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PLoS ONE, ISSN 1932-6203, 2017, Volume 12, Issue 8, p. e0182751
Journal Article
Journal of Rheumatology, ISSN 0315-162X, 04/2016, Volume 43, Issue 4, pp. 771 - 778
Journal Article
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 04/2017, Volume 76, Issue 4, pp. 748 - 755
ObjectiveTo investigate the impact of systemic inhibition of interleukin 6 (IL-6) or signal transducer and activator of transcription (Stat3) in an... 
IN-VITRO | ACTIVATED RECEPTOR 2 | ONCOSTATIN-M | SYNOVIAL-FLUID | GENE-EXPRESSION | ARTICULAR CHONDROCYTES | NECROSIS-FACTOR-ALPHA | RHEUMATOLOGY | INTERLEUKIN-6 | RADIOGRAPHIC KNEE OSTEOARTHRITIS | CARTILAGE DEGRADATION | Synovitis - prevention & control | Interleukin-6 - antagonists & inhibitors | Apoptosis - drug effects | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Osteophyte - prevention & control | ADAMTS5 Protein - metabolism | Receptors, Interleukin-6 - immunology | Cyclic S-Oxides - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Interleukin-6 - metabolism | STAT3 Transcription Factor - metabolism | Disease Models, Animal | Osteoarthritis - prevention & control | Mice, Inbred C57BL | Cells, Cultured | Osteoarthritis - metabolism | Proteoglycans - metabolism | Matrix Metalloproteinase 3 - metabolism | ADAMTS4 Protein - metabolism | Cartilage - metabolism | Matrix Metalloproteinase 13 - metabolism | Antibodies - pharmacology | Animals | MAP Kinase Signaling System - drug effects | Interleukin-6 - pharmacology | Chondrocytes | Mice | STAT3 Transcription Factor - antagonists & inhibitors | Cellular signal transduction | Research | Osteoarthritis | Health aspects | Analysis | Interleukin-6 | Arthritis | Cytokines | Kinases | Pathogenesis | Experiments | Rodents
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 09/2005, Volume 64, Issue 9, pp. 1263 - 1267
Objective: To compare selected immunohistological features of inflammation in synovial tissue from patients with early and late osteoarthritis (OA). Methods:... 
C-REACTIVE PROTEIN | RHEUMATOID-ARTHRITIS | KNEE | MEMBRANE INFLAMMATION | DISEASE | ARTHROSCOPY | RHEUMATOLOGY | QUANTITATIVE-ANALYSIS | EXPRESSION | JOINT | CARTILAGE | Tumor Necrosis Factor-alpha - metabolism | Synovitis - metabolism | Dinoprostone - biosynthesis | Synovitis - complications | Cyclooxygenase 2 | Humans | Middle Aged | Cyclooxygenase 1 | Neovascularization, Pathologic | Synovial Membrane - pathology | NF-kappa B - metabolism | Pain - metabolism | Antigens, CD - analysis | Knee Joint - pathology | Aged, 80 and over | Synovial Membrane - blood supply | Knee Joint - metabolism | Interleukin-1 - metabolism | Cells, Cultured | Leukemic Infiltration | Osteoarthritis, Knee - etiology | Pain - pathology | Synovial Membrane - metabolism | Disease Progression | Synovitis - pathology | Membrane Proteins | Arthroplasty, Replacement | Intercellular Adhesion Molecule-1 - metabolism | Osteoarthritis, Knee - pathology | Prostaglandin-Endoperoxide Synthases - metabolism | Antigens, Differentiation, Myelomonocytic - analysis | Aged | Osteoarthritis, Knee - metabolism | Physiological aspects | Synovitis | Development and progression | Diagnosis | Osteoarthritis | Synovial membranes | Knee | Studies | Biotechnology | Immunoglobulins | Cytokines | Biopsy | Laboratories | Rheumatology | Arthritis | Inflammation | Joint surgery | Extended Report
Journal Article
Osteoarthritis and Cartilage, ISSN 1063-4584, 2013, Volume 21, Issue 12, pp. 1942 - 1949
Summary The study described here tested the hypothesis that early intra-articular inflammation is associated with the development of post-traumatic... 
