Tanikaga, Takamasa and Miyazawa, Takayuki
Journal of General Virology, ISSN 0022-1317, 04/2019, Volume 100, Issue 4, pp. 662 - 668
Retroviral transcripts have cis-acting elements that interact with host and viral proteins to enable efficient nuclear export and/or translation; however, it... 
Human endogenous retrovirus | Post-transcriptional regulation | Syncytin-1 | RNA EXPORT | syncytin-1 | TRANSPORT | TAP | VIROLOGY | HUMAN PLACENTA | HERV-W | CTE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | post-transcriptional regulation | human endogenous retrovirus | EXPRESSION
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7. Full Text The EGF epidermal growth factor counteracts Tat modulation of human endogenous retroviruses of the W family in astrocytes
by Uleri, Elena and Piu, Claudia and Caocci, Maurizio and Ibba, Gabriele and Serra, Caterina and Dolei, Antonina
Journal of NeuroVirology, ISSN 1355-0284, 8/2017, Volume 23, Issue 4, pp. 587 - 592
Human astrocyte cells were exposed to HIV-Tat and/or epidermal growth factor (EGF), to monitor the expression of the neuropathogenic MSRV and Syncytin-1... 
Neurology | Neurosciences | Biomedicine | Immunology | Tat | Epidermal growth factor receptor (EGFR) | Epidermal growth factor (EGF) | NeuroAIDS/neuropathogenicity | Infectious Diseases | Tumor necrosis factor-α (TNFα) | HERV-W/MSRV/Syncytin-1 human endogenous retroviruses | Virology | Epidermal growth factor receptor ( EGFR) | ACTIVATION | PROTEIN | SYNCYTIN-1 | RECEPTOR | AIDS | CNS | CELL-PROLIFERATION | NEUROSCIENCES | VIROLOGY | MULTIPLE-SCLEROSIS | HIV-1 TAT | Tumor necrosis factor-alpha (TNF alpha) | NEUROCOGNITIVE DISORDERS | Astrocytes - drug effects | Cell Line | Receptor, Epidermal Growth Factor - genetics | Antibodies, Monoclonal - pharmacology | Humans | Pregnancy Proteins - genetics | Endogenous Retroviruses - genetics | Pregnancy Proteins - metabolism | Gene Products, env - metabolism | Tumor Necrosis Factor-alpha - pharmacology | Receptor, Epidermal Growth Factor - metabolism | tat Gene Products, Human Immunodeficiency Virus - pharmacology | Endogenous Retroviruses - metabolism | Gene Products, env - genetics | Lipopolysaccharides - pharmacology | Fetus | tat Gene Products, Human Immunodeficiency Virus - antagonists & inhibitors | Epidermal Growth Factor - pharmacology | Endogenous Retroviruses - growth & development | HIV Antibodies - pharmacology | Astrocytes - virology
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8. Full Text The elementary fusion modalities of osteoclasts
by Søe, Kent and Hobolt-Pedersen, Anne-Sofie and Delaisse, Jean-Marie
Bone, ISSN 8756-3282, 2014, Volume 73, pp. 181 - 189
Abstract The last step of the osteoclast differentiation process is cell fusion. Most efforts to understand the fusion mechanism have focused on the... 
Orthopedics | Mobility | Heterogeneity | Fusion | Osteoclast fusion | Fusion partner | DC-STAMP | SYNCYTIN-1 | RECEPTOR | MECHANISMS | IDENTIFICATION | ENDOCRINOLOGY & METABOLISM | CD47 | PRECURSORS | CELL-CELL FUSION | TRANSMEMBRANE PROTEIN | Osteoclasts - cytology | Cell Fusion | Humans | Cell differentiation | Analysis
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9. Epigenetic regulation and human diseases
by Jiang, Shi-Wen
Current Pharmaceutical Design, ISSN 1381-6128, 2014, Volume 20, Issue 11, pp. 1595 - 1597
STEM-CELLS | METHYLATION | INTERPLAY | DISORDERS | PHARMACOLOGY & PHARMACY | SYNCYTIN-1 GENE | OVARIAN-CANCER | EXPRESSION | HDAC | HYPOMETHYLATION
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10. Full Text HERV-W env regulates calcium influx via activating TRPC3 channel together with depressing DISC1 in human neuroblastoma cells
by Chen, Yatang and Chen, Yatang and Yan, Qiujin and Yan, Qiujin and Zhou, Ping and Zhou, Ping and Li, Shan and Li, Shan and Zhu, Fan and Zhu, Fan
Journal of NeuroVirology, ISSN 1355-0284, 2/2019, Volume 25, Issue 1, pp. 101 - 113
The activation and involvement of human endogenous retroviruses W family envelope gene (HERV-W env, also called ERVWE1) have been reported in several... 
