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Arthritis research & therapy, ISSN 1478-6354, 2004, Volume 6, Issue 4, pp. R373 - 383
In the present study, we have shown for the first time that a plant steroid, diosgenin, causes an inhibition of the growth of fibroblast-like synoviocytes from... 
GASTROINTESTINAL TOXICITY | cyclooxygenase-2 | apoptosis | OSTEOSARCOMA CELLS | B SYNOVIOCYTES | RANDOMIZED CONTROLLED-TRIAL | RHEUMATOLOGY | rheumatoid arthritis | CELECOXIB | diosgenin | EXPERIMENTAL OSTEOARTHRITIS | TUMOR-NECROSIS-FACTOR | SYNOVIAL TISSUES | FAMILIAL ADENOMATOUS POLYPOSIS | EXPRESSION | human synoviocyte | Prostaglandin-Endoperoxide Synthases - biosynthesis | Fibroblasts - enzymology | Fibroblasts - secretion | Apoptosis - drug effects | Dinoprostone - biosynthesis | Plant Extracts - pharmacology | Synovial Membrane - enzymology | Cyclooxygenase 2 | Humans | Middle Aged | Synovial Membrane - pathology | Synovial Membrane - drug effects | Arthritis, Rheumatoid - metabolism | Caspases - metabolism | Isoenzymes - metabolism | Interleukin-1 - physiology | Caspase 3 | Interleukin-8 - secretion | DNA Fragmentation - drug effects | Isoenzymes - physiology | Membrane Potentials - drug effects | Interleukin-1 - metabolism | DNA Fragmentation - physiology | Diosgenin - pharmacology | Cells, Cultured | Mitochondria - drug effects | Fibroblasts - pathology | Interleukin-6 - secretion | Dinoprostone - metabolism | Membrane Proteins | Up-Regulation - drug effects | Prostaglandin-Endoperoxide Synthases - metabolism | Fibroblasts - drug effects | Aged | Cell Proliferation - drug effects | Isoenzymes - biosynthesis | Prostaglandin-Endoperoxide Synthases - physiology
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2015, Volume 74, Issue 6, pp. 1311 - 1316
Objective Tofacitinib is an oral Janus kinase (JAK) inhibitor for the treatment of rheumatoid arthritis (RA). The pathways affected by tofacitinib and the... 
TRIAL | PATHOGENESIS | CRITERIA | CYTOKINES | PLACEBO | DISEASE | GENE-EXPRESSION | METHOTREXATE | RHEUMATOLOGY | COMBINATION | CP-690,550 | Humans | Middle Aged | STAT Transcription Factors - metabolism | Chemokines - drug effects | Male | Matrix Metalloproteinase 3 - drug effects | Synovial Membrane - drug effects | Methotrexate - therapeutic use | RNA, Messenger - metabolism | STAT Transcription Factors - drug effects | Arthritis, Rheumatoid - metabolism | Janus Kinase 1 - metabolism | Piperidines - pharmacology | Arthritis, Rheumatoid - drug therapy | Adult | Female | Antirheumatic Agents - pharmacology | Drug Therapy, Combination | Pyrroles - therapeutic use | Matrix Metalloproteinase 1 - genetics | Antirheumatic Agents - therapeutic use | RNA, Messenger - drug effects | Matrix Metalloproteinase 1 - drug effects | Double-Blind Method | Matrix Metalloproteinase 3 - metabolism | Treatment Outcome | Pyrimidines - pharmacology | Chemokines - genetics | Janus Kinase 1 - drug effects | Synovial Membrane - metabolism | Pyrroles - pharmacology | Signal Transduction - drug effects | Piperidines - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Aged | Chemokines - metabolism | Protein Kinase Inhibitors - pharmacology | Matrix Metalloproteinase 1 - metabolism | Matrix Metalloproteinase 3 - genetics | Tofacitinib | Rheumatoid arthritis | Dosage and administration | Genetic aspects | Research | Gene expression | Risk factors | Basic and Translational Research | 1506
Journal Article
Arthritis & Rheumatology, ISSN 2326-5191, 01/2015, Volume 67, Issue 1, pp. 51 - 62
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 03/2012, Volume 71, Issue 3, pp. 424 - 431
Background Histone deacetylase inhibitors (HDACi) display potent therapeutic efficacy in animal models of arthritis and suppress inflammatory cytokine... 
