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Experimental & molecular medicine, ISSN 1226-3613, 2015, Volume 47, Issue 3, pp. e147 - e147
Mammalian cells remove misfolded proteins using various proteolytic systems, including the ubiquitin (Ub)-proteasome system (UPS), chaperone mediated autophagy... 
MEDICINE, RESEARCH & EXPERIMENTAL | UBIQUITIN-PROTEASOME SYSTEM | CHAPERONE-MEDIATED AUTOPHAGY | ALPHA-SYNUCLEIN AGGREGATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | QUALITY CONTROL DEGRADATION | CENTRAL-NERVOUS-SYSTEM | AMYOTROPHIC-LATERAL-SCLEROSIS | SOD1 TRANSGENIC MICE | ENDOPLASMIC-RETICULUM STRESS | END RULE PATHWAY | PARKINSONS-DISEASE | Proteostasis Deficiencies - metabolism | Humans | Ubiquitin - metabolism | tau Proteins - metabolism | Parkinson Disease - drug therapy | Molecular Targeted Therapy | Neurodegenerative Diseases - drug therapy | Amyotrophic Lateral Sclerosis - drug therapy | Autophagy - drug effects | DNA-Binding Proteins - metabolism | PrPSc Proteins - metabolism | Lysosomes - metabolism | Proteolysis | Amyloid beta-Peptides - metabolism | Parkinson Disease - metabolism | Huntington Disease - drug therapy | Superoxide Dismutase - metabolism | Prion Diseases - drug therapy | Alzheimer Disease - drug therapy | Neurodegenerative Diseases - metabolism | Huntington Disease - metabolism | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Huntingtin Protein | Animals | Alzheimer Disease - metabolism | Amyotrophic Lateral Sclerosis - metabolism | Huntington Disease - genetics | Mutation | Proteasome Endopeptidase Complex - metabolism | alpha-Synuclein - metabolism | Prion Diseases - metabolism | Review
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 09/2012, Volume 32, Issue 39, pp. 13454 - 13469
Abnormal deposition and intercellular propagation of alpha-synuclein plays a central role in the pathogenesis of disorders such as Parkinson's Disease (PD) and... 
IMMUNIZATION | PROTEIN | PLASMA | BIOMARKER | ALZHEIMERS-DISEASE | MOUSE MODEL | PATHOLOGY | FC-GAMMA-RIIA | NEUROSCIENCES | NEURODEGENERATIVE DISEASES | PARKINSONS-DISEASE | Synaptic Transmission - physiology | Antibodies - metabolism | Lewy Body Disease - immunology | Humans | alpha-Synuclein - immunology | Extracellular Space - drug effects | Nerve Degeneration - genetics | Cell Communication - physiology | Culture Media, Conditioned - pharmacology | Phosphopyruvate Hydratase - metabolism | Amyloid - ultrastructure | Antigens, CD - metabolism | Neuroglia - drug effects | Brain - metabolism | Lewy Body Disease - genetics | Extracellular Space - metabolism | Amyloid - metabolism | Microfilament Proteins - metabolism | alpha-Synuclein - genetics | Disease Models, Animal | Calcium-Binding Proteins - metabolism | Cell Line | Microscopy, Electron, Transmission | Cytokines - metabolism | Mice, Transgenic | Nerve Degeneration - immunology | Cathepsin D - metabolism | Extracellular Space - immunology | Antibodies - pharmacology | Caveolin 1 - metabolism | Lewy Body Disease - metabolism | Platelet-Derived Growth Factor - metabolism | Animals | Analysis of Variance | Brain - pathology | Immunization, Passive | Neuroglia - metabolism | Mice | Chromatography, Gel | alpha-Synuclein - metabolism | Nerve Degeneration - drug therapy | Astrocytes - metabolism
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2015, Volume 10, Issue 6, pp. e0130624 - e0130624
Neuroinflammation is the local reaction of the brain to infection, trauma, toxic molecules or protein aggregates. The brain resident macrophages, microglia,... 