Neurology | Neurosciences | Biomedicine | Immunology | TRPC3 | Schizophrenia | Infectious Diseases | DISC1 | HERV-W env | Virology | Intracellular Ca 2+ concentration | concentration | Intracellular Ca | Intracellular Ca2+ concentration | SYNCYTIN-1 | RECEPTOR | ENVELOPE PROTEIN | HUMAN ENDOGENOUS RETROVIRUS | NEUROSCIENCES | FAMILY | VIROLOGY | MULTIPLE-SCLEROSIS | GLYCOPROTEIN | MUTATIONS | EXPRESSION
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11. Full Text The Molecular Role of Connexin 43 in Human Trophoblast Cell Fusion1
by Caroline E. Dunk and Alexandra Gellhaus and Sascha Drewlo and Dora Baczyk and Andy J.G. Pötgens and Elke Winterhager and John C.P. Kingdom and Steven J. Lye
Biology of Reproduction, ISSN 0006-3363, 2012, Volume 86, Issue 4
ABSTRACT Connexin expression and gap junctional intercellular communication (GJIC) mediated by connexin 43 (Cx43)/gap junction A1 (GJA1) are required for... 
ERVW-1/SYNCYTIN-1 | trophoblast fusion | SLC1A5/ASCT-2/RDR/ATB | syncytiotrophoblast | connexin 43 (Cx43) | RDR | ASCT-2 | SYNCYTIN-1 | ERVW-1 | SLC1A5 | ATB
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12. Decreased expression and altered methylation of syncytin-1 gene in human placentas associated with preeclampsia
by Zhuang, Xue-Wei and Li, Jinping and Brost, Brian C and Xia, Xi-Yan and Chen, Hai Bin and Wang, Chuan-Xin and Jiang, Shi-Wen
Current Pharmaceutical Design, ISSN 1381-6128, 2014, Volume 20, Issue 11, pp. 1796 - 1802
Syncytin-1 is a protein coded by a human endogenous retrovirus (HERV) gene of the HERV-W family (HERVWE1). Syncytin-1 mediates formation of... 
DNA methylation | Trophoblast | Placenta | Preeclampsia | Syncytin-1 | SYSTEM | FUSION | placenta | PHARMACOLOGY & PHARMACY | preeclampsia | trophoblast | CANCER | Pre-Eclampsia - genetics | Trophoblasts - metabolism | Down-Regulation | Epigenesis, Genetic | Humans | Pregnancy Proteins - genetics | Endogenous Retroviruses - genetics | Promoter Regions, Genetic - drug effects | RNA, Messenger - metabolism | Sequence Analysis, DNA | DNA (Cytosine-5-)-Methyltransferases - metabolism | Placenta - metabolism | Pregnancy | DNA Methylation | Gene Products, env - genetics | Female
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13. Full Text Cell-surface phosphatidylserine regulates osteoclast precursor fusion
by Verma, Santosh K and Leikina, Evgenia and Melikov, Kamran and Gebert, Claudia and Kram, Vardit and Young, Marian F and Uygur, Berna and Chernomordik, Leonid V
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 1, pp. 254 - 270
Bone-resorbing multinucleated osteoclasts that play a central role in the maintenance and repair of our bones are formed from bone marrow myeloid progenitor... 
MEMBRANE-FUSION | DC-STAMP | PROTEIN | VIRUS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MACROPHAGE FUSION | SYNCYTIN-1 | ENVELOPE | ANNEXIN A1 | INTERCELLULAR FUSION | EXPRESSION | Osteogenesis - physiology | Humans | Pregnancy Proteins - metabolism | Phosphatidylserines - physiology | Cell Fusion - methods | Gene Products, env - metabolism | Hematopoiesis | Bone and Bones - metabolism | Bone Resorption - metabolism | Gene Products, env - physiology | Pregnancy Proteins - physiology | Cell Differentiation | Cell Membrane - metabolism | Membrane Proteins - metabolism | Osteoclasts - physiology | Cell Line | Annexins - metabolism | Mice, Inbred C57BL | Phosphatidylserines - metabolism | Mice, Knockout | Nerve Tissue Proteins - metabolism | Animals | Mice | Membrane Fusion - physiology | S100 Calcium-Binding Protein A4 - metabolism | fusion protein | syncytin 1 | S100 proteins | annexin | cell fusion | annexin A5 | osteoclast | phosphatidylserine exposure | Cell Biology | membrane fusion
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14. Full Text Human endogenous retroviruses and multiple sclerosis: Innocent bystanders or disease determinants?