CELLS | ACTIVATION | SYNOVIAL FIBROBLASTS | ACETYLATION | IMMUNE-RESPONSES | INFLAMMATION | IN-VIVO | RHEUMATOLOGY | C-JUN | NF-KAPPA-B | TRICHOSTATIN-A | Antirheumatic Agents - administration & dosage | Humans | Histone Deacetylase Inhibitors - administration & dosage | Synovial Membrane - pathology | Synovial Membrane - drug effects | Transcription Factor AP-1 - metabolism | Dose-Response Relationship, Drug | Arthritis, Rheumatoid - metabolism | Inflammation Mediators - metabolism | Hydroxamic Acids - administration & dosage | Antirheumatic Agents - pharmacology | Hydroxamic Acids - pharmacology | Fibroblasts - metabolism | Interleukin-6 - genetics | RNA, Messenger - genetics | Cells, Cultured | Synovial Membrane - metabolism | Arthritis, Rheumatoid - pathology | Macrophages - metabolism | MAP Kinase Signaling System - drug effects | Signal Transduction - drug effects | Fibroblasts - drug effects | NF-kappa B - physiology | Interleukin-6 - biosynthesis | Histone Deacetylase Inhibitors - pharmacology | Macrophages - drug effects | Enzyme inhibitors | Rheumatoid arthritis | Patient outcomes | Drug targeting | Dosage and administration | Research | Drug therapy | Interleukin-6 | Transcription factors | Cytokines | Colleges & universities | Inflammation | Kinases | Gene expression | Proteins | Rodents | DNA methylation | Epigenetics | Fibroblasts | Tumor necrosis factor-TNF | Deoxyribonucleic acid--DNA
Journal Article
Journal Article
Journal Article
Arthritis Research and Therapy, ISSN 1478-6354, 01/2012, Volume 14, Issue 1, pp. R14 - R14
Journal Article
Journal Article
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 08/2016, Volume 189, pp. 194 - 201
Total glucosides of paeony (TGP) is the first anti-inflammatory immune regulatory drug approved for the treatment of rheumatoid arthritis in China. A novel... 
Adjuvant-induced arthritis | BAFF | CD4 | Fibroblast-like synoviocytes | BAFF-R, Paeoniflorin-6′-O-benzene sulfonate | T cells | BAFF-R | Paeoniflorin-6′-O-benzene sulfonate | COLLAGEN-INDUCED ARTHRITIS | CHEMISTRY, MEDICINAL | BONE-MARROW | RATS | RECEPTOR | DIRECT-CONTACT | PAEONIFLORIN | PLANT SCIENCES | TACI-IG | B-CELLS | BAFF-R, Paeoniflorin-6'-O-benzene sulfonate | INTEGRATIVE & COMPLEMENTARY MEDICINE | CD4(+) | PHARMACOLOGY & PHARMACY | TNF-ALPHA | LYMPHOCYTES | Arthritis, Experimental - drug therapy | Thymocytes - metabolism | Coculture Techniques | Synovial Membrane - immunology | Synovial Membrane - pathology | Male | Synovial Membrane - drug effects | Arthritis, Experimental - metabolism | Arthritis, Experimental - pathology | CD4-Positive T-Lymphocytes - immunology | Monoterpenes - pharmacology | Inflammation Mediators - metabolism | B-Cell Activation Factor Receptor - pharmacology | B-Cell Activation Factor Receptor - drug effects | Fibroblasts - metabolism | Glucosides - pharmacology | Cytokines - metabolism | Anti-Inflammatory Agents - pharmacology | CD4-Positive T-Lymphocytes - metabolism | Cells, Cultured | Arthritis, Experimental - immunology | Fibroblasts - pathology | Rats, Sprague-Dawley | Synovial Membrane - metabolism | Freund's Adjuvant | Thymocytes - immunology | B-Cell Activation Factor Receptor - metabolism | Animals | Signal Transduction - drug effects | Lymphocyte Activation - drug effects | Fibroblasts - drug effects | Paracrine Communication - drug effects | Fibroblasts - immunology | Thymocytes - drug effects | B-Cell Activating Factor - pharmacology | CD4-Positive T-Lymphocytes - drug effects
Journal Article