Rheumatology | Ovine | ACL | Inflammation | Osteoarthritis | Synovium | KNEE | GAIT | PATHOLOGY | RHEUMATOLOGY | ANTERIOR CRUCIATE LIGAMENT | ARTICULAR-CARTILAGE | RUPTURE | ORTHOPEDICS | Synovitis - metabolism | Anterior Cruciate Ligament - surgery | Postoperative Complications - metabolism | RNA, Messenger - analysis | Synovial Membrane - immunology | Interleukin-1beta - genetics | Postoperative Complications - immunology | Collagen Type II - metabolism | Matrix Metalloproteinase 1 - immunology | Versicans - genetics | Matrix Metalloproteinase 3 - immunology | Cartilage, Articular - metabolism | Interleukin-1beta - metabolism | Postoperative Complications - genetics | Synovitis - immunology | Osteoarthritis, Knee - immunology | Synovitis - genetics | Interleukin-6 - metabolism | Matrix Metalloproteinase 1 - genetics | Disease Models, Animal | Versicans - immunology | Collagen Type II - immunology | Aggrecans - immunology | Interleukin-6 - genetics | Synovial Membrane - injuries | Matrix Metalloproteinase 13 - genetics | Interleukin-1beta - immunology | Matrix Metalloproteinase 13 - immunology | Matrix Metalloproteinase 3 - metabolism | Aggrecans - metabolism | Aggrecans - genetics | Synovial Membrane - metabolism | Collagen Type II - genetics | Matrix Metalloproteinase 13 - metabolism | Animals | Osteoarthritis, Knee - genetics | Anterior Cruciate Ligament Reconstruction | Interleukin-6 - immunology | Sheep | Versicans - metabolism | Matrix Metalloproteinase 1 - metabolism | Matrix Metalloproteinase 3 - genetics | Osteoarthritis, Knee - metabolism | Surgery, Plastic | Orthopedic surgery | RNA | Analysis | Models
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 04/2016, Volume 75, Issue 4, pp. 763 - 771
Background and objectivesFor our understanding of the pathogenesis of rheumatoid arthritis (RA), it is important to elucidate the mechanisms underlying early... 
PLATELET FACTOR | CELL INFILTRATE | PEPTIDE-III ISOFORMS | CONNECTIVE-TISSUE ACTIVATION | DIFFERENTIATION | RHEUMATOLOGY | PLATELET-FACTOR-4 | HUMAN MONOCYTES | REGULATED EXPRESSION | SMALL JOINTS | EARLY INFLAMMATORY ARTHRITIS | Immunohistochemistry | beta-Thromboglobulin - metabolism | Humans | Middle Aged | Male | RNA, Messenger - metabolism | Machine Learning | Antigens, CD - metabolism | Arthritis, Rheumatoid - metabolism | Adult | Female | Cytokines - genetics | Real-Time Polymerase Chain Reaction | Platelet Factor 4 - genetics | von Willebrand Factor - metabolism | Cytokines - metabolism | beta-Thromboglobulin - genetics | Reverse Transcriptase Polymerase Chain Reaction | Synovial Membrane - metabolism | Disease Progression | Arthritis, Rheumatoid - genetics | Macrophages - metabolism | Antigens, Differentiation, Myelomonocytic - metabolism | Fluorescent Antibody Technique | Aged | Platelet Factor 4 - metabolism | Platelet Membrane Glycoprotein IIb - metabolism | Synovial Membrane - cytology | Synovitis | Care and treatment | Antirheumatic agents | Rheumatoid arthritis | Influence | Dosage and administration | Research | Gene expression | Studies | Angiogenesis | Ultrasonic imaging | Disease | Cytokines | Biopsy | Inflammation | Chemokines | Rheumatoid Arthritis | Early Rheumatoid Arthritis | Basic and Translational Research | 1506
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 07/2017, Volume 76, Issue 7, pp. 1228 - 12396
ObjectiveTo define the synovial characteristics of patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA) in clinical and ultrasound remission... 