INTERLEUKIN-1 | ACTIVATION | MOLECULAR PLATFORM | INHIBITION | DISTINCT PATHWAYS | NEUROINFLAMMATION | MULTIDISCIPLINARY SCIENCES | IL-1-BETA | MECHANISMS | RECEPTORS | NALP3 INFLAMMASOME | Microglia - metabolism | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Peptide Fragments - toxicity | Caspase 1 - metabolism | Interleukin-1alpha - metabolism | alpha-Synuclein - pharmacology | Interleukin-1beta - metabolism | Interleukin-1beta - secretion | Microglia - cytology | Brain - cytology | Interleukin-1beta - analysis | Enzyme-Linked Immunosorbent Assay | Microglia - drug effects | Amyloid beta-Peptides - toxicity | Mice, Inbred C57BL | Cells, Cultured | Mice, Knockout | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Caspase 1 - genetics | Caspase 1 - deficiency | Receptors, Purinergic P2X7 - metabolism | Mice | Interleukin-18 - metabolism | Astrocytes - metabolism | Cytokines | Health aspects | Nervous system diseases | Brain | Cell culture | Traumatic brain injury | Peptides | Aluminum sulfate | Homeostasis | Nervous system | Activation | Macrophages | Synuclein | Proteins | Rodents | Amyloid | Life sciences | Communication | Immune system | Neurodegenerative diseases | Secretion | Astrocytes | Inflammation | Trauma | Molecular chains | Microglia | Interleukin 18 | Mode of action | Neurological diseases | Nigericin | Brain research | Ligands | Alum | Laboratory animals | Alzheimers disease | Chemokines | Index Medicus
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 2015, Volume 79, pp. 81 - 99
Abstract α-Synuclein (α-syn), a small protein that has the intrinsic propensity to aggregate, is implicated in several neurodegenerative diseases including... 
Neurology | α-Synuclein | Conformation-specific monoclonal antibodies | Parkinson’s disease | Dementia with Lewy bodies | Parkinson's disease | NEURODEGENERATIVE DISORDERS | ALZHEIMERS-DISEASE | VESICLE DOCKING | BRAIN PATHOLOGY | NEUROSCIENCES | MULTIPLE SYSTEM ATROPHY | MEMBRANE-BINDING | ELEVATED LEVELS | SOLUBLE OLIGOMERS | alpha-Synuclein | LEWY BODIES | PARKINSONS-DISEASE | gamma-Synuclein - immunology | Membrane Glycoproteins - metabolism | Escherichia coli | Protein Multimerization | alpha-Synuclein - immunology | Neoplasm Proteins - immunology | tau Proteins - metabolism | Neoplasm Proteins - metabolism | Brain - metabolism | gamma-Synuclein - metabolism | Amyloid beta-Peptides - metabolism | Parkinson Disease - metabolism | beta-Synuclein - immunology | Antibodies, Monoclonal - immunology | Recombinant Proteins - metabolism | Parkinson Disease - pathology | Peptide Fragments - metabolism | Lewy Body Disease - pathology | Islet Amyloid Polypeptide - metabolism | Recombinant Proteins - chemistry | Antibodies, Monoclonal - isolation & purification | alpha-Synuclein - chemistry | Lewy Body Disease - metabolism | Animals | Recombinant Proteins - immunology | Alzheimer Disease - metabolism | Brain - pathology | Protein Conformation | Mice | Antibodies, Monoclonal - metabolism | beta-Synuclein - metabolism | alpha-Synuclein - metabolism | Basic Medicine | Neurosciences | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Neurovetenskaper
Journal Article
Cell Metabolism, ISSN 1550-4131, 07/2014, Volume 20, Issue 1, pp. 145 - 157
Neurodegenerative diseases represent an increasing burden in our aging society, yet the underlying metabolic factors influencing onset and progression remain... 