by Antony, Joseph M and DesLauriers, Andre M and Bhat, Rakesh K and Ellestad, Kristofer K and Power, Christopher
BBA - Molecular Basis of Disease, ISSN 0925-4439, 2011, Volume 1812, Issue 2, pp. 162 - 176
Human endogenous retroviruses (HERVs) constitute 5–8% of human genomic DNA and are replication incompetent despite expression of individual HERV genes from... 
Human endogenous retrovirus | Multiple sclerosis | Neurodegeneration | Neuroinflammation | MSRV | Syncytin-1 | Endoplasmic reticulum stress | C-REACTIVE PROTEIN | HERV-W | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENVELOPE PROTEIN | ENDOPLASMIC-RETICULUM STRESS | HUMAN BREAST-CANCER | REAL-TIME PCR | UNFOLDED PROTEIN RESPONSE | ACID TRANSPORTER ASCT1 | BIOPHYSICS | IMMUNE-RESPONSES | CENTRAL-NERVOUS-SYSTEM | Proteins | Retroviruses
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15. Full Text Involvement of human endogenous retroviral syncytin-1 in human osteoclast fusion
by Søe, Kent and Andersen, Thomas L and Hobolt-Pedersen, Anne-Sofie and Bjerregaard, Bolette and Larsson, Lars-Inge and Delaissé, Jean-Marie
Bone, ISSN 8756-3282, 2010, Volume 48, Issue 4, pp. 837 - 846
Abstract Generation of osteoclasts through fusion of mono-nucleated precursors is a key event of bone physiology and bone resorption is inefficient without... 
Orthopedics | Osteoclast | HERV-W | Cell fusion | ASCT2 | Syncytin-1 | DC-STAMP | PROTEIN | ENVELOPE GLYCOPROTEIN | GIANT-CELLS | CELL FUSIONS | BONE-RESORPTION | FAMILY | MACROPHAGE FUSION | ENDOCRINOLOGY & METABOLISM | DIFFERENTIATION | Amino Acid Sequence | Pregnancy Proteins - chemistry | Endogenous Retroviruses - physiology | Humans | Cells, Cultured | Osteoclasts - cytology | Blotting, Western | Sequence Homology, Amino Acid | Cell Fusion | Gene Products, env - chemistry | Fluorescent Antibody Technique | Polymerase Chain Reaction | Gene Products, env - physiology | Pregnancy Proteins - physiology | Female | Membrane lipids | Cysteine | RNA | Dendritic cells | Analysis | Genomics | Muscle proteins | Cystine
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16. Full Text Syncytin-2 Plays an Important Role in the Fusion of Human Trophoblast Cells
by Vargas, Amandine and Moreau, Julie and Landry, Sébastien and LeBellego, Frédérique and Toufaily, Chirine and Rassart, Éric and Lafond, Julie and Barbeau, Benoit
Journal of Molecular Biology, ISSN 0022-2836, 2009, Volume 392, Issue 2, pp. 301 - 318
Human endogenous retrovirus (HERV)-encoded Syncytin-1 has been suggested to play a major role in trophoblast cell fusion and thereby placenta development.... 
Syncytin-2 | trophoblast cells | cell fusion | Syncytin-1 | HERV-W | PHOSPHATASE INHIBITORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENVELOPE GLYCOPROTEIN | HUMAN ENDOGENOUS RETROVIRUSES | ENV GLYCOPROTEIN | BREAST-CANCER | BEWO CELLS | HUMAN TERM PLACENTA | EXPRESSION | T-CELLS | Cytoplasm - chemistry | Cell Line | Blotting, Western - methods | Humans | Cells, Cultured | Endogenous Retroviruses - genetics | Gene Expression Profiling | Microscopy, Confocal - methods | Pregnancy Proteins - biosynthesis | Cell Membrane - chemistry | Cell Fusion | Trophoblasts - physiology | Gene Products, env - biosynthesis | Reverse Transcriptase Polymerase Chain Reaction - methods | Polymerase chain reaction | Phosphates | Proteins | Retrotransposons | Purines | Cell research | Messenger RNA | Sugars | Monosaccharides
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