Anti-TNF | Synovitis | Rheumatoid Arthritis | Psoriatic Arthritis | Ultrasonography | PROGNOSIS | INFLAMMATION | POWER DOPPLER SONOGRAPHY | METHOTREXATE | RHEUMATOLOGY | ULTRASONOGRAPHY | CLASSIFICATION CRITERIA | WITHDRAWAL | DISCONTINUATION | DAMAGE | VASCULARITY | Immunohistochemistry | Recurrence | Synovitis - metabolism | Humans | Middle Aged | Synovial Membrane - pathology | Male | Methotrexate - therapeutic use | Synovitis - diagnostic imaging | Antigens, CD - metabolism | Arthritis, Rheumatoid - diagnostic imaging | Arthritis, Rheumatoid - metabolism | Arthritis, Psoriatic - pathology | Arthritis, Rheumatoid - drug therapy | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Arthritis, Psoriatic - drug therapy | Adult | Female | Drug Therapy, Combination | Arthritis, Psoriatic - metabolism | Antirheumatic Agents - therapeutic use | Synovial Membrane - diagnostic imaging | Ultrasonography, Doppler | Antigens, CD20 - metabolism | CD3 Complex - metabolism | Remission Induction | Synovial Membrane - metabolism | Arthritis, Rheumatoid - pathology | Synovitis - pathology | Collagen - metabolism | Adalimumab - therapeutic use | Antigens, Differentiation, Myelomonocytic - metabolism | Arthritis, Psoriatic - diagnostic imaging | Aged | Receptors, Complement 3d - metabolism | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Etanercept - therapeutic use | Clinical trials | Research | Tumor necrosis factor inhibitors | Rheumatoid arthritis | Analysis | Psoriatic arthritis | Statistical analysis | Psoriasis | CD3 antigen | Ultrasonic imaging | Etanercept | Biopsy | Tumor necrosis factor | Collagen | Monoclonal antibodies | CD20 antigen | Remission | TNF inhibitors | Tumor necrosis factor-TNF | Pharmaceutical industry | Methotrexate | Health risk assessment | Ultrasound | Hypertrophy | Tumors | Clinical and Epidemiological Research | 1506
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 08/2004, Volume 114, Issue 4, pp. 582 - 588
Cytokines play key roles in spontaneous CD4(+) T cell-mediated chronic autoimmune arthritis in SKG mice, a new model of rheumatoid arthritis. Genetic... 
RHEUMATOID-ARTHRITIS | SIGNAL-TRANSDUCTION | B-CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | COLLAGEN-INDUCED ARTHRITIS | TUMOR-NECROSIS-FACTOR | CARTILAGE DESTRUCTION | SYNOVIUM | INTERLEUKIN-6-DEFICIENT MICE | INTERLEUKIN-10 | TRANSGENIC MICE | Immunohistochemistry | Tumor Necrosis Factor-alpha - metabolism | Interleukin-1 - genetics | Synovitis - metabolism | Arthritis, Experimental - genetics | Autoantibodies - metabolism | Tumor Necrosis Factor-alpha - genetics | Synovial Fluid - metabolism | Proteins - analysis | Tumor Necrosis Factor-alpha - deficiency | RNA, Messenger - metabolism | Fibroblasts - ultrastructure | Arthritis, Experimental - metabolism | Arthritis, Experimental - pathology | CD4-Positive T-Lymphocytes - immunology | T-Lymphocytes - metabolism | Cell Division | Interleukin-1 - immunology | Synovitis - immunology | Tumor Necrosis Factor-alpha - immunology | Interleukin-10 - metabolism | Female | Synovial Fluid - cytology | Interleukin-6 - metabolism | Disease Models, Animal | Fibroblasts - metabolism | Interleukin-1 - metabolism | Macrophages - ultrastructure | Enzyme-Linked Immunosorbent Assay | Interleukin-6 - genetics | CD4-Positive T-Lymphocytes - metabolism | Arthritis, Experimental - immunology | Interleukin-6 - deficiency | Mice, Inbred Strains | Mice, Knockout | Homozygote | Autoantibodies - immunology | Animals | Interleukin-6 - immunology | Heterozygote | T-Lymphocytes - immunology | Mice | Mice, Inbred BALB C | Interleukin-1 - deficiency | Interleukin-10 - immunology
Journal Article