ANTIBODIES | SYSTEM | LIFE-SPAN | LONGEVITY | CAENORHABDITIS-ELEGANS | DISEASE | DAF-16 | ENDOCRINOLOGY & METABOLISM | ALPHA-SYNUCLEIN | GENE-EXPRESSION CHANGES | STRESS | CELL BIOLOGY | Caenorhabditis elegans Proteins - metabolism | Male | Insulin Receptor Substrate Proteins - metabolism | Drosophila Proteins - metabolism | Dopaminergic Neurons - cytology | Glucose-6-Phosphate Isomerase - genetics | RNA Interference | Forkhead Transcription Factors - metabolism | Receptor, Insulin - genetics | Dopaminergic Neurons - metabolism | Aging | Parkinson Disease - metabolism | Insulin Receptor Substrate Proteins - genetics | Cytokines - genetics | Drosophila Proteins - antagonists & inhibitors | Disease Models, Animal | Parkinson Disease - pathology | Caenorhabditis elegans - metabolism | Cytokines - metabolism | Signal Transduction | Cells, Cultured | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | Receptor, Insulin - antagonists & inhibitors | alpha-Synuclein - chemistry | Glucose-6-Phosphate Isomerase - metabolism | Transcription Factors - metabolism | Animals | Caenorhabditis elegans Proteins - antagonists & inhibitors | Glucose-6-Phosphate Isomerase - antagonists & inhibitors | Glucose - metabolism | Glycolysis | Receptor, Insulin - metabolism | Mice | Cytokines - antagonists & inhibitors | Drosophila - metabolism | Drosophila Proteins - genetics | Caenorhabditis elegans Proteins - genetics | alpha-Synuclein - metabolism | Insulin-Like Growth Factor I - metabolism | RNA, Small Interfering - metabolism | Glucose metabolism | Enzymes | Medical colleges | Analysis | Physiological aspects | Cystic fibrosis | Glucose | Dextrose | Neurophysiology | Insulin
Journal Article
Journal Article
Science, ISSN 0036-8075, 12/2003, Volume 302, Issue 5651, pp. 1772 - 1775
Journal Article
Antioxidants & Redox Signaling, ISSN 1523-0864, 03/2016, Volume 24, Issue 7, pp. 376 - 391
Aims: Protein aggregation and oxidative stress are both key pathogenic processes in Parkinson's disease, although the mechanism by which misfolded proteins... 
Original Research Communications | NADPH | LIPID-PEROXIDATION | COMPLEX-I | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUSCEPTIBILITY | ENDOCRINOLOGY & METABOLISM | COMMON MECHANISM | IRON | TRIPLICATION | SUBSTANTIA-NIGRA | EXPRESSION | PROGRESSIVE SUPRANUCLEAR PALSY | Caspase 7 - metabolism | Gene Duplication | Neurons - pathology | Reactive Oxygen Species - metabolism | Oxidative Stress | Glutathione - metabolism | Humans | Protein Multimerization | Caspase 3 - metabolism | Neurons - cytology | Structure-Activity Relationship | Amyloid beta-Peptides - metabolism | Cell Differentiation | Neurons - metabolism | Parkinson Disease - metabolism | alpha-Synuclein - genetics | Induced Pluripotent Stem Cells - cytology | Induced Pluripotent Stem Cells - metabolism | Parkinson Disease - pathology | Rats | Parkinson Disease - genetics | Ions - metabolism | Protein Aggregation, Pathological | alpha-Synuclein - chemistry | Metals - metabolism | Animals | Protein Conformation | Enzyme Activation | alpha-Synuclein - metabolism | Apoptosis | Oligomers | Oxidative stress | Parkinson's disease | Research | Properties | Health aspects | Risk factors | Metal ions | Toxicity | Parkinsons disease | Innovations | Agglomeration | Synuclein | Proteins | Neurotoxicity | Protein folding | Neurodegeneration | Chelation | Amyloid | Species | Movement disorders | Glutathione | Cellular manufacture | Free radicals | Neurodegenerative diseases | Mortality | Death | Chelating agents | Protein interaction | Pluripotency | Index Medicus
Journal Article